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AMKSHQSTSAALLGAGSIGVSFAILFATRGFPVAVFDPDPTAHPRAGADLARRLDQLQAFGQLDEDPDLI IERIRFTTSLPDTVTGAGFVQECAPERAEIKVPLLRDAASLTDGSVPLASSSSAIVPSTLSADLPADVAR RVLVGHPGNPPYLLPVIEVVPGPATAPAIVETTMSVYRTAGLRPVPVRREVEGFVFNRLQGALLREAYCL LRDGVATVDDIDEVVRSGLGRRWAFMGPFETSDLNTRGGLASHAEKMGPAYERMGAERGQHDPWTPGLVA EATAQRRKLLDLDDWDARVLWRDEQLLRLRALFD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3005 | - | - | 100% (315) | 3-hydroxyacyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6791 | - | 3e-22 | 30.25% (238) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4115 | - | 8e-21 | 30.08% (246) | 3-hydroxybutyryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1742 | fadB3a | 1e-15 | 31.19% (202) | 3-hydroxybutyrul-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0106 | - | 1e-13 | 29.36% (235) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv1715 | fadB3 | 1e-24 | 33.06% (242) | 3-hydroxybutyryl-CoA dehydrogenase FADB3 |
| M. leprae Br4923 | MLBr_02461 | fadB2 | 4e-13 | 29.32% (249) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0761c | - | 5e-38 | 39.05% (274) | putative 3-hydroxyacyl-CoA dehydrogenase |
| M. marinum M | MMAR_1322 | fadB3 | 2e-17 | 28.10% (242) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. avium 104 | MAV_4681 | - | 2e-12 | 29.32% (249) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3443 | - | 6e-12 | 30.56% (216) | PUTATIVE 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
| M. ulcerans Agy99 | MUL_2558 | fadB3 | 1e-17 | 28.10% (242) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. vanbaalenii PYR-1 | Mvan_0802 | - | 8e-15 | 33.89% (239) | 3-hydroxybutyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02461|M.leprae_Br4923 ----------MSDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFETTDT
MAV_4681|M.avium_104 MHDKTIGGETVSDAAIQRVGVVGAGQMGSGIAEVSVRADVDVTVFETTEA
TH_3443|M.thermoresistible__bu ------------------------------LRWWHARERCPX-VYDISEE
Mflv_0106|M.gilvum_PYR-GCK -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSDA
Mvan_0802|M.vanbaalenii_PYR-1 -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSEA
MMAR_1322|M.marinum_M --MTGAYTYTFADIRSRPVAVIGAGTLGRRIALMFASRGGTVRIYARRAE
MUL_2558|M.ulcerans_Agy99 --MTGAYTYTFADIRSRPVAVIGAGTLGRRIALMFASRGGTVRIYARRAE
Mb1742|M.bovis_AF2122/97 ---------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAE
Rv1715|M.tuberculosis_H37Rv ---------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAE
MSMEG_3005|M.smegmatis_MC2_155 --------MAMKSHQSTSAALLGAGSIGVSFAILFATRGFPVAVFDPDPT
MAB_0761c|M.abscessus_ATCC_199 -----------MSDQQKTMAVVGAGVIGLSWARLARSHGWRVGITDP---
:
MLBr_02461|M.leprae_Br4923 LVTAGRNRIVKSLERGVSAGKVTERERDSALGHLVFTTDLNDLAD-RQLV
MAV_4681|M.avium_104 LITAGRNRIVKSLERGVSAGKVTERERDRALSKLTFTTDLKDLAD-RQLV
TH_3443|M.thermoresistible__bu LTTAGRERIAKSLTRGVQAGKLSEDERSAALDRLRFTTTLADLSD-RQLV
Mflv_0106|M.gilvum_PYR-GCK LVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLAD-RQLV
Mvan_0802|M.vanbaalenii_PYR-1 LVAAGRDRITASLERAKAKGKLAADDFDATVARLTFTTNLGDLAD-RQLV
MMAR_1322|M.marinum_M QRAQATQYVADNLP------KLLQDRGFGEVGSVTATDCLATALEGAWLA
MUL_2558|M.ulcerans_Agy99 QRAQATQYVADNLP------KLLQDRGFGEVGSVTATDCLATALEGAWLA
Mb1742|M.bovis_AF2122/97 ILHAAAVEAARVAG--------------AGRGSVAAAADLAAAIPDADLV
Rv1715|M.tuberculosis_H37Rv ILHAAAVEAARVAG--------------AGRGSVAAAADLAAAIPDADLV
MSMEG_3005|M.smegmatis_MC2_155 AHPRAGADLARRLDQ-LQAFGQLDEDPDLIIERIRFTTSLPDTVTGAGFV
MAB_0761c|M.abscessus_ATCC_199 ---RDDLDAVVR-----AAFGADDSD-------VFTSHTLADVVAEADLV
. : : * :.
