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TNHEYDRTTLYIDGQWVAPAATGTIDVVDPATEEVIGHVPGGTEADVDVAVAAARRAFDPLIGVDERRQR LDAVITAMEKRLPQIAETITREMGAPIRISQTVQTQVPLAVARGFADALADFEFSERIGNSLVVREPYGV VSAITPWNYPLYQVVAKVLPAIAAGCTVVLKPSNEAPLSVFEFVEALDDAGLPPGVVNLVSGPGSVIGER MAAHPDVDFVSFTGSTEVGARVGELAGRNIKKVALELGGKSANVILDGADLATAVRVGVGNAFLNGGQTC MAWTRMLVPLSRYSEALDLVAAAVAKYTVGDPWDPATRIGPSASQRQFETVLGFIERASRDGARLVAGGP EKIRDTGYYVAPTVFADVLPDSDLGQEEVFGPVLAVIPFRDSDEALEIANGTPYGLSGAVWAADDDTAIA FARQVQTGQLDINGGKYNPAAPFGGYKKSGVGRELGRFGFEEYLQTKSLQLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2881 | - | - | 100% (473) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0455 | - | e-118 | 48.60% (463) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | e-102 | 42.49% (473) | aldehyde dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 2e-93 | 41.26% (475) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1797 | - | 1e-112 | 46.44% (463) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-103 | 43.01% (479) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 1e-57 | 32.32% (461) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-109 | 44.72% (483) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 1e-100 | 42.29% (480) | aldehyde dehydrogenase |
| M. avium 104 | MAV_5202 | - | 1e-116 | 48.71% (464) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4605 | - | 1e-115 | 47.84% (464) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_1122 | - | 2e-99 | 42.29% (480) | aldehyde dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2878 | - | 0.0 | 84.78% (473) | betaine-aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2881|M.smegmatis_MC2_155 -MTNHEYDRTTLYIDGQWVAPAATGTIDVVDPATEEVIGHVPGGTEADVD
Mvan_2878|M.vanbaalenii_PYR-1 -MSNHNYTRTELYIDGAWVAPIGTDAVEVINPATEQALGSVPGGTDADVD
Mflv_1797|M.gilvum_PYR-GCK -----MREYLKHYIDGQWVDPVRPNALDVDNPATEEVSGKIALGSSADVD
TH_4605|M.thermoresistible__bu VEDEGMREYLKFYIDGAWVDPVDLKTLDVDDPATEEVSGRIAIGSATDVD
MAV_5202|M.avium_104 -----MREYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVD
MMAR_0472|M.marinum_M --MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKVPLAAAADVD
MUL_1122|M.ulcerans_Agy99 --MGEKTEYDKLFIGGRWTEPSTSEVIEVHCPATGEYVGKVPLAAAADVD
Rv0223c|M.tuberculosis_H37Rv -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
MAB_4484|M.abscessus_ATCC_1997 -----MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPADVD
Mb0791|M.bovis_AF2122/97 -MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAEDMG
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
. . *** : . ::
MSMEG_2881|M.smegmatis_MC2_155 VAVAAARRAFD--PLIGVD--ERRQRLDAVITAMEKRLPQIAETITREMG
Mvan_2878|M.vanbaalenii_PYR-1 AAVASARRAFD--PSIGVT--ERRERLDAVITAMEKRLPDIAETITSEMG
Mflv_1797|M.gilvum_PYR-GCK LAVTAARRAFG--TWSQTTREERLELLGAIMAEYQNRAADLADAVHEEMG
TH_4605|M.thermoresistible__bu NAVRAARRAFP--AWSQSSREERLELLQGILAEYQKRSADLADAVHEEMG
MAV_5202|M.avium_104 VAVGAARRAFG--RWSQSSREDRLDLLQAILAEYQKRADDLAAAVTEEIG
MMAR_0472|M.marinum_M AAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLLADETG
MUL_1122|M.ulcerans_Agy99 AAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLFADETG
Rv0223c|M.tuberculosis_H37Rv AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
MAB_4484|M.abscessus_ATCC_1997 AAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADETG
Mb0791|M.bovis_AF2122/97 RAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTISEVG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
*: * * * . * *
MSMEG_2881|M.smegmatis_MC2_155 APIRISQTVQTQVPLAVARGFAD-ALADFEFSERI----GNSLVVR----
Mvan_2878|M.vanbaalenii_PYR-1 APVRIAQSVQTQVPLAVARAFAD-ALAAYDFEERI----GNSLVVR----
Mflv_1797|M.gilvum_PYR-GCK APASLASGPQVNLGIGHLATAID-ALKNFQFEEQH----GSTLVVK----
