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M. thermoresistible (build 8) TH_4605 (-)

annotation: aldehyde dehydrogenase
coordinates: 1455758 - 1457197
length: 480

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4605--100% (480)aldehyde dehydrogenase
M. thermoresistible (build 8)TH_3080-e-10042.92% (473) PUTATIVE aldehyde dehydrogenase
M. thermoresistible (build 8)TH_3892-7e-9743.51% (478) PUTATIVE aldehyde dehydrogenase NAD dependent AldA_2

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0791aldA2e-9040.39% (463) aldehyde dehydrogenase NAD dependant AldA
M. gilvum PYR-GCKMflv_1797-0.081.01% (474) aldehyde dehydrogenase
M. tuberculosis H37RvRv0223c-7e-9340.00% (475) aldehyde dehydrogenase
M. leprae Br4923MLBr_02573gabD14e-4528.88% (464) succinic semialdehyde dehydrogenase
M. abscessus ATCC 19977MAB_4484-1e-10042.77% (477) aldehyde dehydrogenase
M. marinum MMMAR_4928aldA4e-9542.79% (458) NAD-dependent aldehyde dehydrogenase, AldA
M. avium 104MAV_5202-0.078.90% (474) aldehyde dehydrogenase
M. smegmatis MC2 155MSMEG_0455-0.081.61% (473) aldehyde dehydrogenase
M. ulcerans Agy99MUL_0477aldA5e-9442.36% (458) NAD-dependent aldehyde dehydrogenase, AldA
M. vanbaalenii PYR-1Mvan_4953-0.079.11% (474) aldehyde dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_4928|M.marinum_M               -MALLADGVSSLFIDGKRCE-GAAGTFATVNPATEETLGVAADADAGDMD
MUL_0477|M.ulcerans_Agy99           -MALLADGVSSLFIDGKRCE-GAAGTFATVNPATEETLGVAADAVAGDMD
Mb0791|M.bovis_AF2122/97            -MALWGDGISALLIDGKLSD-GRAGTFPTVNPATEEVLGVAADADAEDMG
Mflv_1797|M.gilvum_PYR-GCK          -----MREYLKHYIDGQWVDPVRPNALDVDNPATEEVSGKIALGSSADVD
Mvan_4953|M.vanbaalenii_PYR-1       -----MREYLKHYIDGRWVDPVRPNALEVDNPTTEEISGRIALGSSADVD
MSMEG_0455|M.smegmatis_MC2_155      -----MREYLKFYIDGRWVDPVEPRTLDVDNPTTEQVAGRIAIGAAADVD
TH_4605|M.thermoresistible__bu      VEDEGMREYLKFYIDGAWVDPVDLKTLDVDDPATEEVSGRIAIGSATDVD
MAV_5202|M.avium_104                -----MREYLKFYIDGQWVDPVRPNTFDVENPATEQVCGKISLGSAADVD
Rv0223c|M.tuberculosis_H37Rv        -MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVD
MAB_4484|M.abscessus_ATCC_1997      -----MTNYDKLFIGGVWTEPATDQVIEVISPATGQKVGQCPLASPADVD
MLBr_02573|M.leprae_Br4923          ------------------------MSIATINPATGETVKTFTPTTQDEVE
                                                              : .  *:* :     .     :: 

MMAR_4928|M.marinum_M               RAIEAARRAFDDTDWSRNT-ELRVRCVRQLRDAMREHIEELRALTISEVG
MUL_0477|M.ulcerans_Agy99           RAIEAARRAFDDTDWSRNT-ELRVRCVRQLRDAMREHIEELRALTISEVG
Mb0791|M.bovis_AF2122/97            RAIEAARRAFDSTDWSRNT-ELRVRCVRQLRDAMQQHVEELRELTISEVG
Mflv_1797|M.gilvum_PYR-GCK          LAVTAARRAFG--TWSQTTREERLELLGAIMAEYQNRAADLADAVHEEMG
Mvan_4953|M.vanbaalenii_PYR-1       LAVTAARRAFA--TWSQTTREERLELLGAIMAEYQKRAGDLAEAVTEEMG
MSMEG_0455|M.smegmatis_MC2_155      AAVEAARKAFT--TWSQTSRDERLAVLGAILDEYQKRAIDLADAVGEEMG
TH_4605|M.thermoresistible__bu      NAVRAARRAFP--AWSQSSREERLELLQGILAEYQKRSADLADAVHEEMG
MAV_5202|M.avium_104                VAVGAARRAFG--RWSQSSREDRLDLLQAILAEYQKRADDLAAAVTEEIG
Rv0223c|M.tuberculosis_H37Rv        AAVAAARAAFDNGPWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETG
MAB_4484|M.abscessus_ATCC_1997      AAVSAARRAFDNGPWPRLTPHERQAVLQKAVSLLESRKDEICKAIADETG
MLBr_02573|M.leprae_Br4923          DAIARAYARFDN--YRHTTFTQRAKWANATADLLEAEANQSAALMTLEMG
                                     *:  *   *    :   .   *             .          * *

