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VDLGLVDTRVVVTGGASNIGRAIVHEFASEGARIVLNDIDEPQAEKVRGEALERGASAVEVVVADLTLPG SAESAVGRAVESWGGIDVLVNNAGWTAPGFIATDTDRTKWQRIIEINLFSALAATQAAIGPMKDAGVGAI VFIASDAAFGQIRQSVYGASKAAMVALARTTAREHGRHGIRSNVVCPGLVVPEGPDAIGQSSLWSVGQDN IFNEKQIEFMLKDTPLRRLTTAEDVARAVLWFSSPSAARQVTGQIISVSGGYTMP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5089 | - | - | 100% (265) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. avium 104 | MAV_0886 | - | 2e-32 | 37.07% (259) | short-chain dehydrogenase/reductase SDR |
| M. avium 104 | MAV_1395 | - | 7e-31 | 36.90% (252) | 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 2e-26 | 33.33% (258) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2415 | - | 6e-28 | 33.46% (260) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 2e-26 | 33.33% (258) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 8e-20 | 28.85% (260) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0598 | - | 9e-25 | 31.10% (254) | short chain dehydrogenase |
| M. marinum M | MMAR_4765 | - | 3e-30 | 35.00% (260) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3262 | - | 2e-31 | 35.98% (264) | L-xylulose reductase |
| M. thermoresistible (build 8) | TH_3228 | - | 1e-117 | 78.12% (256) | PUTATIVE oxidoreductase, short chain dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_0336 | - | 9e-30 | 34.50% (258) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4237 | - | 1e-30 | 34.96% (266) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------MSGRLIGKVALVSGGA-RGMGASHVRAMVAEGAKVV
Rv2002|M.tuberculosis_H37Rv --------------MSGRLIGKVALVSGGA-RGMGASHVRAMVAEGAKVV
Mflv_2415|M.gilvum_PYR-GCK ---------------MTELAGKVAVVTGGA-SGIGRGIAARFAAEGAAVV
Mvan_4237|M.vanbaalenii_PYR-1 ---------------MTELVGKVAIVTGGA-SGIGRGIAERFAAEGARVV
MMAR_4765|M.marinum_M --------------MVDELAGKIAIVTGGA-SGIGRATVARFIAEGARVV
MUL_0336|M.ulcerans_Agy99 --------------MVDELAGKIAIVTGGA-SGIGRATVARFIAEGARVV
MAV_5089|M.avium_104 --------------MDLGLVDTRVVVTGGA-SNIGRAIVHEFASEGARIV
TH_3228|M.thermoresistible__bu -----------------------VVVTGGA-SNIGRGIVHEFATEGARIV
MSMEG_3262|M.smegmatis_MC2_155 -----MTTTDDRYAGVLRLDGKRALITGAT-KGIGADIARAFAAAGARLV
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGN-RGIGLAVARRLVADGHRVA
MAB_0598|M.abscessus_ATCC_1997 ---MNLAEAPTEIEGHGLLKGKAVVVTAAAGTGIGSSTARRALVEGADVV
:::.. .:* . * :.
