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MNTPGDSAGAPNPGTSTSIRSMNSVLSTLRIFEEVATRQPIGVSDLSRVTGIPKSTVQRCLVTLKQAGWL KVVDTAQTRWGVTARALSLGLRGAGEQDLRQLADPVIKRLAADTGETVHLALRDGNESVIIGRADTTKDV RVILELGTRLPLQATSAGVAMLARLAPAEVAEVLSHEVDQVEGASVPSTDQLRREIEMTAVRGYALNVSS WYRPHVCSVGVAVTDSMDRPIAGIAISIPEMRYDAANEATLAELANAAAAEINGLIRSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3335 | - | - | 100% (269) | transcriptional regulator, IclR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2600 | - | 1e-17 | 29.41% (221) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_3784 | - | 5e-15 | 24.14% (203) | transcriptional regulator, IclR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1802c | - | 1e-10 | 26.88% (253) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3087 | - | 9e-16 | 26.34% (243) | transcriptional regulator, TrmB |
| M. tuberculosis H37Rv | Rv1773c | - | 1e-10 | 26.88% (253) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4380 | - | 6e-17 | 27.42% (248) | IclR family regulatory protein |
| M. marinum M | MMAR_4423 | - | 4e-20 | 26.54% (260) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 3e-18 | 27.41% (259) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3647 | - | 6e-10 | 25.71% (245) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 3e-12 | 28.00% (225) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1018 | - | 6e-18 | 26.09% (253) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1802c|M.bovis_AF2122/97 -----------MPPTEGKSTTNRDEGIQVLRRAVAALDEIAAEP-GHLRL
Rv1773c|M.tuberculosis_H37Rv -----------MPPTEGKSTTNRDEGIQVLRRAVAALDEIAAEP-GHLRL
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQ--PEIRL
TH_3647|M.thermoresistible__bu -VRKRARGA----------IERPTYLLESVDNALRLLQMLRDG--GAVRL
Mflv_3087|M.gilvum_PYR-GCK --------MAQHDKTSTTSPTDAPAAVQSVDRALQVLEIVAAH--GQAGV
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL--GKAGV
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKS---PCGL
MAB_4380|M.abscessus_ATCC_1997 ---------------MDAYGDLVTEAPSVVNRTAALLRAVSSDTGTGVST
Mvan_1018|M.vanbaalenii_PYR-1 ----------------MTEPDISVRKVKSAVRTVELLEYLAARPDDPARL
MSMEG_3335|M.smegmatis_MC2_155 -----MNTPGDSAGAPNPGTSTSIRSMNSVLSTLRIFEEVATR--QPIGV
: :
Mb1802c|M.bovis_AF2122/97 VDLCERLGLAKSTTRRLLVGLVEVGLVSVD--SHGRFALGERLLGFGSVT
Rv1773c|M.tuberculosis_H37Rv VDLCERLGLAKSTTRRLLVGLVEVGLVSVD--SHGRFALGERLLGFGSVT
MAV_3513|M.avium_104 SEATRYLGVASSTAHRLLAMLAYRGFVRQDP-VSKAYLPGPSLTGVAFAI
TH_3647|M.thermoresistible__bu TEAAEELGVAPSTAHRLLAMLVYRGFAVQD--EKRTYLPGPALRAGPAER
Mflv_3087|M.gilvum_PYR-GCK TEIAAELGVHKSTVSRLVAVLEARGYVEQVS-ERGKYRLGFAIPRLAHVA
MMAR_4423|M.marinum_M TEVADELGVHKSTASRLITALEARGYVEQLS-DRGKYQLGIGVSRLARAR
MUL_1967|M.ulcerans_Agy99 AELCERTGLPRATAYRLAAALEVHRLLGRD--EDGRWGLGPAITELAAHV
MAB_4380|M.abscessus_ATCC_1997 TELARRTGIPRATAHRLLESLATEGLVERDA-RSGQWFLGPEIYVLGAAS
Mvan_1018|M.vanbaalenii_PYR-1 REISDALDMPRSSAHALLRTLVCQGWVRSDP-TGTLYGIGIRALLVGTSY
MSMEG_3335|M.smegmatis_MC2_155 SDLSRVTGIPKSTVQRCLVTLKQAGWLKVVDTAQTRWGVTARALSLGLRG
: .: ::. * :
