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TTLAAVSANFTRDLEQNYALIASLADEARHRGVDFLTLPEAAIGGYLSSLGNHGDTVRTTARSLPPAIRL DGPEIARVQQIVGDLVVAIGFCELADDGHTRYNAAAVLDGSTVYGSYRKVHQPLGEGMSYSAGSGYGVFD TPIGRVGLQICYDKAFPEAARIMALRGAQVIASLSAWPAARTATAENLQDDRWTYRFNLFDTARALDNQV FWVASNQSGTFGSLRYVGNAKVVDPGGNILATTLLGSGMAVAEVDIDETFRTMRAGMFHLRDRRPDVYGP ITEVGAGSDLAHA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1224 | - | - | 100% (294) | Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1219 | - | 3e-65 | 45.29% (276) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. vanbaalenii PYR-1 | Mvan_0813 | - | 5e-08 | 23.53% (272) | Nitrilase/cyanide hydratase and apolipoprotein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 2e-09 | 25.48% (263) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 4e-07 | 24.81% (270) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 3e-09 | 25.48% (263) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 2e-14 | 27.64% (275) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2818c | - | 2e-21 | 30.72% (293) | putative hydrolase |
| M. marinum M | MMAR_0805 | - | 1e-11 | 26.34% (262) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 3e-14 | 27.24% (257) | carbon-nitrogen hydrolase |
| M. smegmatis MC2 155 | MSMEG_0571 | - | 1e-150 | 87.63% (299) | hydrolase, carbon-nitrogen family protein |
| M. thermoresistible (build 8) | TH_0873 | - | 4e-10 | 25.93% (270) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4548 | - | 9e-12 | 26.34% (262) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0805|M.marinum_M -------------------------------MRIALAQILSGTDPTANLE
MUL_4548|M.ulcerans_Agy99 -------------------------------MRIALAQILSGTDPTANLE
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSGTDPVANLR
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGTDPAANLQ
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSGTDPAANLQ
MAV_4670|M.avium_104 -------------------------------MRIALAQILSGTDPAANLA
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSSTDPAANLT
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSGTDPSANLN
Mvan_1224|M.vanbaalenii_PYR-1 ------------------------------MTTLAAVSANFTRDLEQNYA
MSMEG_0571|M.smegmatis_MC2_155 -----------------------------MMTTLAAVSANFTRDLEQNFA
MAB_2818c|M.abscessus_ATCC_199 ----------------------------MTVIRAALTQATWTGDKESMLA
* .. *
MMAR_0805|M.marinum_M LVRDYAERAADAGARLVVFPEATMCRFGVPLG-------------PVAQP
MUL_4548|M.ulcerans_Agy99 LVRDYAERAADAGARLVVFPEATMCRFGVPLG-------------PVAQP
MLBr_02449|M.leprae_Br4923 LVREYTGQATDAGATLVVFPEATMCRFGVPLG-------------PVAEP
Mb0490c|M.bovis_AF2122/97 LVGKYAGEAATAGAQLVVFPEATMCRLGVPLR-------------QVAEP
