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PDQDSHRFSPARVAVVQFNPQVGVENLKANSEAVYERLQQAVAGGANLIVLPELATTGYTFESREEAYAH AEPVPSGATVTGWAEFAAAHDVYIVGCLPELDGVELFDTAVLVGPEGYIGKYRKTHLWNEEKLFFSPGDL GYPVFHTRIGRIGLLVCWDIWFPETARIVAQQGADIICIPTGWVWTPPPLYDDSGTCMAAYLTMTAAHVN NVFIATADRIGTERTSGFMGNSLIAGTNGWPIDRIAGPDEDTILYADIDITASRGAPIWNQFNDLHRDRR TDLYDQLLGYRGGQALPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2988 | - | - | 100% (299) | carbon-nitrogen hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_5655 | - | 3e-32 | 32.49% (277) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_3555 | - | 7e-25 | 32.54% (295) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 5e-07 | 25.27% (273) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 3e-09 | 28.36% (268) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 7e-07 | 25.90% (251) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 3e-05 | 26.22% (164) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2818c | - | 1e-25 | 33.57% (280) | putative hydrolase |
| M. marinum M | MMAR_4512 | - | 4e-08 | 32.73% (165) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 1e-07 | 28.69% (244) | carbon-nitrogen hydrolase |
| M. thermoresistible (build 8) | TH_0873 | - | 1e-13 | 30.08% (246) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4683 | - | 2e-08 | 33.73% (169) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_1224 | - | 4e-16 | 27.37% (285) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGT---DPAA
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSGT---DPAA
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSGT---DPVA
MAV_4670|M.avium_104 -------------------------------MRIALAQILSGT---DPAA
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSST---DPAA
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSGT---DPSA
MMAR_4512|M.marinum_M --------------------------MHQVETELVVAVAQPRT---EMGA
MUL_4683|M.ulcerans_Agy99 --------------------------MHQVKTELVVAVAQPRT---VMGA
MAB_2818c|M.abscessus_ATCC_199 ----------------------------MTVIRAALTQATWTG---DKES
Mvan_1224|M.vanbaalenii_PYR-1 ------------------------------MTTLAAVSANFTR---DLEQ
MSMEG_2988|M.smegmatis_MC2_155 --------------------MPDQDSHRFSPARVAVVQFNPQVGVENLKA
. .
Mb0490c|M.bovis_AF2122/97 NLQLVGKYAGEAATAGAQLVVFPEATMCRLGVPLR-------------QV
Rv0480c|M.tuberculosis_H37Rv NLQLVGKYAGEAATAGAQLVVFPEATMCRLGVPLR-------------QV
MLBr_02449|M.leprae_Br4923 NLRLVREYTGQATDAGATLVVFPEATMCRFGVPLG-------------PV
MAV_4670|M.avium_104 NLALVGEYTRRAAGAGARLVVFPEATMCRFGVPLA-------------PI
Mflv_0095|M.gilvum_PYR-GCK NLTLVEEYTRRAVDAGASLVLFPEATMVRFGVPLG-------------GV
TH_0873|M.thermoresistible__bu NLNLVEEYTRRAAATGAGLVLFPEATMCRFGVSLK-------------PV
MMAR_4512|M.marinum_M VAANVDAHAALIRRANARLVVFPELSLT--GYQLK-------------VA
MUL_4683|M.ulcerans_Agy99 VAANVDAHAALIQRANARLVVFPELSLT--GYQLE-------------VA
MAB_2818c|M.abscessus_ATCC_199 MLAKHERFVAQAAARGAQVICFQELFYGPYFGIVQDK--------KYYGY
Mvan_1224|M.vanbaalenii_PYR-1 NYALIASLADEARHRGVDFLTLPEAAIGGYLSSLGNHGDTVRTTARSLPP
MSMEG_2988|M.smegmatis_MC2_155 NSEAVYERLQQAVAGGANLIVLPELATTGYTFESREE---------AYAH
.. .: : *
Mb0490c|M.bovis_AF2122/97 AEPVD-GPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPN
Rv0480c|M.tuberculosis_H37Rv AEPVD-GPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPN
MLBr_02449|M.leprae_Br4923 AEPID-GPWANGVRQIATEAGITIIAGIFTPADDGRVMNTLIAAGPGTPN
MAV_4670|M.avium_104 AEPVD-GPWADGVRRIATEANVTVIAGMFTPSGDGRVKNTLLVAN--SDD
Mflv_0095|M.gilvum_PYR-GCK AEPFD-GPWANAVRDIAARAGIVVVAGMFVPSDDGRSFNTLLATGP----
TH_0873|M.thermoresistible__bu AEPLD-GPWATAVREIAAGAGVVVVAGMFTPSGDGRVTNTLLATGP----
MMAR_4512|M.marinum_M PVDVA-GPVVDRLVLACAATGCSVLVGAPVEDRGRRYIAMVLVDSS----
MUL_4683|M.ulcerans_Agy99 PVDVA-GPVVDRLVLACAATGCSALVGAPVEDRGRRYIAMVLVDSS----
MAB_2818c|M.abscessus_ATCC_199 AEPVP-GPVTERFAKLAREHRMVLVLPVYEQEQPGVLYNTAAVVDS--DG
Mvan_1224|M.vanbaalenii_PYR-1 AIRLD-GPEIARVQQIVGDLVVAIGFCELADDGHTRYNAAAVLDGS----
MSMEG_2988|M.smegmatis_MC2_155 AEPVPSGATVTGWAEFAAAHDVYIVGCLPELDGVELFDTAVLVGPE----
. . *.
