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MPIDPIAQKMLDDAKASGRPNAHLLPVPTARENFENTFAALQKPDVHRVTDVAIETRDGAVIPGRLYVPA EGDDLPLTVYYHGGGWLLGSVDSHDAATRLLAKASGSAVLSVGYRLAPESRFPTAVNDAIDAVEWARAFG ATLGVDTSRLAVAGDSAGGNLAAAVALHYRDAGEPVIRHQLLVYPVTTTDLTKGMDPEYDGVMLERDELQ WHQDNYLPGPDAASDPRVNVLGADLHGLPEATVILAECDPIRPQGELYLQALKDAGVPVESHLTPGQVHG FFGLDEIFPAATAAMTFAGQRLASALAVAGQSTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3829 | - | - | 100% (314) | esterase |
| M. smegmatis MC2 155 | MSMEG_3059 | - | 1e-44 | 40.64% (283) | esterase |
| M. smegmatis MC2 155 | MSMEG_2409 | - | 6e-43 | 38.31% (308) | alpha/beta hydrolase fold family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1434c | lipH | 2e-45 | 39.22% (306) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_4552 | - | 1e-51 | 42.49% (273) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1399c | lipH | 2e-45 | 39.22% (306) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 2e-18 | 28.51% (249) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2039 | - | 2e-48 | 39.33% (300) | lipase LipH (carboxylesterase) |
| M. marinum M | MMAR_1746 | lipN | 2e-45 | 38.26% (298) | lipase/esterase LipN |
| M. avium 104 | MAV_3814 | - | 8e-45 | 38.91% (293) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_2802 | - | 8e-43 | 38.14% (312) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1989 | lipN | 1e-45 | 38.26% (298) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_0613 | - | 1e-139 | 77.67% (309) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3829|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0613|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4552|M.gilvum_PYR-GCK --------------------------------------------------
TH_2802|M.thermoresistible__bu MNHPV---------------------------------------------
Mb1434c|M.bovis_AF2122/97 MTEPT---------------------------------------------
Rv1399c|M.tuberculosis_H37Rv MTEPT---------------------------------------------
MAB_2039|M.abscessus_ATCC_1997 MTSP----------------------------------------------
MMAR_1746|M.marinum_M MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
MUL_1989|M.ulcerans_Agy99 MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
MAV_3814|M.avium_104 MTKPLTDTAPVDPGVQRGSMPLTNRIQGAVTSVGVKVIPWIPTAVRRGLV
MLBr_00314|M.leprae_Br4923 MAISAG--------------------------------------------
MSMEG_3829|M.smegmatis_MC2_155 ---------MPIDPIAQKMLDDAKASGRPNAH-LLPVPTARENFENTFAA
Mvan_0613|M.vanbaalenii_PYR-1 ---------MPIDPIAQKMLDDAKKSGRPNAH-LLPVPTARQNFEDTFGA
Mflv_4552|M.gilvum_PYR-GCK ---------MRLDPQIAALIDALDGGFPAVHT-MTGAQA-RATIRSRFTP
TH_2802|M.thermoresistible__bu ---------PPLDPDAAARIASLGP--PAPMR-RRGLQAVRDAIESAPLP
Mb1434c|M.bovis_AF2122/97 ------VARPDIDPVLKMLLDTFP-VTFTA---ADGVEVARARLRQLKTP
Rv1399c|M.tuberculosis_H37Rv ------VARPDIDPVLKMLLDTFP-VTFTA---ADGVEVARARLRQLKTP
MAB_2039|M.abscessus_ATCC_1997 -----------VDPLLMSVLEASPAVQLDR---PEDLTLARESRRHAAPS
MMAR_1746|M.marinum_M RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
MUL_1989|M.ulcerans_Agy99 RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAASRAHMREAMLG
MAV_3814|M.avium_104 RGRSVIIDGNTLDPTLQLMLSGLRAVGIDGLVVDDDPELSRAQMHESTVG
MLBr_00314|M.leprae_Br4923 APVEIVESGPSIAARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAAR
: .
