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VRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSD LHVNSTLTQLTLTGTLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGVLRAVEG MGAAAAMVVAMAVVRDLYTDKAAATVISRLTLVIGIAPILAPSLGAAVLVHGSWQNVFAALSCLGVLLLI LAVVALPETLPPSARRPLRAGAILRTYRDLLRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQ VFALAFGAGAIAFVAASQLNVVLLKRFEPQQIVRWCLSLALIPAVVLLVLAGFGIGGLVGFVAPVWTLMA LMGFVIPNAPALALSRHGEAAGTSAAVLGAAQFGVGAVIAPLVGALGNNALAVAIVMMIGVVLALAGLAV VRNRVAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1395 | - | - | 100% (427) | Bcr/CflA family multidrug resistance transporter |
| M. abscessus ATCC 19977 | MAB_3142c | - | 3e-17 | 24.02% (383) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1935 | - | 2e-15 | 26.15% (413) | putative drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 3e-16 | 27.86% (201) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2220 | - | 1e-137 | 62.76% (392) | Bcr/CflA subfamily drug resistance transporter |
| M. tuberculosis H37Rv | Rv2333c | - | 8e-16 | 27.86% (201) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 4e-16 | 23.84% (453) | putative transmembrane efflux protein |
| M. marinum M | MMAR_3524 | - | 2e-35 | 28.21% (390) | hypothetical protein MMAR_3524 |
| M. avium 104 | MAV_2832 | - | 1e-11 | 25.83% (333) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_5047 | - | 1e-130 | 62.14% (383) | drug resistance transporter Bcr/CflA subfamily protein |
| M. thermoresistible (build 8) | TH_0755 | - | 5e-50 | 60.61% (165) | drug resistance transporter Bcr/CflA subfamily protein |
| M. ulcerans Agy99 | MUL_1468 | - | 4e-16 | 27.19% (217) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_4475 | - | 1e-136 | 63.43% (391) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------MSLINFMAISPDVKLKAQSPESAGPPS---------
Mvan_4475|M.vanbaalenii_PYR-1 ------------------------------------MAPPG---------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------MPS---------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPATR
MAV_2832|M.avium_104 ----------------------------------MNAPARADTGSGGERI
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MMAR_3524|M.marinum_M ----------------------------------------------MKAS
Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
MUL_1468|M.ulcerans_Agy99 MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
Mflv_2220|M.gilvum_PYR-GCK --RTRMIIVLGLLVALGPLTIDMYLP--ALPKIGEELSVSSSVAQLTLTG
Mvan_4475|M.vanbaalenii_PYR-1 --RTRMILVLGLLVALGPLTIDMYLP--ALPKIAEELSVSSSVAQLTLTG
MSMEG_5047|M.smegmatis_MC2_155 --RTRMILVLGALITLGPLTIDMYLP--ALPKIGEELSVSSSVAQLTLTG
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 LGRAWLITVLGAMVALGPLTIDMYLP--ALPDIGSDLHVNSTLTQLTLTG
MAV_2832|M.avium_104 SPQRRNLIFVAIVLGMLLAALDQTIVATALPTIVANLGDAG-HQSWVVTS
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MMAR_3524|M.marinum_M APSRRIVAVLLCVVPLNQIPMDAYTP--ALPQMETSIGTTATALQSTVTV
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
MUL_1468|M.ulcerans_Agy99 YSLGMAVFIMSAATLADRYGRRRWYLMGIVLFTLGSIACGLAPSIAMLTA
Mflv_2220|M.gilvum_PYR-GCK TLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGI
Mvan_4475|M.vanbaalenii_PYR-1 TLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLGV
MSMEG_5047|M.smegmatis_MC2_155 TLAGLALGQLVVGSLSDSLGRRRPLLAGIVLHMAASVLCFLAPNIAVLGI
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGV
MAV_2832|M.avium_104 YLLASTIVTALVGKLGDLYGRKRVFQAAVLFFVAGSVLCGLAQSMAMLVG
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
MMAR_3524|M.marinum_M FMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLLV
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
