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RSSTLPYATRAAGLVGSVIDSSTSLLHKQTHDIVRFAMGSPAAEAVPSEILAGIAAHQLSRPDAYDYAAT EGDPPLHAALLDMLRGTSDETTAERLTITAGGMQGLDLFCKIFVDPGDLVTVESPTYTNGSATALSYGAT LLEVPVDDEGMDVDALERLVADAGRKPKAIYTIPTFQNPSGVTMSLERRLRLLELARDWGSMILDDDPYG LLRFAGDPLPTLRELGGGDPLVFSVRTFSKIVAPGLRVGWVDTDPELQPLLINAKQAMDTCTNLPAQRLL AGFLTGGHLADHLVTQRAEYRRRKEAMHAALHEHFGGIARWTDPDGGFFLWVTLDGDVDATALFDVALAE GVAYIPGAAFSPSGRFANALRLCFASTPPERIREGIARLRRAVEKLRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2493 | - | - | 100% (399) | aminotransferase, class I and II family protein |
| M. smegmatis MC2 155 | MSMEG_1572 | - | 1e-25 | 30.19% (371) | transcriptional regulator, GntR family protein |
| M. smegmatis MC2 155 | MSMEG_0426 | - | 3e-25 | 24.81% (399) | transcriptional regulator, GntR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 1e-08 | 23.71% (367) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_4275 | - | 4e-24 | 27.16% (324) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3565 | aspB | 1e-08 | 23.71% (367) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_02502 | - | 8e-09 | 22.01% (359) | aminotransferase AlaT |
| M. abscessus ATCC 19977 | MAB_0810c | - | 5e-28 | 27.73% (375) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2376 | - | 3e-14 | 27.27% (363) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 2e-15 | 26.38% (345) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_1831 | - | 9e-11 | 25.77% (260) | PROBABLE AMINOTRANSFERASE |
| M. ulcerans Agy99 | MUL_1552 | - | 3e-14 | 27.27% (363) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 1e-23 | 26.42% (371) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
MAV_3214|M.avium_104 --------------------------------------------MAVQKS
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
Mb3595|M.bovis_AF2122/97 --------------------------------------------------
Rv3565|M.tuberculosis_H37Rv --------------------------------------------------
TH_1831|M.thermoresistible__bu --------------------------------------------------
MSMEG_2493|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0810c|M.abscessus_ATCC_199 -------------------------------MAEQVRGEILALAPGSRIA
MLBr_02502|M.leprae_Br4923 ------------------------------------------MTLYQQIS
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MAV_3214|M.avium_104 ITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYR
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
Mb3595|M.bovis_AF2122/97 -----------------MTDRVALRAGVPP-------FYVMDVWLAAAER
Rv3565|M.tuberculosis_H37Rv -----------------MTDRVALRAGVPP-------FYVMDVWLAAAER
TH_1831|M.thermoresistible__bu ----------------------------------------VAPVIRAALA