Mb0490c|M.bovis_AF2122/97 QPDAHYHKIHLYDAFGFTESRTVAPGRE--PVVVVVDG----VRVGLTVC
Rv0480c|M.tuberculosis_H37Rv QPDAHYHKIHLYDAFGFTESRTVAPGRE--PVVVVVDG----VRVGLTVC
MLBr_02449|M.leprae_Br4923 QPDTHYHKIHLYDAFGFTESRTVTAGHE--PVVITVDD----VQVGLTIC
MAV_4670|M.avium_104 QAVTHYDKIHLYDAFGFTESRTVAPGRE--PVVVGVDG----VRVGLSVC
Mflv_0095|M.gilvum_PYR-GCK GVEARYDKIHLYDAFGFLESKTVAPGRE--PVVISVDTESGPVTVGLTLC
TH_0873|M.thermoresistible__bu GVAAHYHKIHLYDAYGFTESRTVAPGSE--PVTIDVGG----VRVGLTTC
MMAR_4512|M.marinum_M GAEVVYRKTHL----GAAEKARFRPGPG--PRTIDLDG----WRIGLGIC
MUL_4683|M.ulcerans_Agy99 GAEVVYRKTHL----DAAEKARFRPGPG--PRTIDLDG----WRIGLGIC
MAB_2818c|M.abscessus_ATCC_199 RYLGKYRKHHIPHLDRFWEKFYFRPGNLGYPVFDTAVG-----KIGVYIC
Mvan_1224|M.vanbaalenii_PYR-1 TVYGSYRKVHQP----LGEGMSYSAGSG-YGVFDTPIG-----RVGLQIC
MSMEG_2988|M.smegmatis_MC2_155 GYIGKYRKTHLWN----EEKLFFSPGDLGYPVFHTRIG-----RIGLLVC
* * * * .* :*: *
Mb0490c|M.bovis_AF2122/97 YDIRFPALYTELARRGAQLIAVCASWGSGPGKLEQ----------WTLLA
Rv0480c|M.tuberculosis_H37Rv YDIRFPALYTELARRGAQLIAVCASWGSGPGKLEQ----------WTLLA
MLBr_02449|M.leprae_Br4923 YDIRFPALYTELARRGAQLIVVCASWGSGAGKLEQ----------WTLLA
MAV_4670|M.avium_104 YDIRFPELYTELARRGAQLIAVCASWGAGPGKLDQ----------WTLLA
Mflv_0095|M.gilvum_PYR-GCK YDIRFPELYVELADRGAEIITAHASWGTGPGKLEQ----------WTLLA
TH_0873|M.thermoresistible__bu YDIRFPELYVELARRGAELLTVHASWGSGPGKLEQ----------WTLLA
MMAR_4512|M.marinum_M RDTGVPEHVRGTARLGVDLYACGVVHHDW--ELGE----------QRHRA
MUL_4683|M.ulcerans_Agy99 RDTGVPEHVRGTARLGVDLYACGVVHHDG--ELGE----------QRHRA
MAB_2818c|M.abscessus_ATCC_199 YDRHFPEGWRNYGLAGAELVFNPSATKPG-LSNRL----------WELEQ
Mvan_1224|M.vanbaalenii_PYR-1 YDKAFPEAARIMALRGAQVIASLSAWPAARTATAENLQDDRWTYRFNLFD
MSMEG_2988|M.smegmatis_MC2_155 WDIWFPETARIVAQQGADIICIPTGWVWTPPPLYD----DSGTCMAAYLT
* .* . *.::
Mb0490c|M.bovis_AF2122/97 RARALDSMSYVAAAGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVV
Rv0480c|M.tuberculosis_H37Rv RARALDSMSYVAAAGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVV
MLBr_02449|M.leprae_Br4923 RARALDSMSYVAAVGQADPGGALTDSGPSSAAPTGVGGSLVASPLGEVVA
MAV_4670|M.avium_104 RARALDSMSYIAAAGQADPGGSLSASG----APTGVGGSLVASPLGEVVA
Mflv_0095|M.gilvum_PYR-GCK RARAIDTSSVVAAVGQAYPGDEIAALG-----PTGVGGSLVASALGEVLA
TH_0873|M.thermoresistible__bu RARALDTTCVVAAVGQAYPGDEIAAQG-----PTGVGGSLVASATGEVLA
MMAR_4512|M.marinum_M RTIAATCDAPVAMASFAGPTGGGYLHT--------AGHSAIWSATSTLVA
MUL_4683|M.ulcerans_Agy99 RTIAATCTAPVAMASFAGP-------------------------------
MAB_2818c|M.abscessus_ATCC_199 PAAAAANQYFVGANNRIGAESGEFGDQ----AVSFYGSSYFVDPRGNYVG
Mvan_1224|M.vanbaalenii_PYR-1 TARALDNQVFWVASNQSGTFGSLRYVG----------NAKVVDPGGNILA
MSMEG_2988|M.smegmatis_MC2_155 MTAAHVNNVFIATADRIGTERTSGFMG----------NSLIAGTNGWPID
: * . .
Mb0490c|M.bovis_AF2122/97 SAG--TQPQLLVADIDVDNVAAA---RDRIAVLRNQTDFVQIDKAQSRG-
Rv0480c|M.tuberculosis_H37Rv SAG--TQPQLLVADIDVDNVAAA---RDRIAVLRNQTDFVQIDKAQSRG-
MLBr_02449|M.leprae_Br4923 SAG--TESKLVVADIDVDNVTTA---RENIAVLRNRSHFA----------
MAV_4670|M.avium_104 SAG--AQPQLVLADIDVDRVAQA---RKTIAALSNRSDFAQVGRAESVG-
Mflv_0095|M.gilvum_PYR-GCK SAG--DDPELLVCDVDLEAARKA---RQTVAVMQNRSGFAHRGKAESRG-
TH_0873|M.thermoresistible__bu AAG--PEPELLVADLDLDAARRA---RDTIAVLRNRSDVAQWGKAESVG-
MMAR_4512|M.marinum_M EAG--AGPDQIAHTTIGRPPPGR---AGDDHTPKTA--------------
MUL_4683|M.ulcerans_Agy99 -------PEVATYTQRAIRLSGR---RRRRW-------------------
MAB_2818c|M.abscessus_ATCC_199 EIGSATDEEIVIRDLDLSLVRQV---RDDWQFYRDRRPDTYGPIIAP---
Mvan_1224|M.vanbaalenii_PYR-1 TTLLGSGMAVAEVDID-ETFRTM---RAGMFHLRDRRPDVYGPITEVGAG
MSMEG_2988|M.smegmatis_MC2_155 RIAGPDEDTILYADIDITASRGAPIWNQFNDLHRDRRTDLYDQLLGYRGG
Mb0490c|M.bovis_AF2122/97 ------
Rv0480c|M.tuberculosis_H37Rv ------
MLBr_02449|M.leprae_Br4923 ------
MAV_4670|M.avium_104 ------
Mflv_0095|M.gilvum_PYR-GCK ------
TH_0873|M.thermoresistible__bu ------
MMAR_4512|M.marinum_M ------
MUL_4683|M.ulcerans_Agy99 ------
MAB_2818c|M.abscessus_ATCC_199 ------
Mvan_1224|M.vanbaalenii_PYR-1 SDLAHA
MSMEG_2988|M.smegmatis_MC2_155 QALPR-