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TTHNDAEAIAALNLDRLPHHIVGKRVTDLMDLSGKKAFVTGAGGDGLGHAIANRLAGSGADIALVGRTRE PLERRAAEIAQRWGVNTYPVQADMSKWDQIHRGVAEAHDKLGRLDIMINNPVMVAAGPFEKQTKEQIDLT VLGSLTMMMYGAHAALEYLLPQGSGVIINIGSVGGRVQQRGLTVYNACKSGVIGFTRNLAHEVAPRGVNV FCVAPGIMIKEQMKQYLFDPQDDQQRAGRGAIIESITHQVQLGRASLPEEAANMVAFLASEAASYMCGQT IDVAGGQWMG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1832 | - | - | 100% (291) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 2e-30 | 32.69% (260) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_1263 | - | 3e-27 | 32.57% (261) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1385 | fabG | 5e-29 | 31.18% (263) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv1350 | fabG | 5e-29 | 31.18% (263) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 5e-21 | 29.39% (262) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4178c | - | 1e-26 | 31.70% (265) | short chain dehydrogenase |
| M. marinum M | MMAR_4033 | fabG | 3e-31 | 33.33% (261) | 3-oxoacyl- |
| M. avium 104 | MAV_3101 | - | 1e-125 | 78.49% (279) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_2918 | - | 4e-29 | 34.59% (266) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3693 | - | 5e-31 | 32.43% (259) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3898 | fabG | 4e-30 | 33.07% (254) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. vanbaalenii PYR-1 | Mvan_1975 | fabG | 6e-31 | 33.46% (263) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
TH_3693|M.thermoresistible__bu -----------------------------VSLLAGQ--------TAVVTG
Mvan_1975|M.vanbaalenii_PYR-1 -----------------------MRMGEQVSLLTGQ--------TAVITG
Mb1385|M.bovis_AF2122/97 ----------------------------MASLLNAR--------TAVITG
Rv1350|M.tuberculosis_H37Rv ----------------------------MASLLNAR--------TAVITG
MMAR_4033|M.marinum_M ----------------------------MSVSLLNG-------QIAVVTG
MUL_3898|M.ulcerans_Agy99 ----------------------------MCGAHRDRG-----YVYPVVTG
MLBr_01807|M.leprae_Br4923 ----------------------MTDAAAKVSAAPGRGKPAFVSRSILVTG
Mflv_1832|M.gilvum_PYR-GCK MTTHNDAEAIAALNLDRLPHHIVGKRVTDLMDLSGKK-------AFVTGA
MAV_3101|M.avium_104 -----------MLGFDRLPEHIVDKRVTELMDLSGKK-------AVVTGA
MAB_4178c|M.abscessus_ATCC_199 ---------------------------MSLLNFDGKV-------VVVSGI
MSMEG_2918|M.smegmatis_MC2_155 ---------------------------MDLQ-LTGKR-------AIITGG
:
TH_3693|M.thermoresistible__bu GARGLGYAIAERFIAEGARVVIGDIDESATRAAADSLGG--ADVAVGMRC