MMAR_4928|M.marinum_M               APRMLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVR
MUL_0477|M.ulcerans_Agy99           APRMLTAAAQLEGPVNDLAFSADTAESYSWKQDLGAAAPMGIPTRRTVVR
Mb0791|M.bovis_AF2122/97            APRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAR
Mflv_1797|M.gilvum_PYR-GCK          APASLASGPQVNLGIGHLATAIDALKNFQFEEQH---------GSTLVVK
Mvan_4953|M.vanbaalenii_PYR-1       APAGLASGPQVNLGIGHLATTVDALKNFAFEEQH---------GSTLVVK
MSMEG_0455|M.smegmatis_MC2_155      APASLAAGPQVRMGLGHLTTSIEALKKFQFEEQY---------GSTLVVK
TH_4605|M.thermoresistible__bu      APPSLAKGPQVNMGLGHLTTAIDVLKNFSFEEQR---------GATLVVK
MAV_5202|M.avium_104                APPSLAAGPQVFLGIGHLTTAIEVLKNFAFTEQR---------GATLIAR
Rv0223c|M.tuberculosis_H37Rv        QPPTIIETMHWMGSMGAMNYFAGAADKVTWTETRTGSY-----GQSIVSR
MAB_4484|M.abscessus_ATCC_1997      APPMVIETLQWMGGFGAIQYYANAADAVKWKELRNGAY-----GQTLVTR
MLBr_02573|M.leprae_Br4923          KTLQSAKDEAMKCAKGFRYYAEKAETLLADEPAEAAAVG---ASKALARY
                                     .             .       .                          

MMAR_4928|M.marinum_M               EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGE
MUL_0477|M.ulcerans_Agy99           EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAVLGE
Mb0791|M.bovis_AF2122/97            EAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGE
Mflv_1797|M.gilvum_PYR-GCK          EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFTE
Mvan_4953|M.vanbaalenii_PYR-1       EPIGVCGLITPWNWPINQIACKVFPALATGNTMVLKPSEVAPYSAQIFTE
MSMEG_0455|M.smegmatis_MC2_155      EPIGVCGLITPWNWPINQIACKVFPALATGCTMVLKPSEVAPFSAQIFTE
TH_4605|M.thermoresistible__bu      EPIGVCGLITPWNWPLNQIACKVFPALATGCTMVLKPSEVAPYSGQIFTE
MAV_5202|M.avium_104                EPIGVCGLITPWNWPINQVAVKVYPALATGCTVVLKPSEVAPFSSYIFAE
Rv0223c|M.tuberculosis_H37Rv        EPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTANALAE
MAB_4484|M.abscessus_ATCC_1997      EPAGVVAAIAAWNVPLFLALNKIGPAFLAGCAVVLKPAAETPLSSFILAE
MLBr_02573|M.leprae_Br4923          QPLGVVLAVMPWNFPLWQTVRFAAPALMAGNVGLLKHASNVPQCALYLAD
                                    :. **   : .** *         **: :* . :** :  .*  .  : :

MMAR_4928|M.marinum_M               LIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMA
MUL_0477|M.ulcerans_Agy99           LIADCTDIPPGVVNIVTSSEHGLGALLAKDPRVDMVSFTGSTATGRSVMA
Mb0791|M.bovis_AF2122/97            IIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVMA
Mflv_1797|M.gilvum_PYR-GCK          ILDAAG-VPAGVYNLVYGDGPGVGAAISSHPEIDMVSFTGSTRAGIEVAR
Mvan_4953|M.vanbaalenii_PYR-1       IIDAAG-VPAGVYNLVYGDGPGVGASISSHPDIDMVSFTGSTRAGIEIAR
MSMEG_0455|M.smegmatis_MC2_155      IIEAAG-VPAGVYNLVYGDGPGVGSALSSHPDIDMVSFTGSTRAGIDVAR
TH_4605|M.thermoresistible__bu      ILDTAG-VPAGVYNMVFGDGPGVGVALSSHPDVDLVSFTGSTRAGVDVAR
MAV_5202|M.avium_104                ILAAAG-VPAGVFNLVNGDGPGVGAALASHPDIDLVSFTGSTRAGVEVAR
Rv0223c|M.tuberculosis_H37Rv        VFAEVG-LPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGREVGR
MAB_4484|M.abscessus_ATCC_1997      VFAEAG-VPEGVLSVVPG-GAETGRALTNNPDVDVFSFTGSTAVGKEIAE
MLBr_02573|M.leprae_Br4923          VIARGG-FPEDCFQTLLISANGVEAILR-DPRVAAATLTGSEPAGQAVGA
                                    ::     .* .  . :          :  .* :   ::***  .*  :  

