For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SDQQKTMAVVGAGVIGLSWARLARSHGWRVGITDPRDDLDAVVRAAFGADDSDVFTSHTLADVVAEADLV QENGPERLAVKRELFGQFLESAPEHAVLATSSSSIGATLIADGLGAGDRVIVGHPFNPPELMPLVEVVPG TQTSDSTLNAAVDLYRKLGRAPIVIRKEIPGFVANRLQVALTREAQYLVEEGVVSVTDLDTALQNSLGLR WAATGLFEGNTLGGGPEGARHLYEGLGAEVGKITMGTPSSDPRVIEKLIEDIDTAYGTGPENYERLLARR NERTRAVLAALRQLDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0761c | - | - | 100% (297) | putative 3-hydroxyacyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4489c | - | 9e-32 | 36.60% (235) | 3-hydroxyacyl-CoA dehydrogenase family protein |
| M. abscessus ATCC 19977 | MAB_0904 | - | 4e-21 | 33.94% (221) | putative 3-hydroxyacyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1742 | fadB3a | 3e-27 | 41.57% (178) | 3-hydroxybutyrul-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0106 | - | 1e-14 | 32.26% (217) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv1715 | fadB3 | 8e-35 | 41.86% (215) | 3-hydroxybutyryl-CoA dehydrogenase FADB3 |
| M. leprae Br4923 | MLBr_02161 | fadB | 5e-13 | 27.54% (207) | putative fatty oxidation complex alpha subunit |
| M. marinum M | MMAR_1322 | fadB3 | 8e-18 | 29.05% (210) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. avium 104 | MAV_0981 | - | 4e-11 | 26.47% (204) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3005 | - | 7e-38 | 39.05% (274) | 3-hydroxyacyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2033 | fadB | 5e-12 | 26.70% (206) | PROBABLE FATTY OXIDATION PROTEIN FADB |
| M. ulcerans Agy99 | MUL_2558 | fadB3 | 5e-18 | 29.05% (210) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. vanbaalenii PYR-1 | Mvan_0915 | - | 4e-14 | 31.02% (216) | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 MAENTIKWDKDADGIVTLTLDDPTGSANVMNEHYKESMHNAVERLVAEKD
TH_2033|M.thermoresistible__bu MAENTIKWDKDADGIVTLTLDDPTGSANVMNEHYQESMRKAVDRLEAEKD
MLBr_02161|M.leprae_Br4923 MADTAIQWSKDADGIVTLTMNDPSRSANVMNEIYIESMGNAVDRIVAEKD
Mvan_0915|M.vanbaalenii_PYR-1 MTDNTIDWSEDR-GVVTLTIADPGQSVNTMNAAFAASFDVALARLAAIGD
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 SITGVVITSAKKTFFAGGDLKSMINLGPENAGEAFDTVEAVKRDLRALET
TH_2033|M.thermoresistible__bu SITGVVITSAKKTFFAGGDLNGMMTIGPDDAQQAFDMVEAVKRDLRRLET
MLBr_02161|M.leprae_Br4923 SITGVVITSAKRTFFAGGDLTAMINTGSEEAGQCFDTVETVKKQLRTLET
Mvan_0915|M.vanbaalenii_PYR-1 ALTGVVITSGKKTFFAGGDLRDLLEVDADNAAQFTAFLESIKRQLRTLET
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 LGKPVVAAINGAALGGGLEIALACHHRIAADVKGLVVGLPEVTLGLLPGG
TH_2033|M.thermoresistible__bu LGVPVVAAINGAALGGGLEIALACHRRIAADVKGSVIGLPEVTLGLLPGG
MLBr_02161|M.leprae_Br4923 LGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGG
Mvan_0915|M.vanbaalenii_PYR-1 LGVPVVAAINGSALGGGLELALACHHRIALDDPHIRIGLPEVTLGLLPGA
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 GGVTRTVRMFGIQNAFMNILSQGTRFKPDKAKEIGLVDELVGSVEELVPA
TH_2033|M.thermoresistible__bu GGVTRTVRMFGIQKAFMEILSQGTRFRPAKAKEVGLVDELVDSVDELVPR
