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MREYLKFYIDGRWVDPVEPRTLDVDNPTTEQVAGRIAIGAAADVDAAVEAARKAFTTWSQTSRDERLAVL GAILDEYQKRAIDLADAVGEEMGAPASLAAGPQVRMGLGHLTTSIEALKKFQFEEQYGSTLVVKEPIGVC GLITPWNWPINQIACKVFPALATGCTMVLKPSEVAPFSAQIFTEIIEAAGVPAGVYNLVYGDGPGVGSAL SSHPDIDMVSFTGSTRAGIDVARNAAPTVKRVTQELGGKSPNIVLDDADFAKSVAAGVSAMMTNSGQSCN APSRMLVPNSRMGEAITIARGTAAAVKVGDPSDKKAIGPVASKAQFDKIQGLIQKGIDEGATLVAGGTGR PDGLDTGYYVKPTVFADVTNDMTIAREEIFGPVLCILGYDDLDQAVEIANDTEYGLAGYVSGADLETARA VARRIRAGSVAINHGFDLSAPFGGYKRSGNGREWGHFGFDEYLETKAAMGYAPPQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0455 | - | - | 100% (475) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2881 | - | e-118 | 48.60% (463) | aldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0309 | - | 2e-98 | 42.17% (479) | aldehyde dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0791 | aldA | 2e-93 | 41.01% (473) | aldehyde dehydrogenase NAD dependant AldA |
| M. gilvum PYR-GCK | Mflv_1797 | - | 0.0 | 84.99% (473) | aldehyde dehydrogenase |
| M. tuberculosis H37Rv | Rv0223c | - | 1e-100 | 42.71% (480) | aldehyde dehydrogenase |
| M. leprae Br4923 | MLBr_02573 | gabD1 | 3e-44 | 29.49% (451) | succinic semialdehyde dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4484 | - | 1e-103 | 43.98% (482) | aldehyde dehydrogenase |
| M. marinum M | MMAR_0472 | - | 2e-97 | 42.20% (481) | aldehyde dehydrogenase |
| M. avium 104 | MAV_5202 | - | 0.0 | 77.89% (475) | aldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4605 | - | 0.0 | 81.61% (473) | PUTATIVE aldehyde dehydrogenase |
| M. ulcerans Agy99 | MUL_0477 | aldA | 4e-96 | 41.98% (474) | NAD-dependent aldehyde dehydrogenase, AldA |
| M. vanbaalenii PYR-1 | Mvan_4953 | - | 0.0 | 85.84% (473) | aldehyde dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0791|M.bovis_AF2122/97 -MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAEDMG
MUL_0477|M.ulcerans_Agy99 -MALLADGVSSLFIDGKRCE-GAAGTFATVNPATEETLGVAADAVAGDMD
Mflv_1797|M.gilvum_PYR-GCK -----MREYLKHYIDGQWVDPVRPNALDVDNPATEEVSGKIALGSSADVD
Mvan_4953|M.vanbaalenii_PYR-1 -----MREYLKHYIDGRWVDPVRPNALEVDNPTTEEISGRIALGSSADVD
MSMEG_0455|M.smegmatis_MC2_155 -----MREYLKFYIDGRWVDPVEPRTLDVDNPTTEQVAGRIAIGAAADVD
TH_4605|M.thermoresistible__bu VEDEGMREYLKFYIDGAWVDPVDLKTLDVDDPATEEVSGRIAIGSATDVD
MAV_5202|M.avium_104 -----MREYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVD
Rv0223c|M.tuberculosis_H37Rv -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
MMAR_0472|M.marinum_M --MGEKTEYDKLFIGGKWTEPSTSEVIEVHCPATGEYVGKVPLAAAADVD
MAB_4484|M.abscessus_ATCC_1997 -----MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPADVD
MLBr_02573|M.leprae_Br4923 ------------------------MSIATINPATGETVKTFTPTTQDEVE
: . *:* : . ::
Mb0791|M.bovis_AF2122/97 RAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTISEVG
MUL_0477|M.ulcerans_Agy99 RAIEAARRAFDDTDWSRNT-ELRVRCVRQLRDAMREHIEELRALTISEVG
