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VRETPKPSTPGSLAGKVAFVAGASRGIGATIATALAAEGAAVAVAARSERPGKLPGTIDSVASAITDAGG HALPVVCDVTDEQSVERAVAQTVSELGGIDILVANAGVLWLGPIENTPLKRWQLCLDVNLTGVFLVTKAV IPHVRARGGGSLIAITTTGVDMVEHGSNAYWVSKAATERLYTGLAADLRDDNIAVNCLSPSRVVLTEGWQ AGGGGLKIPPEMIEPPEAMARAAVLLAQQDGTGVTGTVQRSEALTL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4872 | - | - | 100% (256) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1894 | - | 2e-34 | 40.09% (222) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4882 | - | 3e-32 | 35.69% (255) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 6e-35 | 37.13% (237) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2396 | - | 1e-113 | 82.04% (245) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3224 | - | 6e-35 | 37.13% (237) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 8e-16 | 31.82% (198) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 2e-33 | 41.50% (200) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 7e-36 | 36.84% (247) | iron-regulated short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_4172 | - | 3e-36 | 37.34% (241) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0664 | - | 2e-35 | 37.55% (245) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 3e-36 | 36.84% (247) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4252 | - | 1e-112 | 81.56% (244) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
Mflv_2396|M.gilvum_PYR-GCK ----------------------------------------------MTLD
Mvan_4252|M.vanbaalenii_PYR-1 ----------------------------------------------MTLH
MSMEG_4872|M.smegmatis_MC2_155 ------------------------------------MRETPKPSTPGSLA
Mb3251|M.bovis_AF2122/97 ----------------------------------------------MSLN
Rv3224|M.tuberculosis_H37Rv ----------------------------------------------MSLN
MMAR_1333|M.marinum_M ----------------------------------------------MSLN
MUL_2546|M.ulcerans_Agy99 ----------------------------------------------MSLN
MAV_4172|M.avium_104 ----------------------------------------------MSLN
TH_0664|M.thermoresistible__bu ----------------------------------------------MSLR
MAB_3946c|M.abscessus_ATCC_199 ---------------------------------------------MGSLA
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
*
Mflv_2396|M.gilvum_PYR-GCK GKVAFVAGASRGIGATVAAALARAGASVAVAARTEQEG-RLPGTIGSVAQ
Mvan_4252|M.vanbaalenii_PYR-1 GKVAFVAGASRGIGATVAAALARAGASVAVAARSEQEG-KLPGTIGSVAQ
MSMEG_4872|M.smegmatis_MC2_155 GKVAFVAGASRGIGATIATALAAEGAAVAVAARSERPG-KLPGTIDSVAS
Mb3251|M.bovis_AF2122/97 GKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAK
Rv3224|M.tuberculosis_H37Rv GKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAK
MMAR_1333|M.marinum_M GKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPKLPGTVYTAAK
MUL_2546|M.ulcerans_Agy99 GKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPKLPGTVYTAAK
MAV_4172|M.avium_104 GKTMFISGASRGIGLAIAKRAAQDGANIALIAKTAEPHPKLPGTVYTAAK
TH_0664|M.thermoresistible__bu GKTMFISGGSRGIGLAIAKRVAADGANVALVAKSAEPHPKLPGTIYTAAK
MAB_3946c|M.abscessus_ATCC_199 GKTIIMSGGSRGIGLAIALRAARDGANVAIMAKTAEPHPKLPGTIYTAAE
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
* :.: *.:* . : : * * : ..
Mflv_2396|M.gilvum_PYR-GCK RITDEGGRALPVVCDVTREESVEAAVAATVAEFGGIDILVANAGVLWLGP
Mvan_4252|M.vanbaalenii_PYR-1 GISAAGGRALPVACDVTSEESVNAAVAETVAEFGGIDILVANAGVLWLGP
MSMEG_4872|M.smegmatis_MC2_155 AITDAGGHALPVVCDVTDEQSVERAVAQTVSELGGIDILVANAGVLWLGP
Mb3251|M.bovis_AF2122/97 ELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGS
Rv3224|M.tuberculosis_H37Rv ELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGS
MMAR_1333|M.marinum_M ELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQFGGIDICVNNASAINLGS
MUL_2546|M.ulcerans_Agy99 ELEEAGGQALPIVGDVRDPDSVSAAVAKTVEQFGGIDICVNNASAINLGS
MAV_4172|M.avium_104 ELEEAGGQALPIVGDVRDPESVEAAVAKTVEQFGGIDICVNNASAINLGP
TH_0664|M.thermoresistible__bu EIEEAGGQALPIVGDIRDGDAVAAAVAKTVEQFGGIDICVNNASAINLGS
MAB_3946c|M.abscessus_ATCC_199 EIEAAGGHALPLLGDVRDDEVVASAVAQTVEKFGGIDIVVNNASALNLAP
MLBr_02565|M.leprae_Br4923 ELRR--GATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGA
: * ::.: . . .: *: : . . *. .: :..
