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MRIRTAAPGTTTPTLALIILLALLNAVTPFSVDMYMSAFPAMAVEFGTSASVVQLTLTTFLIGLATGQLF IGQLSDRLGRRGPLLVGIVACLVASLLCAVSPSIEVLIMLRFVQGFAGAAGIVIARAIISDRSKGSQAAK LYSVMMVIGVLAPILAPVLGGQVVAGFGWRAVFLALAGLNLVMLLGALFMAGESLPPEARRPAGLKAFAG SAASVLTNRRFMGYTLTLSCSGAAMFSYISASPFVLQNIIGLSPRAFSFTFGGCALAVAVSGVISARLVG RFGPRKLLLGGVSAMVVVAALMLLNVTVGGVVPAVTVALMACFMGTVGFTFANATTLAIGEVRHAAGTGS AVIGFLQYGLGAVASPLVGLAGEHSAVPMGVAMFTCAALAATALLVLTRGHIPSYDDELADLDADLTAVS AGESTAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2991 | - | - | 100% (427) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_5047 | - | 1e-63 | 37.41% (401) | drug resistance transporter Bcr/CflA subfamily protein |
| M. smegmatis MC2 155 | MSMEG_4472 | - | 4e-27 | 26.96% (408) | multidrug-efflux transporter protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 2e-21 | 31.17% (231) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_2220 | - | 2e-62 | 36.75% (400) | Bcr/CflA subfamily drug resistance transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 2e-21 | 31.17% (231) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | MLBr_01562 | - | 2e-15 | 22.30% (453) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1395 | - | 7e-63 | 36.22% (392) | Bcr/CflA family multidrug resistance transporter |
| M. marinum M | MMAR_3524 | - | 2e-44 | 31.28% (390) | hypothetical protein MMAR_3524 |
| M. avium 104 | MAV_0729 | - | 2e-17 | 30.57% (157) | EmrB efflux protein |
| M. thermoresistible (build 8) | TH_0755 | - | 3e-17 | 37.50% (160) | drug resistance transporter Bcr/CflA subfamily protein |
| M. ulcerans Agy99 | MUL_0911 | - | 1e-18 | 24.51% (408) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_4475 | - | 2e-61 | 36.78% (397) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2220|M.gilvum_PYR-GCK ----------------MSLINFMAISPDVKLKAQSPESAGPPS-------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------MAPPG-------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 ----------------MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPA
MSMEG_2991|M.smegmatis_MC2_155 ------------------------------MRIRTAAPGTTTP-------
Mb0805c|M.bovis_AF2122/97 --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
Rv0783c|M.tuberculosis_H37Rv --------------MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDR
MAV_0729|M.avium_104 --------------MLSGAMEKTRSAA--FSVPLATASGPSLRDDEYPDK
MMAR_3524|M.marinum_M ----------------------------------MKASAPS---------
MUL_0911|M.ulcerans_Agy99 -------------------------------MRIQPVFRDHP--------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_2220|M.gilvum_PYR-GCK ----RTRMIIVLGLLVALGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
Mvan_4475|M.vanbaalenii_PYR-1 ----RTRMILVLGLLVALGPLTIDMYLPALPKIAEELSVSSSVAQLTLTG
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQLTLTG
MSMEG_2991|M.smegmatis_MC2_155 ----TLALIILLALLNAVTPFSVDMYMSAFPAMAVEFGTSASVVQLTLTT
Mb0805c|M.bovis_AF2122/97 LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
Rv0783c|M.tuberculosis_H37Rv LDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTG
MAV_0729|M.avium_104 LDAALFRIAGVCGLACIMAVLDSTVVAVAQRTFIAQFGANQAIVSWTIAG