MLBr_02161|M.leprae_Br4923 GGVTRTVRMFGIQNAFVNILSQGTRFKPAKAKEIGLVDELLSTVEELVPA
Mvan_0915|M.vanbaalenii_PYR-1 GGVVRTVRLLGLDTALDRVLLPGTAYRPADALQLGLIDDIATDTAALRAA
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 AKAWIKANPDAHEQPWDKKGYKMPGGTPSSPALAGILPSFPALLKKQLKG
TH_2033|M.thermoresistible__bu AKAWIKENPDAHTQPWDAKGYKMPGGTPSSPGLASILPSFPALLKKQLKG
MLBr_02161|M.leprae_Br4923 AKAWIKANPEAHEQPWDKKSYEMPGGTPTSPGLAAILPSFPSLLRKQLKG
Mvan_0915|M.vanbaalenii_PYR-1 ARAWILAHRDAR-QCWD-DGDAVPGGRADDPSVATTLPTRAATLRARHHG
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M -------------------------------------------MTGAYTY
MUL_2558|M.ulcerans_Agy99 -------------------------------------------MTGAYTY
MAV_0981|M.avium_104 APMPAPRAILDAAVEGAQVDFDTASRIESRYFTQLVTGQVAKNMIQAFFF
TH_2033|M.thermoresistible__bu APMPAPRAILNAAVEGAQVDFDSASRIESRYFTQLVTGQTAKNMIQAFFF
MLBr_02161|M.leprae_Br4923 APMPAPRAILAAAVEGAQVDFDTASRIESRYFVSLVTGQVAKNMIQAFFL
Mvan_0915|M.vanbaalenii_PYR-1 APMPAAAAILSAAVESTVVDVETALAVETRYFVQLATGQIAKNIIQGTFF
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 -------------------------------------------MLTSHGF
Rv1715|M.tuberculosis_H37Rv -------------------------------------------MLTSHGF
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M TFADIRS--------------RPVAVIGAGTLGRRIALMFASRGGTVRIY
MUL_2558|M.ulcerans_Agy99 TFADIRS--------------RPVAVIGAGTLGRRIALMFASRGGTVRIY
MAV_0981|M.avium_104 DLQHINGGGSRPEG-IEPVKINKIGVLGAGMMGAGIAYVSAKAGFDVVLK
TH_2033|M.thermoresistible__bu DLQTINSGGSRPQG-IEKTLPKKVGVLGAGMMGAGIAYVTAKAGFEVVLK
MLBr_02161|M.leprae_Br4923 DLQHINSGGSRPDG-IGKTPIKKIGVLGAGMMGAGIAYVSAKAGYNVVLK
Mvan_0915|M.vanbaalenii_PYR-1 DRQTVRSGASRPRGFMPPHRADSVAVLGAGMMGAGIALSAALAGITVKLK
Mflv_0106|M.gilvum_PYR-GCK ------------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVY
Mb1742|M.bovis_AF2122/97 S---------------------RAAVVGAGLMGRRIAGVLASAGLDVAIT
Rv1715|M.tuberculosis_H37Rv S---------------------RAAVVGAGLMGRRIAGVLASAGLDVAIT
MAB_0761c|M.abscessus_ATCC_199 ----------------MSDQQKTMAVVGAGVIGLSWARLARSHGWRVGIT
MSMEG_3005|M.smegmatis_MC2_155 -------------MAMKSHQSTSAALLGAGSIGVSFAILFATRGFPVAVF
.::*** :* * * * :
MMAR_1322|M.marinum_M ARRAEQRAQATQYVADNLPKLLQDRGFGEVGSVTATDCLAT-----ALEG
MUL_2558|M.ulcerans_Agy99 ARRAEQRAQATQYVADNLPKLLQDRGFGEVGSVTATDCLAT-----ALEG
MAV_0981|M.avium_104 DVSLEAAQKGKGYSEKLEAKALQRGKTTEEKSKSLLDRITPTADAADFKG
TH_2033|M.thermoresistible__bu DVTLEAAQKGKGYSEKLEAKALERGRTTPEKSKALLDRIKPTADVADFKG
MLBr_02161|M.leprae_Br4923 DVSLEAAQKGKSYSEKLEAKALERGRTTQEKSDVLLACIAPTGDPTDLKG
Mvan_0915|M.vanbaalenii_PYR-1 DVDCPRAERGKAYAARVLAKRVAAGKHSQAEADAILERICATDDVADLAG
Mflv_0106|M.gilvum_PYR-GCK EPSDALVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLAD
Mb1742|M.bovis_AF2122/97 DTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPD-------------
Rv1715|M.tuberculosis_H37Rv DTNAEILHAAAVEAARVAGAGRGSVAAAADLAAAIPD-------------
MAB_0761c|M.abscessus_ATCC_199 DP------RDDLDAVVR----AAFGADDSD-------VFTSHTLADVVAE