Mflv_2396|M.gilvum_PYR-GCK IESTPLKRWQLCLD---VNTTGVFLVTKAVIPHVRARGGGSLIAVTTTG-
Mvan_4252|M.vanbaalenii_PYR-1 IETTPLKRWQLCLD---VNTTGVFLVTKAVIPHVRARGGGSLIAVTTTG-
MSMEG_4872|M.smegmatis_MC2_155 IENTPLKRWQLCLD---VNLTGVFLVTKAVIPHVRARGGGSLIAITTTG-
Mb3251|M.bovis_AF2122/97 ITEVPMKRFDLMNG---IQVRGTYAVSQACIPHMKGRENPHILTLSPP--
Rv3224|M.tuberculosis_H37Rv ITEVPMKRFDLMNG---IQVRGTYAVSQACIPHMKGRENPHILTLSPP--
MMAR_1333|M.marinum_M ITEVPMKRFDLMNG---IQVRGTYAVSQACIPHLKGRENPHILTLSPP--
MUL_2546|M.ulcerans_Agy99 ITEVPMKRFDLMNG---IQVRGTYAVSQACIPHLKGRENPHILTLSPP--
MAV_4172|M.avium_104 ITEVPMKRFDLMNG---IQVRGTYAVSQACIPHLKGRENPHILTLSPP--
TH_0664|M.thermoresistible__bu IEEVPLKRFDLMNG---IQVRGTYAVSQSCIPHMKGRDNPHILTLSPP--
MAB_3946c|M.abscessus_ATCC_199 SESISMKAYDLMQD---INARGSFSLSTSAIGALKEADNPHILTLSPP--
MLBr_02565|M.leprae_Br4923 ADSTPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESA
. . :: * : * : . ::::
Mflv_2396|M.gilvum_PYR-GCK VTMTDHGAN----AYWVSKAAAERLYLGLAADLKPDN-----IAVNCLSP
Mvan_4252|M.vanbaalenii_PYR-1 VNMTDHGAN----AYWVSKAAVERLYLGLAADLKPDN-----IAVNCLSP
MSMEG_4872|M.smegmatis_MC2_155 VDMVEHGSN----AYWVSKAATERLYTGLAADLRDDN-----IAVNCLSP
Mb3251|M.bovis_AF2122/97 ILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADG-----IASNTLWP
Rv3224|M.tuberculosis_H37Rv ILLEKKWLR--PTAYMMAKYGMTLCALGIAEEMRADG-----IASNTLWP
MMAR_1333|M.marinum_M VQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEG-----IASNTLWP
MUL_2546|M.ulcerans_Agy99 VQLDKKWLK--PTAYMMAKFGMTLCALGIAEEMRDEG-----IASNTLWP
MAV_4172|M.avium_104 VLLGKEWLK--PTAYMMAKFGMTLCALGIAEEMREAG-----IASNTLWP
TH_0664|M.thermoresistible__bu IRLEPKWLR--PTPYMMAKYGMTLCALGIAEELRDAG-----IASNTLWP
MAB_3946c|M.abscessus_ATCC_199 ITLEPKWFERTTTAYTISKFSMSLVAIGLAAELRQYG-----IASNALWP
MLBr_02565|M.leprae_Br4923 AEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGI
. . . . :: .:: * *
Mflv_2396|M.gilvum_PYR-GCK SRVVLTEGWQAGGAGMEIPPEMVEPP---------EAMGRATVMLAQQDA
Mvan_4252|M.vanbaalenii_PYR-1 SRVVLTEGWQAGGAGMQIPPEMVEPP---------EAMADAAVFLAGQDA
MSMEG_4872|M.smegmatis_MC2_155 SRVVLTEGWQAGGGGLKIPPEMIEPP---------EAMARAAVLLAQQDG
Mb3251|M.bovis_AF2122/97 RTMVATAAVQNLLGGDEAMARSRKP----------EVYADAAYVIVNKPA
Rv3224|M.tuberculosis_H37Rv RTMVATAAVQNLLGGDEAMARSRKP----------EVYADAAYVIVNKPA
MMAR_1333|M.marinum_M RTLVATAAVQNLLGGDEAMGRARKP----------DVYADAAYVILNKNS
MUL_2546|M.ulcerans_Agy99 RTLVATAAVQNLLGGEEAMGRARKP----------DVYADAAYVILNKNS
MAV_4172|M.avium_104 RTLVATAAVQNLLGGDEAMGRARKP----------EVYSDAAYVILNKPA
TH_0664|M.thermoresistible__bu RTTVATAAVQNLLGGDEAMARSRKP----------EVYADAAYVVLNKPS
MAB_3946c|M.abscessus_ATCC_199 RTTIDTAAIRNILG-AELVARCRSA----------QIMADAAYEILTKPS
MLBr_02565|M.leprae_Br4923 TRDKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSM
. . . . : .
Mflv_2396|M.gilvum_PYR-GCK SGVTGTIQRSEALAL-----------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 SGITGTIQRSEALTF-----------------------------------
MSMEG_4872|M.smegmatis_MC2_155 TGVTGTVQRSEALTL-----------------------------------
Mb3251|M.bovis_AF2122/97 TEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
Rv3224|M.tuberculosis_H37Rv TEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
MMAR_1333|M.marinum_M REYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 REYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVEEVNPPGYTQP
MAV_4172|M.avium_104 REFTGNMLLCEDVLVESGVTDLSVYNCVPGSQLGVDFWVDGVNPPGYTGP
TH_0664|M.thermoresistible__bu S-YTGNTLLCEDVLLESGVTDLSVYDCVPGSELGVDLWVDSPNPPGYTGP
MAB_3946c|M.abscessus_ATCC_199 REVSGNCFIDDEVLREAGVTDFSQYRECAEEDLELDFWMERA--------
MLBr_02565|M.leprae_Br4923 AGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMT
:*. :
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 AAIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCG
Mflv_2396|M.gilvum_PYR-GCK ------
Mvan_4252|M.vanbaalenii_PYR-1 ------
MSMEG_4872|M.smegmatis_MC2_155 ------
Mb3251|M.bovis_AF2122/97 ------
Rv3224|M.tuberculosis_H37Rv ------
MMAR_1333|M.marinum_M ------
MUL_2546|M.ulcerans_Agy99 ------
MAV_4172|M.avium_104 ------
TH_0664|M.thermoresistible__bu ------
MAB_3946c|M.abscessus_ATCC_199 ------
MLBr_02565|M.leprae_Br4923 QAMLGA