Mvan_1975|M.vanbaalenii_PYR-1 GAQGLGFAIAQRFVEEGARVVLGDVNLDATVAAAEKLGG--EDVARAVRC
Mb1385|M.bovis_AF2122/97 GAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGG--DDVALAVRC
Rv1350|M.tuberculosis_H37Rv GAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGG--DDVALAVRC
MMAR_4033|M.marinum_M GAQGLGLAIAERFVSEGARVVLGDVNLEATEAAAKQLGG--GEVAVAVRC
MUL_3898|M.ulcerans_Agy99 GAQGLGLAIAERFVSEGARVVLGDVNLEATEAAAKQLGG--GEVAVAVRC
MLBr_01807|M.leprae_Br4923 GNRGIGLAVARRLVADGHRVAVTHR---ASVVPDWFFG---------VEC
Mflv_1832|M.gilvum_PYR-GCK GGDGLGHAIANRLAGSGADIALVGRTREPLERRAAEIAQRWGVNTYPVQA
MAV_3101|M.avium_104 GGDGLGQAIANRLGGLGADIALIGRTLEKVQRRGREVEERWGVKTVAISA
MAB_4178c|M.abscessus_ATCC_199 G-PGLGAALAIKFAEAGADVVLAARTQSRLDEVARQIAA-TGRRALAVAT
MSMEG_2918|M.smegmatis_MC2_155 S-KGIGLAIAHALATEGVDVVLAARNQETLEKAAAEVAERTGRRAIPVVA
. *:* *:. : * :.: . :
TH_3693|M.thermoresistible__bu DVTRSDEVEALVGAAVKRFGSLDVMVNNAGITRDA----TMRKMTEQQFD
Mvan_1975|M.vanbaalenii_PYR-1 DVTDSAEVDALIAAAVDGFGSLDIMVNNAGITRDA----TMRKMTEEQFD
Mb1385|M.bovis_AF2122/97 DVTQADDVDILIRTAVERFGGLDVMVNNAGITRDA----TMRTMTEEQFD
Rv1350|M.tuberculosis_H37Rv DVTQADDVDILIRTAVERFGGLDVMVNNAGITRDA----TMRTMTEEQFD
MMAR_4033|M.marinum_M DVTKADEVETLLQTALERFGGLDIMVNNAGITRDA----TMRKMTEEQFD
MUL_3898|M.ulcerans_Agy99 DVTKADEVETLLQAALERFGGLDIMVNNAGITRDA----TMRKMTEEQFD
MLBr_01807|M.leprae_Br4923 DVTDNDAIGAAFKAVEEHQGPVEVLVANAGITSDM----LIMRMSEEQFQ
Mflv_1832|M.gilvum_PYR-GCK DMSKWDQIHRGVAEAHDKLGRLDIMINNPVMVAAG----PFEKQTKEQID
MAV_3101|M.avium_104 DMSDWDQVHNAVREAHWQLGGLDIMVNNPVMVAGG----LFETQTKEQID
MAB_4178c|M.abscessus_ATCC_199 DITDEASAANLVERATEEFGGIDVLVNNAFSIPS---MKSLEKTDYQHIR
MSMEG_2918|M.smegmatis_MC2_155 DTGDDESVKALVARAVEELGGVDILVNNASNQAVGAAFPDLAGTTDEAFW
* . . * ::::: *. : : :
TH_3693|M.thermoresistible__bu EVIAVHLKGTWNGLRAAAAIMREQKRGAIVNMSSISGKVGMVGQTNYSAA
Mvan_1975|M.vanbaalenii_PYR-1 QVIAVHLKGTWNGLRAAAAVMREQKRGAIVNMSSISGKVGMVGQTNYSAA
Mb1385|M.bovis_AF2122/97 QVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAA
Rv1350|M.tuberculosis_H37Rv QVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAA
MMAR_4033|M.marinum_M QVIDVHLKGTWNGIRLAAAIMRENKRGAIVNMSSVSGKVGMVGQTNYSAA
MUL_3898|M.ulcerans_Agy99 QVIDVHLKGTWNGIRLAAAIMRENKRGAIVNMSSVSGKVGMVGQTNYSAA
MLBr_01807|M.leprae_Br4923 KVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVVGLSGVPGQANYAAS
Mflv_1832|M.gilvum_PYR-GCK LTVLGSLTMMMYGAHAALEYLLPQGSGVIINIGSVGGRVQQRGLTVYNAC
