For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRKINTVTVVGAGYMGGGIAQVLALNGFKVQIADVNAEATQEALKRLDREAREFEQQGLFGPGSADTIMS NLTASDSLDDAVSDVDYVMEAVFEDVDVKKEVLARVCASARPDTIIGTNTSTIPVKVLVDAVTHPERFLT VHFSNPAPFIPGVELVAGEATTQEVIDSVKDLLARAGREGAQVADTPGMALNRLQYALLKEATLIVEEGV ATKEDVDTIVRTTFGFRLGFFGPFAIADQAGLDVYVKGYHTLENAFGERMATPKLLTDNVDAGRYGTKNG KGWTGDFDDETKAAVIAYRNKAYSRMGELLRELGPAPKGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6791 | - | - | 100% (320) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4115 | - | 5e-35 | 33.57% (286) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0912 | - | 3e-33 | 33.92% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0477 | fadB2 | 3e-30 | 33.22% (289) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0106 | - | 3e-32 | 31.45% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv1715 | fadB3 | 5e-38 | 37.32% (276) | 3-hydroxybutyryl-CoA dehydrogenase FADB3 |
| M. leprae Br4923 | MLBr_02461 | fadB2 | 6e-30 | 31.45% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4489c | - | 6e-42 | 34.07% (317) | 3-hydroxyacyl-CoA dehydrogenase family protein |
| M. marinum M | MMAR_0793 | fadB2 | 2e-30 | 32.63% (285) | 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
| M. avium 104 | MAV_4681 | - | 6e-30 | 32.51% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2033 | fadB | 1e-26 | 33.33% (204) | PROBABLE FATTY OXIDATION PROTEIN FADB |
| M. ulcerans Agy99 | MUL_4537 | fadB2 | 8e-30 | 32.63% (285) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0802 | - | 4e-32 | 32.51% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu MAENTIKWDKDADGIVTLTLDDPTGSANVMNEHYQESMRKAVDRLEAEKD
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu SITGVVITSAKKTFFAGGDLNGMMTIGPDDAQQAFDMVEAVKRDLRRLET
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu LGVPVVAAINGAALGGGLEIALACHRRIAADVKGSVIGLPEVTLGLLPGG
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu GGVTRTVRMFGIQKAFMEILSQGTRFRPAKAKEVGLVDELVDSVDELVPR
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu AKAWIKENPDAHTQPWDAKGYKMPGGTPSSPGLASILPSFPALLKKQLKG
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu APMPAPRAILNAAVEGAQVDFDSASRIESRYFTQLVTGQTAKNMIQAFFF
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M ---------MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTVFE
MUL_4537|M.ulcerans_Agy99 ---------MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTAFE
MAV_4681|M.avium_104 ----MHDKTIGGETVSDAAIQRVGVVGAGQMGSGIAEVSVRADVDVTVFE
MLBr_02461|M.leprae_Br4923 --------------MSDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFE
Mb0477|M.bovis_AF2122/97 ---------------MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFE
Mflv_0106|M.gilvum_PYR-GCK -----------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYE
Mvan_0802|M.vanbaalenii_PYR-1 -----------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYE
TH_2033|M.thermoresistible__bu DLQTINSGGSRPQGIEKTLPKKVGVLGAGMMGAGIAYVTAKAGFEVVLKD
Rv1715|M.tuberculosis_H37Rv -------------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITD
MAB_4489c|M.abscessus_ATCC_199 ---------------MTNDIRPVCVVGGGRMGAGISQVFALAGFTVFVYE
MSMEG_6791|M.smegmatis_MC2_155 ----------------MRKINTVTVVGAGYMGGGIAQVLALNGFKVQIAD
. *:*.* ** *: * . . * :
MMAR_0793|M.marinum_M TTEALITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLA-D
MUL_4537|M.ulcerans_Agy99 TTEALITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLA-D
MAV_4681|M.avium_104 TTEALITAGRNRIVKSLERGVSAGKVTERERDRALSKLTFTTDLKDLA-D
MLBr_02461|M.leprae_Br4923 TTDTLVTAGRNRIVKSLERGVSAGKVTERERDSALGHLVFTTDLNDLA-D
Mb0477|M.bovis_AF2122/97 PAEALITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLS-D
Mflv_0106|M.gilvum_PYR-GCK PSDALVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLA-D
Mvan_0802|M.vanbaalenii_PYR-1 PSEALVAAGRDRITASLERAKAKGKLAADDFDATVARLTFTTNLGDLA-D
TH_2033|M.thermoresistible__bu VTLEAAQKGKGYSEKLEAKALERGRTTPEKSKALLDRIKPTADVADFK-G
Rv1715|M.tuberculosis_H37Rv TNAEILHAAAVEAARVAGAGR--------GSVAAAA------DLAAAIPD
MAB_4489c|M.abscessus_ATCC_199 VNEQVRTSVVDRVRESLACAE--------LDVAVADRIIITDDLSAAVAD
MSMEG_6791|M.smegmatis_MC2_155 VNAEATQEALKRLDREAREFEQQGLFGPGSADTIMSNLTASDSLDDAVSD
.: .