MUL_1468|M.ulcerans_Agy99 ARGVQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
Mflv_2220|M.gilvum_PYR-GCK ARGLQGMGAAAGMVVAIAVVGDLYKD-NAAATVMSRLMLVLGVAPVLAPS
Mvan_4475|M.vanbaalenii_PYR-1 ARCLQGMGAAAGMVVAIAVVGDLYKD-NVAATVMSRLMLVLGVAPVLAPS
MSMEG_5047|M.smegmatis_MC2_155 ARGLQGMGASAAAVVAIAVVGDLYSG-NTAATVMSRLMLVLGVAPVLAPS
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 LRAVEGMGAAAAMVVAMAVVRDLYTD-KAAATVISRLTLVIGIAPILAPS
MAV_2832|M.avium_104 ARALQGIGGGGITVTASALIGEVVPL-RERGRYQGILGAVFGVTTVIGPL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
MMAR_3524|M.marinum_M LRFLQGGACSAFIVVAIAIAADCFEG-ARLRSVNGLLGAAWSAAPILAPA
Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
MUL_1468|M.ulcerans_Agy99 LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGQLDLSGQA
Mflv_2220|M.gilvum_PYR-GCK LGAAVLLHGSWHWVFAALVVVAAALLVMAVLALPETLPVDHRRPLKVRGI
Mvan_4475|M.vanbaalenii_PYR-1 FGAAVLLHGSWHWVFAALVVVAGALLVMSVLALPETLPADHRRPLKARGI
MSMEG_5047|M.smegmatis_MC2_155 LGAAVLLKASWHWVFVALVILAGLLLVMAALALPETLPTSHRRPLKVGGI
TH_0755|M.thermoresistible__bu ---------------------------MSEEPLGEXX-------------
MAB_1395|M.abscessus_ATCC_1997 LGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLRAGAI
MAV_2832|M.avium_104 LGGYFTDYLSWRWAFWVNVPVSVIVIFVAAAAIPALAASAKPVIDYAGIV
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGAI
MMAR_3524|M.marinum_M VGGFIVEYASWRYVFVLIAALSVVVGLAVTWALPETLDQESRTRFELGQT
:
Mb2361c|M.bovis_AF2122/97 LFIV-AVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN
Rv2333c|M.tuberculosis_H37Rv LFIV-AVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSN
MUL_1468|M.ulcerans_Agy99 LFIV-TVGAFVYAVIEGPQIGWTSPLILTLLMTAIVGCALFLWLEGRSAD
Mflv_2220|M.gilvum_PYR-GCK AATY-LELVRDARFVILVLVAALGMSGLFAYIAGAS----FVLQGRFG--
Mvan_4475|M.vanbaalenii_PYR-1 ALTY-LELLRDVRFVILVFVGALGMSGLFAYIAGAS----FVLQGRFG--
MSMEG_5047|M.smegmatis_MC2_155 MRTY-GRLLHDARFVILVLVAALGMSGLFAYISAAP----FVLQGRYG--
TH_0755|M.thermoresistible__bu -----------------------------XYISGAA----FVLQDGYG--
MAB_1395|M.abscessus_ATCC_1997 LRTY-RDLLRDKVFVVLVLVAGLSLSGLFAYISGAS----FVLQGQYG--
MAV_2832|M.avium_104 FVGLGAAGLTLATSWGGSRYPWGSPTIIGLFAAAAVALGVFVVVERRAAE
MLBr_01562|M.leprae_Br4923 LATL-ACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAEN
MMAR_3524|M.marinum_M WQVL-TATARNRVFLALAAIFGLLAGPQLSFGVAAP----FLYQDEMG--
. * .
Mb2361c|M.bovis_AF2122/97 PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG
Rv2333c|M.tuberculosis_H37Rv PMMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTG
MUL_1468|M.ulcerans_Agy99 PMMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLHNVRGYTQ----
Mflv_2220|M.gilvum_PYR-GCK --LDQTAFALVFGAGAVALIGTTQCNVILLKRFTPQQIMVWALAASSVFG
Mvan_4475|M.vanbaalenii_PYR-1 --LDQTAFALVFGAGAIALIGTTQFNVVLLKRFAPQQIMVWALVAASLSG
MSMEG_5047|M.smegmatis_MC2_155 --LDQQMFAAVFAAGAVALIGSTQFNVVLLRRFTPQAITVAALASATVVG
TH_0755|M.thermoresistible__bu --LNQQAFALVFGAGAIALIGATQFNVVLLRRFDPSTIVVTALAVASVLG
MAB_1395|M.abscessus_ATCC_1997 --MNQQVFALAFGAGAIAFVAASQLNVVLLKRFEPQQIVRWCLSLALIPA
MAV_2832|M.avium_104 PILPVRLFASPVFTVCCVLSFVVGFAMLGAMTFLPTYMQYVDGVSATTSG
MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAG
MMAR_3524|M.marinum_M --FSPSAYGLIALVVGVAVLLGSFSTGMLATRMAFRRLAFADWTLYMVGA
. : :
Mb2361c|M.bovis_AF2122/97 LMILPFSAAVAIVSPLVGHLVGRIG--ARVPILAGLCMLMLGLLMLIFSE
Rv2333c|M.tuberculosis_H37Rv LMILPFSAAVAIVSPLVGHLVGRIG--ARVPILAGLCMLMLGLLMLIFSE
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK LVFVALAAAG------VGGVFGFVI--PVWAILAAMGLVIPNAPAVALTR
Mvan_4475|M.vanbaalenii_PYR-1 AVFVALAAAH------IGGLWGFVI--PVWAILAAMGLVIPNAPAVALTR
MSMEG_5047|M.smegmatis_MC2_155 AVFVGLTIAD------VGGLIGFLV--PVMAILTAMGFVIPNAPAVALSR
TH_0755|M.thermoresistible__bu FVFVGLAVTG------VGGLAGFVL--PVWGVLGAMGFVLPNAPALALSR
