For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MRQWIAGAPPGAQLPSNRVLVAQYGASPVTVASAMRTLRGLGLIETRPGVGTFVRATRSSRSPDYAWQTA ALGSPRARIPVLSAPMRYGAPDAVALHSGYPARELLPHRLVRAALTRAARSEAALSRSAVTGLPDLQAWF AQELAEAVPAGRSAPGPRDVVVLPGSQSGLSSAFRALVGHGQPLLIESPTYWGAIIAAAQAGVRIVPVPS GVEGPDPDELARAFDDTGARVFYAQPNFANPTGAQWSTERVEQILDVVRTRKAFLIDDNWAHDFGIDSTS RPVAAHDDDGHVIYLRSLTKSVSPAMRVAAVIARGPVRERIVADRGAESMYVSGALQAAVLDVVTQPAWR SHLRDLRAQLRQRRDHLVACLADHVNVARLEQVPPGGLHLWLRLPDQTDLDRLVRDCEAEKVLVAAGTEW FPAEPSGRYLRLNFSGPEPDRFEEAARVIGRSLRRQL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_0426 | - | - | 100% (457) | transcriptional regulator, GntR family protein |
M. smegmatis MC2 155 | MSMEG_1572 | - | 7e-27 | 28.16% (451) | transcriptional regulator, GntR family protein |
M. smegmatis MC2 155 | MSMEG_2493 | - | 3e-25 | 24.81% (399) | aminotransferase, class I and II family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3595 | aspB | 3e-06 | 23.94% (376) | aspartate aminotransferase |
M. gilvum PYR-GCK | Mflv_1181 | - | 6e-24 | 27.38% (420) | GntR family transcriptional regulator |
M. tuberculosis H37Rv | Rv3565 | aspB | 3e-06 | 23.94% (376) | aspartate aminotransferase |
M. leprae Br4923 | MLBr_02336 | - | 1e-05 | 25.41% (185) | hypothetical protein MLBr_02336 |
M. abscessus ATCC 19977 | MAB_0810c | - | 2e-69 | 36.40% (467) | GntR family transcriptional regulator |
M. marinum M | MMAR_2376 | - | 1e-20 | 27.09% (454) | GntR family transcriptional regulator |
M. avium 104 | MAV_3214 | - | 7e-25 | 27.79% (457) | GntR-family protein transcriptional regulator |
M. thermoresistible (build 8) | TH_1831 | - | 2e-07 | 24.01% (354) | PROBABLE AMINOTRANSFERASE |
M. ulcerans Agy99 | MUL_1552 | - | 8e-21 | 27.09% (454) | GntR family transcriptional regulator |
M. vanbaalenii PYR-1 | Mvan_5625 | - | 6e-22 | 26.80% (459) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_0426|M.smegmatis_MC2_155 ----MRQWIAGAPPGAQLPSNRVLVAQYGASPVTVASAMRTLRGLGLIET MAB_0810c|M.abscessus_ATCC_199 MAEQVRGEILALAPGSRIASHRELVRRFHVSASTVADALSLLAQQGLIES Mflv_1181|M.gilvum_PYR-GCK ---MVSSWSNSGSRDLHLDLREALRPGARGNRNALVAALREAVRSGRLSA Mvan_5625|M.vanbaalenii_PYR-1 ----MTSWANSATRDLHLDLRDALVPGARGTKDALISALRDAARSGRLTA MMAR_2376|M.marinum_M -----------------MPVQYRIAGGG---AESIAASIESAISQGGLAP MUL_1552|M.ulcerans_Agy99 -----------------MPVQNRIAGGG---AGSIAASIESAISQGGLAP MAV_3214|M.avium_104 -----------------MAVQKSITGTG---AESIAASIEAAISAGSLAP Mb3595|M.bovis_AF2122/97 -------------------------------------------------- Rv3565|M.tuberculosis_H37Rv -------------------------------------------------- TH_1831|M.thermoresistible__bu -------------------------------------------------- MLBr_02336|M.leprae_Br4923 -----------------MRGVPYLGGAVTSAYGSGSAHDLRMSHSVRWRK MSMEG_0426|M.smegmatis_MC2_155 ---RPGVGTFVRATRSSRSP-DYAWQTAALGS-PRARIP-----VLSAP- MAB_0810c|M.abscessus_ATCC_199 ---RPGAGSFRTENRPVPRPGDTSWQETALELGPQEESPPGIRRVFDAPG Mflv_1181|M.gilvum_PYR-GCK GTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAG-TWVVDTAR Mvan_5625|M.vanbaalenii_PYR-1 GTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAG-TWVADVT- MMAR_2376|M.marinum_M GDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRG-TRVRDRPA MUL_1552|M.ulcerans_Agy99 GDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRG-TRVRDRPA MAV_3214|M.avium_104 GDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRG-TRVRHRPA Mb3595|M.bovis_AF2122/97 ----------MTDRVALRAGVPPFYVMDVWLAAAERQRTHG--------- Rv3565|M.tuberculosis_H37Rv ----------MTDRVALRAGVPPFYVMDVWLAAAERQRTHG--------- TH_1831|M.thermoresistible__bu -------------------------------------------------- MLBr_02336|M.leprae_Br4923 GVPLVSFDSLSPDELAAVHARHQQDYAELQGRKLALDLTRG--------- MSMEG_0426|M.smegmatis_MC2_155 ----MRYGAPDAVALHSGYPARELLPHRLVRAALTRAARSEAALSRSAVT MAB_0810c|M.abscessus_ATCC_199 LLSTLAPSAADVVDLNGGYLHPDLQPLSMLTASLARAARRPEAWDRPPPG Mflv_1181|M.gilvum_PYR-GCK ----ASSQPPPVPPRPHGARVAPVHNLMPGSPDVAEFPRSQWAASARRAL Mvan_5625|M.vanbaalenii_PYR-1 -------TPAHTPPRPHGVRVAPTHNLMPGSPDVAEFPRSQWLASTRRAL MMAR_2376|M.marinum_M ----STPRSSLDLGVPAGARDLSTGNPAPELLPLAAVG-WPDGSVLPLLY MUL_1552|M.ulcerans_Agy99 ----STPRSSLDLGVPAGARDLSTGNPAPELLPLAAVG-WPDGSVLPLLY MAV_3214|M.avium_104 ----TTPRSLLGLDVPAGVRDLSTGNPHPALLPLAAAAPARPASGRAVLY Mb3595|M.bovis_AF2122/97 ----------DLVNLSAGQPSAGAPEPVR---AAAAAALHLNQLGYSVAL Rv3565|M.tuberculosis_H37Rv ----------DLVNLSAGQPSAGAPEPVR---AAAAAALHLNQLGYSVAL TH_1831|M.thermoresistible__bu ----------------------------VAPVIRAALAEASAAPGYPTTA MLBr_02336|M.leprae_Br4923 --------------KPSPEQLNLSNQLLYLPGDDYRDSEGVDTRNYGGLH MSMEG_0426|M.smegmatis_MC2_155 GLPDLQAWFAQEL-----AEAVPAGRSAPGPRDVVVLPGSQSGLSSAFRA MAB_0810c|M.abscessus_ATCC_199 GLPELRDWFAAEL-----GGGL-------GRQDILICGAGQSALSTSLRA Mflv_1181|M.gilvum_PYR-GCK THAPTDAFRMGDP-----RGRPELRS--ALAEYLARARGVRTSPESLVIC Mvan_5625|M.vanbaalenii_PYR-1 GGAPTEALRMGDP-----RGRPELRS--ALAEYLARARGVRTSPESIVIC MMAR_2376|M.marinum_M GAPAMSAELVDYA-----RAALAADG--VAADHLAVTNGALDGIERALSA MUL_1552|M.ulcerans_Agy99 GAPAMSAELVDYA-----RAALAADG--VAADHLAVTNGALDGIERALSA MAV_3214|M.avium_104 GEPAISPALAEYA-----RAALSADG--VPADHLALTSGALDGIERALTA Mb3595|M.bovis_AF2122/97 GIPELRDAIAADY-----QRRHGITV---EPDAVVITTGSSGGFLLAFLA Rv3565|M.tuberculosis_H37Rv GIPELRDAIAADY-----QRRHGITV---EPDAVVITTGSSGGFLLAFLA TH_1831|M.thermoresistible__bu GTPALRASAAAAL-----ERRYGITG--LTPDAVLPAIGTKELIAWLPTL MLBr_02336|M.leprae_Br4923 GLPGLRAIFAELLGIPVPNLIAGINSSLELMHDLVVFLVLYGGLDSSRPW . : MSMEG_0426|M.smegmatis_MC2_155 L----------VGHGQPLLIESPTYWGAIIAAAQAGVRIVPVPSGVEGPD MAB_0810c|M.abscessus_ATCC_199 L----------CQPGDPVLLESPCYPGATAAARAAGLRPIAIPLDINGIR Mflv_1181|M.gilvum_PYR-GCK AGVRHAVELLARTLGGPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAV Mvan_5625|M.vanbaalenii_PYR-1 AGVRHAVELLTRALGGPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAV MMAR_2376|M.marinum_M N----------LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPL MUL_1552|M.ulcerans_Agy99 N----------LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPL MAV_3214|M.avium_104 H----------LRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPL Mb3595|M.bovis_AF2122/97 C----------FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRF Rv3565|M.tuberculosis_H37Rv C----------FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRF TH_1831|M.thermoresistible__bu LG---------LGGDDTVVVPELAYPTYDVGARLAGARVFRADSLTQLG- MLBr_02336|M.leprae_Br4923 K----------DEASVKFLCPVPGYDRHFAITETMGIEMIPIPMRHDGPD . . * MSMEG_0426|M.smegmatis_MC2_155 PDELARAFD-DTGARVFYAQPNFANPTGAQWSTERVEQILDVVRTRKAFL MAB_0810c|M.abscessus_ATCC_199 PDRLNEALS-HTNARAIVVQPLFQNPTGASLTPQRRDELREIARRHGAFL Mflv_1181|M.gilvum_PYR-GCK IADLD-----DTSARSVLLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYI Mvan_5625|M.vanbaalenii_PYR-1 VDELD-----GLDVPAVLLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFV MMAR_2376|M.marinum_M VADLQRAL--GRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEV MUL_1552|M.ulcerans_Agy99 VADLQRAL--GRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEV MAV_3214|M.avium_104 PEDLARAL--GRGARALVLTTRAQNPTGAALSAERAAALRDLLSGRADDV Mb3595|M.bovis_AF2122/97 QPTAQMLAE-IDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRL Rv3565|M.tuberculosis_H37Rv QPTAQMLAE-IDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRL TH_1831|M.thermoresistible__bu -----------PQTPALIYLNSPSNPTGRVLGVDHLRKVVGWARDRGVIV MLBr_02336|M.leprae_Br4923 VELIEELVVVDPTIKGMWTVPVFGNPTGVTYSWETVRRLVQMRTAAPDFR ** * : MSMEG_0426|M.smegmatis_MC2_155 IDDNWAHDFGIDSTS-------RPVAAHDDDGHVIYLRSLTKSVSPA-MR MAB_0810c|M.abscessus_ATCC_199 IEDDFARYMAHDDGKP----LVPPLISDDPDGTVVHIRSMTKVTSPN-LR Mflv_1181|M.gilvum_PYR-GCK LDDDYDGEFRYDRQP-------VGALQALRPDRVAYLGSTSKSLSQA-LR Mvan_5625|M.vanbaalenii_PYR-1 LDDDYDGEFRYDRQP-------VGALQSLRPDRVAYLGSTSKSLSQT-LR MMAR_2376|M.marinum_M LLVEDDHCAGIAGVP-------LHTLAGAT-QHWAFVRSAAKAYGPD-LR MUL_1552|M.ulcerans_Agy99 LLVEDDHCAGIAGVP-------LHTLAGAT-QHWAFVRSAAKAYGPD-LR MAV_3214|M.avium_104 LLVEDDHCAGISGAA-------LHPVAGCT-THWAFVRSASKAYGPD-LR Mb3595|M.bovis_AF2122/97 ISDEVYHGLVYQGAP-------QTSCAWQTSRNAVVVNSFSKYYAMTGWR Rv3565|M.tuberculosis_H37Rv ISDEVYHGLVYQGAP-------QTSCAWQTSRNAVVVNSFSKYYAMTGWR TH_1831|M.thermoresistible__bu ASDECYLGLGWDETPVS---VLHPTVCGGDHTNLLAIHSLSKTSSLAGYR MLBr_02336|M.leprae_Br4923 LFWDNAYAVHTLTHDFIRQVDVLGLAAKAGNPHRPYVFASTSKITFAGGG : : : :. MSMEG_0426|M.smegmatis_MC2_155 VAAVIARGPVRERIVADRGAESMYVSGALQAAVLDVVTQPAWRSHLRDLR MAB_0810c|M.abscessus_ATCC_199 VGAIAARGPVMARLRAASVIDTMLVPAPLQYTTLEVVTSPSWRRGLATLG Mflv_1181|M.gilvum_PYR-GCK LGWMALPAELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMR Mvan_5625|M.vanbaalenii_PYR-1 LGWMALPDNLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMR MMAR_2376|M.marinum_M LAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQ MUL_1552|M.ulcerans_Agy99 LAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQ MAV_3214|M.avium_104 VAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAE Mb3595|M.bovis_AF2122/97 LGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLA Rv3565|M.tuberculosis_H37Rv LGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLA TH_1831|M.thermoresistible__bu AGFVAGDPALVAELLAVRKHAGMMVPTPVQAAMVAALDDDAHE---RQQR MLBr_02336|M.leprae_Br4923 VSFLGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDAEGVRLHMLRH . : * MSMEG_0426|M.smegmatis_MC2_155 AQLRQRRDHLVACLADHVN---VARLEQVPPGGLHLWLRLPDQT-DLDRL MAB_0810c|M.abscessus_ATCC_199 KTLKHRRATARDAIAAAF----PTELTHYPRGGYHLWVSLPPQS-DSRQF Mflv_1181|M.gilvum_PYR-GCK MRYRRRRDMLVSALSPFA------VGIGGLAAGVNLLVTLPDGA-EPELI Mvan_5625|M.vanbaalenii_PYR-1 MRYRRRRDVLVSALSPFD------VGIGGLAAGVNLLVTLPDGA-EPEVM MMAR_2376|M.marinum_M ERYADARGRLCAALSARG------VAAHG-RSGLNVWIPVPD---ETAAI MUL_1552|M.ulcerans_Agy99 ERYADARGRLCAALSARG------VAAHG-RSGLNVWIPVPD---ETAAI MAV_3214|M.avium_104 RRYADRRRRLCGALAERG------VDAHG-RSGLNVWVRVPD---EAVAV Mb3595|M.bovis_AF2122/97 S-YAINRSLLLDGLRRIG-----IDRLAPTDGAFYVYADVSDFTSDSLAF Rv3565|M.tuberculosis_H37Rv S-YAINRSLLLDGLRRIG-----IDRLAPTDGAFYVYADVSDFTSDSLAF TH_1831|M.thermoresistible__bu ERYQRRRRELLPALQQAG------FTVDHSEAGLYLWATRGE---PCRAT MLBr_02336|M.leprae_Br4923 QQILAPKFALVEEILKQRLGDSNIASWSEPKGGYFINLDVLPG--TARRT : : .. : MSMEG_0426|M.smegmatis_MC2_155 VRDCEAEKVLVA------AGTEWFPAEPSGRYLRLN-FSGPEPDRFEEAA MAB_0810c|M.abscessus_ATCC_199 AAEALTRGVAIT------PGDNYFTSGGGRPHIRISYVAAPSPADISEGI Mflv_1181|M.gilvum_PYR-GCK RRAGEAGIALVGLSMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSAL Mvan_5625|M.vanbaalenii_PYR-1 RRAGESGLAVSGLSIMRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAAL MMAR_2376|M.marinum_M TRLLNRGWAAA-------PGARFRIRSAPGIRVTIAGLSAEEIEPLADAI MUL_1552|M.ulcerans_Agy99 TRLLNRGWAAA-------PGARFRVRSAPGIRVTIAGLSAEEIEPLADAI MAV_3214|M.avium_104 SRLLGAGWAAA-------PGARFRMQTPAGIRITIADLTPDEIEPLADAV Mb3595|M.bovis_AF2122/97 CSKLLADTGVAIA-----PGIDFDTARGGS-FVRISFAGPSG--DIEEAL Rv3565|M.tuberculosis_H37Rv CSKLLADTGVAIA-----PGIDFDTARGGS-FVRISFAGPSG--DIEEAL TH_1831|M.thermoresistible__bu VDWLARRGILVAP--------GEFYGPRGAEHVRIALTAPDE--RITAAA MLBr_02336|M.leprae_Br4923 VALAKAAGIAVTEAG--ASFPYRKDPDDKNIRVAPSYPSMSELRNAVDGL : . MSMEG_0426|M.smegmatis_MC2_155 RVIGRSLRRQL------ MAB_0810c|M.abscessus_ATCC_199 RRLEPLVSKYIAEGAG- Mflv_1181|M.gilvum_PYR-GCK CEVLRASGL-------- Mvan_5625|M.vanbaalenii_PYR-1 CDVLRASGL-------- MMAR_2376|M.marinum_M AEAIQRTGRPTV----- MUL_1552|M.ulcerans_Agy99 AGAIQRTGRPTV----- MAV_3214|M.avium_104 AQAVRPSGRPIV----- Mb3595|M.bovis_AF2122/97 RRIGSWLPSQ------- Rv3565|M.tuberculosis_H37Rv RRIGSWLPSQ------- TH_1831|M.thermoresistible__bu ARLAQAG---------- MLBr_02336|M.leprae_Br4923 ATCALLAASESLLNARC