MMAR_4928|M.marinum_M               DGAATIKRMFLELGGKSAFIVLDDADLAAASSVSAFTASMHAGQGCAITT
MUL_0477|M.ulcerans_Agy99           DGAATIKRMFLELGGKSAFIVLDDADLAAASSVSAFTASMHAGQGCAITT
Mb0791|M.bovis_AF2122/97            DAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAITT
Mflv_1797|M.gilvum_PYR-GCK          NAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAPS
Mvan_4953|M.vanbaalenii_PYR-1       NAAPTVKRVTQELGGKSPNIVLDDDDFAKSVAAGTSVMMVNSGQSCNAPS
MSMEG_0455|M.smegmatis_MC2_155      NAAPTVKRVTQELGGKSPNIVLDDADFAKSVAAGVSAMMTNSGQSCNAPS
TH_4605|M.thermoresistible__bu      NAAPTVKRVTQELGGKSANIVLDDADFAKSVTAGVTTMMLNSGQSCNAPS
MAV_5202|M.avium_104                NAAPTVKRVTQELGGKSPNIVLDDGGFADAVRAGVANMMPNSGQSCNAPS
Rv0223c|M.tuberculosis_H37Rv        RAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQT
MAB_4484|M.abscessus_ATCC_1997      IAAKNLKKVTLELGGKSAAIVLEDADLAAALPMLVFSGLMNAGQGCVNQT
MLBr_02573|M.leprae_Br4923          IAGNEIKPTVLELGGSDPFIVMPSADLDAAVATAVTGRVQNNGQSCIAAK
                                     ..  :*    ****... ::: . .:  :    .     : **.*   .

MMAR_4928|M.marinum_M               RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVQGY
MUL_0477|M.ulcerans_Agy99           RLVVPRARYDEAVAIAAGTMSSIKPGDPDDARTVCGPLISQRQRDRVEGY
Mb0791|M.bovis_AF2122/97            RLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGY
Mflv_1797|M.gilvum_PYR-GCK          RMLVPNSRMDEAIAVARETAGAVKVGDPGD-QSAIGPVASRAQFEKIQGL
Mvan_4953|M.vanbaalenii_PYR-1       RMLVPNSRMDEAIAVARETAAAVKVGDPSD-KTAIGPVASKAQFDKIQGL
MSMEG_0455|M.smegmatis_MC2_155      RMLVPNSRMGEAITIARGTAAAVKVGDPSD-KKAIGPVASKAQFDKIQGL
TH_4605|M.thermoresistible__bu      RMLVPNSRMDEAIEIARETAAQVAVGDPDN-KTAIGPVVSRVQFDKIQRL
MAV_5202|M.avium_104                RMLVPASRMAEAISIAREVAEQVQVGDPDD-ATAIGPVASRAQFEKVQRL
Rv0223c|M.tuberculosis_H37Rv        RILAPRSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGY
MAB_4484|M.abscessus_ATCC_1997      RVLAPRSRYDEVVDGIVGMVSLMGVGLPDDPATQVGPLITEKQRTRVEGY
MLBr_02573|M.leprae_Br4923          RFIAHADIYDEFVEKFVARMETLRVGDPTDPDTDVGPLATESGRAQVEQQ
                                    *.:.      * :         :  * * :     **: :     :::  

MMAR_4928|M.marinum_M               LDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTNDARPAREEIFGP
MUL_0477|M.ulcerans_Agy99           LDLAIAEGGTFACGG-GRPAGRQVGYFIEPTVIAGLTTDARPAREEIFGP
Mb0791|M.bovis_AF2122/97            LDLAVAEGGRFACGG-ARPADREVGFYIEPTVIAGLTNDARVAREEIFGP
Mflv_1797|M.gilvum_PYR-GCK          IQKGIDEGATLVVGGTGRPDGVDKGYYVKPTVFANVTNDMTIAREEIFGP
Mvan_4953|M.vanbaalenii_PYR-1       IQKGIDEGATLVIGGTGRPDGIDKGYYVKPTVFANVTNDMTIAREEIFGP
MSMEG_0455|M.smegmatis_MC2_155      IQKGIDEGATLVAGGTGRPDGLDTGYYVKPTVFADVTNDMTIAREEIFGP
TH_4605|M.thermoresistible__bu      IQQGIDEGATVVVGGPGRPDGLEVGYYVKPTVFANVKNDMTIAREEIFGP
MAV_5202|M.avium_104                IQQGIDEGATVVAGGPGRPAGLDQGYYVKPTVFADVTNDMTIAREEIFGP
Rv0223c|M.tuberculosis_H37Rv        IAKGIEEGARLVCGG-GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGP
MAB_4484|M.abscessus_ATCC_1997      IAKGIAEGARLAYGG-KRPEGLDGGYFVQPTIFADVDNSMTIAQEEIFGP
MLBr_02573|M.leprae_Br4923          VDAAAAAGAVIRCGG-KRPD--RPGWFYPPTVITDITKDMALYTDEVFGP
                                    :  .   *. .  **  **     *::  **:::.: ..     :*:***