Mflv_1797|M.gilvum_PYR-GCK LAVTAARRAFG--TWSQTTREERLELLGAIMAEYQNRAADLADAVHEEMG
Mvan_4953|M.vanbaalenii_PYR-1 LAVTAARRAFA--TWSQTTREERLELLGAIMAEYQKRAGDLAEAVTEEMG
MSMEG_0455|M.smegmatis_MC2_155 AAVEAARKAFT--TWSQTSRDERLAVLGAILDEYQKRAIDLADAVGEEMG
TH_4605|M.thermoresistible__bu NAVRAARRAFP--AWSQSSREERLELLQGILAEYQKRSADLADAVHEEMG
MAV_5202|M.avium_104 VAVGAARRAFG--RWSQSSREDRLDLLQAILAEYQKRADDLAAAVTEEIG
Rv0223c|M.tuberculosis_H37Rv AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
MMAR_0472|M.marinum_M AAVAAARAAFDNGPWPSTPPKERATVIANALKLLEERKDHFAKLLADETG
MAB_4484|M.abscessus_ATCC_1997 AAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADETG
MLBr_02573|M.leprae_Br4923 DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
*: * * : . * . * *
Mb0791|M.bovis_AF2122/97 APRMLTASAQLEGPVGDLSFAAD-TAESYPWKQDLGEASPLGIATRRTLA
MUL_0477|M.ulcerans_Agy99 APRMLTAAAQLEGPVNDLAFSAD-TAESYSWKQDLGAAAPMGIPTRRTVV
Mflv_1797|M.gilvum_PYR-GCK APASLASGPQVNLGIGHLATAID-ALKNFQFEEQH---------GSTLVV
Mvan_4953|M.vanbaalenii_PYR-1 APAGLASGPQVNLGIGHLATTVD-ALKNFAFEEQH---------GSTLVV
MSMEG_0455|M.smegmatis_MC2_155 APASLAAGPQVRMGLGHLTTSIE-ALKKFQFEEQY---------GSTLVV
TH_4605|M.thermoresistible__bu APPSLAKGPQVNMGLGHLTTAID-VLKNFSFEEQR---------GATLVV
MAV_5202|M.avium_104 APPSLAAGPQVFLGIGHLTTAIE-VLKNFAFTEQR---------GATLIA
Rv0223c|M.tuberculosis_H37Rv QPPTIIETMHWMGSMGAMNYFAG-AADKVTWTETRTGSY-----GQSIVS
MMAR_0472|M.marinum_M QPPMTVETMHWMGSIGALNFFAGPAVDQVRWKEIRNGSY-----GQTIVH
MAB_4484|M.abscessus_ATCC_1997 APPMVIETLQWMGGFGAIQYYAN-AADAVKWKELRNGAY-----GQTLVT
MLBr_02573|M.leprae_Br4923 KTLQSAKDEAMKCAKGFRYYAEK--AETLLADEPAEAAAVG--ASKALAR
. . . :
Mb0791|M.bovis_AF2122/97 REAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALG
MUL_0477|M.ulcerans_Agy99 REAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLG
Mflv_1797|M.gilvum_PYR-GCK KEPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFT
Mvan_4953|M.vanbaalenii_PYR-1 KEPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFT
MSMEG_0455|M.smegmatis_MC2_155 KEPIGVCGLITPWNWPINQIACKVFPALATGCTMVLKPSEVAPFSAQIFT
TH_4605|M.thermoresistible__bu KEPIGVCGLITPWNWPLNQIACKVFPALATGCTMVLKPSEVAPYSGQIFT
MAV_5202|M.avium_104 REPIGVCGLITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFA
Rv0223c|M.tuberculosis_H37Rv REPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALA
MMAR_0472|M.marinum_M REPIGVVGAIVAWNVPLFLAINKLGPALLAGCTVVLKPAAETPLTANALA
MAB_4484|M.abscessus_ATCC_1997 REPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFILA
MLBr_02573|M.leprae_Br4923 YQPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLA
:. ** : .** * **: :* . :** : .* . :
Mb0791|M.bovis_AF2122/97 EIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVM
MUL_0477|M.ulcerans_Agy99 ELIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVM
Mflv_1797|M.gilvum_PYR-GCK EILDAAG-VPAGVYNLVYGDGPGVGAAISSHPEIDMVSFTGSTRAGIEVA
Mvan_4953|M.vanbaalenii_PYR-1 EIIDAAG-VPAGVYNLVYGDGPGVGASISSHPDIDMVSFTGSTRAGIEIA