Mb2025|M.bovis_AF2122/97 FGDILDEEGKAVAAEL----ADAARYVHLDVTQPAQWTAAVDTAVTAFGG
Rv2002|M.tuberculosis_H37Rv FGDILDEEGKAVAAEL----ADAARYVHLDVTQPAQWTAAVDTAVTAFGG
Mflv_2415|M.gilvum_PYR-GCK IADVRDDLGEALVRELNES-GAKTVYRHTDVGDQAQVADLVSSTVETFGA
Mvan_4237|M.vanbaalenii_PYR-1 IADVRDDLGEPLAAELNSR-GAKTVYRHTDVGDQRQVAELVAAAVDTFGG
MMAR_4765|M.marinum_M IADVEEERGESLAAAL----GADAMFCRTDVSQPEQVAAVVAAAVENFGG
MUL_0336|M.ulcerans_Agy99 IADVEEERGESLAAAL----GADAMFCRTDVSQPEQVAAVVAAAVDNFGG
MAV_5089|M.avium_104 LNDIDEPQAEKVRGEALERGASAVEVVVADLTLPGSAESAVGRAVESWGG
TH_3228|M.thermoresistible__bu ISDIDRTQSVKVREEALDRGAAAVELAIGDLTEPGAADAAIGVAVDRWGG
MSMEG_3262|M.smegmatis_MC2_155 LSGRDVSELDAARRALGEQFGTDVHTVAIDLAEPDAPAELARRAAEAFGG
MLBr_01807|M.leprae_Br4923 VTHRASVVP------------DWFFGVECDVTDNDAIGAAFKAVEEHQGP
MAB_0598|M.abscessus_ATCC_1997 VSDYHERRLTETRDELAALGLGKVAAVVCDVTSTEAVDALITESVAALGR
. *: *
Mb2025|M.bovis_AF2122/97 LHVLVNNAGILN--IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKE
Rv2002|M.tuberculosis_H37Rv LHVLVNNAGILN--IGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKE
Mflv_2415|M.gilvum_PYR-GCK LNVMVNNAGISSPLRKGLFHEDLEEFDRVMRVNLLGVMAGTRDAARHMAD
Mvan_4237|M.vanbaalenii_PYR-1 LDVMVNNAGISSPLRKGLFHEDLEEFDRVMRVNLLGVMAGTRDAGRYMAD
MMAR_4765|M.marinum_M LHVMVNNAGVSGVMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAA
MUL_0336|M.ulcerans_Agy99 LHVMVNNAGVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAA
MAV_5089|M.avium_104 IDVLVNNAGWTAPGFIATDTDR-TKWQRIIEINLFSALAATQAAIGPMKD
TH_3228|M.thermoresistible__bu IDVLVNNAGWSVPGFIASDTDR-AKWQRTIEVNLFTAIAATQAAIGPMKE
MSMEG_3262|M.smegmatis_MC2_155 LDVLVNNAGISHP-QPVVDTDP-QLFDATIAVNLRAPALLASAVGKAMVA
MLBr_01807|M.leprae_Br4923 VEVLVANAGITSDMLIMRMSEE--QFQKVIDVNLTGVFRVAKLASRNMIK
MAB_0598|M.abscessus_ATCC_1997 IDVLVNNAGLGGETPVADMTDD--QWDRVLDVTLTSTFRATRAALRYFRE
:.*:* *** :. : :.: . :
Mb2025|M.bovis_AF2122/97 AG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRV
Rv2002|M.tuberculosis_H37Rv AG-RGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALELGPSGIRV
Mflv_2415|M.gilvum_PYR-GCK HG-GGSVINLGSIGGIQAGGGVSTYRASKAAIIHFTKCAAIELAHYEVRV
Mvan_4237|M.vanbaalenii_PYR-1 HG-GGSIINLGSIGGIQAGGGVSTYRASKAAIIHFTKCAAIELAHYEVRV
MMAR_4765|M.marinum_M HG-GGSIVNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEIRV
MUL_0336|M.ulcerans_Agy99 HG-GGSIVNLTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYEIRV
MAV_5089|M.avium_104 AG-VGAIVFIASDAAFGQIRQS-VYGASKAAMVALARTTAREHGRHGIRS
TH_3228|M.thermoresistible__bu AG-GGSIVFIASDAAFGQIRQG-VYGASKAAMVALARTTAREHGRHGIRS
