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PILRRVAGVVFGVCLLAGCAALHPPQQSSAPTGPDGKGTKADAVMKVVRDFMGPAHLRSVIVRVSVDGKE IVTDAVGDSMTGVPASTDMHFRNGAVAISYVATLLLKLVDEHKLSLDDKLSKWLPDFPHADRVTLGQLAQ MTSGYPDYVLGNDEFGDALYADPFRQWTPQELLAQISSRPLLYEPGTNWNYAHTNYVLLGLALEKATGQD MATLLKQKVLAPLGLTATANSETPSIPDPALHAFSAERRAFLKIPADTPFSEESTFWNPSWTITHGAIQT TTIYDMEATAVGIGSGKLLSADSYQKMVSTALRGKTRAQPDCPTCFEQSEGYTYGLGIVISGHWLLQNPL FSGYAATEAYLPSQRVAIAVALTYTPEAFDDEGNYPNQADILFRKIAAALVPDDAPPMPPGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0696 | lpqK | - | 100% (413) | lipoprotein, LpqK |
| M. marinum M | MMAR_2827 | - | 2e-18 | 27.73% (321) | lipoprotein |
| M. marinum M | MMAR_3399 | - | 1e-10 | 28.91% (211) | hypothetical protein MMAR_3399 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0405c | lpqK | 0.0 | 79.18% (413) | lipoprotein LpqK |
| M. gilvum PYR-GCK | Mflv_3749 | - | 6e-12 | 29.17% (168) | beta-lactamase |
| M. tuberculosis H37Rv | Rv0399c | lpqK | 0.0 | 79.18% (413) | lipoprotein LpqK |
| M. leprae Br4923 | MLBr_00119 | lipE | 7e-05 | 27.52% (149) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0330 | - | 2e-40 | 30.20% (404) | Beta-lactamase |
| M. avium 104 | MAV_3991 | - | 2e-11 | 26.83% (205) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_1586 | - | 3e-43 | 32.07% (368) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3520 | - | 2e-40 | 31.14% (350) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_1772 | - | 5e-10 | 24.27% (206) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_3510 | - | 1e-161 | 67.07% (413) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3749|M.gilvum_PYR-GCK ---------------------------------------------MNLDR
MUL_1772|M.ulcerans_Agy99 ------MGVARPRWRGPRAAWFAGARKPSDGRRLTRRPPAANLNPVNLDA
Mb0405c|M.bovis_AF2122/97 ----------MPVLRRLGCSVLALGLLAGCA---PPRTGPASS-PTNNGA
Rv0399c|M.tuberculosis_H37Rv ----------MPVLRRLGCSVLALGLLAGCA---PPRTGPASS-PTNNGA
MMAR_0696|M.marinum_M ----------MPILRRVAGVVFGVCLLAGCAALHPPQQSSAPTGPDGKGT
Mvan_3510|M.vanbaalenii_PYR-1 ----------MTVLRRLAAACILP-ILAACA---PPAVAPDSDAPKADPA
MAB_0330|M.abscessus_ATCC_1997 MPELSTRCFDESSLMRRILAVVLTIALLVSACGKHSAIVVAELDPQTTAK
