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LLKDASICVSLLGTETRFVDVDGVRTRTIQAGEGPDLILMHGGGGHAEAFARNVTALSRHFRVHALDLLG HGLTSGCEVAPKRKDYVSHLLGYMDQEGIDRAHLAGESLGGWIAAWTALEHPDRVDRLIYVCGARLTLEV GADAEARTAAGRAELARVTRQFLADPSPANVRERMAWLFHHPDRDLTDELVALRWALYQSEESRSALTNA TAPPSAATAEDNLTAERLTSLTRPTLVLWTSHNPSATVEFGRRAAELIPGAEFALMEDCGHWPQWERPEE FNQILTNYLQGDRESRGQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0538 | - | - | 100% (299) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4246 | - | 4e-49 | 37.91% (277) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_4414 | - | 2e-24 | 29.32% (266) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 2e-25 | 30.74% (283) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_0627 | - | 1e-174 | 99.33% (299) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 2e-25 | 30.74% (283) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_02269 | - | 7e-07 | 22.26% (265) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 3e-17 | 25.45% (279) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_4778 | bphD_1 | 5e-48 | 39.34% (272) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD_1 |
| M. avium 104 | MAV_0877 | - | 1e-48 | 38.57% (280) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 7e-49 | 38.01% (271) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
| M. thermoresistible (build 8) | TH_4528 | - | 3e-51 | 39.35% (277) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 7e-25 | 30.14% (282) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 ----------------MTATEELTFESTSRFAEVDVDGPLKLHYHEAG-V
Rv3569c|M.tuberculosis_H37Rv ----------------MTATEELTFESTSRFAEVDVDGPLKLHYHEAG-V
MUL_4140|M.ulcerans_Agy99 ------------MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAG-V
MAB_3810|M.abscessus_ATCC_1997 --------------------MDVTYEGTKRELATDEG---TLRYHEAGTA
Mvan_0538|M.vanbaalenii_PYR-1 -----------MLKDASICVSLLGTETRFVDVDG------VRTRTIQAGE
Mflv_0627|M.gilvum_PYR-GCK -----------MLKDASICVSLLGAETRFVDVDG------VRTRTIQAGE
MSMEG_4867|M.smegmatis_MC2_155 MTSTAAAGTASAVEFESIWSDLQGVAFSQGYLDVPVGDRKIRTRYLHAGN
TH_4528|M.thermoresistible__bu -----------------VWSDLQGVAFTQGYLDAGG----VRTRYLHAGE
MMAR_4778|M.marinum_M -----------MTDFESVWSDLQGVMFEQGYLTTAQG---VRTRYLRAGE
MAV_0877|M.avium_104 -----------MAEFESIWSDLQGVAFEQGYLD-AGG---IRTRYLRAGD
MLBr_02269|M.leprae_Br4923 -----------------------------------------MINLAYEDR
Mb3600c|M.bovis_AF2122/97 GNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA
Rv3569c|M.tuberculosis_H37Rv GNDQTVVLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA
MUL_4140|M.ulcerans_Agy99 GNDQTVVLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRA
MAB_3810|M.abscessus_ATCC_1997 GEGEPLILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVP
Mvan_0538|M.vanbaalenii_PYR-1 --GPDLILMHGGG---GHAEAFARNVTALSRHFRVHALDLLGHGLTSG-C
Mflv_0627|M.gilvum_PYR-GCK --GPDLILMHGGG---GHAEAFARNVTALSRHFRVHALDLLGHGLTSG-C
MSMEG_4867|M.smegmatis_MC2_155 PQAPALLFLHGSG---GHAEAYVRNLAAHAEHFSTWSIDMLGHGYTDK-P
TH_4528|M.thermoresistible__bu ADKPVLIFLHGSG---GHAEAYVRNLEAHAEHFSTWSIDMLGHGYTDK-P
MMAR_4778|M.marinum_M PDRPLLMLLHGSG---GHAEAYVRNLAAHAEHFWTWAIDMLGHGYTDK-P
MAV_0877|M.avium_104 PGKPVLVLLHGSG---GHAEAYVRNLAAHADHFWTWSIDMLGHGYTDK-P
MLBr_02269|M.leprae_Br4923 GTGEPVVFIAGRG-GAGRTWQPHQVPAFLAAGYRVITFDNRGIGATEN--
:::: * * : : . .: * * :.