TH_4605|M.thermoresistible__bu APPSLAKGPQVNMGLGHLTTAID-VLKNFSFEEQR----GATLVVK----
MAV_5202|M.avium_104 APPSLAAGPQVFLGIGHLTTAIE-VLKNFAFTEQR----GATLIAR----
MMAR_0472|M.marinum_M QPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQTIVHR----
MUL_1122|M.ulcerans_Agy99 QPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSYGQTIVHR----
Rv0223c|M.tuberculosis_H37Rv QPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSYGQSIVSR----
MAB_4484|M.abscessus_ATCC_1997 APPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAYGQTLVTR----
Mb0791|M.bovis_AF2122/97 APRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPLGIATRRTLA
MLBr_02573|M.leprae_Br4923 KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVGASKALAR----
. . :
MSMEG_2881|M.smegmatis_MC2_155 -EPYGVVSAITPWNYPLYQVVAKVLPAIAAGCTVVLKPSNEAPLSVFEFV
Mvan_2878|M.vanbaalenii_PYR-1 -EPYGVVAAITPWNYPLYQVVAKVLPAIAAGCTVVLKPSNEAPLSVFEFV
Mflv_1797|M.gilvum_PYR-GCK -EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFT
TH_4605|M.thermoresistible__bu -EPIGVCGLITPWNWPLNQIACKVFPALATGCTMVLKPSEVAPYSGQIFT
MAV_5202|M.avium_104 -EPIGVCGLITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFA
MMAR_0472|M.marinum_M -EPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPLTANALA
MUL_1122|M.ulcerans_Agy99 -EPIGVVGAIVAWNVPLFLAINKLGPAPLAGCTVVLKPAAETPLTANALA
Rv0223c|M.tuberculosis_H37Rv -EPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALA
MAB_4484|M.abscessus_ATCC_1997 -EPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFILA
Mb0791|M.bovis_AF2122/97 REAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALG
MLBr_02573|M.leprae_Br4923 YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLA
:. ** : .** * ** :* . :** : .* :
MSMEG_2881|M.smegmatis_MC2_155 EALDDAG-LPPGVVNLVSGPGSVIGERMAAHPDVDFVSFTGSTEVGARVG
Mvan_2878|M.vanbaalenii_PYR-1 EALEDAG-LPPGVVNLVSGPGRVIGERMAAHPDVDFVSFTGSTDVGSRVG
Mflv_1797|M.gilvum_PYR-GCK EILDAAG-VPAGVYNLVYGDGPGVGAAISSHPEIDMVSFTGSTRAGIEVA
TH_4605|M.thermoresistible__bu EILDTAG-VPAGVYNMVFGDGPGVGVALSSHPDVDLVSFTGSTRAGVDVA
MAV_5202|M.avium_104 EILAAAG-VPAGVFNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVA
MMAR_0472|M.marinum_M EVFAEAG-LPEGVLSVVPG-GVETGQALTSNPGVDLFTFTGSSAVGKEIG
MUL_1122|M.ulcerans_Agy99 EVFAEAG-LPEGVLSVVPG-GVETGQALTSNPGVDLFTFTGSSAVGKEIG
Rv0223c|M.tuberculosis_H37Rv EVFAEVG-LPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGREVG
MAB_4484|M.abscessus_ATCC_1997 EVFAEAG-VPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVGKEIA
Mb0791|M.bovis_AF2122/97 EIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVM
MLBr_02573|M.leprae_Br4923 DVIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVG
: : .* . . : . : .* : ::*** .* :
MSMEG_2881|M.smegmatis_MC2_155 ELAGRNIKKVALELGGKSANVILDGADLATAVRVGVGNAFLNGGQTCMAW
Mvan_2878|M.vanbaalenii_PYR-1 ELAGKSIKKVALELGGKSANVILDGADLATAVKVGVGNAFLNGGQTCMAW
Mflv_1797|M.gilvum_PYR-GCK RNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAP
TH_4605|M.thermoresistible__bu RNAAPTVKRVTQELGGKSANIVLDDADFAKSVTAGVTTMMLNSGQSCNAP
MAV_5202|M.avium_104 RNAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNAP
MMAR_0472|M.marinum_M RRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQACVGQ
MUL_1122|M.ulcerans_Agy99 RRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQACVGQ
Rv0223c|M.tuberculosis_H37Rv RRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQ
MAB_4484|M.abscessus_ATCC_1997 EIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVNQ
Mb0791|M.bovis_AF2122/97 ADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAIT
MLBr_02573|M.leprae_Br4923 AIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAA
*. :* ****... ::: . .: : . : ** *
MSMEG_2881|M.smegmatis_MC2_155 TRMLVPLSRYSEALDLVAAAVAKYTVGDPWDPATRIGPSASQRQFETVLG
Mvan_2878|M.vanbaalenii_PYR-1 TRMLVPESRYGEALDLIGAAVSKYPVGDPTDPTTRIGPSASQSQYQSVLG