MAV_3101|M.avium_104 FTVLGSLTMMMYGAHAALQFLLPQGSGKIINIGSVGGRIQQRGLVVYNAC
MAB_4178c|M.abscessus_ATCC_199 DSVELTVVGTLRLTQRVAAAL-AQSKGAVVNINSMVIRHSQVRYGSYKIA
MSMEG_2918|M.smegmatis_MC2_155 GDVNVKVVGYLRAARAVAPHLKAQGWGRIINISGLGYWQTHSIVRS--IR
: : : . : . * : :..:
TH_3693|M.thermoresistible__bu KAGIVGMTKAASKELAYLGVRVNAIQPGLIR------------SAMTEAM
Mvan_1975|M.vanbaalenii_PYR-1 KAGIVGMTKAASKELAYLGVRVNAIQPGLIR------------SAMTEAM
Mb1385|M.bovis_AF2122/97 KAGIVGMTKAAAKELAHLGIRVNAIAPGLIR------------SAMTEAM
Rv1350|M.tuberculosis_H37Rv KAGIVGMTKAAAKELAHLGIRVNAIAPGLIR------------SAMTEAM
MMAR_4033|M.marinum_M KAGIVGMTKAAAKELAHVGVRVNAIAPGLIR------------SAMTEAM
MUL_3898|M.ulcerans_Agy99 KAGIVGMTKAAAKELAHVGVRVNAIAPGLIR------------SAMTEAM
MLBr_01807|M.leprae_Br4923 KSGLIGMARSLARELGSRSITANVVAPGFID------------TEMTRAM
Mflv_1832|M.gilvum_PYR-GCK KSGVIGFTRNLAHEVAPRGVNVFCVAPGIMIKEQMKQYLFDPQDDQQRAG
MAV_3101|M.avium_104 KAGVIGFTRNLAHEVALRGVNVLGVAPGIMLNPQLKQYVLDPQDDQERAG
MAB_4178c|M.abscessus_ATCC_199 KAALLAMSQSLATELGPQGVRVNSVVPGYMWGENLKG-YFEHQAKKYGGT
MSMEG_2918|M.smegmatis_MC2_155 NVSVAALTKNLADELGPHGINVTVVHPGQTRTESKTA-QFEAAARAAGID
: .: .::: : *:. .: . : **
TH_3693|M.thermoresistible__bu PQRIWDEKLAEIPMGRAGEPEEVAKVALFLASDLSSYMTGTVLEVTGGRH
Mvan_1975|M.vanbaalenii_PYR-1 PQRIWDSKVAEVPMGRAGEPEEVANVALFLASDLSSYMTGTVLEVTGGRH
Mb1385|M.bovis_AF2122/97 PQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRF
Rv1350|M.tuberculosis_H37Rv PQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRF
MMAR_4033|M.marinum_M PQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVTGGRF
MUL_3898|M.ulcerans_Agy99 PQRIWDQKLAEVPMGRAGEPSEVASVALFLACDLSSYMTGTVLDVTGGRF
MLBr_01807|M.leprae_Br4923 DSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLG
Mflv_1832|M.gilvum_PYR-GCK RGAIIESITHQVQLGRASLPEEAANMVAFLASEAASYMCGQTIDVAGGQW
MAV_3101|M.avium_104 RDAMIEAITQQVQLGRASLPEEAANMVAFLATEAADYLCGQTIDVAGGQW
MAB_4178c|M.abscessus_ATCC_199 VEQIYEYTAANSDLKRLPTTDEVANAVLFLASDLASGITGQALDVNCGEF
MSMEG_2918|M.smegmatis_MC2_155 VAD-YERQIADNAIGRVVDAAEVADVVAFLASPRSVSITGDAVAVGGGLL
: : * * * . *** : : * .: * *
TH_3693|M.thermoresistible__bu L----
Mvan_1975|M.vanbaalenii_PYR-1 L----
Mb1385|M.bovis_AF2122/97 I----
Rv1350|M.tuberculosis_H37Rv I----
MMAR_4033|M.marinum_M I----
MUL_3898|M.ulcerans_Agy99 I----
MLBr_01807|M.leprae_Br4923 MGH--
Mflv_1832|M.gilvum_PYR-GCK MG---
MAV_3101|M.avium_104 MG---
MAB_4178c|M.abscessus_ATCC_199 HA---
MSMEG_2918|M.smegmatis_MC2_155 GTVNY