MSMEG_1586|M.smegmatis_MC2_155 ---MMSAWPLVPGFVRAATGAVIAAITFVAAS----ACATAPAAPPIAAQ
TH_3520|M.thermoresistible__bu ------------MRAVRTLAALLLAVFAVSAG-----PSAAGQPPDLAAA
MAV_3991|M.avium_104 -----MLTLVAASSTGRVVHTSPSEAPPASMTPHASLVPESTSPAEDFTT
MLBr_00119|M.leprae_Br4923 ----------MTSDGKIRVPTDLDAVTAIGDE------DHSDIDSAAVER
Mflv_3749|M.gilvum_PYR-GCK NKASIVDAIDAGLLAGAVTLVWHAG--EVRQVNELGYRDVDAQ-------
MUL_1772|M.ulcerans_Agy99 NQADIREVCDAGLLSGAVTVVWQHG--EVLQVNEIGYRDVEAG-------
Mb0405c|M.bovis_AF2122/97 KADAVIRIVRDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTG-------
Rv0399c|M.tuberculosis_H37Rv KADAVIRIVRDFMTQAHLKAVLVRVTVAGKEVVTRAVGDSMTG-------
MMAR_0696|M.marinum_M KADAVMKVVRDFMGPAHLRSVIVRVSVDGKEIVTDAVGDSMTG-------
Mvan_3510|M.vanbaalenii_PYR-1 KADAVMRIVRETMAEAHLKAVIVRVTVDGREVLTEAAGESMTG-------
MAB_0330|M.abscessus_ATCC_1997 LDSAINEILTSAAVPGAIVGVWGP---KGQYVRTFGVANTATR-------
MSMEG_1586|M.smegmatis_MC2_155 LDDAVGKVMADLSIPGAVVGFWGP---DVTYVRAFGVADTATR-------
TH_3520|M.thermoresistible__bu LDRAIELRLDQMGVPGAIVSLSIPG--KIEYTRAFGVGDTATG-------
MAV_3991|M.avium_104 ISKLVNDAIAARGLPGAVVMVGHGG--KVVFHQAYGSRKLAGEPGLDGAP
MLBr_00119|M.leprae_Br4923 IWQATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDP----HD
. . . .
Mflv_3749|M.gilvum_PYR-GCK ---LPMQRDTIFRIASMTKPVT-VAAAMSLVEEGRLSLTDRVATWLPELA
MUL_1772|M.ulcerans_Agy99 ---LPMQRDTLFRIASMTKPVT-VAAAMSMVDEGKIALRDPITRWAPELR
Mb0405c|M.bovis_AF2122/97 ---VPATTAMHFRNGAVAISYV-ATLLLKLVDEKKLRLDDKLSRWLPDF-
Rv0399c|M.tuberculosis_H37Rv ---VPATTAMHFRNGAVAISYV-ATLLLKLVDEKKLRLDDKLSRWLPDF-
MMAR_0696|M.marinum_M ---VPASTDMHFRNGAVAISYV-ATLLLKLVDEHKLSLDDKLSKWLPDF-
Mvan_3510|M.vanbaalenii_PYR-1 ---VPANTAMHFRNGAVAISYV-ATLLLKLAEEGTVSLDDKLSTWLPRI-
MAB_0330|M.abscessus_ATCC_1997 ---APLRPDFYHRIGSVTKTFT-VTAVLQLVDEGKVELDDPIAKYVDKV-
MSMEG_1586|M.smegmatis_MC2_155 ---APMQADMYTRIGSLTKTFT-ITALLTLIDQGKAGLDDPISMYVADV-
TH_3520|M.thermoresistible__bu ---TPMLVDNHHRIGSVTKTFI-GTAILQLADQGRIRLSDPISRYVEGV-
MAV_3991|M.avium_104 APAEPMTEDTIFDLASLTKCLATAVAVMQLYEQGKVAFDDPVQKYLPAFN
MLBr_00119|M.leprae_Br4923 AEKIPVTTDTPFCAYSAAKAIT-ATVVHMLVERGHFSLDDRVCEYLPTYT
* : : . : :. : * : :
Mflv_3749|M.gilvum_PYR-GCK DMRVLAEPRGALDRTVPAQRHITIEDLMTHRSGLAYMFSVLGPLSDAYRK