Mflv_1797|M.gilvum_PYR-GCK SRMLVPNSRMDEAIAVARETAGAVKVGDPGD-QSAIGPVASRAQFEKIQG
TH_4605|M.thermoresistible__bu SRMLVPNSRMDEAIEIARETAAQVAVGDPDN-KTAIGPVVSRVQFDKIQR
MAV_5202|M.avium_104 SRMLVPASRMAEAISIAREVAEQVQVGDPDD-ATAIGPVASRAQFEKVQR
MMAR_0472|M.marinum_M TRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQRARVEG
MUL_1122|M.ulcerans_Agy99 TRILAPRSRYEEIVEAVSAFVQTLPVGPPSDPAAQIGSLISEKQRARVEG
Rv0223c|M.tuberculosis_H37Rv TRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEG
MAB_4484|M.abscessus_ATCC_1997 TRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVEG
Mb0791|M.bovis_AF2122/97 TRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQG
MLBr_02573|M.leprae_Br4923 KRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQ
.*.:. * : * * : : *. : :
MSMEG_2881|M.smegmatis_MC2_155 FIERASRDGARLVAGGPEKIR--DTGYYVAPTVFADVLPDSDLGQEEVFG
Mvan_2878|M.vanbaalenii_PYR-1 FIERAQRDGARLLTGGTEKVR--DVGYYVSPTVFADVDPGSELGQEEVFG
Mflv_1797|M.gilvum_PYR-GCK LIQKGIDEGATLVVGGTGRPDGVDKGYYVKPTVFANVTNDMTIAREEIFG
TH_4605|M.thermoresistible__bu LIQQGIDEGATVVVGGPGRPDGLEVGYYVKPTVFANVKNDMTIAREEIFG
MAV_5202|M.avium_104 LIQQGIDEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFG
MMAR_0472|M.marinum_M YIAKGIEEGARLVSGG-GRPEGLDNGFFVQPTVFADVDNKMTIAQEEIFG
MUL_1122|M.ulcerans_Agy99 YIAKGIEEGARLVSGG-GRPESLDNGFFVQPTVFADVDNKMTIAQEEIFG
Rv0223c|M.tuberculosis_H37Rv YIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFG
MAB_4484|M.abscessus_ATCC_1997 YIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEEIFG
Mb0791|M.bovis_AF2122/97 YLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARVAREEIFG
MLBr_02573|M.leprae_Br4923 QVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDEVFG
: . *. . ** : *:: **:::.: : :*:**
MSMEG_2881|M.smegmatis_MC2_155 PVLAVIPFRDSDEALEIANGTPYGLSGAVWAADDDTAIAFARQVQTGQLD
Mvan_2878|M.vanbaalenii_PYR-1 PVLAVIPYRDADDALAIANGTPYGLSGAVWAADDDTAVAFARQVQTGQLD
Mflv_1797|M.gilvum_PYR-GCK PVLCILGYDDLDQAVAIGNDTEYGLAGYVSGSDLEQARAVARRIRAGSVA
TH_4605|M.thermoresistible__bu PVLCILGYDDLDDAIEIANDTDYGLAGYVSGSDLEQARALARRIRAGSIA
MAV_5202|M.avium_104 PVLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREVAGKIRAGWVT
MMAR_0472|M.marinum_M PVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTGTYA
MUL_1122|M.ulcerans_Agy99 PVLVVIPYDTKEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTGTYA
Rv0223c|M.tuberculosis_H37Rv PVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYG
MAB_4484|M.abscessus_ATCC_1997 PVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGTYG
Mb0791|M.bovis_AF2122/97 PVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVN
MLBr_02573|M.leprae_Br4923 PVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVF
** : :.*: :.* : :**.. . : . .: .*
MSMEG_2881|M.smegmatis_MC2_155 INGGK-YNPAAPFGGYKKSGVGRELGRFGFEEYLQTKSLQ--LP------
Mvan_2878|M.vanbaalenii_PYR-1 INGGR-YNPAAPFGGYKKSGIGRELGRIGFEEYLQVKSLQ--LP------
Mflv_1797|M.gilvum_PYR-GCK INHG--FDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAALGYAPA-----
TH_4605|M.thermoresistible__bu INHG--FDLNAPFGGYKRSGNGREWSDYGFHEYLETKAILGYSPS-----
MAV_5202|M.avium_104 INHA--FDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSILGYAPAQADR-
MMAR_0472|M.marinum_M INWYA-FDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTLES-
MUL_1122|M.ulcerans_Agy99 INWYA-FDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTLES-
Rv0223c|M.tuberculosis_H37Rv INWYA-FDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA--
MAB_4484|M.abscessus_ATCC_1997 INWYA-FDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLESI
Mb0791|M.bovis_AF2122/97 VNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN------
MLBr_02573|M.leprae_Br4923 INGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA--------
:* **** *.** *** . .. .: : *