Rv0480c|M.tuberculosis_H37Rv LVGKYAGEAATAGAQLVVFPEATMCRLGVPLR-------------QVAEP
MAV_4670|M.avium_104 LVGEYTRRAAGAGARLVVFPEATMCRFGVPLA-------------PIAEP
Mflv_0095|M.gilvum_PYR-GCK LVEEYTRRAVDAGASLVLFPEATMVRFGVPLG-------------GVAEP
TH_0873|M.thermoresistible__bu LVEEYTRRAAATGAGLVLFPEATMCRFGVSLK-------------PVAEP
Mvan_1224|M.vanbaalenii_PYR-1 LIASLADEARHRGVDFLTLPEAAIGGYLSSLGNHGDTVRTTARSLPPAIR
MSMEG_0571|M.smegmatis_MC2_155 LIADLAEQAREKGVDFLVLPEAAIGGYLSSLGNHGDTVRATSRSLPPAIR
MAB_2818c|M.abscessus_ATCC_199 KHERFVAQAAARGAQVICFQELFYGPYFGIVQDK--------KYYGYAEP
. .* *. .: : * : *
MMAR_0805|M.marinum_M LDGPWANGVRRIAAQTGITVVAGMFTPADAGRVSNTLFAAGPGAPNQPDD
MUL_4548|M.ulcerans_Agy99 LDGPWANGVRRIAAQTGITVVAGMFTPADAGRVSNTLFAAGPGAPNQPDD
MLBr_02449|M.leprae_Br4923 IDGPWANGVRQIATEAGITIIAGIFTPADDGRVMNTLIAAGPGTPNQPDT
Mb0490c|M.bovis_AF2122/97 VDGPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDA
Rv0480c|M.tuberculosis_H37Rv VDGPWANGVRRIATEAGITVIAGMFTPTGDGRVTNTLIAAGPGTPNQPDA
MAV_4670|M.avium_104 VDGPWADGVRRIATEANVTVIAGMFTPSGDGRVKNTLLVAN--SDDQAVT
Mflv_0095|M.gilvum_PYR-GCK FDGPWANAVRDIAARAGIVVVAGMFVPSDDGRSFNTLLATGPGVEAR---
TH_0873|M.thermoresistible__bu LDGPWATAVREIAAGAGVVVVAGMFTPSGDGRVTNTLLATGPGVAAH---
Mvan_1224|M.vanbaalenii_PYR-1 LDGPEIARVQQIVG--DLVVAIGFCELADDGHTRYNAAAVLDGSTVYG--
MSMEG_0571|M.smegmatis_MC2_155 LDGPEIARVQQIVG--DLVVAIGFCELADDGETRYNAAAVLDRFDVYG--
MAB_2818c|M.abscessus_ATCC_199 VPGPVTERFAKLAREHRMVLVLPVYEQEQPGVLYNTAAVVDSDGRYLG--
. ** . :. :.: . * . ..
MMAR_0805|M.marinum_M HYHKIHLYDAFGFAESRTVAPGHE--PVVITVDD----VQVGLTVCYDIR
MUL_4548|M.ulcerans_Agy99 HYHKIHLYDAFGFAESRTVAPGHE--PVVITVDD----FQVGLTVCYDIR
MLBr_02449|M.leprae_Br4923 HYHKIHLYDAFGFTESRTVTAGHE--PVVITVDD----VQVGLTICYDIR
Mb0490c|M.bovis_AF2122/97 HYHKIHLYDAFGFTESRTVAPGRE--PVVVVVDG----VRVGLTVCYDIR
Rv0480c|M.tuberculosis_H37Rv HYHKIHLYDAFGFTESRTVAPGRE--PVVVVVDG----VRVGLTVCYDIR
MAV_4670|M.avium_104 HYDKIHLYDAFGFTESRTVAPGRE--PVVVGVDG----VRVGLSVCYDIR
Mflv_0095|M.gilvum_PYR-GCK -YDKIHLYDAFGFLESKTVAPGRE--PVVISVDTESGPVTVGLTLCYDIR
TH_0873|M.thermoresistible__bu -YHKIHLYDAYGFTESRTVAPGSE--PVTIDVGG----VRVGLTTCYDIR
Mvan_1224|M.vanbaalenii_PYR-1 SYRKVHQPLGEGMSYSAGSGYG-----VFDTPIG-----RVGLQICYDKA
MSMEG_0571|M.smegmatis_MC2_155 SYRKVHQPLGEGMSYSAGSDYG-----VFDTPVG-----RVGLQICYDKA
MAB_2818c|M.abscessus_ATCC_199 KYRKHHIPHLDRFWEKFYFRPGNLGYPVFDTAVG-----KIGVYICYDRH
* * * : . * * :*: ***
MMAR_0805|M.marinum_M FPALYTELARRGAELIVVSASWGSGPGKLDQ----------WTLLARARA
MUL_4548|M.ulcerans_Agy99 FPALYTELARRGAELIVVSASWGSGPGKLDQ----------WTLLARARA
MLBr_02449|M.leprae_Br4923 FPALYTELARRGAQLIVVCASWGSGAGKLEQ----------WTLLARARA
Mb0490c|M.bovis_AF2122/97 FPALYTELARRGAQLIAVCASWGSGPGKLEQ----------WTLLARARA
Rv0480c|M.tuberculosis_H37Rv FPALYTELARRGAQLIAVCASWGSGPGKLEQ----------WTLLARARA