MUL_1772|M.ulcerans_Agy99 DIRVLDDPHGPLDRTHPTRRPILIEDLLTHTSGLAYSFSVSGDISRAYMR
Mb0405c|M.bovis_AF2122/97 ----------------PHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYA
Rv0399c|M.tuberculosis_H37Rv ----------------PHADRVTLGQLAQMTSGYPDYVLGNEAFDAELYA
MMAR_0696|M.marinum_M ----------------PHADRVTLGQLAQMTSGYPDYVLGNDEFGDALYA
Mvan_3510|M.vanbaalenii_PYR-1 ----------------PHADRVTLRQLAQMTSGYVDYVIGTTAMNDAFLA
MAB_0330|M.abscessus_ATCC_1997 ----------------PNGNKITLRELARMQSGLFNYSM-SLAFSRDLEA
MSMEG_1586|M.smegmatis_MC2_155 ----------------PSGDTITLRHLAQMQSGLVTYDG-VPEFEAAFLA
TH_3520|M.thermoresistible__bu ----------------PSGDVITLDMLARMRSGLADYTE-TDEFVERLYR
MAV_3991|M.avium_104 ------------TTNDPQRAKVTIRMLLTNTSGEGIDVSLRDPWGLAGPD
MLBr_00119|M.leprae_Br4923 S---------------YGKHRTTIRHVLTHSAGVPFPTGPRPDVTRADDH
: : :*
Mflv_3749|M.gilvum_PYR-GCK LPTR------QDQDRWLTELSALPLVHQPGERLTYSHA-TDVLGIALSRI
MUL_1772|M.ulcerans_Agy99 LPFG------HGSDAWLAELAALPLVHQPGERVTYSHA-IDLLGVIMSRI
Mb0405c|M.bovis_AF2122/97 NPFR-----QWTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKA
Rv0399c|M.tuberculosis_H37Rv NPFR-----QWTTQELLDQISSRPLLYDPGTNWNYAHTNYLLLGLALEKA
MMAR_0696|M.marinum_M DPFR-----QWTPQELLAQISSRPLLYEPGTNWNYAHTNYVLLGLALEKA
Mvan_3510|M.vanbaalenii_PYR-1 DPFR-----AWTTHDLLSYATSKPLLYEPGTNWNYAHTNYVLLGLALEKA
MAB_0330|M.abscessus_ATCC_1997 DPRR-----QYSTHELLDYAFAQPSNFVPGQGYEYSNTNAVLLGQVVEKV
MSMEG_1586|M.smegmatis_MC2_155 DPQR-----TFTPQQLLGYALDKPLQFPPGTQYDYCNTNTVLLGLVVEKL
TH_3520|M.thermoresistible__bu ESPSGPDAFAVTPRELVESAFARPLNFAPGSEFEYSNTNTVLLGMVVERV
MAV_3991|M.avium_104 KAEG------------IHRALTTPLQSAPAGEFRYSDINYLLLGALLEKI
MLBr_00119|M.leprae_Br4923 AYAQ------------QKLSELRPFYRPGLVHIYHALTWGPLMREIIWTA
* :. :: :
Mflv_3749|M.gilvum_PYR-GCK EGKPLSEVLAERIFEPLGMTDTGFS-------------------------
MUL_1772|M.ulcerans_Agy99 DDKPFYQVLDERILGPAGMTDTGFF-------------------------
Mb0405c|M.bovis_AF2122/97 AGQDMPTLLQRKVLSPLGLTATANS-------------------------
Rv0399c|M.tuberculosis_H37Rv AGQDMPTLLQRKVLSPLGLTATANS-------------------------
MMAR_0696|M.marinum_M TGQDMATLLKQKVLAPLGLTATANS-------------------------
Mvan_3510|M.vanbaalenii_PYR-1 TGETMSDLLSDKVLRPLGLTDTAAS-------------------------