MMAR_0793|M.marinum_M RQLVIEAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATK
MUL_4537|M.ulcerans_Agy99 RQLVIEAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATK
MAV_4681|M.avium_104 RQLVIEAIIEDDAVKAQVFAELDRVVTDPDAVLASNTSSIPIMKLAAATK
MLBr_02461|M.leprae_Br4923 RQLVIEAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATK
Mb0477|M.bovis_AF2122/97 RQLVIEAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATK
Mflv_0106|M.gilvum_PYR-GCK RQLVIEAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATK
Mvan_0802|M.vanbaalenii_PYR-1 RQLVIEAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATK
TH_2033|M.thermoresistible__bu VDFVIEAVFENTELKHKVFAEIEDIV-DPKAILGSNTSTLPITGLAAGVK
Rv1715|M.tuberculosis_H37Rv ADLVIEAVVENLAVKQELFERL-ATLAP-DAVLATNTSVLPIGAVTERVE
MAB_4489c|M.abscessus_ATCC_199 ACFVTEAVGEKLELKREVLAGI-AAAAPHDAILASNTSVIPISEIAAGSP
MSMEG_6791|M.smegmatis_MC2_155 VDYVMEAVFEDVDVKKEVLARV-CASARPDTIIGTNTSTIPVKVLVDAVT
* **: *. :* ::: : .:::.:*** :*: :.
MMAR_0793|M.marinum_M NPRRVLGLHFFNPVPVLPLVELVSTLVTDEAAVARTEEFASAVLGKQVVR
MUL_4537|M.ulcerans_Agy99 NPRRVLGLHFFNPVPVLPLVELVNTLVTDEAAVARTEEFASAVLGKQVVR
MAV_4681|M.avium_104 NPQRVLGLHFFNPVPVLPLVELVSTLVTDEAAAARTEEFASAVLGKQVVR
MLBr_02461|M.leprae_Br4923 NPQRVLGLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVR
Mb0477|M.bovis_AF2122/97 QPQRVLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVR
Mflv_0106|M.gilvum_PYR-GCK NPSRVLGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVVR
Mvan_0802|M.vanbaalenii_PYR-1 NPSRVLGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVR
TH_2033|M.thermoresistible__bu RQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTPIV
Rv1715|M.tuberculosis_H37Rv DGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRV
MAB_4489c|M.abscessus_ATCC_199 AIDRIVGTHWWNPAPLIPLVEVVQATGTSVETVSRTMKLLAAIGKKPMHV
MSMEG_6791|M.smegmatis_MC2_155 HPERFLTVHFSNPAPFIPGVELVAGEATTQEVIDSVKDLLARAGREGAQV
.: *: .* :* **:: * . .
