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MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSEALVAAGRDRITASLERAKAKGKLAADDFDATVAR LTFTTNLGDLADRQLVIEAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATKNPSRVLGL HFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVRCGDRSGFVVNALLVPYLLSAIRMAEAGV ATVEDIDTAVVAGLSHPMGPLRLSDLIGLDTMKLIADSMYDEYKDPHYAPPPLLQRMVEAGQLGKKSGKG FYTY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0802 | - | - | 100% (284) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5066 | - | 2e-42 | 36.68% (289) | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding |
| M. vanbaalenii PYR-1 | Mvan_0915 | - | 8e-35 | 36.11% (288) | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0477 | fadB2 | 1e-123 | 77.03% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0106 | - | 1e-145 | 91.55% (284) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv0468 | fadB2 | 1e-123 | 77.03% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_02461 | fadB2 | 1e-120 | 75.97% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4094c | - | 1e-119 | 75.53% (282) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. marinum M | MMAR_0793 | fadB2 | 1e-123 | 77.39% (283) | 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
| M. avium 104 | MAV_4681 | - | 1e-119 | 75.27% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0912 | - | 1e-121 | 75.62% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3443 | - | 1e-110 | 77.56% (254) | PUTATIVE 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
| M. ulcerans Agy99 | MUL_4537 | fadB2 | 1e-124 | 77.39% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0793|M.marinum_M -----MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTVFETTEA
MUL_4537|M.ulcerans_Agy99 -----MG----SDAAIQRVGVVGAGQMGSGIAEVSVRAGVEVTAFETTEA
MAV_4681|M.avium_104 MHDKTIGGETVSDAAIQRVGVVGAGQMGSGIAEVSVRADVDVTVFETTEA
MLBr_02461|M.leprae_Br4923 ----------MSDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFETTDT
Mb0477|M.bovis_AF2122/97 -----------MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEA
Rv0468|M.tuberculosis_H37Rv -----------MSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEA
MSMEG_0912|M.smegmatis_MC2_155 -----------MSNAIERVGVVGAGQMGSGIAEVSARAGVDVLVYDTTDA
MAB_4094c|M.abscessus_ATCC_199 -----------MTDGITRVGVIGAGQMGAGIAEVSARAGVDVLVFETTEA
TH_3443|M.thermoresistible__bu ------------------------------LRWWHARERCPX-VYDISEE
Mvan_0802|M.vanbaalenii_PYR-1 -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSEA
Mflv_0106|M.gilvum_PYR-GCK -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSDA
: .: .:: ::
MMAR_0793|M.marinum_M LITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLADRQLVI
MUL_4537|M.ulcerans_Agy99 LITAGRNRIVKSLERGVSSGKVTERERDRALSRLTFTTDLNDLADRQLVI
MAV_4681|M.avium_104 LITAGRNRIVKSLERGVSAGKVTERERDRALSKLTFTTDLKDLADRQLVI
MLBr_02461|M.leprae_Br4923 LVTAGRNRIVKSLERGVSAGKVTERERDSALGHLVFTTDLNDLADRQLVI
Mb0477|M.bovis_AF2122/97 LITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVI
Rv0468|M.tuberculosis_H37Rv LITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLSDRQLVI
MSMEG_0912|M.smegmatis_MC2_155 FVTAGRNRITKSLERAVSAGKVTEREKDEALGRLRFTTSLADMADRQLVI
MAB_4094c|M.abscessus_ATCC_199 LTTAGRDRITKSLDRGVSAGKITERERDAAVANLKFTTDLADFADRQLVI
TH_3443|M.thermoresistible__bu LTTAGRERIAKSLTRGVQAGKLSEDERSAALDRLRFTTTLADLSDRQLVI
Mvan_0802|M.vanbaalenii_PYR-1 LVAAGRDRITASLERAKAKGKLAADDFDATVARLTFTTNLGDLADRQLVI
Mflv_0106|M.gilvum_PYR-GCK LVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLADRQLVI
: ***:**. ** *. **:: : . :: * *** * *::******
MMAR_0793|M.marinum_M EAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATKNPRRV
MUL_4537|M.ulcerans_Agy99 EAIIEDEAVKTKVFADLDRVVTDPDAVLASNTSSIPIMKVAAATKNPRRV