MSMEG_2493|M.smegmatis_MC2_155 ----------------------MRSSTLPYATRAAGLVGSVIDSSTSLLH
MAB_0810c|M.abscessus_ATCC_199 SHRELVRRFHVSASTVADALSLLAQQGLIESRPGAGSFRTENRPVPRPGD
MLBr_02502|M.leprae_Br4923 VDGSGTMSDVTTHQLPMHTPGYHRQRAFAQSSKLQDVLYEIRGPVSQHAT
MMAR_2376|M.marinum_M LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAGARDLSTGNPAPEL
MUL_1552|M.ulcerans_Agy99 LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAGARDLSTGNPAPEL
MAV_3214|M.avium_104 LLRHRGAVETAGRRGTRVRHRPATTPRSLLGLDVPAGVRDLSTGNPHPAL
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLN--ARRGARSTTALPLTPTPALRP-VTATANLAAATLAAPAS
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLN--ARRGARSTTALPLRPAAPAPL-APTGANLAAATLAAPAA
Mb3595|M.bovis_AF2122/97 QRTHGDLVN--------------------LSAGQPSAGAPEPVRAAAAAA
Rv3565|M.tuberculosis_H37Rv QRTHGDLVN--------------------LSAGQPSAGAPEPVRAAAAAA
TH_1831|M.thermoresistible__bu EAS--------------------------AAPGYPTTAGTPALRASAAAA
MSMEG_2493|M.smegmatis_MC2_155 KQTHDIVR---------------------FAMGSPAAEAVPSEILAGIAA
MAB_0810c|M.abscessus_ATCC_199 TSWQETALELGPQEESPPGIRRVFDAPGLLSTLAPSAADVVDLNGGYLHP
MLBr_02502|M.leprae_Br4923 RLETEG-----------------------HRILKLNIGNPALFGFDAPDV
MMAR_2376|M.marinum_M LPLAAVG-WPDGSVLPLLYGAPAMS--AELVDYARAALAADGVAAD--HL
MUL_1552|M.ulcerans_Agy99 LPLAAVG-WPDGSVLPLLYGAPAMS--AELVDYARAALAADGVAAD--HL
MAV_3214|M.avium_104 LPLAAAAPARPASGRAVLYGEPAIS--PALAEYARAALSADGVPAD--HL
Mflv_4275|M.gilvum_PYR-GCK VTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARGLPTDVDEI
Mvan_2084|M.vanbaalenii_PYR-1 IAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTDPDEI
Mb3595|M.bovis_AF2122/97 LHLNQLG-------YSVALGIPELR-----DAIAADYQRRHGITVEPDAV
Rv3565|M.tuberculosis_H37Rv LHLNQLG-------YSVALGIPELR-----DAIAADYQRRHGITVEPDAV
TH_1831|M.thermoresistible__bu LER---------------------------------RYGITGLTPDAVLP
MSMEG_2493|M.smegmatis_MC2_155 HQLSRPD----------AYDYAATEGDPPLHAALLDMLRGTSDETTAERL
MAB_0810c|M.abscessus_ATCC_199 DLQPLSMLTASLARAARRPEAWDRPPPGGLPELRDWFAAELGGGLGRQDI
MLBr_02502|M.leprae_Br4923 IMRDMIQALPYAQGYSDSQGILPAR----RAVVTRYELVDGFPRFDVDDV
MMAR_2376|M.marinum_M AVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGV
MUL_1552|M.ulcerans_Agy99 AVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGV
MAV_3214|M.avium_104 ALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEPVRV
Mflv_4275|M.gilvum_PYR-GCK MVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAAMASRGLRPVPVAM
Mvan_2084|M.vanbaalenii_PYR-1 MVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMASRGLRTVPVAM
Mb3595|M.bovis_AF2122/97 VITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPC
Rv3565|M.tuberculosis_H37Rv VITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPC
TH_1831|M.thermoresistible__bu AIGTKELIAWLPTLLG-LGGDDTVVVPELAYP----------TYDVGARL
MSMEG_2493|M.smegmatis_MC2_155 TITAGGMQGLDLFCKIFVDPGDLVTVESPTYTNGSATALSYGATLLEVPV
MAB_0810c|M.abscessus_ATCC_199 LICGAGQSALSTSLRALCQPGDPVLLESPCYPGATAAARAAGLRPIAIPL
MLBr_02502|M.leprae_Br4923 YLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPVHYLC
: .* * : . :
MMAR_2376|M.marinum_M DDDGPLVADLQRALGRG--VRAVVVTSR-AQNPTGAALSAARAEELREVL
MUL_1552|M.ulcerans_Agy99 DDDGPLVADLQRALGRG--VRAVVVTSR-AQNPTGAALSAARAEELREVL
MAV_3214|M.avium_104 DDAGPLPEDLARALGRG--ARALVLTTR-AQNPTGAALSAERAAALRDLL
Mflv_4275|M.gilvum_PYR-GCK APDGWELDAVEAAIRQL--APELAYLIPDNQNPTGMTMPVGDRARLARII
Mvan_2084|M.vanbaalenii_PYR-1 APDGWELDAVEAAIRQL--APNLAYLVPDNHNPTGMTLPVPERKRLAHII
Mb3595|M.bovis_AF2122/97 GPQTRFQPTAQMLAEID--PPLRGVVVASPANPTGTVIPPEELAAIASWC
Rv3565|M.tuberculosis_H37Rv GPQTRFQPTAQMLAEID--PPLRGVVVASPANPTGTVIPPEELAAIASWC
TH_1831|M.thermoresistible__bu AGARVFRADSLTQLGPQ--TPALIYLNS-PSNPTGRVLGVDHLRKVVGWA
MSMEG_2493|M.smegmatis_MC2_155 DDEGMDVDALERLVADAGRKPKAIYTIPTFQNPSGVTMSLERRLRLLELA
MAB_0810c|M.abscessus_ATCC_199 DINGIRPDRLNEALSHT--NARAIVVQPLFQNPTGASLTPQRRDELREIA
MLBr_02502|M.leprae_Br4923 DETQGWQPDIADVESKIT-ERTKALVVINPNNPTGAVYSNEILNQIVDLA
**:* :
MMAR_2376|M.marinum_M SQGAEEVLLVEDDHCAGIAGVPLHTLAGATQHWA-----FVRSAAKAYGP
MUL_1552|M.ulcerans_Agy99 SQGAEEVLLVEDDHCAGIAGVPLHTLAGATQHWA-----FVRSAAKAYGP
MAV_3214|M.avium_104 SGRADDVLLVEDDHCAGISGAALHPVAGCTTHWA-----FVRSASKAYGP
Mflv_4275|M.gilvum_PYR-GCK SETKTRTIIDETITDMWLDEQVPPPLATEVTSRPDL-VMTVGSMSKSFWG
Mvan_2084|M.vanbaalenii_PYR-1 SDTRTRTIVDETITDMWLDEPVPAPLAASMTGRRDL-VLTVGSMSKSFWG
Mb3595|M.bovis_AF2122/97 DASDVRLISDEVYHGLVYQGAPQTSCAWQTSRNA----VVVNSFSKYYAM
Rv3565|M.tuberculosis_H37Rv DASDVRLISDEVYHGLVYQGAPQTSCAWQTSRNA----VVVNSFSKYYAM
TH_1831|M.thermoresistible__bu RDRGVIVASDECYLGLGWDETPVSVLHPTVCGGDHTNLLAIHSLSKTSSL
MSMEG_2493|M.smegmatis_MC2_155 RDWGSMILDDDPYGLLRFAGDPLPTLRELGGGDP--LVFSVRTFSKIVAP
MAB_0810c|M.abscessus_ATCC_199 RRHGAFLIEDDFARYMAHDDG-KPLVPPLISDDPDGTVVHIRSMTKVTSP
MLBr_02502|M.leprae_Br4923 RKHQLLLLADEIYDKILYDDTKHISVASIAPDLLC---LTFNGLSKAYRV
: . :*
MMAR_2376|M.marinum_M -DLRLAVLAGDQ-----RTVERVHGRLRLGPGWVSHILQDLAVRLFADDA
MUL_1552|M.ulcerans_Agy99 -DLRLAVLAGDQ-----RTVERVHGRLRLGPGWVSHILQDLAVRLFADDA
MAV_3214|M.avium_104 -DLRVAVLAGDQ-----RTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTA
Mflv_4275|M.gilvum_PYR-GCK -GLRIGWIRAER-----STLATIA-TLRPAIDMGTPIVEQLAAARLLAAD
Mvan_2084|M.vanbaalenii_PYR-1 -GLRIGWIRAER-----STLATVA-VQRPAVDMGTPIFEQLAAAKLLASE
Mb3595|M.bovis_AF2122/97 TGWRLGWLLVP------TVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPE
Rv3565|M.tuberculosis_H37Rv TGWRLGWLLVP------TVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPE
TH_1831|M.thermoresistible__bu AGYRAGFVAGDP-----ALVAELLAVRKHAGMMVP---TPVQAAMVAALD
MSMEG_2493|M.smegmatis_MC2_155 -GLRVGWVDTDP-----ELQPLLINAKQAMDTCTNLPAQRLLAGFLTGGH
MAB_0810c|M.abscessus_ATCC_199 -NLRVGAIAARG-----PVMARLRAASVIDTMLVPAPLQYTTLEVVTSPS
MLBr_02502|M.leprae_Br4923 AGYRSGWLAITGPKDHASSFIGGINLLANMRLCPNVPAQHAIQVALGGHQ
. * . :
MMAR_2376|M.marinum_M ATGLVRQAQERYADARGRLCAALSARG----VAAHGRSGLNVWIPVPDET
MUL_1552|M.ulcerans_Agy99 ATGLVRQAQERYADARGRLCAALSARG----VAAHGRSGLNVWIPVPDET
MAV_3214|M.avium_104 ASELVATAERRYADRRRRLCGALAERG----VDAHGRSGLNVWVRVPDEA
Mflv_4275|M.gilvum_PYR-GCK E-EVLPERRDILRSRRALLLRLLAEHLP-DWQPVPGKGGMSVWVRLPAPM
Mvan_2084|M.vanbaalenii_PYR-1 D-EVLPERREILRSRRALLLALLAEHLP-DWRPAPGKGGLSLWVRLPAPM
Mb3595|M.bovis_AF2122/97 ATAEADGNLASYAINRSLLLDGLRRIG--IDRLAPTDGAFYVYADVSDFT
Rv3565|M.tuberculosis_H37Rv ATAEADGNLASYAINRSLLLDGLRRIG--IDRLAPTDGAFYVYADVSDFT
TH_1831|M.thermoresistible__bu DDAHERQQRERYQRRRRELLPALQQAG---FTVDHSEAGLYLWATRGEPC
MSMEG_2493|M.smegmatis_MC2_155 LADHLVTQRAEYRRRKEAMHAALHEHFGGIARWTDPDGGFFLWVTLDGDV
MAB_0810c|M.abscessus_ATCC_199 WRRGLATLGKTLKHRRATARDAIAAAFP-TELTHYPRGGYHLWVSLPPQS
MLBr_02502|M.leprae_Br4923 SIEDLVLPGGRLLEQRDVAWTKLNEIPG--VSCVKPTGALYAFPRLDPEV
: : .. :
MMAR_2376|M.marinum_M AAIT---RLLN-----RGWAAAPGARFRIRSAPG----IRVTIAG-LSAE
MUL_1552|M.ulcerans_Agy99 AAIT---RLLN-----RGWAAAPGARFRVRSAPG----IRVTIAG-LSAE
MAV_3214|M.avium_104 VAVS---RLLG-----AGWAAAPGARFRMQTPAG----IRITIAD-LTPD
Mflv_4275|M.gilvum_PYR-GCK SSAL---SAAAS---RMGLEIPPGPRFGVDGTLERFIRVPYTLPDAQLVE
Mvan_2084|M.vanbaalenii_PYR-1 SSAL---SAAAS---RMGLEIPPGPRFGVDGSLERFIRVPYTLPDGQLVE
Mb3595|M.bovis_AF2122/97 SDSL---AFCSKLLADTGVAIAPGIDFDTARGGS---FVRISFAG--PSG
Rv3565|M.tuberculosis_H37Rv SDSL---AFCSKLLADTGVAIAPGIDFDTARGGS---FVRISFAG--PSG
TH_1831|M.thermoresistible__bu RATV---DWLAR----RGILVAPGEFYGPRGAEH----VRIALTA--PDE
MSMEG_2493|M.smegmatis_MC2_155 DATA---LFDVA--LAEGVAYIPGAAFSPSGRFAN--ALRLCFAS-TPPE
MAB_0810c|M.abscessus_ATCC_199 DSRQ---FAAEA--LTRGVAITPGDNYFTSGGGRP--HIRISYVAAPSPA
MLBr_02502|M.leprae_Br4923 YGIVDDEQLVLDLLLQEKILVTQGSGFNWPAPDH------LRLVTLPWSR
* :
MMAR_2376|M.marinum_M EIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 EIEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 EIEPLADAVAQAVRPSGRPIV----
Mflv_4275|M.gilvum_PYR-GCK AIELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 AIELLARAWRSVTGMTASEPTAVVV
Mb3595|M.bovis_AF2122/97 DIEEALRRIGSWLPSQ---------
Rv3565|M.tuberculosis_H37Rv DIEEALRRIGSWLPSQ---------
TH_1831|M.thermoresistible__bu RITAAAARLAQAG------------
MSMEG_2493|M.smegmatis_MC2_155 RIREGIARLRRAVEKLRP-------
MAB_0810c|M.abscessus_ATCC_199 DISEGIRRLEPLVSKYIAEGAG---
MLBr_02502|M.leprae_Br4923 DLAAAIDRLGNFLVSYRQ-------
: