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MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAEILHAAAVEAARVAGAGRGSVAAAADLAAA IPDADLVIEAVVENLAVKQELFERLATLAPDAVLATNTSVLPIGAVTERVEDGSRVIGTHFWNPPDLIPV VEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDVPGFIGNRLQHAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1742 | fadB3a | - | 100% (187) | 3-hydroxybutyrul-CoA dehydrogenase |
| M. bovis AF2122 / 97 | Mb0477 | fadB2 | 2e-21 | 38.58% (197) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. bovis AF2122 / 97 | Mb0883 | fadB | 4e-21 | 34.74% (190) | fatty oxidation protein FadB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0106 | - | 2e-23 | 38.02% (192) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv1715 | fadB3 | 1e-100 | 100.00% (187) | 3-hydroxybutyryl-CoA dehydrogenase FADB3 |
| M. leprae Br4923 | MLBr_02161 | fadB | 2e-20 | 33.68% (190) | putative fatty oxidation complex alpha subunit |
| M. abscessus ATCC 19977 | MAB_4489c | - | 4e-34 | 42.62% (183) | 3-hydroxyacyl-CoA dehydrogenase family protein |
| M. marinum M | MMAR_4676 | fadB | 4e-21 | 34.21% (190) | fatty oxidation protein FadB |
| M. avium 104 | MAV_0981 | - | 9e-21 | 33.51% (191) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6791 | - | 2e-24 | 38.74% (191) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2033 | fadB | 3e-20 | 32.80% (189) | PROBABLE FATTY OXIDATION PROTEIN FADB |
| M. ulcerans Agy99 | MUL_0295 | fadB | 4e-22 | 34.74% (190) | fatty oxidation protein FadB |
| M. vanbaalenii PYR-1 | Mvan_0802 | - | 3e-23 | 39.79% (191) | 3-hydroxybutyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0981|M.avium_104 MAENTIKWDKDADGIVTLTLDDPTGSANVMNEHYKESMHNAVERLVAEKD
TH_2033|M.thermoresistible__bu MAENTIKWDKDADGIVTLTLDDPTGSANVMNEHYQESMRKAVDRLEAEKD
MMAR_4676|M.marinum_M MADNTIQWDKDADGIVTLTMDDPSGSANVMNEAYIESMGKAVDRLVAEKD
MUL_0295|M.ulcerans_Agy99 MADNTIQWDKDADGIVTLTMDDPSGSANVMNEAYIESMGKAVDRLVAEKD
MLBr_02161|M.leprae_Br4923 MADTAIQWSKDADGIVTLTMNDPSRSANVMNEIYIESMGNAVDRIVAEKD
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 SITGVVITSAKKTFFAGGDLKSMINLGPENAGEAFDTVEAVKRDLRALET
TH_2033|M.thermoresistible__bu SITGVVITSAKKTFFAGGDLNGMMTIGPDDAQQAFDMVEAVKRDLRRLET
MMAR_4676|M.marinum_M SITGVVITSAKKTFFAGGDLTSMIQAGPEDAGQSFDTVETVKRQLRTLET
MUL_0295|M.ulcerans_Agy99 SITGVVITSAKKTFFAGGDLTSMIQAGPEDAGQSFDTVETVKRQLRTLET
MLBr_02161|M.leprae_Br4923 SITGVVITSAKRTFFAGGDLTAMINTGSEEAGQCFDTVETVKKQLRTLET
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 LGKPVVAAINGAALGGGLEIALACHHRIAADVKGLVVGLPEVTLGLLPGG
TH_2033|M.thermoresistible__bu LGVPVVAAINGAALGGGLEIALACHRRIAADVKGSVIGLPEVTLGLLPGG
MMAR_4676|M.marinum_M LGKPVVAAINGAALGGGLEIALACHHRIAADAKGSQLGLPEVTLGLLPGG
MUL_0295|M.ulcerans_Agy99 LGKPVVAAINGAALGGGLEIALACHHRIAADAKGSQLGLPEATLGLLPGG
MLBr_02161|M.leprae_Br4923 LGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGG
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 GGVTRTVRMFGIQNAFMNILSQGTRFKPDKAKEIGLVDELVGSVEELVPA
