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LTIHDPRTGELVGRTPIATASECDAAIARARGAAAGWARTPAGERAAVLTSAAADVRAAADELAELNERE TGKLRADARGGVDAAVSTLVQYAELGPLHRGRSLHGNWSATDLMVPGPRGVVAVLTPWNDPVAVAAGLLG AALVTGNTVVHKPSERCPATGRRFAELLAQHLPKGVLEILDGDATIGAQLAAAGDVDVVAHVGSSVTGRA ITRACAERGAKALLENGGNDALVVDAGIDPGWAAAQAALGSFANAGQICVSVERIFVVGAVEAMVEAFIR ALVDEAESWAERIGPLVDERQREQVHRHVTDAVKRGATVAAGGEAPSGPGTFYPPTVLTDCTKDMLVFQE ETFGPVAAVRVVPDFDAAITEAADDRYGLAASVLTPDMGHAQQAWRDLPVGTVKINDVFGGAPGGASQPR KASGSGFGFGPELLDEMTTMKVVHWSPPPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3304 | - | - | 100% (450) | succinate semialdehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6491 | - | 1e-57 | 34.73% (455) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6687 | - | 4e-56 | 34.04% (423) | aldehyde dehydrogenase, thermostable |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1760 | gabD2 | 1e-52 | 33.55% (471) | succinic semialdehyde dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4860 | - | 5e-56 | 34.86% (459) | gamma-aminobutyraldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 4e-55 | 32.90% (462) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 5e-38 | 28.26% (453) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3328 | - | 2e-57 | 35.53% (456) | gamma-aminobutyraldehyde dehydrogenase |
| M. marinum M | MMAR_2571 | gabD2 | 4e-56 | 33.90% (469) | succinate-semialdehyde dehydrogenase |
| M. avium 104 | MAV_2101 | - | 6e-55 | 32.76% (464) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_3080 | - | 7e-52 | 32.83% (466) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_3190 | gabD2 | 6e-56 | 33.90% (469) | succinic semialdehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0014 | - | 3e-57 | 34.94% (478) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0223c|M.tuberculosis_H37Rv -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
TH_3080|M.thermoresistible__bu ------VHPEELFIGGEWATPSSAQRIEVISPHTEEPVAAVAAACPDDVD
Mvan_0014|M.vanbaalenii_PYR-1 ---MSDIPHYRMYIDGAWR--DAADTIEVRSPATGELVATVAYGGVTTVD
MAV_2101|M.avium_104 ----------------------MSTTIPVFNPSTEEQIAEVPDSDQAAVD
Mflv_4860|M.gilvum_PYR-GCK ------MTVASSWID-GAPVKTGGAQHTVINPATGESVAEFALAQPGDVD
MAB_3328|M.abscessus_ATCC_1997 ------MSVPSSWIN-GRPVATHGDTHRVINPATGEAVADLKLATTADVD
MSMEG_3304|M.smegmatis_MC2_155 --------------------------MTIHDPRTGELVGRTPIATASECD
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
MMAR_2571|M.marinum_M MPVPSSAVFERLLSLAAIKDVDARPTRTIDEVFTGKPLTTIPVGTAEDVE
MUL_3190|M.ulcerans_Agy99 MPVPSSAVFECLLSLAAIKDVDARPTRTIDEVFTGKPLTTIPVGTAEDVE
Mb1760|M.bovis_AF2122/97 MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAADVE
* : : :
Rv0223c|M.tuberculosis_H37Rv AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
TH_3080|M.thermoresistible__bu RAVAAARAAFDTGPWPRMDPAERVAVIRGLAERYGERRSELAELITAQIG
Mvan_0014|M.vanbaalenii_PYR-1 DAVAAAKAADEAGVWRNTSAQQRADVLDAIADNLAARTDELTALQVAENG