MSMEG_3829|M.smegmatis_MC2_155 LQKP-DVHRVTDVAIETRDGAVIPGRLYVPAE---GDDLPLTVYYHGGGW
Mvan_0613|M.vanbaalenii_PYR-1 LAKP-QIHRVTDVEIPTRDGQTIPGRLYLPAEE--AAALPLTVYYHGGGW
Mflv_4552|M.gilvum_PYR-GCK AAEPEPVHSVHDMAVPVD-DGEVPVRVYRPAG---PAPLPALVFAHGGGF
TH_2802|M.thermoresistible__bu TDMP-AMASIVDRAVPGP-GGDIPVRIHRPERG-CGDPAPAVLYFHGGGL
Mb1434c|M.bovis_AF2122/97 PELLPEL-RIEERTVGYDGLTDIPVRVYWPP--VVRDNLPVVVYYHGGGW
Rv1399c|M.tuberculosis_H37Rv PELLPEL-RIEERTVGYDGLTDIPVRVYWPP--VVRDNLPVVVYYHGGGW
MAB_2039|M.abscessus_ATCC_1997 DAQLPTVGRVKDTSIPVTDAPPIAVRIYWPAGFESAGELPLVLYYHGGGF
MMAR_1746|M.marinum_M FPGPQIHVDVEELTLPGP-AGDISARHYRPPG---DAAAPLLVFYHGGGW
MUL_1989|M.ulcerans_Agy99 FPGPQIHVDVEELTLPGP-AGDISARHYRPPG---DAAAPLLVFYHGGGW
MAV_3814|M.avium_104 FPGPQIHVDVAELALPGP-AGDIPARHYRPAGG--ETQAPLLVFYHGGGW
MLBr_00314|M.leprae_Br4923 VLLPVTNAARAEVNLSNTSAQLVRAAGVRPAD----GSGRIVLYLHGGAF
: : : * :: ***.
MSMEG_3829|M.smegmatis_MC2_155 LLGSVDSHDAATRLLAKASGSAVLSVGYRLAPESRFPTAVNDAIDAVEWA
Mvan_0613|M.vanbaalenii_PYR-1 LLGSIDSHDVATRLLANASGSAVLSVGYRRGPESRFPTAVDDAVDALIWA
Mflv_4552|M.gilvum_PYR-GCK VFCDLDSHDGLCRNLSNRLGAVVISVGYRLAPEHRWPTAAEDMYAVTRWV
TH_2802|M.thermoresistible__bu VMGSNHSFEPLARGLAAASGAVVVAVDYRLAPEHPPPAQFDDAWATTRWV
Mb1434c|M.bovis_AF2122/97 SLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWV
Rv1399c|M.tuberculosis_H37Rv SLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWV
MAB_2039|M.abscessus_ATCC_1997 ALGSIDTHDWVARSICAHIEAVVVSVDYRLAPENPYPAAVDDAFAALSWA
MMAR_1746|M.marinum_M ALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEDRAPAAIDDAFAAFEWA
MUL_1989|M.ulcerans_Agy99 ALGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAAFEWA
MAV_3814|M.avium_104 SIGDLDTHDSLCRLTCRDAGIHVLSIDYRLAPEHPAPAAIDDAYAAFTWA
MLBr_00314|M.leprae_Br4923 LGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWL
. .:. . . :: :.** *: :* *
MSMEG_3829|M.smegmatis_MC2_155 RAFGATLGVDTSRLAVAGDSAGGNLAAAVALHYRDAGEPVIRHQLLVYPV
Mvan_0613|M.vanbaalenii_PYR-1 AGPASGLGVDTTRLAVAGDSAGGNLAGAVALHVRHTGAPALRHQLLVYPV
Mflv_4552|M.gilvum_PYR-GCK SGDADALGVDPARIAVGGDSAGGNLAAVTALMARDRGGPALRAQLLLYPV
TH_2802|M.thermoresistible__bu AAHADELGLDTSRLAVAGDSAGGALAAAVALAARDRGGPELLAQLLMYPG
Mb1434c|M.bovis_AF2122/97 GENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPT
Rv1399c|M.tuberculosis_H37Rv GENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPT
MAB_2039|M.abscessus_ATCC_1997 AEHAPELGADPARIAVAGDSAGGNLATVAAQLAEIRGGPHLKFQLLWYPG
MMAR_1746|M.marinum_M HAHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYPR
MUL_1989|M.ulcerans_Agy99 HAHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYPR
MAV_3814|M.avium_104 HEHAGELGAIPGRVAVGGDSAGGNLAAVVSQLARDAGGPAPVLQWLIYPR
