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VPPTEGKSTTNRDEGIQVLRRAVAALDEIAAEPGHLRLVDLCERLGLAKSTTRRLLVGLVEVGLVSVDSH GRFALGERLLGFGSVTGAHIAAAFRPTVERVARATDGETVDLSVLRGQRMWFVDQIESSYRLRAVSAVGL RFPLNGTANGKAALAALDDADAEAALCRLDPMVAEGLRREIVEIRRTGIAFDRNEHTPGISAAAIARRAL GDNVIAISVPAPTARFLEKEQRIIAALRAAADSPDWTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1802c | - | - | 100% (248) | transcriptional regulatory protein |
| M. bovis AF2122 / 97 | Mb1748 | - | 3e-36 | 40.08% (242) | transcriptional regulatory protein |
| M. bovis AF2122 / 97 | Mb3013 | - | 2e-12 | 29.87% (231) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4551 | - | 5e-18 | 31.65% (237) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1773c | - | 1e-136 | 100.00% (248) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 1e-21 | 32.03% (231) | IclR family transcriptional regulator |
| M. marinum M | MMAR_1725 | - | 2e-17 | 33.48% (233) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 6e-16 | 31.78% (214) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2483 | - | 2e-22 | 34.80% (227) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_2042 | - | 1e-18 | 32.05% (234) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_1967 | - | 3e-17 | 33.05% (233) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0155 | - | 7e-75 | 63.60% (239) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1802c|M.bovis_AF2122/97 MPPTEGK----STTNRDEGIQVLRRAVAALDEIAAEPGHLRLVDLCERLG
Rv1773c|M.tuberculosis_H37Rv MPPTEGK----STTNRDEGIQVLRRAVAALDEIAAEPGHLRLVDLCERLG
Mvan_0155|M.vanbaalenii_PYR-1 MPGADQNGRIDATEGRDDGLQVLRRAAAALDEIATAPGRLRLVDVGTNLG
MMAR_1725|M.marinum_M -------------MRQDSGIGVIDKAVGLLRATAESP--CGLAELCERTG
MUL_1967|M.ulcerans_Agy99 -------------MRQDSGIGVIDKAVGLLRATAKSP--CGLAELCERTG
TH_2042|M.thermoresistible__bu -------------MRKDSGIGVLDKAVSVLHSVAESP--CGLAELCERTG
MAB_4493|M.abscessus_ATCC_1997 -------------------MSVLTRAAQILDALAESNSGLSVRELAEATG
MSMEG_2483|M.smegmatis_MC2_155 -------------------MADIGRSTLVLDALAEASKPLTLSELATRTG
Mflv_4551|M.gilvum_PYR-GCK -----------MTTPVETPSAVIDRVSLVLDAFDGPG-RLTLAQIVRRTG
MAV_3024|M.avium_104 -----------MPAPAETPTAVIDRISLVLDAFDGPG-RLTLAQIVRRTG
: : * : :: *
Mb1802c|M.bovis_AF2122/97 LAKSTTRRLLVGLVEVGLVSVDSHGR-FALGERLLGFG--SVTGAHIAAA
Rv1773c|M.tuberculosis_H37Rv LAKSTTRRLLVGLVEVGLVSVDSHGR-FALGERLLGFG--SVTGAHIAAA
Mvan_0155|M.vanbaalenii_PYR-1 LAKSTARRLLVALVDVGFAAVDDSGR-YHLGDRLLGLT--SADGSTLAAR
MMAR_1725|M.marinum_M LPRATAYRLAAALEVHRLLGRDEDGR-WGLGPAITELA--AHVDDPLLTA
MUL_1967|M.ulcerans_Agy99 LPRATAYRLAAALEVHRLLGRDEDGR-WGLGPAITELA--AHVDDPLLTA
TH_2042|M.thermoresistible__bu LPRATAHRLAAGLEVHRLLARDGDGR-WCLGPAVTELA--ARVDDPLLAA
MAB_4493|M.abscessus_ATCC_1997 LPKSSVHRIVQELTVSQYVMAGGRGGSYQLGPGLLKLG--LNNRRQFVAP
MSMEG_2483|M.smegmatis_MC2_155 LPRSTVHRIVQSLERSLYLVRGVDRHGYSLGPGLLKFG--MNAHLRLLAG
Mflv_4551|M.gilvum_PYR-GCK LPRSSAHRMLERLVQLRWLRR--TGRDYELGMRLVELGSLAVHQDRVHRA
MAV_3024|M.avium_104 LPRSSAHRMLERLVQLRWLRR--SGRDYELGMRLVELGSLAVHQDRLVRA
*.:::. *: * : ** : : .