MSMEG_3005|M.smegmatis_MC2_155 DPDPTAHPRAGADLARRLDQLQAFGQLDEDPDLIIERIRFTTSLPDTVTG
MMAR_1322|M.marinum_M AWLAVESVPEKLEIKTALWGQIDQAA-PPDTIFATNSSSFPSRLMADNVR
MUL_2558|M.ulcerans_Agy99 AWLAVESVPEKLEIKTALWGQIDQAA-PPDTIFATNSSSFPSRLMADNVR
MAV_0981|M.avium_104 VDFVIEAVFENQELKHKVFQEIEDIV-EPNALLGSNTSTLPITGLATGVK
TH_2033|M.thermoresistible__bu VDFVIEAVFENTELKHKVFAEIEDIV-DPKAILGSNTSTLPITGLAAGVK
MLBr_02161|M.leprae_Br4923 VDFVIEAVFENQELKHKVFQEIEDIV-DPNAVLGSNTSTLPITGLATGVK
Mvan_0915|M.vanbaalenii_PYR-1 CDLVIEAVFEDPELKGQVFREVLDAV-APDALLASNTSTLPITGLARSVD
Mflv_0106|M.gilvum_PYR-GCK RQLVIEAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATK
Mb1742|M.bovis_AF2122/97 ADLVIEAVVENLAVKQELFERLATLA--PDAVLATNTSVLPIGAVTERVE
Rv1715|M.tuberculosis_H37Rv ADLVIEAVVENLAVKQELFERLATLA--PDAVLATNTSVLPIGAVTERVE
MAB_0761c|M.abscessus_ATCC_199 ADLVQENGPERLAVKRELFGQFLESA-PEHAVLATSSSSIGATLIADGLG
MSMEG_3005|M.smegmatis_MC2_155 AGFVQECAPERAEIKVPLLRDAASLT-DGSVPLASSSSAIVPSTLSADLP
:. * * :* : . . :.:.:* : ::
MMAR_1322|M.marinum_M DK--TRLCNTHFYMPPQFNALDLMSDGE--TDRGLLDTLLTVLPEFGVHP
MUL_2558|M.ulcerans_Agy99 DK--TRLCNTHFYMPPQFNALDLMSDGE--TDRGLLDTLLTVLPEFGVHP
MAV_0981|M.avium_104 RQ--EDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTP
TH_2033|M.thermoresistible__bu RQ--EDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTP
MLBr_02161|M.leprae_Br4923 RQ--EDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYA-LAIGKTP
Mvan_0915|M.vanbaalenii_PYR-1 RP--ADFIGLHFFSPVERMDLVEIVVGEQTSEATLAKAFDIV-LQLGKTP
Mflv_0106|M.gilvum_PYR-GCK NP--SRVLGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKV
Mb1742|M.bovis_AF2122/97 DG--SRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALL-TQVGKLP
Rv1715|M.tuberculosis_H37Rv DG--SRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALL-TQVGKLP
MAB_0761c|M.abscessus_ATCC_199 AG--DRVIVGHPFNPPELMPLVEVVPGTQTSDSTLNAAVDLY-RKLGRAP
MSMEG_3005|M.smegmatis_MC2_155 ADVARRVLVGHPGNPPYLLPVIEVVPGPATAPAIVETTMSVY-RTAGLRP
. * * : : : . *
MMAR_1322|M.marinum_M FEARRECTGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNW---RV
MUL_2558|M.ulcerans_Agy99 FEARRECTGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNW---RV
MAV_0981|M.avium_104 IVVN-DSRGFFTSRVIGTFVNEALAMLGEGVAPASIEHAGSQAG-----Y
TH_2033|M.thermoresistible__bu IVVN-DSRGFYTSRVIGTFVNEALAMLGEGVEPASIEQAGGQAG-----Y
MLBr_02161|M.leprae_Br4923 IVVN-DSRGFFTSRVIGTFVNEALAMLGEGVEPSSIEQAGAQAG-----Y
Mvan_0915|M.vanbaalenii_PYR-1 IVVG-DGRGFFTSRVILARLLEAAAMLGEGIAPASIEQASLQAG-----Y
Mflv_0106|M.gilvum_PYR-GCK VRCG-DRSGFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGL---SH
Mb1742|M.bovis_AF2122/97 VRVGRDVPGFIGNRLQHAL-------------------------------
Rv1715|M.tuberculosis_H37Rv VRVGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLA
MAB_0761c|M.abscessus_ATCC_199 IVIRKEIPGFVANRLQVALTREAQYLVEEGVVSVTDLDTALQNSLGLRWA
MSMEG_3005|M.smegmatis_MC2_155 VPVRREVEGFVFNRLQGALLREAYCLLRDGVATVDDIDEVVRSGLGRRWA
. : ** . : .