MLBr_02461|M.leprae_Br4923 IEAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATKNP--
MAV_4681|M.avium_104 IEAIIEDDAVKAQVFAELDRVVTDPDAVLASNTSSIPIMKLAAATKNP--
TH_3443|M.thermoresistible__bu IEAIVEDENVKATVFAELDELLTDPDAVLASNTSSIPIMKLAAATKNP--
Mflv_0106|M.gilvum_PYR-GCK IEAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATKNP--
Mvan_0802|M.vanbaalenii_PYR-1 IEAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATKNP--
MMAR_1322|M.marinum_M VESVPEKLEIKTALWGQIDQAAP-PDTIFATNSSSFPSRLMADNVRDK--
MUL_2558|M.ulcerans_Agy99 VESVPEKLEIKTALWGQIDQAAP-PDTIFATNSSSFPSRLMADNVRDK--
Mb1742|M.bovis_AF2122/97 IEAVVENLAVKQELFERLATLAP--DAVLATNTSVLPIGAVTERVEDG--
Rv1715|M.tuberculosis_H37Rv IEAVVENLAVKQELFERLATLAP--DAVLATNTSVLPIGAVTERVEDG--
MSMEG_3005|M.smegmatis_MC2_155 QECAPERAEIKVPLLRDAASLTD-GSVPLASSSSAIVPSTLSADLPADVA
MAB_0761c|M.abscessus_ATCC_199 QENGPERLAVKRELFGQFLESAP-EHAVLATSSSSIGATLIADGLGAG--
* * :* : . :*:.:* : ::
MLBr_02461|M.leprae_Br4923 QRVLGLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVRCS
MAV_4681|M.avium_104 QRVLGLHFFNPVPVLPLVELVSTLVTDEAAAARTEEFASAVLGKQVVRCS
TH_3443|M.thermoresistible__bu GRVLGLHFFNPVPVLPLVELINTLVTTDEAIARTEKFAAEVLGKQVVRCG
Mflv_0106|M.gilvum_PYR-GCK SRVLGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVVRCG
Mvan_0802|M.vanbaalenii_PYR-1 SRVLGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVRCG
MMAR_1322|M.marinum_M TRLCNTHFYMP-PQFNALDLMSDGETDRGLLDTLLTVLPEFGVHPFEARR
MUL_2558|M.ulcerans_Agy99 TRLCNTHFYMP-PQFNALDLMSDGETDRGLLDTLLTVLPEFGVHPFEARR
Mb1742|M.bovis_AF2122/97 SRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGR
Rv1715|M.tuberculosis_H37Rv SRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGR
MSMEG_3005|M.smegmatis_MC2_155 RRVLVGHPGNPPYLLPVIEVVPGPATAPAIVETTMSVYRTAGLRPVPVRR
MAB_0761c|M.abscessus_ATCC_199 DRVIVGHPFNPPELMPLVEVVPGTQTSDSTLNAAVDLYRKLGRAPIVIRK
*: * * : :::: * . .