TH_2033|M.thermoresistible__bu GGVTRTVRMFGIQKAFMEILSQGTRFRPAKAKEVGLVDELVDSVDELVPR
MMAR_4676|M.marinum_M GGVTRTVRMFGIQNAFVSILSQGTRFKPAKAKEIGLVDEVLPTVEELVPA
MUL_0295|M.ulcerans_Agy99 GGVTRTVRMFGIQNAFVSILSQGTRFKPAKAKEIGLVDEVLPTVEELVPA
MLBr_02161|M.leprae_Br4923 GGVTRTVRMFGIQNAFVNILSQGTRFKPAKAKEIGLVDELLSTVEELVPA
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 AKAWIKANPDAHEQPWDKKGYKMPGGTPSSPALAGILPSFPALLKKQLKG
TH_2033|M.thermoresistible__bu AKAWIKENPDAHTQPWDAKGYKMPGGTPSSPGLASILPSFPALLKKQLKG
MMAR_4676|M.marinum_M AKAWIKANPDSHEQPWDKKGYKIPGGTPSSPGLASILPSFPALLRKQLKG
MUL_0295|M.ulcerans_Agy99 AKAWIKANPDSHEQPWDKKGYKIPGGTPSSPGLASILPSFPALLRKQLKG
MLBr_02161|M.leprae_Br4923 AKAWIKANPEAHEQPWDKKSYEMPGGTPTSPGLAAILPSFPSLLRKQLKG
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 APMPAPRAILDAAVEGAQVDFDTASRIESRYFTQLVTGQVAKNMIQAFFF
TH_2033|M.thermoresistible__bu APMPAPRAILNAAVEGAQVDFDSASRIESRYFTQLVTGQTAKNMIQAFFF
MMAR_4676|M.marinum_M APMPAPKAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMIQAFFF
MUL_0295|M.ulcerans_Agy99 APMPAPKAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMIQAFFF
MLBr_02161|M.leprae_Br4923 APMPAPRAILAAAVEGAQVDFDTASRIESRYFVSLVTGQVAKNMIQAFFL
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 DLQHINGGGSRPEGIEPVKINKIGVLGAGMMGAGIAYVSAKAGFDVVLKD
TH_2033|M.thermoresistible__bu DLQTINSGGSRPQGIEKTLPKKVGVLGAGMMGAGIAYVTAKAGFEVVLKD
MMAR_4676|M.marinum_M DLQAINAGKSRPDGIGKTPITKIGVLGAGMMGAGIAYVSAKAGYDVVLKD
MUL_0295|M.ulcerans_Agy99 DLQAINAGKSRPDGIGKTPITKIGVLGAGMMGAGIAYVSAKAGYDVVLKD
MLBr_02161|M.leprae_Br4923 DLQHINSGGSRPDGIGKTPIKKIGVLGAGMMGAGIAYVSAKAGYNVVLKD
Mflv_0106|M.gilvum_PYR-GCK -----------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYE
Mvan_0802|M.vanbaalenii_PYR-1 -----------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYE
Mb1742|M.bovis_AF2122/97 -------------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITD
Rv1715|M.tuberculosis_H37Rv -------------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITD
MAB_4489c|M.abscessus_ATCC_199 ---------------MTNDIRPVCVVGGGRMGAGISQVFALAGFTVFVYE
MSMEG_6791|M.smegmatis_MC2_155 ----------------MRKINTVTVVGAGYMGGGIAQVLALNGFKVQIAD
*:*.* ** *: * * * * : :
MAV_0981|M.avium_104 VSLEAAQKGKGYSEKLEAKALQRGKTTEEKSKSLLDR--ITPTADAADFK
TH_2033|M.thermoresistible__bu VTLEAAQKGKGYSEKLEAKALERGRTTPEKSKALLDR--IKPTADVADFK
MMAR_4676|M.marinum_M VSAEAAAKGKGYSEKLVAKALERGRTTQEKGDALLAR--ITPTSDPADLK
MUL_0295|M.ulcerans_Agy99 VSAEAAAKGKGYSEKLVAKALERGRTTQEKGDALLAR--ITPTSDAADLK
MLBr_02161|M.leprae_Br4923 VSLEAAQKGKSYSEKLEAKALERGRTTQEKSDVLLAC--IAPTGDPTDLK
Mflv_0106|M.gilvum_PYR-GCK PSDALVNAGRERITASLERAKAKGKLAADDFEITLAR--LTFTTDLADLA
Mvan_0802|M.vanbaalenii_PYR-1 PSEALVAAGRDRITASLERAKAKGKLAADDFDATVAR--LTFTTNLGDLA
Mb1742|M.bovis_AF2122/97 TNAEILHAAAVEAARVA---------GAGRGSVAAAA------DLAAAIP
Rv1715|M.tuberculosis_H37Rv TNAEILHAAAVEAARVA---------GAGRGSVAAAA------DLAAAIP
MAB_4489c|M.abscessus_ATCC_199 VNEQVRTSVVDRVRESL---------ACAELDVAVADRIIITDDLSAAVA
MSMEG_6791|M.smegmatis_MC2_155 VNAEATQEALKRLDREAREFEQQGLFGPGSADTIMSN-LTASDSLDDAVS
. . .