MMAR_1322|M.marinum_M PAGPFQLMDQVGLDVVLDIENHYADEFPYLP-----TNVRDLLRSYVDAG
MUL_2558|M.ulcerans_Agy99 PAGPFQLMDQVGLDVVLDIENHYADEFPYLP-----TNVRDLLRSYVDAG
MAV_0981|M.avium_104 PSPPLQLSDELNLELMHKIAVATRKGIEDAGGTYEPHPAEAVVEKMIEIG
TH_2033|M.thermoresistible__bu PAPPLQLSDELNLELMQKIATETRKGVEAAGGTYEPHPAEAVVNTMIELG
MLBr_02161|M.leprae_Br4923 PAPPLQLSDELNLELMHKIAIATRKGVEDAGGMYESHPAETVVEKMIKLG
Mvan_0915|M.vanbaalenii_PYR-1 PVGTLALLDELTLTLPHKIYGQFRDEARTTDAQFVEHPGDAVLATMIEDA
Mflv_0106|M.gilvum_PYR-GCK PMGPLRLSDLIGLDTMKLIADSMYDEYKDPN-----FAPPPLLQRMVEAG
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv TLGPLENADYIGLDLTLAIHDAVIPSLNHDP------HPSPLLRELVAAG
MAB_0761c|M.abscessus_ATCC_199 ATGLFEGNTLGGGPEGARHLYEGLGAEVGKITMGTPSSDPRVIEKLIEDI
MSMEG_3005|M.smegmatis_MC2_155 FMGPFETSDLN-TRGGLASHAEKMGPAYERMGAERGQHDPWTPGLVAEAT
MMAR_1322|M.marinum_M -KLGVKTGEGFYTYPNSSDT------------------------------
MUL_2558|M.ulcerans_Agy99 -KLGVKTGEGFYTYPNSSDT------------------------------
MAV_0981|M.avium_104 -RPSRLKGAGFYEYVDGKRTRLWPGLQETFNSGSTSIPLQDMIDRMLFAE
TH_2033|M.thermoresistible__bu -RPGRAKGAGFYEYADGKRAGLWPGLREAFKSGSSTPPLQDMIDRMLFAE
MLBr_02161|M.leprae_Br4923 -RSGRLKGAGFYEYVDGKRSGLWLGLRETFKSGSSQPPLQDMIDRMLFAE
Mvan_0915|M.vanbaalenii_PYR-1 NRPGRSAGAGFYDYADGRRVRLWAGLNERFGPGRPGHDLSELIDRLLIAE
Mflv_0106|M.gilvum_PYR-GCK -QLGKKSGKGFYSY------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv -QLGARTGHGFLDWPAGAREATTARLAQHIAAQLQANEKGRGT-------
MAB_0761c|M.abscessus_ATCC_199 DTAYGTGPENYERLLARRNERTRAVLAALRQLDA----------------
MSMEG_3005|M.smegmatis_MC2_155 AQRR--KLLDLDDWDARVLWRDEQLLRLRALFD-----------------
MMAR_1322|M.marinum_M --------------------------------------------------
MUL_2558|M.ulcerans_Agy99 --------------------------------------------------
MAV_0981|M.avium_104 ALETQKCLDEGVLTSTADANIGSIMGIGFPPYTGGSAQFIVGYSGAGGTG
TH_2033|M.thermoresistible__bu ALETQKCLDEGVITSTADANIGSIMGIGFPPWTGGTAQFIVGYQGELGTG
MLBr_02161|M.leprae_Br4923 ALETQKCLDENVLTSTADANIGSIMGIGFPPWTGGSAQFIAGYSGPAGTG
Mvan_0915|M.vanbaalenii_PYR-1 ALETARCLESGLLRSTADANVGSLLGIGFPLWTGGAAQFIAGYPG----G
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0761c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1322|M.marinum_M ------------------------------------
MUL_2558|M.ulcerans_Agy99 ------------------------------------
MAV_0981|M.avium_104 KEAFVARAKELAARYGDRFLPPASLTS---------
TH_2033|M.thermoresistible__bu KEAFVARAKQLAERYGDRFNPPESLL----------
MLBr_02161|M.leprae_Br4923 QQAFVSRARELVAKYGDRFLPPESLL----------
Mvan_0915|M.vanbaalenii_PYR-1 LAAFGARSRQLAEEFGPRFTPPASLVSWPTEPVGVN
Mflv_0106|M.gilvum_PYR-GCK ------------------------------------
Mb1742|M.bovis_AF2122/97 ------------------------------------
Rv1715|M.tuberculosis_H37Rv ------------------------------------
MAB_0761c|M.abscessus_ATCC_199 ------------------------------------
MSMEG_3005|M.smegmatis_MC2_155 ------------------------------------