Mb1802c|M.bovis_AF2122/97 G--AHIAAAFRPTVERVARATDGETVDLSVLRGQRMWFVDQIESSYRLR-
Rv1773c|M.tuberculosis_H37Rv G--AHIAAAFRPTVERVARATDGETVDLSVLRGQRMWFVDQIESSYRLR-
MAV_3513|M.avium_104 FGRLDIARSAAPIMRALSEQLR-ETVHVGMLDGASVRFVAAVEGPAAVR-
TH_3647|M.thermoresistible__bu GWTREFTDVCLPHLEALSTVCG-ETVNLVIRVGTGVRFLTSVESTAMLR-
Mflv_3087|M.gilvum_PYR-GCK GGQNDLVKLGQAACDMLSAGVG-ETANLAVLDADRIVNIVEAIGPSEIT-
MMAR_4423|M.marinum_M SGHSDLVKLSQDACDKLAADLG-ETANLAILDENRAVNIVEAVSTAEIA-
MUL_1967|M.ulcerans_Agy99 D--DPLLTAGATVLPRLCETTG-ESVQLYRREGTSRVCVAALEPPAGLR-
MAB_4380|M.abscessus_ATCC_1997 APRYNITEKAAADVAALARDTG-ESAFFSLRRGDHTVVLLAEDGDFPIRS
Mvan_1018|M.vanbaalenii_PYR-1 LDSDPYLPLITPFLEDLRAEQD-ETFHLGRLDGTDIVYLATRESTQYTR-
MSMEG_3335|M.smegmatis_MC2_155 AGEQDLRQLADPVIKRLAADTG-ETVHLALRDGNESVIIGRADTTKDVR-
: *: . :
Mb1802c|M.bovis_AF2122/97 AVSAVGLRFPLNGTANGKAALAALDDADAEAALCRL--------DPMVAE
Rv1773c|M.tuberculosis_H37Rv AVSAVGLRFPLNGTANGKAALAALDDADAEAALCRL--------DPMVAE
MAV_3513|M.avium_104 VASRLGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRA
TH_3647|M.thermoresistible__bu VGDRRGQVLPAERTAGGRALLAELDDEVVERLYADR--------SAGQRA
Mflv_3087|M.gilvum_PYR-GCK LRTWVGQSCPAYATSSGKVLLAGLDPAELPARIRPP-LTEFTDSTLCGLA
MMAR_4423|M.marinum_M LQTWVGQSCPVHATSSGKVLLAGLDADEVRQRVGAT-LDSFTENTIVTID
MUL_1967|M.ulcerans_Agy99 DTVPVGARLPMTAGSGAKVLLAHSDPATQQAVLPTA-------------K
MAB_4380|M.abscessus_ATCC_1997 HVLYEGARFPLGVVSSGMAVLAYLPDAAIHAYLERADLQSEWG-NGFRID
Mvan_1018|M.vanbaalenii_PYR-1 TSSRVGRRLPAYATSLGKALLAERFGTERDEHVPAA-LKSLTPHTITDRT
MSMEG_3335|M.smegmatis_MC2_155 VILELGTRLPLQATSAGVAMLARLAPAEVAEVLSHE-VDQVEGASVPSTD
* * : . . **
Mb1802c|M.bovis_AF2122/97 GLRREIVEIRRTGIAFDRNEHT-PGISAAAIARR-ALGDNVIAISVPAP-
Rv1773c|M.tuberculosis_H37Rv GLRREIVEIRRTGIAFDRNEHT-PGISAAAIARR-ALGDNVIAISVPAP-
MAV_3513|M.avium_104 ALETELAAIRERGYATNREESE-EGVASVAVPIPTRAPGLRLALNAAAPQ
TH_3647|M.thermoresistible__bu ELLTELAAVREVGFGLNVEHTE-EGVAAFGAVVRNRLGRAVGAVTVAVPI
Mflv_3087|M.gilvum_PYR-GCK ELQDELAAVRERGWACVREELE-VGLNAVAAPVYDVHAQVIAALSVSGPS
MMAR_4423|M.marinum_M ALEAQLAATRAAGWASAREELE-IGLNAVAAPVYDSTGRVAAALSVSGPA
MUL_1967|M.ulcerans_Agy99 FTDRVLAEVRRRGWAQSVAERE-PGVASVSAPVRDGRGVVVAAISVSGPI
MAB_4380|M.abscessus_ATCC_1997 AVWERVALTRKTGWAVNPGQVV-EGSWGMAAAVFDANQNPIGALTLTGIE
Mvan_1018|M.vanbaalenii_PYR-1 ELDHALDEVRIRGYACDDEENT-TGLRCFAVPLR-YCRPAQDAISASVPV
MSMEG_3335|M.smegmatis_MC2_155 QLRREIEMTAVRGYALNVSSWYRPHVCSVGVAVTDSMDRPIAGIAISIPE
: * . . .: .
Mb1802c|M.bovis_AF2122/97 ----TARFLEKEQRIIAALRAAADSPDWTR--------
Rv1773c|M.tuberculosis_H37Rv ----TARFLEKEQRIIAALRAAADSPDWTR--------
MAV_3513|M.avium_104 NRLDAARYPAVAAALVAAAKEIGDQLG-----------
TH_3647|M.thermoresistible__bu VRYQRHARGDLVRQLFRTADEISVDLDGRFDSLEP---
Mflv_3087|M.gilvum_PYR-GCK YRLAVDRFDEVAKQTVAAAEQISRRLGWTTRN------
MMAR_4423|M.marinum_M YRLPAADFEEVAQQTIAAADAVSRGLGWTDRIS-----
MUL_1967|M.ulcerans_Agy99 DRIGRRPGARWAADLLAAADELARRL------------
MAB_4380|M.abscessus_ATCC_1997 ARFNADRQPVLGQLLLRHAHRLSRTVRR----------
Mvan_1018|M.vanbaalenii_PYR-1 ERLDPQRQREIIDALRAVGDKVSRVVRPLANGDKWFAS
MSMEG_3335|M.smegmatis_MC2_155 MRYDAANEATLAELANAAAAEINGLIRSA---------