MAB_1395|M.abscessus_ATCC_1997 VVLLVLAGFG------IGGLVGFVA--PVWTLMALMGFVIPNAPALALSR
MAV_2832|M.avium_104 LRTLPMVVGMLFTSTGSGTIVGRTGRYKIFPVAGTALMALAFLLMSRMQP
MLBr_01562|M.leprae_Br4923 IGFIPFVIAMGIGLGVSSQLVSRFSP-RVLTIGGGWLLMVAMLYGWAFMN
MMAR_3524|M.marinum_M ALLLGSAPVVG--------VNPWAITLAVSLAVAGCGALVPQAQAAALGA
Mb2361c|M.bovis_AF2122/97 HRSSALV--LVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASG-IMSA
Rv2333c|M.tuberculosis_H37Rv HRSSALV--LVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASG-IMSA
MUL_1468|M.ulcerans_Agy99 ----------------GSGVVD----------------------------
Mflv_2220|M.gilvum_PYR-GCK HP-------------DAAGTAAALLGAVQFGGGAAIAPVVGVLGN-DELA
Mvan_4475|M.vanbaalenii_PYR-1 HP-------------DAAGTAAALLGAVQFGMGAAIAPVVGVLGN-DELA
MSMEG_5047|M.smegmatis_MC2_155 HS-------------EAAGTAAALLGAAQFGIGALVAPLVGALGN-GALA
TH_0755|M.thermoresistible__bu HP-------------EASGTAAALLGCGQFGLGAVISPLVGVLGN-SAPA
MAB_1395|M.abscessus_ATCC_1997 HG-------------EAAGTSAAVLGAAQFGVGAVIAPLVGALGN-NALA
MAV_2832|M.avium_104 STSAVIQ--SLYLFILGAGIGLSMQVLILIVQNTSDFEDLGVATS-GVTF
MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSA-IALM
MMAR_3524|M.marinum_M FS-------------RNLGLVSGLFGTLTYLIIAAIMAIVGVSPERTQAP
*
Mb2361c|M.bovis_AF2122/97 QRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSA
Rv2333c|M.tuberculosis_H37Rv QRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEIIIDSA
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK MAVVMAAGVIIALGALLVTG-AHRNTEPAR----------VPDEAVAEPA
Mvan_4475|M.vanbaalenii_PYR-1 MAVVMAAGVIVALTALLVTG-VHRNTAPAA----------VPGEAVAEPA
MSMEG_5047|M.smegmatis_MC2_155 LSGVMTAGMAIALVALLLVGGSHADDETHDGNEDGPGSDDVVAEAVAEPA
TH_0755|M.thermoresistible__bu MAAVMTGGVLIALVALLAAG-VRPGAEHRD-----------TADMLVEHA
MAB_1395|M.abscessus_ATCC_1997 VAIVMMIGVVLALAGLAVVR-----------------------NRVAA--
MAV_2832|M.avium_104 FRTIGSSFGAAIFGSLFVNFLNRRIGPALAASGAPPGAVSSPGALHRQPH
MLBr_01562|M.leprae_Br4923 LQSLGGPLVLAVIQAVITSRTLYLGGTTGP--------VKFMNDAQLRAL
MMAR_3524|M.marinum_M LGWLYVLCGALVFAALAWVTPRVQGEKPTPG-------------------
Mb2361c|M.bovis_AF2122/97 NPRAHVGGIVPR---RHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVF
Rv2333c|M.tuberculosis_H37Rv NPRAHVGGIVPR---RHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVF
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 EVAAPIVAAYAESLTEVFFWAAPVALVGFVLALFLREIPLRDIHDSTVDL
MLBr_01562|M.leprae_Br4923 DHGYTYG----------LLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKE
MMAR_3524|M.marinum_M --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 LAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG----------------
Rv2333c|M.tuberculosis_H37Rv LAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA----
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 GDAFGMPTTETPDQMLENAIARMLRGETGMRLRSIAMRPDCRLDVAGLWG
MLBr_01562|M.leprae_Br4923 AVDAGEL-------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 VLRINRYTQMYGTARLTDMAEYLRIPFEVLEPTFSRLVTAGYAGSDGDRL
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2832|M.avium_104 WLTPAGAQQVGYVHSLLLAWLVDKLGRSPGFEGRPDRQAVQAALERVAYR
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 ---------------------
Rv2333c|M.tuberculosis_H37Rv ---------------------
MUL_1468|M.ulcerans_Agy99 ---------------------
Mflv_2220|M.gilvum_PYR-GCK ---------------------
Mvan_4475|M.vanbaalenii_PYR-1 ---------------------
MSMEG_5047|M.smegmatis_MC2_155 ---------------------
TH_0755|M.thermoresistible__bu ---------------------
MAB_1395|M.abscessus_ATCC_1997 ---------------------
MAV_2832|M.avium_104 VLAQRDWHDAQPTAAITAAAR
MLBr_01562|M.leprae_Br4923 ---------------------
MMAR_3524|M.marinum_M ---------------------