MAB_0330|M.abscessus_ATCC_1997 SGQTLPAFVQEHITGPLGMRRTSFP-------------------------
MSMEG_1586|M.smegmatis_MC2_155 SGQSLADYVRQHILVPLKLTHTSIP-------------------------
TH_3520|M.thermoresistible__bu SGVPLARYLQDNIFGPVGLTQTSYP-------------------------
MAV_3991|M.avium_104 TGEDEDDYVQHHVFGPLGMHDTRYLPPAKACGPHIIRGAAIAWAPNGEPM
MLBr_00119|M.leprae_Br4923 TGKEIRDILAAEILDPLGFRWTNFG-------------------------
. : .: * : *
Mflv_3749|M.gilvum_PYR-GCK --------VGSEGRRRAATMYQLDKDGTLR----HDVMGPAPIVDPPFCT
MUL_1772|M.ulcerans_Agy99 --------VSTQAQRRAATMYRLDELDQLR----HDVMGPPHVRPPSFCN
Mb0405c|M.bovis_AF2122/97 --------DTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTI
Rv0399c|M.tuberculosis_H37Rv --------DTPAIPEPALHAFTSERRAALKIPAGVPFYEESTFWNPSWTI
MMAR_0696|M.marinum_M --------ETPSIPDPALHAFSAERRAFLKIPADTPFSEESTFWNPSWTI
Mvan_3510|M.vanbaalenii_PYR-1 --------LTADIPSPVLHAFTSERREALRIPPDTPFYEESTFWNPSWTI
MAB_0330|M.abscessus_ATCC_1997 --------ETSAIADPHARGYTQLTP--------TGSLVDSTDWNPSWAS
MSMEG_1586|M.smegmatis_MC2_155 --------TSPAFPEPHPQGYTVLD----------GTPRVTTDWNPSWAW
TH_3520|M.thermoresistible__bu --------ADGRLPAPYTHGYNQGP---------DGAIVDTTLWNPAWAD
MAV_3991|M.avium_104 TECPEWTWRTTLLPRIAPTARDEESRDDPSKNPDYYALLRGTVHDPTARR
MLBr_00119|M.leprae_Br4923 -------VAEEDVPLVALSHATGRPLPPIIAAIFRKAIGGTVHEVIPYTN
.
Mflv_3749|M.gilvum_PYR-GCK GG----AGLFSTVDDYLRFARMLLNGGTLDGT-----------RVLSEDS
MUL_1772|M.ulcerans_Agy99 AG----GGLWSTADDYLRFVRLLLGDGTIDGV-----------RVLSPES
Mb0405c|M.bovis_AF2122/97 TH----GAIQTTTIYDMEATAVGIGSG----------------RLLSADS
Rv0399c|M.tuberculosis_H37Rv TH----GAIQTTTIYDMEATAVGIGSG----------------RLLSADS
MMAR_0696|M.marinum_M TH----GAIQTTTIYDMEATAVGIGSG----------------KLLSADS
Mvan_3510|M.vanbaalenii_PYR-1 TH----GAIQTTNIYDLEATAVGIGSG----------------RLLKPES
MAB_0330|M.abscessus_ATCC_1997 WA----GAMIST-LDDLRIWVPALATG----------------VLLKPDS
MSMEG_1586|M.smegmatis_MC2_155 SN----GNMIST-LDDMRVWAQKLSSG----------------ELLSENL
TH_3520|M.thermoresistible__bu AA----GKIVSN-VHDMRTWARALGSG----------------ALLRPDT
MAV_3991|M.avium_104 MGGVAGNAGVFSTAHDVGVYAQALLDRLAGRPSDFPLQQGTVELMTTPQQ
MLBr_00119|M.leprae_Br4923 TP-----PFLTTIVPSSNTVSTANELS-----------------RFAEIW
.