MAV_2101|M.avium_104 AAVARARETFESGVWRKAPASHRANVLFRAARIIEERKDELAALESQDNG
Mflv_4860|M.gilvum_PYR-GCK RAVVSARAALPG--WKGATPAERSAVLAKLAKLADDATADLVAEEVSQTG
MAB_3328|M.abscessus_ATCC_1997 AAVAAARAAGPA--WASSTPVDRSSVLAKLAAVLSANADTLVADEVAQTG
MSMEG_3304|M.smegmatis_MC2_155 AAIARARGAAAG--WARTPAGERAAVLTSAAADVRAAADELAELNERETG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
MMAR_2571|M.marinum_M AAFAEARAAQAN--WAKRPVSERAEVIRRYRDLVIENREFLMDLLQAEAG
MUL_3190|M.ulcerans_Agy99 AAFAEAREAQAN--WAKRPVSERAEVIRRYRDLVIENREFLMDLLQAEAG
Mb1760|M.bovis_AF2122/97 AAFAEARAAQTD--WAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAG
*.. * : .* : *
Rv0223c|M.tuberculosis_H37Rv QPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSYG-------QSI-
TH_3080|M.thermoresistible__bu APISFAQRAQVGLPWTMMSAFCTLAENHPWQQTRAGMYG-------ADVH
Mvan_0014|M.vanbaalenii_PYR-1 ATVRAAGAFLIGYAIAHLRYFAGLARTYAFQSSGPLMEAPT----LAAGM
MAV_2101|M.avium_104 MNLTAAG-HIIPVSVDMLKYYAGWVGKIHGESANLVSDGLLGTWETYHTF
Mflv_4860|M.gilvum_PYR-GCK KPVRLATEFDVPGSVDNIDFFAGAARHLEGKASAEYSGD-------HTSS
MAB_3328|M.abscessus_ATCC_1997 KPVRLASEFDVPGSIDNVEFFAGAARHLEGKATAEYSAD-------HTSS
MSMEG_3304|M.smegmatis_MC2_155 -KLRADARGGVDAAVSTLVQYAELGPLHRGRSLHGNWSA--------TDL
MLBr_02573|M.leprae_Br4923 KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVG------ASKAL
MMAR_2571|M.marinum_M KARWAAQEEVVDLVANANYYARVSAGLLKPRTVQALLPG------IGKTT
MUL_3190|M.ulcerans_Agy99 KARWAAQEEVVDLVANANYYARVSAGLLKPRTVQALLPG------IGKTT
Mb1760|M.bovis_AF2122/97 KARWAAQEEIVDLIANANYYARVCVDLLKPRKAQPLLPG------IGKTT
Rv0223c|M.tuberculosis_H37Rv VSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANA
TH_3080|M.thermoresistible__bu VRREPVGVVAAIVPWNMPQFLIVTKLIPALLAGCTVVLKPAPESPLDALL
Mvan_0014|M.vanbaalenii_PYR-1 IVRDPVGVCAGMIPWNFPLLLAVWKLGPALAAGNTVVLKPDDQTPLTLLE
MAV_2101|M.avium_104 TQLEPVGVVGLIIPWNGPFFVAMLKVAPALAAGCSAVLKPAEETPLTALK
Mflv_4860|M.gilvum_PYR-GCK IRREAVGVVATITPWNYPLQMAVWKVIPALAAGCSVVIKPAEITPLTTLT
MAB_3328|M.abscessus_ATCC_1997 IRREAAGVVATITPWNYPLQMAVWKVLPALAAGCTVVIKPSELTPLTTLT
MSMEG_3304|M.smegmatis_MC2_155 MVPGPRGVVAVLTPWNDPVAVAAGLLGAALVTGNTVVHKPSERCPATGRR
MLBr_02573|M.leprae_Br4923 ARYQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALY
MMAR_2571|M.marinum_M VGYQPKGVVGVISPWNYPMTLTASDSVPALIAGNAVVLKPDSQTPYCALA
MUL_3190|M.ulcerans_Agy99 VGYQPKGVVGVISPWNYPMTLTASDSVPALIAGNAVVLKPDSQTPYCALA
Mb1760|M.bovis_AF2122/97 VCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVLKPDSQTPYCALA
. ** : .** * .** :* : * *
Rv0223c|M.tuberculosis_H37Rv LAEVFAEVGLPEGVLSVVPGG-IETGQALTSNPDIDMFTFTGSSAVGREV
TH_3080|M.thermoresistible__bu LAELIADSGIPSGVVNVLPGP-AGVGERLVRHPGVDKVSFTGSTAAGRAV
Mvan_0014|M.vanbaalenii_PYR-1 LARAADEVGLPAGVLNVVTGAGPTVGARLAEHPDVRKVAFTGSTEVGKSV
MAV_2101|M.avium_104 LEEIFREAGLPDGVLNVITGYGETTGAALTAHPDVDKISFTGSTEVGRLI
Mflv_4860|M.gilvum_PYR-GCK LARLASEAGLPDGVLNVVTGSGADVGAALAGHADVDMVTFTGSTPVGRRV