MAV_4670|M.avium_104 FPELYTELARRGAQLIAVCASWGAGPGKLDQ----------WTLLARARA
Mflv_0095|M.gilvum_PYR-GCK FPELYVELADRGAEIITAHASWGTGPGKLEQ----------WTLLARARA
TH_0873|M.thermoresistible__bu FPELYVELARRGAELLTVHASWGSGPGKLEQ----------WTLLARARA
Mvan_1224|M.vanbaalenii_PYR-1 FPEAARIMALRGAQVIASLSAWPAARTATAENLQDDRWTYRFNLFDTARA
MSMEG_0571|M.smegmatis_MC2_155 FPEAARLMALGGAQIIASLSAWPAARTATAQNLQDDRWTYRFNLFDMARA
MAB_2818c|M.abscessus_ATCC_199 FPEGWRNYGLAGAELVFNPS--ATKPGLSNR---------LWELEQPAAA
** . **::: : : . : * * *
MMAR_0805|M.marinum_M LDSASYVAAAGQADPGDTASDPGGGSGAPRGVGGSLVASPLGEVVASAG-
MUL_4548|M.ulcerans_Agy99 LDSASYVAAAGQADPGDTASDPGGGSGAPRGVGGSLVTSPLGEVVASAG-
MLBr_02449|M.leprae_Br4923 LDSMSYVAAVGQADPGGALTDSGPSSAAPTGVGGSLVASPLGEVVASAG-
Mb0490c|M.bovis_AF2122/97 LDSMSYVAAAGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAG-
Rv0480c|M.tuberculosis_H37Rv LDSMSYVAAAGQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAG-
MAV_4670|M.avium_104 LDSMSYIAAAGQADPGGSLS----ASGAPTGVGGSLVASPLGEVVASAG-
Mflv_0095|M.gilvum_PYR-GCK IDTSSVVAAVGQAYPGDEIAALG-----PTGVGGSLVASALGEVLASAG-
TH_0873|M.thermoresistible__bu LDTTCVVAAVGQAYPGDEIAAQG-----PTGVGGSLVASATGEVLAAAG-
Mvan_1224|M.vanbaalenii_PYR-1 LDNQVFWVASNQSGTFGSLR----------YVGNAKVVDPGGNILATTL-
MSMEG_0571|M.smegmatis_MC2_155 LDNQVFWVASNQSGSFGSLR----------YVGNAKVVDPGGNVLATTL-
MAB_2818c|M.abscessus_ATCC_199 AANQYFVGANNRIGAESGEFG----DQAVSFYGSSYFVDPRGNYVGEIGS
. * .: . . *.: .... *: :
MMAR_0805|M.marinum_M -SDPQLVVADIDLAK-VGAARDNIGVLRNQSRFTQTDKAQSRR-------
MUL_4548|M.ulcerans_Agy99 -SDPQLVVADIDLAK-VGAARDNIGMLRNQSRFTQTDKAQSRR-------
MLBr_02449|M.leprae_Br4923 -TESKLVVADIDVDN-VTTARENIAVLRNRSHFA----------------
Mb0490c|M.bovis_AF2122/97 -TQPQLLVADIDVDN-VAAARDRIAVLRNQTDFVQIDKAQSRG-------
Rv0480c|M.tuberculosis_H37Rv -TQPQLLVADIDVDN-VAAARDRIAVLRNQTDFVQIDKAQSRG-------
MAV_4670|M.avium_104 -AQPQLVLADIDVDR-VAQARKTIAALSNRSDFAQVGRAESVG-------
Mflv_0095|M.gilvum_PYR-GCK -DDPELLVCDVDLEA-ARKARQTVAVMQNRSGFAHRGKAESRG-------
TH_0873|M.thermoresistible__bu -PEPELLVADLDLDA-ARRARDTIAVLRNRSDVAQWGKAESVG-------
Mvan_1224|M.vanbaalenii_PYR-1 -LGSGMAVAEVDIDETFRTMRAGMFHLRDRRPDVYGPITEVGAG-----S
MSMEG_0571|M.smegmatis_MC2_155 -LDSGMAVAEVDIDETFRTMRAGMFHLRDRRPDVYAPLTDSDGPRTAKWR
MAB_2818c|M.abscessus_ATCC_199 ATDEEIVIRDLDLSL-VRQVRDDWQFYRDRRPDTYGPIIAP---------
: : ::*: * :: .
MMAR_0805|M.marinum_M -----
MUL_4548|M.ulcerans_Agy99 -----
MLBr_02449|M.leprae_Br4923 -----
Mb0490c|M.bovis_AF2122/97 -----
Rv0480c|M.tuberculosis_H37Rv -----
MAV_4670|M.avium_104 -----
Mflv_0095|M.gilvum_PYR-GCK -----
TH_0873|M.thermoresistible__bu -----
Mvan_1224|M.vanbaalenii_PYR-1 DLAHA
MSMEG_0571|M.smegmatis_MC2_155 ELAHA
MAB_2818c|M.abscessus_ATCC_199 -----