MLBr_00314|M.leprae_Br4923 RR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEEPAALVAISPLL
** . ::.:.****** :: . : . * :
MSMEG_3829|M.smegmatis_MC2_155 TTTDLTKG-MDPEYDGVMLERDELQWHQDNYLPGPD------AASDPRVN
Mvan_0613|M.vanbaalenii_PYR-1 TTTDLEIG-FDDEYQGVMLERDEMQWHQDNYLPSPE------AATDARVS
Mflv_4552|M.gilvum_PYR-GCK IAADFDTESYRLFGHGFYNPEPALRWYWDQYVPALS-----DRQHPYASP
TH_2802|M.thermoresistible__bu LDRDLAAPSIVAMPEAPMLSRDDIVYLHELADLGAG-----TPHDPYRVP
Mb1434c|M.bovis_AF2122/97 TMADLSLPSFTENADAPILDRDVIDAFLAWYVPGL--DISDHTMLPTTLA
Rv1399c|M.tuberculosis_H37Rv TMADLSLPSFTENADAPILDRDVIDAFLAWYVPGL--DISDHTMLPTTLA
MAB_2039|M.abscessus_ATCC_1997 TTSDLSLPSVVENADGPVLSRDIMRIFGQAYLGELS-ETADPTALPFTVA
MMAR_1746|M.marinum_M TDFAGRTRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPRVSPLRAE
MUL_1989|M.ulcerans_Agy99 TDFAGRTRSASLFARGFLLTKRDIDWFHSQYLKGSGIEPTDPRVSPLRAE
MAV_3814|M.avium_104 TDFTARTRSLSLFSRGFLLTKRDIDWFESQYLRNSGLDRTDPRVSPALAE
MLBr_00314|M.leprae_Br4923 QLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEE-LYE
:
MSMEG_3829|M.smegmatis_MC2_155 VLGADLHGLPEATVILAECDPIRPQGELYLQALKDAGVPVESHLTPGQVH
Mvan_0613|M.vanbaalenii_PYR-1 ILGADLTGVPAATVILAECDPIRPQGELYAKALEAAGVPTATHLTPGMVH
Mflv_4552|M.gilvum_PYR-GCK LHG-ELTGLPPAVMVMTGHDPLRDEAVAYAQALTDAGVPVVRCEFDGAVH
TH_2802|M.thermoresistible__bu AYATDLGGLPQTIIVTGACDPIRDWGERYAGRLRDAGVQTTVTRYPGMYH
Mb1434c|M.bovis_AF2122/97 PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVH
Rv1399c|M.tuberculosis_H37Rv PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVH
MAB_2039|M.abscessus_ATCC_1997 PVNGKLDGLPPAYIATAQHDPLRDDGKIYATRLADAGVPVQLRNADTLVH
MMAR_1746|M.marinum_M S----LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTH
MUL_1989|M.ulcerans_Agy99 S----LAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTH
MAV_3814|M.avium_104 S----LAGLAPALIAVAGFDPLRDEGQSYAEALRAAGTPVDLRYLGSLTH
MLBr_00314|M.leprae_Br4923 PLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVH
*:. : : : : . * .*. . *
MSMEG_3829|M.smegmatis_MC2_155 GFFGLDEIFPAATAAMTFAGQRLASALAVAGQSTR---
Mvan_0613|M.vanbaalenii_PYR-1 GFFGLDEVFPTATEAMTFAGKQLSEALAVVDR------
Mflv_4552|M.gilvum_PYR-GCK GFMTMP-MLDIAHEARRRSCQELTALLHG---------
TH_2802|M.thermoresistible__bu GFL----MRYESTARGRLALAEIGALLRAKFANPLPF-
Mb1434c|M.bovis_AF2122/97 GYVNFALVVPAAAEATGRGLAALKRALHA---------
Rv1399c|M.tuberculosis_H37Rv GYVNFALVVPAAAEATGRGLAALKRALHA---------
MAB_2039|M.abscessus_ATCC_1997 GYLDFARIVPAANEEFRLSLDACKTALQASPRPKAGP-
MMAR_1746|M.marinum_M GFLNLFPLGGGCAAATSELISALRAHLTRV--------
MUL_1989|M.ulcerans_Agy99 GFLNLFPLGGGCAAATSELISALRAHLTRV--------
MAV_3814|M.avium_104 GFANLFQLGGDSMVATSELISALRAHLSRV--------
MLBr_00314|M.leprae_Br4923 VFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
: : .