MSMEG_0455|M.smegmatis_MC2_155 EIIEAAG-VPAGVYNLVYGDGPGVGSALSSHPDIDMVSFTGSTRAGIDVA
TH_4605|M.thermoresistible__bu EILDTAG-VPAGVYNMVFGDGPGVGVALSSHPDVDLVSFTGSTRAGVDVA
MAV_5202|M.avium_104 EILAAAG-VPAGVFNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVA
Rv0223c|M.tuberculosis_H37Rv EVFAEVG-LPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGREVG
MMAR_0472|M.marinum_M EVFAEAG-LPEGVLSVVPG-GVETGQALTSNPGVDLFTFTGSSAVGKEIG
MAB_4484|M.abscessus_ATCC_1997 EVFAEAG-VPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVGKEIA
MLBr_02573|M.leprae_Br4923 DVIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVG
::: .* . . : : .* : ::*** .* :
Mb0791|M.bovis_AF2122/97 ADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAIT
MUL_0477|M.ulcerans_Agy99 ADGAATIKRMFLELGGKSAFIVLDDADLAAASSVSAFTASMHAGQGCAIT
Mflv_1797|M.gilvum_PYR-GCK RNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAP
Mvan_4953|M.vanbaalenii_PYR-1 RNAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAP
MSMEG_0455|M.smegmatis_MC2_155 RNAAPTVKRVTQELGGKSPNIVLDDADFAKSVAAGVSAMMTNSGQSCNAP
TH_4605|M.thermoresistible__bu RNAAPTVKRVTQELGGKSANIVLDDADFAKSVTAGVTTMMLNSGQSCNAP
MAV_5202|M.avium_104 RNAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNAP
Rv0223c|M.tuberculosis_H37Rv RRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQ
MMAR_0472|M.marinum_M RRAAEMLKPCTLELGGKSAAILLEDVDLSTAVPMMVFSGIMNTGQACVGQ
MAB_4484|M.abscessus_ATCC_1997 EIAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVNQ
MLBr_02573|M.leprae_Br4923 AIAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAA
.. :* ****... ::: . .: : . : **.*
Mb0791|M.bovis_AF2122/97 TRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQG
MUL_0477|M.ulcerans_Agy99 TRLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVEG
Mflv_1797|M.gilvum_PYR-GCK SRMLVPNSRMDEAIAVARETAGAVKVGDPGD-QSAIGPVASRAQFEKIQG
Mvan_4953|M.vanbaalenii_PYR-1 SRMLVPNSRMDEAIAVARETAAAVKVGDPSD-KTAIGPVASKAQFDKIQG
MSMEG_0455|M.smegmatis_MC2_155 SRMLVPNSRMGEAITIARGTAAAVKVGDPSD-KKAIGPVASKAQFDKIQG
TH_4605|M.thermoresistible__bu SRMLVPNSRMDEAIEIARETAAQVAVGDPDN-KTAIGPVVSRVQFDKIQR
MAV_5202|M.avium_104 SRMLVPASRMAEAISIAREVAEQVQVGDPDD-ATAIGPVASRAQFEKVQR
Rv0223c|M.tuberculosis_H37Rv TRILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEG
MMAR_0472|M.marinum_M TRILAPRSRYEEIVEAVSAFVQALPVGPPSDPAAQIGSLISEKQRARVEG
MAB_4484|M.abscessus_ATCC_1997 TRVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVEG
MLBr_02573|M.leprae_Br4923 KRFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQ
.*.:. * : : * * : *.: : :::
Mb0791|M.bovis_AF2122/97 YLDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARVAREEIFG
MUL_0477|M.ulcerans_Agy99 YLDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTTDARPAREEIFG
Mflv_1797|M.gilvum_PYR-GCK LIQKGIDEGATLVVGGTGRPDGVDKGYYVKPTVFANVTNDMTIAREEIFG
Mvan_4953|M.vanbaalenii_PYR-1 LIQKGIDEGATLVIGGTGRPDGIDKGYYVKPTVFANVTNDMTIAREEIFG