MMAR_3524|M.marinum_M -----RRIVAVLLCVVPLNQIPMDAYTPALPQMETSIGTTATALQSTVTV
MUL_0911|M.ulcerans_Agy99 -----ILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
Mflv_2220|M.gilvum_PYR-GCK TLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGI
Mvan_4475|M.vanbaalenii_PYR-1 TLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLGV
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGV
MSMEG_2991|M.smegmatis_MC2_155 FLIGLATGQLFIGQLSDRLGRRGPLLVGIVACLVASLLCAVSPSIEVLIM
Mb0805c|M.bovis_AF2122/97 YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
Rv0783c|M.tuberculosis_H37Rv YMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLII
MAV_0729|M.avium_104 YMLAFATVIPITGWAADRFGTKRLFMGSVLIFTLGSLLCAVAPNILLLIL
MMAR_3524|M.marinum_M FMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLLV
MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
Mflv_2220|M.gilvum_PYR-GCK ARGLQGMGAAAGMVVAIAVVGDLYKDNA-AATVMSRLMLVLGVAPVLAPS
Mvan_4475|M.vanbaalenii_PYR-1 ARCLQGMGAAAGMVVAIAVVGDLYKDNV-AATVMSRLMLVLGVAPVLAPS
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 LRAVEGMGAAAAMVVAMAVVRDLYTDKA-AATVISRLTLVIGIAPILAPS
MSMEG_2991|M.smegmatis_MC2_155 LRFVQGFAGAAGIVIARAIISDRSKGSQ-AAKLYSVMMVIGVLAPILAPV
Mb0805c|M.bovis_AF2122/97 FRVVQGFGGGMLTPVSFAILAREAGPKR-LGRVMAVVGIPMLLGPVGGPI
Rv0783c|M.tuberculosis_H37Rv FRVVQGFGGGMLTPVSFAILAREAGPKR-LGRVMAVVGIPMLLGPVGGPI
MAV_0729|M.avium_104 FRVVQGVGGGMLLPLSFVILTREAGPKR-VGRLMAVGGIPILLGPIGGPI
MMAR_3524|M.marinum_M LRFLQGGACSAFIVVAIAIAADCFEGAR-LRSVNGLLGAAWSAAPILAPA
MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
Mflv_2220|M.gilvum_PYR-GCK LGAAVLLHGSWHWVFAALVVVAAALLVMAVLALP-----ETLPVDHRRPL
Mvan_4475|M.vanbaalenii_PYR-1 FGAAVLLHGSWHWVFAALVVVAGALLVMSVLALP-----ETLPADHRRPL
TH_0755|M.thermoresistible__bu ---------------------------MSEEPLG-----EXX--------
MAB_1395|M.abscessus_ATCC_1997 LGAAVLVHGSWQNVFAALSCLGVLLLILAVVALP-----ETLPPSARRPL
MSMEG_2991|M.smegmatis_MC2_155 LGGQVVAGFGWRAVFLALAGLNLVMLLGALFMAG-----ESLPPEARRPA
Mb0805c|M.bovis_AF2122/97 LGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLL
Rv0783c|M.tuberculosis_H37Rv LGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLL
MAV_0729|M.avium_104 LGGWLIGAYGWKWIFLINLPIGLTAFALAALLFPKDRSAPSEALDITGAL
MMAR_3524|M.marinum_M VGGFIVEYASWRYVFVLIAALSVVVGLAVTWALP-----ETLDQESRTRF
MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHET-HKERMKLDAAGAI
Mflv_2220|M.gilvum_PYR-GCK KVRGIAATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFGLD
Mvan_4475|M.vanbaalenii_PYR-1 KARGIALTYLELLRDVRFVILVFVGALGMSGLFAYIAGASFVLQGRFGLD
TH_0755|M.thermoresistible__bu ---------------------------------XYISGAAFVLQDGYGLN
MAB_1395|M.abscessus_ATCC_1997 RAGAILRTYRDLLRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMN
MSMEG_2991|M.smegmatis_MC2_155 GLKAFAGSAASVLTNRRFMGYTLTLSCSGAAMFSYISASPFVLQNIIGLS
Mb0805c|M.bovis_AF2122/97 LLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTE
Rv0783c|M.tuberculosis_H37Rv LLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTE
MAV_0729|M.avium_104 LLSPGVAIFLCGVCSIPGRHTVADRYVLVPALVGLVLIAAFILHAWYRTE
MMAR_3524|M.marinum_M ELGQTWQVLTATARNRVFLALAAIFGLLAGPQLSFGVAAPFLYQDEMGFS
MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRS--S
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
. : .
Mflv_2220|M.gilvum_PYR-GCK QTAFALVFGAG---------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 QTAFALVFGAG---------------------------------------
TH_0755|M.thermoresistible__bu QQAFALVFGAG---------------------------------------
MAB_1395|M.abscessus_ATCC_1997 QQVFALAFGAG---------------------------------------
MSMEG_2991|M.smegmatis_MC2_155 PRAFSFTFGGC---------------------------------------
Mb0805c|M.bovis_AF2122/97 HPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQS
Rv0783c|M.tuberculosis_H37Rv HPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQS
MAV_0729|M.avium_104 HPLIDLRLFRNPVVTQVNVTLLVFAAASVGVGLLVPSYFQIVGHETPMQS
MMAR_3524|M.marinum_M PSAYGLIALVVG--------------------------------------
MUL_0911|M.ulcerans_Agy99 HPMLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQT
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGG--VIFSLTVSIGLYIQDILGYSALRA
.
Mflv_2220|M.gilvum_PYR-GCK -------AVALIGTTQCNVILLKRFTPQQIMVWALAASSVFGLVFVALAA
Mvan_4475|M.vanbaalenii_PYR-1 -------AIALIGTTQFNVVLLKRFAPQQIMVWALVAASLSGAVFVALAA
TH_0755|M.thermoresistible__bu -------AIALIGATQFNVVLLRRFDPSTIVVTALAVASVLGFVFVGLAV
MAB_1395|M.abscessus_ATCC_1997 -------AIAFVAASQLNVVLLKRFEPQQIVRWCLSLALIPAVVLLVLAG
MSMEG_2991|M.smegmatis_MC2_155 -------ALAVAVSGVISARLVGRFGPRKLLLGGVSAMVVVAALMLLNVT
Mb0805c|M.bovis_AF2122/97 GVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVA
Rv0783c|M.tuberculosis_H37Rv GVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVA
MAV_0729|M.avium_104 GLHMLPIGVGAVLTMPLGGAVMDKHGPGKIVLTGLPLMAVGLAVFTYGVA
MMAR_3524|M.marinum_M --------VAVLLGSFSTGMLATRMAFRRLAFADWTLYMVGAALLLGSAP
MUL_0911|M.ulcerans_Agy99 GVRLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWASTADA
MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMN
.. : : :
Mflv_2220|M.gilvum_PYR-GCK AGVGGVFGFVIPVWAILAAMG-LVIPNAPAVALTRHPDAAGTAAALLGAV
Mvan_4475|M.vanbaalenii_PYR-1 AHIGGLWGFVIPVWAILAAMG-LVIPNAPAVALTRHPDAAGTAAALLGAV
TH_0755|M.thermoresistible__bu TGVGGLAGFVLPVWGVLGAMG-FVLPNAPALALSRHPEASGTAAALLGCG
MAB_1395|M.abscessus_ATCC_1997 FGIGGLVGFVAPVWTLMALMG-FVIPNAPALALSRHGEAAGTSAAVLGAA
MSMEG_2991|M.smegmatis_MC2_155 VGGVVPAVTVALMACFMGTVG-FTFANATTLAIGEVRHAAGTGSAVIGFL
Mb0805c|M.bovis_AF2122/97 RQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIARGSTLISVN
Rv0783c|M.tuberculosis_H37Rv RQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIARGSTLISVN
MAV_0729|M.avium_104 RQAAYSPVLVCGLAIMGLGIGLTTTPLSAALMQALAPHQVARGTTLISVN
MMAR_3524|M.marinum_M VVGVNPWAITLAVSLAVAGCG-ALVPQAQAAALGAFSRNLGLVSGLFGTL