MSMEG_3262|M.smegmatis_MC2_155 AGEGGAIITVASAAALAPLPDHYAYCTSKAGLVMATKVLARELGPHGIRA
MLBr_01807|M.leprae_Br4923 QR-FGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITA
MAB_0598|M.abscessus_ATCC_1997 AGHGGVIVNNASVLGWRAQYGQSHYAAAKAGVMALTRCSAIEAVEHGVRV
* : * . * ::* .: :: * * :
Mb2025|M.bovis_AF2122/97 NSIHPGLVKTPMTDWVPEDI--FQT-----------------ALGRAAEP
Rv2002|M.tuberculosis_H37Rv NSIHPGLVKTPMTDWVPEDI--FQT-----------------ALGRAAEP
Mflv_2415|M.gilvum_PYR-GCK NCLAPGNIPTPILASSATDE--DRERLEKFEARIRQQMRDDRPLKREGTA
Mvan_4237|M.vanbaalenii_PYR-1 NCLAPGNIPTPILASSATDE--DRERLERFEARIRRQMRDDRPLKREGTA
MMAR_4765|M.marinum_M NAIAPGNIPTPLLASSAAGM--DQEQVERFTAQIRQTMREDRPLKREGTP
MUL_0336|M.ulcerans_Agy99 NAIAPGNIPTPLLASSAAGL--DQEQVERFTAQIRQTMREDRPLKREGTP
MAV_5089|M.avium_104 NVVCPGLVVPEGPDAIGQSSLWSVGQDNIFNEKQIEFMLKDTPLRRLTTA
TH_3228|M.thermoresistible__bu NIVCPGLVIPDGNDAVGETSLWAVGQDNVFNPNQIEYLLKDTPTRQLTTA
MSMEG_3262|M.smegmatis_MC2_155 NSVCPTVVLTEMGQRVWG------------DEAKSAPMIARIPLGRFAVP
MLBr_01807|M.leprae_Br4923 NVVAPGFIDTEMTRAMDSKY--------------QEAALQAIPLGRIGAV
MAB_0598|M.abscessus_ATCC_1997 NAVAPSIARHKFLDKVTSSD-------------LLDKLSSDEAFGRAAEP
* : * . :
Mb2025|M.bovis_AF2122/97 VEVSNLVVYLAS-DESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEW
Rv2002|M.tuberculosis_H37Rv VEVSNLVVYLAS-DESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEW
Mflv_2415|M.gilvum_PYR-GCK DDVAEAALYLAT-DRSRYVTGTVLPIDGGTVA-------GKVIVRKPKDQ
Mvan_4237|M.vanbaalenii_PYR-1 EDVAEAALYLAT-DRSRYITGTVLPVDGGTVA-------GKVIVRKPPPA
MMAR_4765|M.marinum_M EDIAEAALYFAG-ERSRYVTGTVLPVDGGTVA-------GKVIRRSR---
MUL_0336|M.ulcerans_Agy99 EDIAEAALYFAG-ERSRYVTGTVLPVDGGTVA-------GKVIRRSR---
MAV_5089|M.avium_104 EDVARAVLWFSSPSAARQVTGQIISVSGGYTMP-----------------
TH_3228|M.thermoresistible__bu EDIGRAVLWLSSARAARQVTGQLISVSGGYTMP-----------------
MSMEG_3262|M.smegmatis_MC2_155 HEVSDAVVWLAS-DAASMINGVDIPVDGGYTMG-----------------
MLBr_01807|M.leprae_Br4923 EEIAGAVSFLAS-EDAGYISGAVIPVDGGLGMGH----------------
MAB_0598|M.abscessus_ATCC_1997 WEVAATIAFLAS-DYSSYLTGEVISVSSQRA-------------------
::. ::: : .* : :..
Mb2025|M.bovis_AF2122/97 VT--
Rv2002|M.tuberculosis_H37Rv VT--
Mflv_2415|M.gilvum_PYR-GCK Q---
Mvan_4237|M.vanbaalenii_PYR-1 EAAT
MMAR_4765|M.marinum_M ----
MUL_0336|M.ulcerans_Agy99 ----
MAV_5089|M.avium_104 ----
TH_3228|M.thermoresistible__bu ----
MSMEG_3262|M.smegmatis_MC2_155 ----
MLBr_01807|M.leprae_Br4923 ----
MAB_0598|M.abscessus_ATCC_1997 ----