Mb3600c|M.bovis_AF2122/97 EHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGR
Rv3569c|M.tuberculosis_H37Rv EHGQFNRYAAMALKGLFDQLGLGRVPLVGNSLGGGTAVRFALDYPARAGR
MUL_4140|M.ulcerans_Agy99 EHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAVRFALDYPDRAGR
MAB_3810|M.abscessus_ATCC_1997 GHPVLT--AGASVIRFMDGLGISSAAVVGNSMGGVVGINLAIKHPDRITK
Mvan_0538|M.vanbaalenii_PYR-1 EVAPKRKDYVSHLLGYMDQEGIDRAHLAGESLGGWIAAWTALEHPDRVDR
Mflv_0627|M.gilvum_PYR-GCK EVAPKRKDYVSHLLGYMDQEGIDRAHLVGESLGGWIAAWTALEHPDRVDR
MSMEG_4867|M.smegmatis_MC2_155 GHPLEVAHYVDHVIAFLDTIGAQRAHISGESLGGWVAARVAVDHPDRVEK
TH_4528|M.thermoresistible__bu GHPLEVRHYVEHLAAVLDAIGADRAHISGESLGGWVASRFAIDRPDRLDR
MMAR_4778|M.marinum_M GHPLEIRHYVEHLMAVLRAIGAQRASISGESLGGWVAARAAVDHPEAVER
MAV_0877|M.avium_104 GHPLEVRHYVEHLMTVLRTIGVERASISGESLGGWVAARAAIDHPDVVDR
MLBr_02269|M.leprae_Br4923 TEGFTTQTMVADTAVLIESLGAVPARIVGVSMGSFIAQELMVARPELVRA
: * . : * *:*. . : *
Mb3600c|M.bovis_AF2122/97 LVLMGPG-------GLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRV
Rv3569c|M.tuberculosis_H37Rv LVLMGPG-------GLSINLFAPDPTEGVKRLSKFSVAPTRENLEAFLRV
MUL_4140|M.ulcerans_Agy99 LVLMGPG-------GLSINLFAPDPTEGVKRLGKFSVAPTRENLEAFLRV
MAB_3810|M.abscessus_ATCC_1997 LVTIG---------GVGPNIFSPSPSEGLRLLQEFTDNPDRDKLIRWLNS
Mvan_0538|M.vanbaalenii_PYR-1 LIYVCGARLTLEVGADAEARTAAGRAELARVTRQFLADPSPANVRERMAW
Mflv_0627|M.gilvum_PYR-GCK LIYVCGARLTLEVGADAEARTAAGRAELARVTRQFLADPSPANVRERMAW
MSMEG_4867|M.smegmatis_MC2_155 LVLNTAG------GSQADPEVMKR---IITLSMAAAENPTWDTVQARIKW
TH_4528|M.thermoresistible__bu LVLNTAG------GSQADPEVMKR---IITLSMAAAENPSWDTVQARITW
MMAR_4778|M.marinum_M LVLNTAG------GSQADPEVMAR---IVTLSMAAAENPTWETVQARIKW
MAV_0877|M.avium_104 LVLNTAG------GSQADPVVMQR---IIALSMAAAENPTWETVQARIKW
MLBr_02269|M.leprae_Br4923 AVLMATR---------GRLDRTRQFFHAAEAEFHDSGIQLPSGYNAKVRL
: . :
Mb3600c|M.bovis_AF2122/97 MVYDKNLIT-PELVDQRFALASTPESLTATRAMG--KSFAG-----ADFE
Rv3569c|M.tuberculosis_H37Rv MVYDKNLIT-PELVDQRFALASTPESLTATRAMG--KSFAG-----ADFE
MUL_4140|M.ulcerans_Agy99 MVYDQKLIT-PELVDQRFELARTPESLAATRAMG--KSFAA-----ADFE
MAB_3810|M.abscessus_ATCC_1997 MVWDPAVVT-DELIEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLANAD
Mvan_0538|M.vanbaalenii_PYR-1 LFHHPDRDLTDELVALRWALYQSEESRSALTNATAPP-SAAT------AE
Mflv_0627|M.gilvum_PYR-GCK LFHHPDRDLTDELVALRWALYQSEESRSALTNATAPP-SAAT------AE
MSMEG_4867|M.smegmatis_MC2_155 LMADKSKDY-DDIVASRQRVYRQPGFVAAMSDIMALQDPQIR------AR
TH_4528|M.thermoresistible__bu LMADKSKGY-DDIVASRQKIYRQPGFVDAMRNIMALQDPEIR------AR
MMAR_4778|M.marinum_M LMADKSKDY-DDLVASRQRIYRQPGFVAAMRDIMALQDPQIR------AR
MAV_0877|M.avium_104 LMADKSRDY-DDLVASRQRVYRQPGFVAAMRDIMALQDPEIR------AR
MLBr_02269|M.leprae_Br4923 LENLSRKTLNDDVAVADWIAMFNMWPIKSTPGLRCQTDVAPQ--------
: :: :
Mb3600c|M.bovis_AF2122/97 AGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
Rv3569c|M.tuberculosis_H37Rv AGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
MUL_4140|M.ulcerans_Agy99 LGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCG
MAB_3810|M.abscessus_ATCC_1997 IPPYWAMMHKIKCPTLLTWGRDDRVSPPDMAIVPMRLIPNAELHIFPNSG
Mvan_0538|M.vanbaalenii_PYR-1 DNLTAERLTSLTRPTLVLWTSHNPSATVEFGRRAAELIPGAEFALMEDCG
Mflv_0627|M.gilvum_PYR-GCK DNLTAERLTSLTRPTLVLWTSHNPSATVEFGRRAAELIPGAEFALMEDCG
MSMEG_4867|M.smegmatis_MC2_155 NLLGQAEYGSITAPTLVVWTSDDPTADVAEGRRIASMIPGARFEVMPGCG
TH_4528|M.thermoresistible__bu NLLGPEEYGAITAPTLVVWTSDDPTADVDEGKRIASMIPGARFEVMPGCG
MMAR_4778|M.marinum_M NLLGPAEYGAIKAPTLVLWTSHDPTADVTEGRRIASMIPGARFEVMSGCG
MAV_0877|M.avium_104 NILGPAEYGSIIAPTLVLWTSDDPTADVSEGRRIASMIPGARFEVMPGCG
MLBr_02269|M.leprae_Br4923 -NNRLPAYRSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQIPDAG
: *.*: .: . :* .. : .*
Mb3600c|M.bovis_AF2122/97 HWVQVEKFDEFNKLTIEFLGGGR------
Rv3569c|M.tuberculosis_H37Rv HWVQVEKFDEFNKLTIEFLGGGR------
MUL_4140|M.ulcerans_Agy99 HWAQVEKFDEFNRLTIDFLGGAR------
MAB_3810|M.abscessus_ATCC_1997 HWVMIEAKQAFEQTVVDFLRR--------
Mvan_0538|M.vanbaalenii_PYR-1 HWPQWERPEEFNQILTNYLQGDRESRGQR
Mflv_0627|M.gilvum_PYR-GCK HWPQWERPEEFNQILTNYLQGDRESRGQR
MSMEG_4867|M.smegmatis_MC2_155 HWPQYEDPATFNALHLDFLLGR-------
TH_4528|M.thermoresistible__bu HWPQYEDPATFNRLHIDFLLGRS------
MMAR_4778|M.marinum_M HWPQYEDAKSFNRRHLDFLMGH-------
MAV_0877|M.avium_104 HWPQYEDAKTFNRLHLDFLLGR-------
MLBr_02269|M.leprae_Br4923 HLGFFERPEAVNAAALQFFAGVKGEWP--
* * .: :::