MMAR_0793|M.marinum_M CSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGL---SHPMG
MUL_4537|M.ulcerans_Agy99 CSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGL---SHPMG
MAV_4681|M.avium_104 CSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGL---SHPMG
MLBr_02461|M.leprae_Br4923 CSDRSGFVVNALLVPYLLSAIRIVEAGFATVEDVDKAVLAGL---SHPMG
Mb0477|M.bovis_AF2122/97 CSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGL---SHPMG
Mflv_0106|M.gilvum_PYR-GCK CGDRSGFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGL---SHPMG
Mvan_0802|M.vanbaalenii_PYR-1 CGDRSGFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGL---SHPMG
TH_2033|M.thermoresistible__bu VNDSRGFYTSRVIGTFVNEALAMLGEGVEPASIEQAGGQAG-----YPAP
Rv1715|M.tuberculosis_H37Rv GRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLG
MAB_4489c|M.abscessus_ATCC_199 RKEVPGFVGNRLQHALWREAIALVQEGVCDATTVDDVVKNSFGLRLAVLG
MSMEG_6791|M.smegmatis_MC2_155 -ADTPGMALNRLQYALLKEATLIVEEGVATKEDVDTIVRTTFGFRLGFFG
: *: . : . .* : *. :
MMAR_0793|M.marinum_M PLRLSDLVGLDTLKLIADKMFEEFKEP-----HYGPPPLLLRMVEAGQLG
MUL_4537|M.ulcerans_Agy99 PLRLSDLVGLDTLKLIADKMFEEFKEP-----HYGPPPLLLRMVEAGQLG
MAV_4681|M.avium_104 PLRLSDLVGLDTLKLIADKMFEEFKEP-----QYGAPPLLLRMVEAGRLG
MLBr_02461|M.leprae_Br4923 PLRLSDLVGLDTLKLIADKMFEEFKEP-----HYGPPPLLLRMVEAGLLG
Mb0477|M.bovis_AF2122/97 PLRLSDLVGLDTLKLIADKMFEEFKEP-----HYGPPPLLLRMVEAGQLG
Mflv_0106|M.gilvum_PYR-GCK PLRLSDLIGLDTMKLIADSMYDEYKDP-----NFAPPPLLQRMVEAGQLG
Mvan_0802|M.vanbaalenii_PYR-1 PLRLSDLIGLDTMKLIADSMYDEYKDP-----HYAPPPLLQRMVEAGQLG
TH_2033|M.thermoresistible__bu PLQLSDELNLELMQKIATETRKGVEAAGGTYEPHPAEAVVNTMIELGRPG
Rv1715|M.tuberculosis_H37Rv PLENADYIGLDLTLAIHDAVIPSLNHD------PHPSPLLRELVAAGQLG
MAB_4489c|M.abscessus_ATCC_199 PLENADLVGLDLTLDIHRVVVPALDCQ------GGPNPVLVDKVARGMLG
MSMEG_6791|M.smegmatis_MC2_155 PFAIADQAGLDVYVKGYHTLENAFGER------MATPKLLTDNVDAGRYG
*: :* .*: . :: : * *
MMAR_0793|M.marinum_M KKSGQGFYTY----------------------------------------
MUL_4537|M.ulcerans_Agy99 KKSGQGFYTY----------------------------------------
MAV_4681|M.avium_104 KKTGQGFYTY----------------------------------------
MLBr_02461|M.leprae_Br4923 KKSGQGFYTY----------------------------------------
Mb0477|M.bovis_AF2122/97 KKSGRGFYTY----------------------------------------
Mflv_0106|M.gilvum_PYR-GCK KKSGKGFYSY----------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 KKSGKGFYTY----------------------------------------
TH_2033|M.thermoresistible__bu RAKGAGFYEYADGKRAGLWPGLREAFKSGSSTPPLQDMIDRMLFAEALET
Rv1715|M.tuberculosis_H37Rv ARTGHGFL----DWPAGAREATTARLAQHIAAQLQANEKGRGT-------
MAB_4489c|M.abscessus_ATCC_199 CKTGEGFR----RWSPADIAEMNNRLEGHLVRLLHPRNTGPVG-------
MSMEG_6791|M.smegmatis_MC2_155 TKNGKGWTGDFDDETKAAVIAYRNKAYSRMGELLRELGPAPKGA------
.* *:
MMAR_0793|M.marinum_M --------------------------------------------------
MUL_4537|M.ulcerans_Agy99 --------------------------------------------------
MAV_4681|M.avium_104 --------------------------------------------------
MLBr_02461|M.leprae_Br4923 --------------------------------------------------
Mb0477|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2033|M.thermoresistible__bu QKCLDEGVITSTADANIGSIMGIGFPPWTGGTAQFIVGYQGELGTGKEAF
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0793|M.marinum_M ----------------------
MUL_4537|M.ulcerans_Agy99 ----------------------
MAV_4681|M.avium_104 ----------------------
MLBr_02461|M.leprae_Br4923 ----------------------
Mb0477|M.bovis_AF2122/97 ----------------------
Mflv_0106|M.gilvum_PYR-GCK ----------------------
Mvan_0802|M.vanbaalenii_PYR-1 ----------------------
TH_2033|M.thermoresistible__bu VARAKQLAERYGDRFNPPESLL
Rv1715|M.tuberculosis_H37Rv ----------------------
MAB_4489c|M.abscessus_ATCC_199 ----------------------
MSMEG_6791|M.smegmatis_MC2_155 ----------------------