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MTVIARYADVDATLGVHSDTLALQLAHRSVRKFLPDAVSDEHLSALVAAAQSAATSSNLQPWSVVAVRDP QRKARLAVLAKNQQFINDAPLFLVWVADLGRARRIAERAGVPLDGADYLETTIIGFVDTALAAQNAVLAA ESLGLGTVFVGAIRNHPEEVAAELGLPPSAVATFGLAVGFPDPTENAGIKPRLPREAVLHHEQYDAQTAD SHVPAYDERLADYNTRHGLTGTWSERVLARLAGPQSLSGRHLLRTQLERLGLGIR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2921 | - | - | 100% (265) | NADPH-flavin oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6053 | bluB | 2e-08 | 28.73% (181) | cob(II)yrinic acid a,c-diamide reductase |
| M. smegmatis MC2 155 | MSMEG_6627 | - | 8e-06 | 25.12% (203) | nitroreductase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3290 | fbiB | 2e-05 | 24.75% (198) | F420-0--gamma-glutamyl ligase |
| M. gilvum PYR-GCK | Mflv_0353 | - | 2e-05 | 27.32% (194) | cob(II)yrinic acid a,c-diamide reductase |
| M. tuberculosis H37Rv | Rv3262 | fbiB | 2e-05 | 24.75% (198) | F420-0--gamma-glutamyl ligase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3351c | - | 6e-05 | 28.71% (202) | putative nitroreductase |
| M. marinum M | MMAR_1739 | - | 9e-12 | 30.00% (200) | nitroreductase |
| M. avium 104 | MAV_4540 | - | 1e-07 | 25.27% (182) | nitroreductase family protein |
| M. thermoresistible (build 8) | TH_3507 | - | 3e-09 | 29.23% (195) | PUTATIVE putative nitroreductase |
| M. ulcerans Agy99 | MUL_1982 | - | 9e-08 | 37.04% (81) | nitroreductase |
| M. vanbaalenii PYR-1 | Mvan_3115 | - | 1e-06 | 25.85% (205) | nitroreductase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3507|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDVVVVTS
Rv3262|M.tuberculosis_H37Rv MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDVVVVTS
MMAR_1739|M.marinum_M --------------------------------------------MYDLDE
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MAV_4540|M.avium_104 --------------------------------------------------
MSMEG_2921|M.smegmatis_MC2_155 --------------------------------------------------
TH_3507|M.thermoresistible__bu ----------------------VELVEAMRTTGTCR-YFRPDPVPDEVLY
Mvan_3115|M.vanbaalenii_PYR-1 ------MPEPIPSAAEALARLDMPLVEAMMTQRAIR-RVLPDPVDDEIVL
Mflv_0353|M.gilvum_PYR-GCK -----------------MSAETAALYDVINRRRDTRREFTGAPTDDEVLE
MAB_3351c|M.abscessus_ATCC_199 ----------------------MDVYQAIATRRDVRAEFTGQVVDDATLM
Mb3290|M.bovis_AF2122/97 KVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLG
Rv3262|M.tuberculosis_H37Rv KVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLG
MMAR_1739|M.marinum_M TIRLRRSTRMFLPRPVPRRLVQEALELAMCAPSNSNVQPWHVVFTSGAAR
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MAV_4540|M.avium_104 ----------------------MEAWDAICARRNVR-EYQPRAIAGEDLD
MSMEG_2921|M.smegmatis_MC2_155 ------MTVIARYADVDATLGVHSDTLALQLAHRSVRKFLPDAVSDEHLS
TH_3507|M.thermoresistible__bu QAFDHARFAPQGGNRQPVRWIVVRDPARKAALQDLYLPLWKNYLSG-IAD
Mvan_3115|M.vanbaalenii_PYR-1 KCLELALRAPTGANGQNWEFVVVKDPKIKRKLQRRYRLAWRVFHRTSIRD
Mflv_0353|M.gilvum_PYR-GCK RVLLAAHAAPSVGMSQPWDFVLVRSPETLRAFRDHVAGEREVFAAELSGE
MAB_3351c|M.abscessus_ATCC_199 KLLQAAHRAPSVGNSQPWDFVVIREPGMLDDFAAHVALQRQRFADSLPEG