MMAR_4928|M.marinum_M               VLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGTVNV
MUL_0477|M.ulcerans_Agy99           VLTVLAHDGDDDAVRIANDSPYGLSGTVYGGDPQRAADVAARLRVGAVNV
Mb0791|M.bovis_AF2122/97            VLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNV
Mflv_1797|M.gilvum_PYR-GCK          VLCILGYDDLDQAVAIGNDTEYGLAGYVSGSDLEQARAVARRIRAGSVAI
Mvan_4953|M.vanbaalenii_PYR-1       VLCILGYDDLDQAVEIGNDTEYGLAGYVSGADLDKARAVARRIRAGSVAI
MSMEG_0455|M.smegmatis_MC2_155      VLCILGYDDLDQAVEIANDTEYGLAGYVSGADLETARAVARRIRAGSVAI
TH_4605|M.thermoresistible__bu      VLCILGYDDLDDAIEIANDTDYGLAGYVSGSDLEQARALARRIRAGSIAI
MAV_5202|M.avium_104                VLCILGYDDLDHAVRLANDTDYGLAGYVSGADLDTAREVAGKIRAGWVTI
Rv0223c|M.tuberculosis_H37Rv        VLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIKISQQIRTGTYGI
MAB_4484|M.abscessus_ATCC_1997      VLSIIAYDSVDEAVKIANDSNYGLAGSVWTTDVQKGLEVAAQIRTGTYGI
MLBr_02573|M.leprae_Br4923          VASVYCATNIDDAIEIANATPFGLGSNAWTQNESEQRHFIDNIVAGQVFI
                                    *  :      :.*: :.* : :**.. .   :      .  .: .*   :

MMAR_4928|M.marinum_M               NGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIA-----TAAN--
MUL_0477|M.ulcerans_Agy99           NGGVWYCADAPFGGYKQSGIGREMGLAGFEEYLETKLIA-----TAAN--
Mb0791|M.bovis_AF2122/97            NGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIA-----TAAN--
Mflv_1797|M.gilvum_PYR-GCK          N--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA---
Mvan_4953|M.vanbaalenii_PYR-1       N--HGFDMAAPFGGYKRSGNGREWGPFAFDEFLEVKAAL---GYAPA---
MSMEG_0455|M.smegmatis_MC2_155      N--HGFDLSAPFGGYKRSGNGREWGHFGFDEYLETKAAM---GYAPPQ--
TH_4605|M.thermoresistible__bu      N--HGFDLNAPFGGYKRSGNGREWSDYGFHEYLETKAIL---GYSPS---
MAV_5202|M.avium_104                N--HAFDLNAPFGGYKRSGNGREWSDFGFHEYLEVKSIL---GYAPAQAD
Rv0223c|M.tuberculosis_H37Rv        NW-YAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMGYTVA---
MAB_4484|M.abscessus_ATCC_1997      NW-YAFDPSCPFGGYKQSGIGRENGPEGIEEYCELKSVLLPMGYTLESI-
MLBr_02573|M.leprae_Br4923          NGMTVSYPELPFGGIKRSGYGRELSTHGIREFCNIKTVWIA---------
                                    *         **** *.** *** .  .. .: : *              

MMAR_4928|M.marinum_M               -
MUL_0477|M.ulcerans_Agy99           -
Mb0791|M.bovis_AF2122/97            -
Mflv_1797|M.gilvum_PYR-GCK          -
Mvan_4953|M.vanbaalenii_PYR-1       -
MSMEG_0455|M.smegmatis_MC2_155      -
TH_4605|M.thermoresistible__bu      -
MAV_5202|M.avium_104                R
Rv0223c|M.tuberculosis_H37Rv        -
MAB_4484|M.abscessus_ATCC_1997      -
MLBr_02573|M.leprae_Br4923          -