MLBr_02461|M.leprae_Br4923 DRSGFVVNALLVPYLLSAIRIVEAGFATVEDVDKAVLAGLSHPMG---PL
MAV_4681|M.avium_104 DRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMG---PL
TH_3443|M.thermoresistible__bu DRSGFVVNALLVPYLLSAIRMVESGYASVEDVDKAVVAGLSHPMG---PL
Mflv_0106|M.gilvum_PYR-GCK DRSGFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMG---PL
Mvan_0802|M.vanbaalenii_PYR-1 DRSGFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMG---PL
MMAR_1322|M.marinum_M ECTGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNWRVPAG---PF
MUL_2558|M.ulcerans_Agy99 ECTGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNWRVPAG---PF
Mb1742|M.bovis_AF2122/97 DVPGFIGNRLQHAL------------------------------------
Rv1715|M.tuberculosis_H37Rv DVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPL
MSMEG_3005|M.smegmatis_MC2_155 EVEGFVFNRLQGALLREAYCLLRDGVATVDDIDEVVRSGLGRRWAFMGPF
MAB_0761c|M.abscessus_ATCC_199 EIPGFVANRLQVALTREAQYLVEEGVVSVTDLDTALQNSLGLRWAATGLF
: **: * : .
MLBr_02461|M.leprae_Br4923 RLSDLV-GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGLLGKKSGQG
MAV_4681|M.avium_104 RLSDLV-GLDTLKLIADKMFEEFKEPQYGAPPLLLRMVEAGRLGKKTGQG
TH_3443|M.thermoresistible__bu RLSDLV-GLDTLKLIADKMFDEFKEPHYGPPPLLVRMVEAGHLGKKTGRG
Mflv_0106|M.gilvum_PYR-GCK RLSDLI-GLDTMKLIADSMYDEYKDPNFAPPPLLQRMVEAGQLGKKSGKG
Mvan_0802|M.vanbaalenii_PYR-1 RLSDLI-GLDTMKLIADSMYDEYKDPHYAPPPLLQRMVEAGQLGKKSGKG
MMAR_1322|M.marinum_M QLMDQV-GLDVVLDIENHYADEFPYLPTNVRDLLRSYVDAGKLGVKTGEG
MUL_2558|M.ulcerans_Agy99 QLMDQV-GLDVVLDIENHYADEFPYLPTNVRDLLRSYVDAGKLGVKTGEG
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv ENADYI-GLDLTLAIHDAVIPSLNHDPH-PSPLLRELVAAGQLGARTGHG
MSMEG_3005|M.smegmatis_MC2_155 ETSDLN-TRGGLASHAEKMGPAYERMGAERGQHDPWTPGLVAEATAQRR-
MAB_0761c|M.abscessus_ATCC_199 EGNTLGGGPEGARHLYEGLGAEVGKITMGTPSSDPRVIEKLIEDIDTAYG
MLBr_02461|M.leprae_Br4923 FYTY-----------------------------
MAV_4681|M.avium_104 FYTY-----------------------------
TH_3443|M.thermoresistible__bu FYTY-----------------------------
Mflv_0106|M.gilvum_PYR-GCK FYSY-----------------------------
Mvan_0802|M.vanbaalenii_PYR-1 FYTY-----------------------------
MMAR_1322|M.marinum_M FYTYPNSSDT-----------------------
MUL_2558|M.ulcerans_Agy99 FYTYPNSSDT-----------------------
Mb1742|M.bovis_AF2122/97 ---------------------------------
Rv1715|M.tuberculosis_H37Rv FLDWPAGAREATTARLAQHIAAQLQANEKGRGT
MSMEG_3005|M.smegmatis_MC2_155 -KLLDLDDWDARVLWRDEQLLRLRALFD-----
MAB_0761c|M.abscessus_ATCC_199 TGPENYERLLARRNERTRAVLAALRQLDA----