MAV_4681|M.avium_104 EAIIEDDAVKAQVFAELDRVVTDPDAVLASNTSSIPIMKLAAATKNPQRV
MLBr_02461|M.leprae_Br4923 EAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATKNPQRV
Mb0477|M.bovis_AF2122/97 EAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRV
Rv0468|M.tuberculosis_H37Rv EAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQRV
MSMEG_0912|M.smegmatis_MC2_155 EAVIEDENIKGEIFAELDRVITDPDAVLASNTSSIPIMKIAASTENPERV
MAB_4094c|M.abscessus_ATCC_199 EAVIEDESIKSSIFAKLDEVITDPDAVLASNTSSIPIMKIAAATKNPGRV
TH_3443|M.thermoresistible__bu EAIVEDENVKATVFAELDELLTDPDAVLASNTSSIPIMKLAAATKNPGRV
Mvan_0802|M.vanbaalenii_PYR-1 EAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATKNPSRV
Mflv_0106|M.gilvum_PYR-GCK EAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATKNPSRV
**::*:: :* :**.** ::******************:**:*::* **
MMAR_0793|M.marinum_M LGLHFFNPVPVLPLVELVSTLVTDEAAVARTEEFASAVLGKQVVRCSDRS
MUL_4537|M.ulcerans_Agy99 LGLHFFNPVPVLPLVELVNTLVTDEAAVARTEEFASAVLGKQVVRCSDRS
MAV_4681|M.avium_104 LGLHFFNPVPVLPLVELVSTLVTDEAAAARTEEFASAVLGKQVVRCSDRS
MLBr_02461|M.leprae_Br4923 LGLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVRCSDRS
Mb0477|M.bovis_AF2122/97 LGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRS
Rv0468|M.tuberculosis_H37Rv LGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDRS
MSMEG_0912|M.smegmatis_MC2_155 LGLHFFNPVPVLPLVELVSTLVTSEAAADRVEQFAGSVLGKQVVRCSDRS
MAB_4094c|M.abscessus_ATCC_199 LGLHFFNPVPVLPLVELISTLVTTPEAAARTEAFASEVLGKQVVRAADRS
TH_3443|M.thermoresistible__bu LGLHFFNPVPVLPLVELINTLVTTDEAIARTEKFAAEVLGKQVVRCGDRS
Mvan_0802|M.vanbaalenii_PYR-1 LGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVRCGDRS
Mflv_0106|M.gilvum_PYR-GCK LGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVVRCGDRS
****************:: **** * *.* **. ****:***..***
MMAR_0793|M.marinum_M GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MUL_4537|M.ulcerans_Agy99 GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MAV_4681|M.avium_104 GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MLBr_02461|M.leprae_Br4923 GFVVNALLVPYLLSAIRIVEAGFATVEDVDKAVLAGLSHPMGPLRLSDLV
Mb0477|M.bovis_AF2122/97 GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
Rv0468|M.tuberculosis_H37Rv GFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLV
MSMEG_0912|M.smegmatis_MC2_155 GFVVNFLLVPYLLSAIRMVEGGVATIEDVDKAVVAGLSHPMGPLRLSDLV
MAB_4094c|M.abscessus_ATCC_199 GFVVNFLLVPYLLAAIRMAESGFATVEDIDKAVVAGLSHPMGPLRLSDLV
TH_3443|M.thermoresistible__bu GFVVNALLVPYLLSAIRMVESGYASVEDVDKAVVAGLSHPMGPLRLSDLV
Mvan_0802|M.vanbaalenii_PYR-1 GFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPLRLSDLI
Mflv_0106|M.gilvum_PYR-GCK GFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPLRLSDLI
**:** *******:***:.*.* *::**:*.**:***************:
MMAR_0793|M.marinum_M GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGQGFYTY---
MUL_4537|M.ulcerans_Agy99 GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGQGFYTY---
MAV_4681|M.avium_104 GLDTLKLIADKMFEEFKEPQYGAPPLLLRMVEAGRLGKKTGQGFYTY---
MLBr_02461|M.leprae_Br4923 GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGLLGKKSGQGFYTY---
Mb0477|M.bovis_AF2122/97 GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY---
Rv0468|M.tuberculosis_H37Rv GLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY---
MSMEG_0912|M.smegmatis_MC2_155 GLDTLKLIADKMFDEFKEPLYAAPPLLLRMVEAGQLGKKTGKGFYTY---
MAB_4094c|M.abscessus_ATCC_199 GLDTLKLIADSMYDEYKEPLYAAPPLLLRMVEAGRLGKKSGVGFYEYKAK
TH_3443|M.thermoresistible__bu GLDTLKLIADKMFDEFKEPHYGPPPLLVRMVEAGHLGKKTGRGFYTY---
Mvan_0802|M.vanbaalenii_PYR-1 GLDTMKLIADSMYDEYKDPHYAPPPLLQRMVEAGQLGKKSGKGFYTY---
Mflv_0106|M.gilvum_PYR-GCK GLDTMKLIADSMYDEYKDPNFAPPPLLQRMVEAGQLGKKSGKGFYSY---
****:*****.*::*:*:* :..**** ****** ****:* *** *