Mb3290|M.bovis_AF2122/97 LVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITD
Rv3262|M.tuberculosis_H37Rv LVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITD
MMAR_1739|M.marinum_M DRLVAAMLERARSEPPNVARLPP----AFTHLRSALGAQVYGAMGIARDD
MUL_1982|M.ulcerans_Agy99 --------------------MPP----AFTHLRSALGAQVYGAMGIARDD
MAV_4540|M.avium_104 RIVEAGWRAPSAKNRQPWDFVIVTDRTQLQELSTVWRGAG----------
MSMEG_2921|M.smegmatis_MC2_155 ALVAAAQSAATSSNLQPWSVVAVRDPQRKARLAVLAKNQQFINDAPLFLV
: :
TH_3507|M.thermoresistible__bu GTVNVGALPKTVRDADYFAEHLAEAPAIVVACAELDGL------------
Mvan_3115|M.vanbaalenii_PYR-1 IASYDEEMAKSVRAIEWQLEHFHEIPVLVIACLRLSAR------------
Mflv_0353|M.gilvum_PYR-GCK RADVFDRIK---------IEGICESGLGIVVGYDPTR-------------
MAB_3351c|M.abscessus_ATCC_199 RRNTFDPIK---------IEGIRESGTGVVVTYDHGR-------------
Mb3290|M.bovis_AF2122/97 TMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAA
Rv3262|M.tuberculosis_H37Rv TMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAA
MMAR_1739|M.marinum_M TQARQT--------------AVLRNWEFFRAPLG----------------
MUL_1982|M.ulcerans_Agy99 TQARQT--------------AVLRNWEFFRAPLG----------------
MAV_4540|M.avium_104 --------------------HIAGAPAAIAIVVP----------------
MSMEG_2921|M.smegmatis_MC2_155 WVADLG--------------RARRIAERAGVPLD----------------
TH_3507|M.thermoresistible__bu ---------HPTDTDLGRLSIVGG--------------------------
Mvan_3115|M.vanbaalenii_PYR-1 ---------EGKVPYVPMPHAAASAF------------------------
Mflv_0353|M.gilvum_PYR-GCK -----------GGPAVLGRHAIPDAG------------------------
MAB_3351c|M.abscessus_ATCC_199 -----------GGPHILGRHTISDAG------------------------
Mb3290|M.bovis_AF2122/97 AADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLFWLGTAEALE
Rv3262|M.tuberculosis_H37Rv AADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLFWLGTAEALE
MMAR_1739|M.marinum_M -----------GIVSMHQELGLVDS-------------------------
MUL_1982|M.ulcerans_Agy99 -----------GIVSMHQELGLVDS-------------------------
MAV_4540|M.avium_104 ------------EPPDERRLVTDN--------------------------
MSMEG_2921|M.smegmatis_MC2_155 ------------GADYLETTIIG---------------------------
TH_3507|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 LGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHHTRPTRFVWL
Rv3262|M.tuberculosis_H37Rv LGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHHTRPTRFVWL
MMAR_1739|M.marinum_M --------------------------------------------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MAV_4540|M.avium_104 --------------------------------------------------
MSMEG_2921|M.smegmatis_MC2_155 --------------------------------------------------
TH_3507|M.thermoresistible__bu --------------------------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0353|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3351c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3290|M.bovis_AF2122/97 QTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQILYDAPEVVIP
Rv3262|M.tuberculosis_H37Rv QTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQILYDAPEVVIP
MMAR_1739|M.marinum_M --------------------------------------------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MAV_4540|M.avium_104 --------------------------------------------------
MSMEG_2921|M.smegmatis_MC2_155 --------------------------------------------------
TH_3507|M.thermoresistible__bu ------------------------ASVYPTVQNFCLALRNLGVGSALTTL
Mvan_3115|M.vanbaalenii_PYR-1 -----------------------FGSIYPSVQNLLLAARAMGLGASLITL
Mflv_0353|M.gilvum_PYR-GCK -----------------------LYSVVCAIQNLWLAATAEGLGVGWVS-
MAB_3351c|M.abscessus_ATCC_199 -----------------------LFSAVLAIQNLWLAAVTEGIGVGWVS-
Mb3290|M.bovis_AF2122/97 MLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIGS
Rv3262|M.tuberculosis_H37Rv MLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIGS
MMAR_1739|M.marinum_M ------------------------MGVGMFLQNLMLALTARGLGTCVQVS
MUL_1982|M.ulcerans_Agy99 ------------------------MGVGMFLQNLMLALTARGLGTCVQVS
MAV_4540|M.avium_104 ------------------------YDVGQATMAMMIAATDLGIGAGHSS-
MSMEG_2921|M.smegmatis_MC2_155 -----------------------FVDTALAAQNAVLAAESLGLGTVFVGA
:* *:*
TH_3507|M.thermoresistible__bu LCQVEPEVRELLAIPEGVATAAHIAIG-------YPRDPFPAKLTRLPVE
Mvan_3115|M.vanbaalenii_PYR-1 PLWNLTSARRVLKLPTEVTPCCVVPLG-------WPRGRY-GPTTRRPVD
Mflv_0353|M.gilvum_PYR-GCK -FYREETLRSLVGMPDHVRPVAWLCVGPVADLPDVPDLERFGWQARRSLD
MAB_3351c|M.abscessus_ATCC_199 -FYEEQFLAELIDAPAHIRPIAWLCVGPVREFAERPDLERFGWRTGRPLE
Mb3290|M.bovis_AF2122/97 TIFAADLVRDELDLPVDWEPLGAIAIG-------YADEPSG------LRD
Rv3262|M.tuberculosis_H37Rv TIFAADLVRDELDLPVDWEPLGAIAIG-------YADEPSG------LRD
MMAR_1739|M.marinum_M IAGYPEIVRKQVGIPSHLTILCGLAIG-------YPDPDFAGNQLRVGRD
MUL_1982|M.ulcerans_Agy99 IAGYPEIVRKQVGIPSHLTILCGLAIG-------YPDPDFAGNQLRVGRD
MAV_4540|M.avium_104 -VGDQDKARAILGVPDGHLVAFLLGVG----YPADRPLTPIRKPNRRPFT
MSMEG_2921|M.smegmatis_MC2_155 IRNHPEEVAAELGLPPSAVATFGLAVG------FPDPTENAGIKPRLPRE
: * : :*
TH_3507|M.thermoresistible__bu DVVAAETY-DQPFFAPTTV-------------------------------
Mvan_3115|M.vanbaalenii_PYR-1 EVVHLDRYGNRAWFGPRGADRP----------------------------
Mflv_0353|M.gilvum_PYR-GCK TVVHRERYPEP---------------------------------------
MAB_3351c|M.abscessus_ATCC_199 DAVHWGRYRA----------------------------------------
Mb3290|M.bovis_AF2122/97 PVPAADLLILK---------------------------------------
Rv3262|M.tuberculosis_H37Rv PVPAADLLILK---------------------------------------
MMAR_1739|M.marinum_M DVAEHVVFLDD---------------------------------------
MUL_1982|M.ulcerans_Agy99 DVAEHVVFLDD---------------------------------------
MAV_4540|M.avium_104 EVVHRGRW------------------------------------------
MSMEG_2921|M.smegmatis_MC2_155 AVLHHEQYDAQTADSHVPAYDERLADYNTRHGLTGTWSERVLARLAGPQS
.
TH_3507|M.thermoresistible__bu -------------------
Mvan_3115|M.vanbaalenii_PYR-1 -------------------
Mflv_0353|M.gilvum_PYR-GCK -------------------
MAB_3351c|M.abscessus_ATCC_199 -------------------
Mb3290|M.bovis_AF2122/97 -------------------
Rv3262|M.tuberculosis_H37Rv -------------------
MMAR_1739|M.marinum_M -------------------
MUL_1982|M.ulcerans_Agy99 -------------------
MAV_4540|M.avium_104 -------------------
MSMEG_2921|M.smegmatis_MC2_155 LSGRHLLRTQLERLGLGIR