MAB_3328|M.abscessus_ATCC_1997 LARLAAEAGLPEGVLNVVTGRGDDVGYALASHPDVDLVTFTGSTAVGRKV
MSMEG_3304|M.smegmatis_MC2_155 FAELLAQH-LPKGVLEILDGD-ATIGAQLAAAGDVDVVAHVGSSVTGRAI
MLBr_02573|M.leprae_Br4923 LADVIARGGFPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAV
MMAR_2571|M.marinum_M CAELLYRAGLPRALYAIVPGPGSVVGTAIA--DNCDYLMFTGSSATGSRL
MUL_3190|M.ulcerans_Agy99 CAELLYRAGLPRALYAIVPGPGSVVGTAIA--DNCDYLMFTGSSATGSRL
Mb1760|M.bovis_AF2122/97 CAELLYRAGLPRALYAIVPGPGSVVGTAIT--DNCDYLMFTGSSATGSRL
:* : : .** .* :
Rv0223c|M.tuberculosis_H37Rv GRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVN
TH_3080|M.thermoresistible__bu AAAAAAGLKRVSLELGGKSAAVVLSDADPAAVATAVRSASLSNSGQICNA
Mvan_0014|M.vanbaalenii_PYR-1 MRAAADTVKKVTLELGGKGASIVLDDADLDLAVDGSLFAFLLMSGQACES
MAV_2101|M.avium_104 VKAAAGNLKRLTLELGGKSPLIMFDDANLDKAIMGAGMGLLAGSGQNCSC
Mflv_4860|M.gilvum_PYR-GCK MLAAAAHGHRTQLELGGKAPFVVFDDADLDAAIQGAVAGALINTGQDCTA
MAB_3328|M.abscessus_ATCC_1997 MAAAAVHGHRTQLELGGKAPFVVFDDADMDAAIAGAVAGAIINSGQDCTA
MSMEG_3304|M.smegmatis_MC2_155 TRACAERGAKALLENGGNDALVVDAGIDPGWAAAQAALGSFANAGQICVS
MLBr_02573|M.leprae_Br4923 GAIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIA
MMAR_2571|M.marinum_M AEHAGRRLIGFSAELGGKNAMIVTRGVNLDKVAKAATRACFSNAGQLCIS
MUL_3190|M.ulcerans_Agy99 AERAGRRLIGFSAELGGKNAMIVTRGVNLDKVAKAATRACFSNAGQLCIS
Mb1760|M.bovis_AF2122/97 AEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCIS
.. * **. . :: . : . . . ** *
Rv0223c|M.tuberculosis_H37Rv QTRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVE
TH_3080|M.thermoresistible__bu LTRILMPAGRAAEFTDALAAEMESLVIGDPTDAETQIGPLVARRQQERVR
Mvan_0014|M.vanbaalenii_PYR-1 GTRLLVHESIHDEFVRRMVARAETLVMGDPMSLASDLGPLVSAKQKARVE
MAV_2101|M.avium_104 TSRIYVQRGIYDQVVEGLAEFAMMLPMGGSDDPNSVLGPLISEKQRQRVE
Mflv_4860|M.gilvum_PYR-GCK ATRAIVAEGLYDDFVAGVAEVMSKVVIGDPADPDTDLGPLISAVHREKVA
MAB_3328|M.abscessus_ATCC_1997 ATRALVARDLYDDFVAGVGEVMSKVVVGDPLDPDTDIGPLISAAHRAKVS
MSMEG_3304|M.smegmatis_MC2_155 VERIFVVG-----AVEAMVEAFIRALVDEAESWAERIGPLVDERQREQVH
MLBr_02573|M.leprae_Br4923 AKRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVE
MMAR_2571|M.marinum_M IERIYVEKDIADEFTRKFGDAVRSMKLGTAYDFSVDMGSLISEGQLKTVS
MUL_3190|M.ulcerans_Agy99 IERIYVEKDIADEFTRKFGDAVRSMKLGTAYDFSVDMGSLISEGQLKTVS
Mb1760|M.bovis_AF2122/97 IERIYVEKDIAEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVS
* . . :. . . :*.* *
Rv0223c|M.tuberculosis_H37Rv GYIAKGIEEGARLVCGG-GRPEG--LDNGFFIQPTVFADVDNKMTIAQEE
TH_3080|M.thermoresistible__bu GYIEAGCAEGARLVTGGPGLPAG--VDRGWYVQPTLFADADNSMRIAREE
Mvan_0014|M.vanbaalenii_PYR-1 KYIALGQEEGCKLAYQG-TVPTDPALAQGHWVPPTILTGATNDMRIAREE
MAV_2101|M.avium_104 GIVNDGVAAGAKVITGG--KPMD---RKGYFYEATIITNTTPDMRLIREE
Mflv_4860|M.gilvum_PYR-GCK GMVERAPGEGGRVVTGG-VAPDG----PGSFYRPTLIADVAESSEVWRDE
MAB_3328|M.abscessus_ATCC_1997 SIVDRAPAQGGRIVTGA-TAPDL----PGSFYRPTLIADVAETSEVYRDE
MSMEG_3304|M.smegmatis_MC2_155 RHVTDAVKRGATVAAGG-EAPSG----PGTFYPPTVLTDCTKDMLVFQEE
