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MISGRIVEFFASQPVRVSAVLRLPLIGLIFVLVMVWEVDHWLPGLYAVILGLYAAAAVLWLVVVIRGPMP RWAEWASTAVDGLVLLALCAVSGGATAALLPVFFLLPISVAFQDRPLLTAMLGTATATGYLGAWIFYSKR DDTVGLPNVVYMQVGFLLWLAVATTALSLVLVRRSARVRALLDVRRRLVQESARADELRDAELAEALHDG PLQTLLAARLELDELRERNPDPALDVVHAALQQTATGLRSTVTALHPQVLAQLGLAPAVRELLRQYENRG DLVIRANIADVGQPEAQALLYRAARELLANVHKHARAATVTVRLFRQGERTVLTVVDDGVGFDPDIVAQS VAEGHIGLASLQVRIEAMGGAMTISSEEGFGTQVTVIL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0106 | - | - | 100% (388) | sensory histidine kinase |
| M. smegmatis MC2 155 | MSMEG_1493 | - | 2e-18 | 32.14% (224) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2248 | - | 9e-17 | 32.57% (218) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 3e-43 | 33.51% (388) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_0729 | - | 1e-148 | 68.25% (378) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 4e-43 | 33.51% (388) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0061 | - | 1e-99 | 49.87% (381) | two component sensor kinase |
| M. marinum M | MMAR_4781 | - | 5e-37 | 32.13% (389) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 1e-38 | 32.90% (389) | hypothetical protein MAV_0874 |
| M. thermoresistible (build 8) | TH_4203 | - | 3e-17 | 33.63% (226) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 7e-37 | 32.13% (389) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 4e-18 | 32.47% (231) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------MPSYGNLGRLGG
Rv0845|M.tuberculosis_H37Rv --------------------------------------MPSYGNLGRLGG
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
MAV_0874|M.avium_104 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mvan_1357|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------MISGRIVEFFASQPVRVSAVLRLPLIGLIFVLVMVW
Mflv_0729|M.gilvum_PYR-GCK ---------MTGPFRFPSAWREFLAAEPVRVSAVLRLPLIGLIAVLVWIW
MAB_0061|M.abscessus_ATCC_1997 -------------MTRLDNMADYFAAEPMRVSAWLRLPLIGLIVLLGSDP
Mb0868|M.bovis_AF2122/97 -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVG
Rv0845|M.tuberculosis_H37Rv -RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVG
MMAR_4781|M.marinum_M ---------MVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MAV_0874|M.avium_104 --------MAVAGDAELERVRAVHQMRSYRIGSVLRVGVVGLMVAAMIIG
TH_4203|M.thermoresistible__bu ----VTSGPHPDPVRDLSEQLLTADRELVLLRELIQAASRGPGVEPLAAA
Mvan_1357|M.vanbaalenii_PYR-1 ----------------MSRPLLTADRELALLRELIQAASSGPGVEPLAAA
. : ::
MSMEG_0106|M.smegmatis_MC2_155 EVDHWLPGLYAVILGLYAAAAVLWLVVVIR-----------GPMPRWAEW
Mflv_0729|M.gilvum_PYR-GCK EVNHWLPGLYAAILGSYAVVAVVWLLAVSR-----------GPVPRWADW
MAB_0061|M.abscessus_ATCC_1997 NIQMWHNGVYYGVLAAYTLSAVVWVGIAVR-----------GQVADWVAP
Mb0868|M.bovis_AF2122/97 TSRSEWP-QQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPF
Rv0845|M.tuberculosis_H37Rv TSRSEWP-QQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPF
MMAR_4781|M.marinum_M TPRREWG-AQTALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPL
MUL_0350|M.ulcerans_Agy99 TPRREWG-AQTALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPL
MAV_0874|M.avium_104 TARSEWP-QESVLILLYGIIALGAVALAFAPFRRWIGIGRLAGVGRLEPF
TH_4203|M.thermoresistible__bu AARMITAATASDVCFVHVLDDTERSLTLAG-----------ATPPFDKEV
Mvan_1357|M.vanbaalenii_PYR-1 AARMITAATDSDVCFVHVLDDTERSLTLAG-----------ATPPFDSEV
: :
MSMEG_0106|M.smegmatis_MC2_155 ASTAVDGLVLLALCAVSGGATAALLPVFFLLPISVAFQDRPLLTAMLGTA
Mflv_0729|M.gilvum_PYR-GCK ASSAVDVLVIVSLCVVSGGATAALLPVFFLLPISVAFQDRPALTAIIGSV
MAB_0061|M.abscessus_ATCC_1997 AATSADIAAVVMLCLASGAGNTELLPVFFLLPVSVAFQERPAITAILGII
Mb0868|M.bovis_AF2122/97 AFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLDVSTRRAAVVLAC
Rv0845|M.tuberculosis_H37Rv AFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLDVSTRRAAVVLAC
MMAR_4781|M.marinum_M AFTAVDVLALTGFQLLSTDGIYSLL-IMTLLPVLVALDISSRRAAVVLAL
MUL_0350|M.ulcerans_Agy99 AFTAVDVLALTGFQLLSTDGIYSLL-IMTLLPVLVALDISSRRAAVVLAL
MAV_0874|M.avium_104 AFTVVDILALTIFQLLSTNGIYPLL-IMAMLPVLLGLDVSSRRAAVVLIF
TH_4203|M.thermoresistible__bu GKIRLPLGQGISGWVASHREPVVITENKEADPRYLPFQSLRGRDFTSMVS
Mvan_1357|M.vanbaalenii_PYR-1 GKIRLPLGQGISGWVASNREPVVIRRDKESDPRYLPFRSLRGRDFTSMVS
. * : * : :
MSMEG_0106|M.smegmatis_MC2_155 TATGYLGAWIFYSKRDDTVGLPNVVYMQVGFLLWLAVATTALSLVLVRRS
Mflv_0729|M.gilvum_PYR-GCK TAVAYLTVWVFYSRRDDEVGLPNMVYTQFGFLVWMAVATTALSFVLAHRA
MAB_0061|M.abscessus_ATCC_1997 TAVAYFGILVYYIADGNLERIPGDEYVTWAALLWLTVFTTGMCFVLKRRS
Mb0868|M.bovis_AF2122/97 TLVGFAVAVLGDPVMLRAIGWPETIFR-FALYAFLCATALMVVRIEERHT
Rv0845|M.tuberculosis_H37Rv TLVGFAVAVLGDPVMLRAIGWPETIFR-FALYAFLCATALMVVRIEERHT
MMAR_4781|M.marinum_M TLVGFALALAQDPVVIRMNGWPEAIFR-FGLYAFLCATALMVVRSEERHA
MUL_0350|M.ulcerans_Agy99 TLVGFGLALAQDPVVIRMNGWPEAIFR-FGLYAFLCATALMVVRSEERHA
MAV_0874|M.avium_104 SMLGFAIAVLQDPVMSSSVRLPEAGFR-FLLYGFLCCAAFLVVRIEERHT
TH_4203|M.thermoresistible__bu VPMETDPGGLVGVLNVHTVERREFTRRDVDLLLVIGRLIAGGLH-QARLH
Mvan_1357|M.vanbaalenii_PYR-1 VPMETDPGGLVGVLNVHTVAERDFGDRDVGLLLVIGRLIAGAMH-QARLH
: :
MSMEG_0106|M.smegmatis_MC2_155 ARVRALLDVRRRLVQESARADELRDAELAEALHDGPLQTLLAARLELDEL
Mflv_0729|M.gilvum_PYR-GCK VRLRNLQEVRVQLVSEAMQSDERHNREVAESLHDGPLQTLLAARLELDEA
MAB_0061|M.abscessus_ATCC_1997 ARVVQLVHIREQLVLESMRADERRNREVAERLHDGPLQNLLAARLRIEEV
Mb0868|M.bovis_AF2122/97 RSVAGLSALREELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIEL
Rv0845|M.tuberculosis_H37Rv RSVAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIEL
MMAR_4781|M.marinum_M RSVATLSVIREELLAQTMTASEVLQRRISESIHDGPLQDVLAARQELIEL
MUL_0350|M.ulcerans_Agy99 RSVATLSVIREELLAQTMTASEVLQRRISESIHDGPLQDVLAARQELIEL
MAV_0874|M.avium_104 RSVAGLSALREELLAQTMNASDVSQRRISEFIHDGPLQDILAVRQELVEL
TH_4203|M.thermoresistible__bu RQLVARERAHEIFVEQVIEAQELERRRLAADIHDGISQRLVTLSYRLDAA
Mvan_1357|M.vanbaalenii_PYR-1 RQLVARERAHEHFVEQVIEAQELERRRLAGDIHDGISQRLVTLSYRLDAA
: : :: : :.: .:: :*** * ::: .:
MSMEG_0106|M.smegmatis_MC2_155 RERNP--------DPALDVVHAALQQTATGLRSTVTALHPQVLAQLGLAP
Mflv_0729|M.gilvum_PYR-GCK RERNP--------DPALDAVYAALQETADGLRATVTELHPQVLAQLGLTA
MAB_0061|M.abscessus_ATCC_1997 LERQS--------DPVLTAVHSSLRETAAELRGAVSSLHPQVLIELGLTA
Mb0868|M.bovis_AF2122/97 DAVTPG-------DERVGRALAGLQSASERLRQATFELHPAVLEQVGLGP
Rv0845|M.tuberculosis_H37Rv DAVTPG-------DERVGRALAGLQSASERLRQATFELHPAVLEQVGLGP
MMAR_4781|M.marinum_M RAAAPH-------DQRVSTALAGLQSASDLLRQATFELHPAVLEQVGLGA
MUL_0350|M.ulcerans_Agy99 RAAAPH-------DQRVSTALAGLQSASDLLRQATFELHPAVLEQVGLGA
MAV_0874|M.avium_104 DAAVPD-------DERIGRALAGLQLASERLRQATFELHPAVLEQVGLGA
TH_4203|M.thermoresistible__bu IRAVD---DPATVTEQLSKARELADLTLEETRAAISGLRPPVLDDLGLSG
Mvan_1357|M.vanbaalenii_PYR-1 AQAATSPGDPDALHEQLDRARELAELTLQEARAAISGLRPPVLDDLGLSG
: . : * : *:* ** ::**
MSMEG_0106|M.smegmatis_MC2_155 AVRELLRQYENRG-DLVIRANIADVGQPE-AQALLYRAARELLANVHKHA
Mflv_0729|M.gilvum_PYR-GCK GIRELLRQLQSRH-LLEVDAELEEVGEPQ-SQALLYRAARELLTNIVKHA
MAB_0061|M.abscessus_ATCC_1997 AIRELARQHTARG-IVDVSTAVEEVGSPP-AQPLVYRAAKELLTNAVKHG
Mb0868|M.bovis_AF2122/97 AVKQLAASTAQRS-GIKISTDIDYPIRSG-IDPIVFGVVRELLSNVVRHS
Rv0845|M.tuberculosis_H37Rv AVKQLAASTAQRS-GIKISTDIDYPIRSG-IDPIVFGVVRELLSNVVRHS
MMAR_4781|M.marinum_M AVEQLASFHAQRS-GIRITDDVDYPIRDE-IDPIVFGVARELLSNVVQHS
MUL_0350|M.ulcerans_Agy99 AVEQLASFHAQRS-GIRITDDVDYPIRDE-IDPIVFGVARELLSNVVQHS
MAV_0874|M.avium_104 AVQQLAEFTAQRS-GIEISTDIDYSGRSA-IDAVVFGVVRELLSNVVQHS
TH_4203|M.thermoresistible__bu GLASLAQSVGQLDIGVDIEVDLAETRLPDHIELALYRIAQECLQNVVKHA
Mvan_1357|M.vanbaalenii_PYR-1 GLASLARTIPQ----VTIDVDLVDTRLPDHIELALYRIAQECLQNVVKHA
.: .* : : : : :: .:* * * :*.
MSMEG_0106|M.smegmatis_MC2_155 RAATVTVRLFR----QGERTVLTVVDDGVGFDPDIVAQS-VAEGHIGLAS
Mflv_0729|M.gilvum_PYR-GCK DATTVRVRLAR----RGDRVVLSVADDGAGFDPAILGTS-LGQGHIGLGS
MAB_0061|M.abscessus_ATCC_1997 RAKNIRVELSS----RRCWLTLVVTDDGRGFDPRDLVLS-VADGHIGLAS
Mb0868|M.bovis_AF2122/97 GATTASVRLGI----TDEKCVLDVADDGVGVTGDTMARR-LGEGHIGLAS
Rv0845|M.tuberculosis_H37Rv GATTASVRLGI----TDEKCVLDVADDGVGVTGDTMARR-LGEGHIGLAS
MMAR_4781|M.marinum_M RARNASVALGI----SDGVCVLDVADDGVGVSGETMARR-LGQGHIGLAS
MUL_0350|M.ulcerans_Agy99 RARNASVALGI----SDGVCVLDVADDGVGVSGETMARR-LGQGHIGLAS
MAV_0874|M.avium_104 RARTAAIMLGR----TDGTCVLHVVDDGVGFNQETVARR-LGEGHIGLAS
TH_4203|M.thermoresistible__bu RARTARLTYAVDRGEHGEVARLEIVDDGVGFDTFEHPLGGDDMSGYGLLS
Mvan_1357|M.vanbaalenii_PYR-1 RASRARLTFALDRGDHGDLARLEIADDGIGFDTLEHPLGGDEMGGYGLLS
* : * :.*** *. . ** *
MSMEG_0106|M.smegmatis_MC2_155 LQVRIEAMGGAMTISSEEGFGTQVTVIL-------
Mflv_0729|M.gilvum_PYR-GCK LIARFDAMGGSMRITSSDGQGTEVTATSPPEPA--
MAB_0061|M.abscessus_ATCC_1997 LTVPIEAAGGAVTITSAPGAGTRVSVTAPADMAA-
Mb0868|M.bovis_AF2122/97 HRARVDAAGGVLVFLATP-RGTHVCVELPLKR---
Rv0845|M.tuberculosis_H37Rv HRARVDAAGGVLVFLATP-RGTHVCVELPLKR---
MMAR_4781|M.marinum_M HRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG---
MUL_0350|M.ulcerans_Agy99 HRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG---
MAV_0874|M.avium_104 HRARVEAAGGELVFLDVP-VGTHVCVEVPLRN---
TH_4203|M.thermoresistible__bu MAERAEIVGGRLNIRSRPGAGTAVIATIPLPPATR
Mvan_1357|M.vanbaalenii_PYR-1 MAERAEIVGGRLNIRSRPGAGTTVTATIPLPANRE
: ** : : ** * .