MUL_0911|M.ulcerans_Agy99 TTP--YTQITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTT
MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALML
: * . : : . : :
Mflv_2220|M.gilvum_PYR-GCK QFGGGAAIAPVVG------VLGND-ELAMAVVMAAGVIIALGALLVTGAH
Mvan_4475|M.vanbaalenii_PYR-1 QFGMGAAIAPVVG------VLGND-ELAMAVVMAAGVIVALTALLVTGVH
TH_0755|M.thermoresistible__bu QFGLGAVISPLVG------VLGNS-APAMAAVMTGGVLIALVALLAAGVR
MAB_1395|M.abscessus_ATCC_1997 QFGVGAVIAPLVG------ALGNN-ALAVAIVMMIGVVLALAGLAVVRNR
MSMEG_2991|M.smegmatis_MC2_155 QYGLGAVASPLVG------LAGEHSAVPMGVAMFTCAALAATALLVLTRG
Mb0805c|M.bovis_AF2122/97 QQVGGSIGTALMS------VLLTYQFN-HSEIIATAKKVALTPESGAGRG
Rv0783c|M.tuberculosis_H37Rv QQVGGSIGTALMS------VLLTYQFN-HSEIIATAKKVALTPESGAGRG
MAV_0729|M.avium_104 QQVGGSIGAALMA------VILTNQFNRNPALMAANEAAGMHPVTGK-RG
MMAR_3524|M.marinum_M TYLIIAAIMAIVG------VSPERTQAPLGWLYVLCGALVFAALAWVTPR
MUL_0911|M.ulcerans_Agy99 RELGGTLGVAIAGSVFASVYSGQLGSASALATLPSDVRSAMKGSMAVAHK
MLBr_01562|M.leprae_Br4923 QSLGGPLVLAVIQ------AVITSRTLYLGGTTGPVKFMNDAQLRALDHG
. .:
Mflv_2220|M.gilvum_PYR-GCK RNTEPARVPD-----EAVAEPA----------------------------
Mvan_4475|M.vanbaalenii_PYR-1 RNTAPAAVPG-----EAVAEPA----------------------------
TH_0755|M.thermoresistible__bu PGAEHRDTAD-----MLVEHA-----------------------------
MAB_1395|M.abscessus_ATCC_1997 VAA-----------------------------------------------
MSMEG_2991|M.smegmatis_MC2_155 HIPSYDDELA-----DLDADLTAVSAGESTAR------------------
Mb0805c|M.bovis_AF2122/97 AAVDPSSLPR---QTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFL
Rv0783c|M.tuberculosis_H37Rv AAVDPSSLPR---QTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFL
MAV_0729|M.avium_104 LPVDPSTVPRPAMTPELAGHVSHHLSHAYTAVFVLAVVLVACTIIPASFL
MMAR_3524|M.marinum_M VQGEKPTPG-----------------------------------------
MUL_0911|M.ulcerans_Agy99 VIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCAGIALAAAIVVGWLLPAR
MLBr_01562|M.leprae_Br4923 YTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------
Mflv_2220|M.gilvum_PYR-GCK ----------------
Mvan_4475|M.vanbaalenii_PYR-1 ----------------
TH_0755|M.thermoresistible__bu ----------------
MAB_1395|M.abscessus_ATCC_1997 ----------------
MSMEG_2991|M.smegmatis_MC2_155 ----------------
Mb0805c|M.bovis_AF2122/97 PKQQASHRRAPLLSA-
Rv0783c|M.tuberculosis_H37Rv PKQQASHRRAPLLSA-
MAV_0729|M.avium_104 PRKPPSPPAGD-----
MMAR_3524|M.marinum_M ----------------
MUL_0911|M.ulcerans_Agy99 AGQPTPAQTEPALAQV
MLBr_01562|M.leprae_Br4923 ----------------