MLBr_02573|M.leprae_Br4923 QQVDAAAAAGAVIRCGG-KRPDR----PGWFYPPTVITDITKDMALYTDE
MMAR_2571|M.marinum_M GHVDDATAKGAKVIAGGKARPDVG----PLFYEPTVLTDVTHEMECADNE
MUL_3190|M.ulcerans_Agy99 GHVDDATAKGAKVIAGGKARPDVG----PLFYEPTVLTDVTHEMECADNE
Mb1760|M.bovis_AF2122/97 GHVDDATAKGAKVIAGGKARPDIG----PLFYEPTVLTNVAPEMECAANE
: . * : . * : .*:::. :*
Rv0223c|M.tuberculosis_H37Rv IFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTG
TH_3080|M.thermoresistible__bu IFGPVLTVIPYPDEDAAVAIANDSDYGLAGSVFTADTERGLAIAARIRTG
Mvan_0014|M.vanbaalenii_PYR-1 IFGPVLVVLTYGDDDEAVAIANDSEYGLSAGVWSADRERALGIARRLQSG
MAV_2101|M.avium_104 IFGPVGCVIPFDDEDEVIAAANDTHYGLAGAIWTENLSRAHRVVNELRAG
Mflv_4860|M.gilvum_PYR-GCK IFGPVLTVRSFTDDDDAIRQANDTKYGLAASAWTRDVYRAQRASREIHAG
MAB_3328|M.abscessus_ATCC_1997 IFGPVLTVRPFTDDDDALRQANDTAYGLAASAWTRDVYRAQRASREIRAG
MSMEG_3304|M.smegmatis_MC2_155 TFGPVAAVRVVPDFDAAITEAADDRYGLAASVLTPDMGHAQQAWRDLPVG
MLBr_02573|M.leprae_Br4923 VFGPVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAG
MMAR_2571|M.marinum_M TFGPLVSIYPVADVEEAVEKANDTEYGLNASVWAGSTAEGEKIAARLRSG
MUL_3190|M.ulcerans_Agy99 TFGPLVSIYPVADVEEAVEKANDTEYGLNASVWAGSTPEGEKIAARLRSG
Mb1760|M.bovis_AF2122/97 TFGPVVSIYPVADVDEAVEKANDTDYGLNASVWAGSTAEGQRIAARLRSG
***: : : .: * :** . : . . : *
Rv0223c|M.tuberculosis_H37Rv TYGIN-WYAFDP---GSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMG
TH_3080|M.thermoresistible__bu TFGVNQGYTMDP---FAPFGGVKGSGYGRELGPEGIDAYTDVKSISVAPA
Mvan_0014|M.vanbaalenii_PYR-1 TVWVNDWHMINA---MYPFGGVKQSGLGRELGPDALDEYTEPKFIHVDMT
MAV_2101|M.avium_104 QIWVNSALAADP---SMPISGHKQSGWGGERGRKGIEAYFNTKAVYIGL-
Mflv_4860|M.gilvum_PYR-GCK CVWINDHIPIIS---EMPHGGFGASGFGKDMSQYSLEEYLSIKHVMSDIT
MAB_3328|M.abscessus_ATCC_1997 CVWINDHIPIIS---EMPHGGFGASGFGKDMSDYSLEEYLTVKHVMSDIT
MSMEG_3304|M.smegmatis_MC2_155 TVKINDVFGGAP---GGASQPRKASGSGFGFGPELLDEMTTMKVVHWSPP
MLBr_02573|M.leprae_Br4923 QVFINGMTVSYP---ELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA--
MMAR_2571|M.marinum_M TVNVNEGYAFAWGSLSAPMGGMGISGVGRRHGPEGLLKYTESQTIATARV
MUL_3190|M.ulcerans_Agy99 TVNVNEGYAFAWGSLSAPMGGMGISGVGRRHGPEGLLKYTESQTIATARV
Mb1760|M.bovis_AF2122/97 TVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHGPEGLLKYTESQTIATARV
:: . ** * . : : :
Rv0223c|M.tuberculosis_H37Rv YTVA----------------------------
TH_3080|M.thermoresistible__bu STT-----------------------------
Mvan_0014|M.vanbaalenii_PYR-1 DDRRKHVYPVVISAAAQG--------------
MAV_2101|M.avium_104 --------------------------------
Mflv_4860|M.gilvum_PYR-GCK SAVDKDWHRTIFTKR-----------------
MAB_3328|M.abscessus_ATCC_1997 GTADKDWHRTIFAKR-----------------
MSMEG_3304|M.smegmatis_MC2_155 PT------------------------------
MLBr_02573|M.leprae_Br4923 --------------------------------
MMAR_2571|M.marinum_M FNLDPPMGVPPTLWQKSLLPIVRTVMKLPGRK
MUL_3190|M.ulcerans_Agy99 FNLDPPMGVPPTLWQKSLLPIVRTVMKLPGRK
Mb1760|M.bovis_AF2122/97 FNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR