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M. leprae Br4923 MLBr_02461 (fadB2)

annotation: 3-hydroxybutyryl-CoA dehydrogenase
coordinates: 2933984 - 2934847
length: 287

SDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFETTDTLVTAGRNRIVKSLERGVSAGKVTERERDSAL
GHLVFTTDLNDLADRQLVIEAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATKNPQRVL
GLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVRCSDRSGFVVNALLVPYLLSAIRIVEA
GFATVEDVDKAVLAGLSHPMGPLRLSDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGLLGKKSG
QGFYTY*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. leprae Br4923 MLBr_02461 fadB2 - 100% (287) 3-hydroxybutyryl-CoA dehydrogenase
M. leprae Br4923 MLBr_02161 fadB 1e-36 31.16% (292) putative fatty oxidation complex alpha subunit

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0477 fadB2 1e-142 89.90% (287) 3-hydroxybutyryl-CoA dehydrogenase
M. gilvum PYR-GCK Mflv_0106 - 1e-119 74.91% (283) 3-hydroxybutyryl-CoA dehydrogenase
M. tuberculosis H37Rv Rv0468 fadB2 1e-142 89.90% (287) 3-hydroxybutyryl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_4094c - 1e-125 79.43% (282) 3-hydroxybutyryl-CoA dehydrogenase
M. marinum M MMAR_0793 fadB2 1e-147 92.31% (286) 3-hydroxybutyryl-CoA dehydrogenase FadB2
M. avium 104 MAV_4681 - 1e-144 90.94% (287) 3-hydroxybutyryl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_0912 - 1e-131 83.39% (283) 3-hydroxybutyryl-CoA dehydrogenase
M. thermoresistible (build 8) TH_3443 - 1e-112 79.53% (254) PUTATIVE 3-hydroxybutyryl-CoA dehydrogenase FadB2
M. ulcerans Agy99 MUL_4537 fadB2 1e-146 91.61% (286) 3-hydroxybutyryl-CoA dehydrogenase
M. vanbaalenii PYR-1 Mvan_0802 - 1e-120 75.97% (283) 3-hydroxybutyryl-CoA dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0477|M.bovis_AF2122/97            -----------MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEA
Rv0468|M.tuberculosis_H37Rv         -----------MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEA
MMAR_0793|M.marinum_M               -----MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTVFETTEA
MUL_4537|M.ulcerans_Agy99           -----MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTAFETTEA
MAV_4681|M.avium_104                MHDKTIGGETVSDAAIQRVGVVGAGQMGSGIAEVSVRADVDVTVFETTEA
MLBr_02461|M.leprae_Br4923          ----------MSDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFETTDT
MSMEG_0912|M.smegmatis_MC2_155      -----------MSNAIERVGVVGAGQMGSGIAEVSARAGVDVLVYDTTDA
MAB_4094c|M.abscessus_ATCC_199      -----------MTDGITRVGVIGAGQMGAGIAEVSARAGVDVLVFETTEA
TH_3443|M.thermoresistible__bu      ------------------------------LRWWHARERCPX-VYDISEE
Mflv_0106|M.gilvum_PYR-GCK          -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSDA
Mvan_0802|M.vanbaalenii_PYR-1       -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSEA
                                                                  :    .:      .:: :: 

Mb0477|M.bovis_AF2122/97            LITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVI
Rv0468|M.tuberculosis_H37Rv         LITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVI
MMAR_0793|M.marinum_M               LITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLADRQLVI
MUL_4537|M.ulcerans_Agy99           LITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLADRQLVI
MAV_4681|M.avium_104                LITAGRNRIVKSLERGVSAGKVTERERDRALSKLTFTTDLKDLADRQLVI
MLBr_02461|M.leprae_Br4923          LVTAGRNRIVKSLERGVSAGKVTERERDSALGHLVFTTDLNDLADRQLVI
MSMEG_0912|M.smegmatis_MC2_155      FVTAGRNRITKSLERAVSAGKVTEREKDEALGRLRFTTSLADMADRQLVI
MAB_4094c|M.abscessus_ATCC_199      LTTAGRDRITKSLDRGVSAGKITERERDAAVANLKFTTDLADFADRQLVI
TH_3443|M.thermoresistible__bu      LTTAGRERIAKSLTRGVQAGKLSEDERSAALDRLRFTTTLADLSDRQLVI
Mflv_0106|M.gilvum_PYR-GCK          LVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLADRQLVI
Mvan_0802|M.vanbaalenii_PYR-1       LVAAGRDRITASLERAKAKGKLAADDFDATVARLTFTTNLGDLADRQLVI
                                    :  ***:**. ** *.   **::  : . ::  * *** * *::******

Mb0477|M.bovis_AF2122/97            EAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRV
Rv0468|M.tuberculosis_H37Rv         EAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRV
MMAR_0793|M.marinum_M               EAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATKNPRRV
MUL_4537|M.ulcerans_Agy99           EAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATKNPRRV
MAV_4681|M.avium_104                EAIIEDDAVKAQVFAELDRVVTDPDAVLASNTSSIPIMKLAAATKNPQRV
MLBr_02461|M.leprae_Br4923          EAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATKNPQRV
MSMEG_0912|M.smegmatis_MC2_155      EAVIEDENIKGEIFAELDRVITDPDAVLASNTSSIPIMKIAASTENPERV
MAB_4094c|M.abscessus_ATCC_199      EAVIEDESIKSSIFAKLDEVITDPDAVLASNTSSIPIMKIAAATKNPGRV
TH_3443|M.thermoresistible__bu      EAIVEDENVKATVFAELDELLTDPDAVLASNTSSIPIMKLAAATKNPGRV
Mflv_0106|M.gilvum_PYR-GCK          EAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATKNPSRV
Mvan_0802|M.vanbaalenii_PYR-1       EAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATKNPSRV
                                    **::*:: :*  :**.** ::******************:**:*::* **

Mb0477|M.bovis_AF2122/97            LGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRS
Rv0468|M.tuberculosis_H37Rv         LGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRS
MMAR_0793|M.marinum_M               LGLHFFNPVPVLPLVELVSTLVTDEAAVARTEEFASAVLGKQVVRCSDRS
MUL_4537|M.ulcerans_Agy99           LGLHFFNPVPVLPLVELVNTLVTDEAAVARTEEFASAVLGKQVVRCSDRS
MAV_4681|M.avium_104                LGLHFFNPVPVLPLVELVSTLVTDEAAAARTEEFASAVLGKQVVRCSDRS
MLBr_02461|M.leprae_Br4923          LGLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVRCSDRS
MSMEG_0912|M.smegmatis_MC2_155      LGLHFFNPVPVLPLVELVSTLVTSEAAADRVEQFAGSVLGKQVVRCSDRS
MAB_4094c|M.abscessus_ATCC_199      LGLHFFNPVPVLPLVELISTLVTTPEAAARTEAFASEVLGKQVVRAADRS
TH_3443|M.thermoresistible__bu      LGLHFFNPVPVLPLVELINTLVTTDEAIARTEKFAAEVLGKQVVRCGDRS
Mflv_0106|M.gilvum_PYR-GCK          LGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVVRCGDRS
Mvan_0802|M.vanbaalenii_PYR-1       LGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVRCGDRS
                                    ****************:: ****   *  *.* **. ****:***..***

Mb0477|M.bovis_AF2122/97            GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
Rv0468|M.tuberculosis_H37Rv         GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MMAR_0793|M.marinum_M               GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MUL_4537|M.ulcerans_Agy99           GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MAV_4681|M.avium_104                GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MLBr_02461|M.leprae_Br4923          GFVVNALLVPYLLSAIRIVEAGFATVEDVDKAVLAGLSHPMGPLRLSDLV
MSMEG_0912|M.smegmatis_MC2_155      GFVVNFLLVPYLLSAIRMVEGGVATIEDVDKAVVAGLSHPMGPLRLSDLV
MAB_4094c|M.abscessus_ATCC_199      GFVVNFLLVPYLLAAIRMAESGFATVEDIDKAVVAGLSHPMGPLRLSDLV
TH_3443|M.thermoresistible__bu      GFVVNALLVPYLLSAIRMVESGYASVEDVDKAVVAGLSHPMGPLRLSDLV
Mflv_0106|M.gilvum_PYR-GCK          GFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPLRLSDLI
Mvan_0802|M.vanbaalenii_PYR-1       GFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPLRLSDLI
                                    **:** *******:***:.*.* *::**:*.**:***************:

Mb0477|M.bovis_AF2122/97            GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY---
Rv0468|M.tuberculosis_H37Rv         GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY---
MMAR_0793|M.marinum_M               GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGQGFYTY---
MUL_4537|M.ulcerans_Agy99           GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGQGFYTY---
MAV_4681|M.avium_104                GLDTLKLIADKMFEEFKEPQYGAPPLLLRMVEAGRLGKKTGQGFYTY---
MLBr_02461|M.leprae_Br4923          GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGLLGKKSGQGFYTY---
MSMEG_0912|M.smegmatis_MC2_155      GLDTLKLIADKMFDEFKEPLYAAPPLLLRMVEAGQLGKKTGKGFYTY---
MAB_4094c|M.abscessus_ATCC_199      GLDTLKLIADSMYDEYKEPLYAAPPLLLRMVEAGRLGKKSGVGFYEYKAK
TH_3443|M.thermoresistible__bu      GLDTLKLIADKMFDEFKEPHYGPPPLLVRMVEAGHLGKKTGRGFYTY---
Mflv_0106|M.gilvum_PYR-GCK          GLDTMKLIADSMYDEYKDPNFAPPPLLQRMVEAGQLGKKSGKGFYSY---
Mvan_0802|M.vanbaalenii_PYR-1       GLDTMKLIADSMYDEYKDPHYAPPPLLQRMVEAGQLGKKSGKGFYTY---
                                    ****:*****.*::*:*:* :..**** ****** ****:* *** *

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_02461	fadB2	-	100% (287)	3-hydroxybutyryl-CoA dehydrogenase
M. leprae Br4923	MLBr_02161	fadB	1e-36	31.16% (292)	putative fatty oxidation complex alpha subunit