MAV_0981|M.avium_104 GVDFVIEAVFENQELKHKVFQEIEDIV-EPNALLGSNTSTLPITGLATGV
TH_2033|M.thermoresistible__bu GVDFVIEAVFENTELKHKVFAEIEDIV-DPKAILGSNTSTLPITGLAAGV
MMAR_4676|M.marinum_M GVDFVIEAVFENQELKHKVFQEIEDIV-EPNAVLGSNTSTLPITGLATGV
MUL_0295|M.ulcerans_Agy99 GVDFVIEAVFENQELKHKVFQEIEDIV-EPNAVLGSNTSTLPITGLATGV
MLBr_02161|M.leprae_Br4923 GVDFVIEAVFENQELKHKVFQEIEDIV-DPNAVLGSNTSTLPITGLATGV
Mflv_0106|M.gilvum_PYR-GCK DRQLVIEAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAAT
Mvan_0802|M.vanbaalenii_PYR-1 DRQLVIEAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAAT
Mb1742|M.bovis_AF2122/97 DADLVIEAVVENLAVKQELFER-LATLAP-DAVLATNTSVLPIGAVTERV
Rv1715|M.tuberculosis_H37Rv DADLVIEAVVENLAVKQELFER-LATLAP-DAVLATNTSVLPIGAVTERV
MAB_4489c|M.abscessus_ATCC_199 DACFVTEAVGEKLELKREVLAG-IAAAAPHDAILASNTSVIPISEIAAGS
MSMEG_6791|M.smegmatis_MC2_155 DVDYVMEAVFEDVDVKKEVLAR-VCASARPDTIIGTNTSTIPVKVLVDAV
. * **: *. :* ::: .:::.:*** :*: :.
MAV_0981|M.avium_104 KRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTPI
TH_2033|M.thermoresistible__bu KRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTPI
MMAR_4676|M.marinum_M KRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTPI
MUL_0295|M.ulcerans_Agy99 KRQEDFIGVHFFSPVDKMPLVEIIKGEKTSDEALARVFDYT-LAIGKTPI
MLBr_02161|M.leprae_Br4923 KRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYA-LAIGKTPI
Mflv_0106|M.gilvum_PYR-GCK KNPSRVLGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVV
Mvan_0802|M.vanbaalenii_PYR-1 KNPSRVLGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVV
Mb1742|M.bovis_AF2122/97 EDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVR
Rv1715|M.tuberculosis_H37Rv EDGSRVIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVR
MAB_4489c|M.abscessus_ATCC_199 PAIDRIVGTHWWNPAPLIPLVEVVQATGTSVETVSRTMKLLAAIGKKPMH
MSMEG_6791|M.smegmatis_MC2_155 THPERFLTVHFSNPAPFIPGVELVAGEATTQEVIDSVKDLLARAGREGAQ
. .: *: .* :* **:: *: :. .
MAV_0981|M.avium_104 VVNDSRGFFTSRVIGTFVNEALAMLGEGVAPASIEHAGSQAG--YPSPPL
TH_2033|M.thermoresistible__bu VVNDSRGFYTSRVIGTFVNEALAMLGEGVEPASIEQAGGQAG--YPAPPL
MMAR_4676|M.marinum_M VVNDSRGFFTSRVIGTFVNEALAMLGEGVEPSSIEQAGSQAG--YPAPPL
MUL_0295|M.ulcerans_Agy99 VVNDGRGFFASRVIGTFVNEALAMLGEGVEPSSIEQAGSQAG--YPAPPL
MLBr_02161|M.leprae_Br4923 VVNDSRGFFTSRVIGTFVNEALAMLGEGVEPSSIEQAGAQAG--YPAPPL
Mflv_0106|M.gilvum_PYR-GCK RCGDRSGFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPL
Mvan_0802|M.vanbaalenii_PYR-1 RCGDRSGFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMGPL
Mb1742|M.bovis_AF2122/97 VGRDVPGFIGNRLQHAL---------------------------------
Rv1715|M.tuberculosis_H37Rv VGRDVPGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATL
MAB_4489c|M.abscessus_ATCC_199 VRKEVPGFVGNRLQHALWREAIALVQEGVCDATTVDDVVKNSFGLRLAVL
MSMEG_6791|M.smegmatis_MC2_155 VA-DTPGMALNRLQYALLKEATLIVEEGVATKEDVDTIVRTTFGFRLGFF
: *: . : .