Mflv_3749|M.gilvum_PYR-GCK AMSMRTDRLTAEQKRQDFLGAPFWIGRGFGLNLSVVTDPAKSRQLFGPGG
MUL_1772|M.ulcerans_Agy99 VRLMRTDRLSDEHKRHNFLGAPFWVGRGFGLNLSVVTDPVQSTPLFGPGG
Mb0405c|M.bovis_AF2122/97 YKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVIS---------GHW
Rv0399c|M.tuberculosis_H37Rv YKKMVSTELRGKTRAQPGCPTCFEQNDGYSYGLGIVIS---------GHW
MMAR_0696|M.marinum_M YQKMVSTALRGKTRAQPDCPTCFEQSEGYTYGLGIVIS---------GHW
Mvan_3510|M.vanbaalenii_PYR-1 YRQMVSTDLRGKTRSQPGCATCRPMDERYTYGLGVVIS---------GNW
MAB_0330|M.abscessus_ATCC_1997 QQQRLQTVA------------MPPVPDDIRYGLGIFDA---------RGW
MSMEG_1586|M.smegmatis_MC2_155 RDERFRT-A------------LP-MSENAKYGVGAFDT---------NGW
TH_3520|M.thermoresistible__bu HAERIHG--------------GSSVVPGVDYSFAIFNA---------QGW
MAV_3991|M.avium_104 PGHDPRQLEAANRAARSGTPNYPAIKGQNLFGFGWDIDTGYSRPRGRVFP
MLBr_00119|M.leprae_Br4923 LRGGELDGIRVLRSETLLGAVAECRRLRPDFVVGLMPAR------WGTGF
..
Mflv_3749|M.gilvum_PYR-GCK LGTFSWPGAYGTWWQADPSADVILIYLIQNLPSMSVDVAAAIAGNTSLAK
MUL_1772|M.ulcerans_Agy99 LGTFSWPGAYGTWWQADPGADLILLYLIQHCPDLSVNAAAAVAGNPGLAK
Mb0405c|M.bovis_AF2122/97 LLQNPMFAGYAAVEAYLPS-QRVAVAVAVTYAPEAFDDQGNYRNQADILF
Rv0399c|M.tuberculosis_H37Rv LLQNPMFAGYAAVEAYLPS-QRVAVAVAVTYAPEAFDDQGNYRNQADILF
MMAR_0696|M.marinum_M LLQNPLFSGYAATEAYLPS-QRVAIAVALTYTPEAFDDEGNYPNQADILF
Mvan_3510|M.vanbaalenii_PYR-1 LLQNPMFAGYAGVEAYLPA-QKIAIAVATTFAPEAFDDSGDYRNEAETLF
MAB_0330|M.abscessus_ATCC_1997 IGHSGSIPGYQTLAIYSPAEQTTVVALLNTDVAKQPAQPSTLFGTAITKV
MSMEG_1586|M.smegmatis_MC2_155 IGHSGITPGFETVVVGLPEAQSTLVVFVNTDVPHEVG---TAVATAVTGV
TH_3520|M.thermoresistible__bu LGHNGDIPGYATVVVYLPERDATLVVFVNSDVPEPHS--AGQIAYVVTEM
MAV_3991|M.avium_104 IGSFGNTGFTGTTLWMDPGSDTYVILLSNSIHLRGSPPISNLRGDVATAA
MLBr_00119|M.leprae_Br4923 ILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLISSGKPGQDP
:
Mflv_3749|M.gilvum_PYR-GCK LQTAQPKFVRSTYQALEL----
MUL_1772|M.ulcerans_Agy99 LRTAQPRFVRRTYRALGL----
Mb0405c|M.bovis_AF2122/97 RKIGAEVAPNDAPPMPPGR---
Rv0399c|M.tuberculosis_H37Rv RKIGAEVAPNDAPPMPPGR---
MMAR_0696|M.marinum_M RKIAAALVPDDAPPMPPGR---
Mvan_3510|M.vanbaalenii_PYR-1 RRIGAEMAPDDAPPGPAPR---
MAB_0330|M.abscessus_ATCC_1997 ISPDHVFLLENAIPQPR-----
MSMEG_1586|M.smegmatis_MC2_155 VTPDNVYR--------------
TH_3520|M.thermoresistible__bu VTPEHIYELGPQPPQMLDEPAA
MAV_3991|M.avium_104 ARALHLYGAAPP----------
MLBr_00119|M.leprae_Br4923 NAGRYGALMNTITAEIPVH---