MSMEG_0455|M.smegmatis_MC2_155 LIQKGIDEGATLVAGGTGRPDGLDTGYYVKPTVFADVTNDMTIAREEIFG
TH_4605|M.thermoresistible__bu LIQQGIDEGATVVVGGPGRPDGLEVGYYVKPTVFANVKNDMTIAREEIFG
MAV_5202|M.avium_104 LIQQGIDEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFG
Rv0223c|M.tuberculosis_H37Rv YIAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFG
MMAR_0472|M.marinum_M YIAKGIEEGARLVSGG-GRPEGLDNGFFVQPTVFADVDNKMTIAQEEIFG
MAB_4484|M.abscessus_ATCC_1997 YIAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEEIFG
MLBr_02573|M.leprae_Br4923 QVDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDEVFG
: . *. . ** ** *:: **:::.: .. :*:**
Mb0791|M.bovis_AF2122/97 PVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVN
MUL_0477|M.ulcerans_Agy99 PVLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGAVN
Mflv_1797|M.gilvum_PYR-GCK PVLCILGYDDLDQAVAIGNDTEYGLAGYVSGSDLEQARAVARRIRAGSVA
Mvan_4953|M.vanbaalenii_PYR-1 PVLCILGYDDLDQAVEIGNDTEYGLAGYVSGADLDKARAVARRIRAGSVA
MSMEG_0455|M.smegmatis_MC2_155 PVLCILGYDDLDQAVEIANDTEYGLAGYVSGADLETARAVARRIRAGSVA
TH_4605|M.thermoresistible__bu PVLCILGYDDLDDAIEIANDTDYGLAGYVSGSDLEQARALARRIRAGSIA
MAV_5202|M.avium_104 PVLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREVAGKIRAGWVT
Rv0223c|M.tuberculosis_H37Rv PVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYG
MMAR_0472|M.marinum_M PVLVVIPYDTEEDAIKIANDSVYGLAGSVWTSNVPKGIEISEKIRTGTYA
MAB_4484|M.abscessus_ATCC_1997 PVLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGTYG
MLBr_02573|M.leprae_Br4923 PVASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVF
** : :.*: :.* : :**.. . : . .: .*
Mb0791|M.bovis_AF2122/97 VNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIA-----TAAN-
MUL_0477|M.ulcerans_Agy99 VNGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIA-----TAAN-
Mflv_1797|M.gilvum_PYR-GCK IN--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA--
Mvan_4953|M.vanbaalenii_PYR-1 IN--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA--
MSMEG_0455|M.smegmatis_MC2_155 IN--HGFDLSAPFGGYKRSGNGREWGHFGFDEYLETKAAM---GYAPPQ-
TH_4605|M.thermoresistible__bu IN--HGFDLNAPFGGYKRSGNGREWSDYGFHEYLETKAIL---GYSPS--
MAV_5202|M.avium_104 IN--HAFDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSIL---GYAPAQA
Rv0223c|M.tuberculosis_H37Rv INW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA--
MMAR_0472|M.marinum_M INW-YAFDPCCPFGGYKNSGIGRENGPEGVEHFTQQKSVLMPMGYTLES-
MAB_4484|M.abscessus_ATCC_1997 INW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLESI
MLBr_02573|M.leprae_Br4923 INGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA--------
:* **** *.** *** . .. .: : *
Mb0791|M.bovis_AF2122/97 --
MUL_0477|M.ulcerans_Agy99 --
Mflv_1797|M.gilvum_PYR-GCK --
Mvan_4953|M.vanbaalenii_PYR-1 --
MSMEG_0455|M.smegmatis_MC2_155 --
TH_4605|M.thermoresistible__bu --
MAV_5202|M.avium_104 DR
Rv0223c|M.tuberculosis_H37Rv --
MMAR_0472|M.marinum_M --
MAB_4484|M.abscessus_ATCC_1997 --
MLBr_02573|M.leprae_Br4923 --