MAV_0981|M.avium_104 QLSDELNLELMHKIAVATRKGIEDAGGTYEPHPAEAVVEKMIEIGRPSRL
TH_2033|M.thermoresistible__bu QLSDELNLELMQKIATETRKGVEAAGGTYEPHPAEAVVNTMIELGRPGRA
MMAR_4676|M.marinum_M QLSDELNLELMHKIATATRKGVEDAGGTYEPHPAEAVVEKMIEVGRSGRL
MUL_0295|M.ulcerans_Agy99 QLSDELNLELMHKIATATRKGVEDAGGTYEPHPAEAVVEKMIEVGRSGRL
MLBr_02161|M.leprae_Br4923 QLSDELNLELMHKIAIATRKGVEDAGGMYESHPAETVVEKMIKLGRSGRL
Mflv_0106|M.gilvum_PYR-GCK RLSDLIGLDTMKLIADSMYDEYKDP--NFAPPP---LLQRMVEAGQLGKK
Mvan_0802|M.vanbaalenii_PYR-1 RLSDLIGLDTMKLIADSMYDEYKDP--HYAPPP---LLQRMVEAGQLGKK
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv GPLENADYIGLDLTLAIHDAVIPSLNHDPHPSP---LLRELVAAGQLGAR
MAB_4489c|M.abscessus_ATCC_199 GPLENADLVGLDLTLDIHRVVVPALDCQGGPNP---VLVDKVARGMLGCK
MSMEG_6791|M.smegmatis_MC2_155 GPFAIADQAGLDVYVKGYHTLENAFGERMATPK---LLTDNVDAGRYGTK
MAV_0981|M.avium_104 KGAGFYEYVDGKRTRLWPGLQETFNSGSTSIPLQDMIDRMLFAEALETQK
TH_2033|M.thermoresistible__bu KGAGFYEYADGKRAGLWPGLREAFKSGSSTPPLQDMIDRMLFAEALETQK
MMAR_4676|M.marinum_M KGAGFYEYPEGKRAGLWPGLRETFKSGTSEPPLQDMIDRMLFAEALETQK
MUL_0295|M.ulcerans_Agy99 KGAGFYEYPEGKRAGLWPGLRETFKSGTSEPPLQDMIDRMLFAEALETQK
MLBr_02161|M.leprae_Br4923 KGAGFYEYVDGKRSGLWLGLRETFKSGSSQPPLQDMIDRMLFAEALETQK
Mflv_0106|M.gilvum_PYR-GCK SGKGFYSY------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 SGKGFYTY------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv TGHGFL----DWPAGAREATTARLAQHIAAQLQANEKGRGT---------
MAB_4489c|M.abscessus_ATCC_199 TGEGFR----RWSPADIAEMNNRLEGHLVRLLHPRNTGPVG---------
MSMEG_6791|M.smegmatis_MC2_155 NGKGWTGDFDDETKAAVIAYRNKAYSRMGELLRELGPAPKGA--------
MAV_0981|M.avium_104 CLDEGVLTSTADANIGSIMGIGFPPYTGGSAQFIVGYSGAGGTGKEAFVA
TH_2033|M.thermoresistible__bu CLDEGVITSTADANIGSIMGIGFPPWTGGTAQFIVGYQGELGTGKEAFVA
MMAR_4676|M.marinum_M CLDENVLMSTADANIGSIMGIGFPPWTGGSAQYIVGYEGALGRGKEAFVA
MUL_0295|M.ulcerans_Agy99 CLDENVLMSTADANIGSIMGIGFPPWTGGSAQYIVGYEGALGRGKEAFVT
MLBr_02161|M.leprae_Br4923 CLDENVLTSTADANIGSIMGIGFPPWTGGSAQFIAGYSGPAGTGQQAFVS
Mflv_0106|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1742|M.bovis_AF2122/97 --------------------------------------------------
Rv1715|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4489c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_6791|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0981|M.avium_104 RAKELAARYGDRFLPPASLTS
TH_2033|M.thermoresistible__bu RAKQLAERYGDRFNPPESLL-
MMAR_4676|M.marinum_M RARELAAKYGDRFLPPDSLT-
MUL_0295|M.ulcerans_Agy99 RARELAAKYGDRFLPPDSLT-
MLBr_02161|M.leprae_Br4923 RARELVAKYGDRFLPPESLL-
Mflv_0106|M.gilvum_PYR-GCK ---------------------
Mvan_0802|M.vanbaalenii_PYR-1 ---------------------
Mb1742|M.bovis_AF2122/97 ---------------------
Rv1715|M.tuberculosis_H37Rv ---------------------
MAB_4489c|M.abscessus_ATCC_199 ---------------------
MSMEG_6791|M.smegmatis_MC2_155 ---------------------