Mb1802c|M.bovis_AF2122/97 FRPTVERVARATDGETVDLSVLRGQRMWFVDQIESSYRLRAVSAVGLRFP
Rv1773c|M.tuberculosis_H37Rv FRPTVERVARATDGETVDLSVLRGQRMWFVDQIESSYRLRAVSAVGLRFP
Mvan_0155|M.vanbaalenii_PYR-1 LRPVIERLALAT-GETVDLSVLRGRQMWFVDQIESAHRLRAVSAVGGRFP
MMAR_1725|M.marinum_M GATVLPRLRETT-GESVQLYRREGTSRVCVAALEPPAGLRDTVPVGARLP
MUL_1967|M.ulcerans_Agy99 GATVLPRLCETT-GESVQLYRREGTSRVCVAALEPPAGLRDTVPVGARLP
TH_2042|M.thermoresistible__bu AAVVLPRLREIT-GESVQLYRREGTSRICVAALEPPAGLRDTVPVGTRLP
MAB_4493|M.abscessus_ATCC_1997 MRKAIATVAREV-NENIDLAMLSGGELVIIEQIATVRNLPTVTVVGRTFA
MSMEG_2483|M.smegmatis_MC2_155 NRPLLARLVREV-GENVELAIFSGREVVVVDQLASVNRLHGVTKVGKSFS
Mflv_4551|M.gilvum_PYR-GCK ATPLLHDLHRAT-GLVVHLAVLDGSDVVYLDKIGDGMASAIPTRVGGRQP
MAV_3024|M.avium_104 ATPLLVELHRAT-GLVVHLAVLDGPDVVYLEKVGDRLNSVIPSRVGGRQP
: : . . :.* * : : ** .
Mb1802c|M.bovis_AF2122/97 LNGTANGKAALAALDDADAEAALCR-------LDPMVAEGLRREIVEIRR
Rv1773c|M.tuberculosis_H37Rv LNGTANGKAALAALDDADAEAALCR-------LDPMVAEGLRREIVEIRR
Mvan_0155|M.vanbaalenii_PYR-1 LHDTANGKAALALMEDD------------------AIPDGLLDEIAEVRR
MMAR_1725|M.marinum_M MTAGSGAKVLLAHSDPATQQAVLP------------TAKFTDRVLAEVRR
MUL_1967|M.ulcerans_Agy99 MTAGSGAKVLLAHSDPATQQAVLP------------TAKFTDRVLAEVRR
TH_2042|M.thermoresistible__bu MTAGSGAKVLLAYADSTTQQAVLS------------NAKFSERALAEVHK
MAB_4493|M.abscessus_ATCC_1997 LHASSIGKALLSQLPPDQVRNMLPADLEVFTTNTITDVTALLRELDDVRS
MSMEG_2483|M.smegmatis_MC2_155 LHASCIGLALLAHLPDDQVAGLLSPPLQRFTEHTVTDLPAIMGRLDEVRR
Mflv_4551|M.gilvum_PYR-GCK AHCTAVGKAMLAFNDD-VDVDLQSR----MTKYSIGTAAQLAAELAKVRA
MAV_3024|M.avium_104 AHCTAVGKAILAYRDEATDLDLGAR----PTKYSISSAPQLAAELAKVRA
. . . *: : .::
Mb1802c|M.bovis_AF2122/97 TGIAFDRNEHTPGISAAAIARR-ALGDNVIAISVPAPTARFLEKE-----
Rv1773c|M.tuberculosis_H37Rv TGIAFDRNEHTPGISAAAIARR-ALGDNVIAISVPAPTARFLEKE-----
Mvan_0155|M.vanbaalenii_PYR-1 TGIAYDRDEHTAGISAAGIAVR-LPGGHVVAISVPAPTERFRAQE-----
MMAR_1725|M.marinum_M RGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPIDRIGRRP-----
MUL_1967|M.ulcerans_Agy99 RGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPIDRIGRRP-----
TH_2042|M.thermoresistible__bu RGWAQSVAEREPGVASVSAPVRDGRGTVVAAVSVSGPIDRIGRRP-----
MAB_4493|M.abscessus_ATCC_1997 TGVAFDHEEHDVGISSVAVPLP-HPAAIPQAMAIVAPTPRFAQRK-----
MSMEG_2483|M.smegmatis_MC2_155 TQIAVDTEEHDVGICAVATAFP-GPTGALQAVAVVMPTARFRAKR-----
Mflv_4551|M.gilvum_PYR-GCK HGVAYEREESLPGFGCVAAAIG-RPGEAVAAVSVCGPMNRMAFER-LAAP
MAV_3024|M.avium_104 HGVAFEREESLLGFGCVAAPIG-GPGEAAAAVSVCGPLQRMALDQRLAAP
* . * *. ... . *::: * *:
Mb1802c|M.bovis_AF2122/97 ----------------QRIIAALRAAADSPDWTR--------------
Rv1773c|M.tuberculosis_H37Rv ----------------QRIIAALRAAADSPDWTR--------------
Mvan_0155|M.vanbaalenii_PYR-1 ----------------STIVDALRAAAADPVWAGGVS-----------
MMAR_1725|M.marinum_M ----------------GARWAADLLAAADELARRL-------------
MUL_1967|M.ulcerans_Agy99 ----------------GARWAADLLAAADELARRL-------------
TH_2042|M.thermoresistible__bu ----------------GARWAADLLAAAEALTRRL-------------
MAB_4493|M.abscessus_ATCC_1997 ----------------TKYVAALDSLTKRANST---------------
MSMEG_2483|M.smegmatis_MC2_155 ----------------ERAVESLQRINPLLAHRN--------------
Mflv_4551|M.gilvum_PYR-GCK VRVTAMGIWRNAEDGPARVTPTLQPLRPLRGGPAARPVAVRNDALQYA
MAV_3024|M.avium_104 VRMTAMGVWRNVEGGPQRVAPTLQRLRPLPPMRPQHPVPKPRPALQYA
: