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M. smegmatis MC2 155 MSMEG_0426 (-)

annotation: transcriptional regulator, GntR family protein
coordinates: 499923 - 501296
length: 457

MRQWIAGAPPGAQLPSNRVLVAQYGASPVTVASAMRTLRGLGLIETRPGVGTFVRATRSSRSPDYAWQTA
ALGSPRARIPVLSAPMRYGAPDAVALHSGYPARELLPHRLVRAALTRAARSEAALSRSAVTGLPDLQAWF
AQELAEAVPAGRSAPGPRDVVVLPGSQSGLSSAFRALVGHGQPLLIESPTYWGAIIAAAQAGVRIVPVPS
GVEGPDPDELARAFDDTGARVFYAQPNFANPTGAQWSTERVEQILDVVRTRKAFLIDDNWAHDFGIDSTS
RPVAAHDDDGHVIYLRSLTKSVSPAMRVAAVIARGPVRERIVADRGAESMYVSGALQAAVLDVVTQPAWR
SHLRDLRAQLRQRRDHLVACLADHVNVARLEQVPPGGLHLWLRLPDQTDLDRLVRDCEAEKVLVAAGTEW
FPAEPSGRYLRLNFSGPEPDRFEEAARVIGRSLRRQL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_0426--100% (457)transcriptional regulator, GntR family protein
M. smegmatis MC2 155MSMEG_1572-7e-2728.16% (451) transcriptional regulator, GntR family protein
M. smegmatis MC2 155MSMEG_2493-3e-2524.81% (399) aminotransferase, class I and II family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3595aspB3e-0623.94% (376) aspartate aminotransferase
M. gilvum PYR-GCKMflv_1181-6e-2427.38% (420) GntR family transcriptional regulator
M. tuberculosis H37RvRv3565aspB3e-0623.94% (376) aspartate aminotransferase
M. leprae Br4923MLBr_02336-1e-0525.41% (185) hypothetical protein MLBr_02336
M. abscessus ATCC 19977MAB_0810c-2e-6936.40% (467) GntR family transcriptional regulator
M. marinum MMMAR_2376-1e-2027.09% (454) GntR family transcriptional regulator
M. avium 104MAV_3214-7e-2527.79% (457) GntR-family protein transcriptional regulator
M. thermoresistible (build 8)TH_1831-2e-0724.01% (354) PROBABLE AMINOTRANSFERASE
M. ulcerans Agy99MUL_1552-8e-2127.09% (454) GntR family transcriptional regulator
M. vanbaalenii PYR-1Mvan_5625-6e-2226.80% (459) GntR family transcriptional regulator

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_0426|M.smegmatis_MC2_155      ----MRQWIAGAPPGAQLPSNRVLVAQYGASPVTVASAMRTLRGLGLIET
MAB_0810c|M.abscessus_ATCC_199      MAEQVRGEILALAPGSRIASHRELVRRFHVSASTVADALSLLAQQGLIES
Mflv_1181|M.gilvum_PYR-GCK          ---MVSSWSNSGSRDLHLDLREALRPGARGNRNALVAALREAVRSGRLSA
Mvan_5625|M.vanbaalenii_PYR-1       ----MTSWANSATRDLHLDLRDALVPGARGTKDALISALRDAARSGRLTA
MMAR_2376|M.marinum_M               -----------------MPVQYRIAGGG---AESIAASIESAISQGGLAP
MUL_1552|M.ulcerans_Agy99           -----------------MPVQNRIAGGG---AGSIAASIESAISQGGLAP
MAV_3214|M.avium_104                -----------------MAVQKSITGTG---AESIAASIEAAISAGSLAP
Mb3595|M.bovis_AF2122/97            --------------------------------------------------
Rv3565|M.tuberculosis_H37Rv         --------------------------------------------------
TH_1831|M.thermoresistible__bu      --------------------------------------------------
MLBr_02336|M.leprae_Br4923          -----------------MRGVPYLGGAVTSAYGSGSAHDLRMSHSVRWRK
                                                                                      

MSMEG_0426|M.smegmatis_MC2_155      ---RPGVGTFVRATRSSRSP-DYAWQTAALGS-PRARIP-----VLSAP-
MAB_0810c|M.abscessus_ATCC_199      ---RPGAGSFRTENRPVPRPGDTSWQETALELGPQEESPPGIRRVFDAPG
Mflv_1181|M.gilvum_PYR-GCK          GTTLPPSRALAADLGLARNTVADAYAELVAEGWLASRQGAG-TWVVDTAR
Mvan_5625|M.vanbaalenii_PYR-1       GTMLPSSRTLATDLGLARNTVAEAYAELVAEGWLASRQGAG-TWVADVT-
MMAR_2376|M.marinum_M               GDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRG-TRVRDRPA
MUL_1552|M.ulcerans_Agy99           GDALPSIREVAGQLGVNPNTVAAAYRLLRDRGTVETAGRRG-TRVRDRPA
MAV_3214|M.avium_104                GDALPPVRELAARLGVNANTAAAAYRLLRHRGAVETAGRRG-TRVRHRPA
Mb3595|M.bovis_AF2122/97            ----------MTDRVALRAGVPPFYVMDVWLAAAERQRTHG---------
Rv3565|M.tuberculosis_H37Rv         ----------MTDRVALRAGVPPFYVMDVWLAAAERQRTHG---------
TH_1831|M.thermoresistible__bu      --------------------------------------------------
MLBr_02336|M.leprae_Br4923          GVPLVSFDSLSPDELAAVHARHQQDYAELQGRKLALDLTRG---------
                                                                                      

MSMEG_0426|M.smegmatis_MC2_155      ----MRYGAPDAVALHSGYPARELLPHRLVRAALTRAARSEAALSRSAVT
MAB_0810c|M.abscessus_ATCC_199      LLSTLAPSAADVVDLNGGYLHPDLQPLSMLTASLARAARRPEAWDRPPPG
Mflv_1181|M.gilvum_PYR-GCK          ----ASSQPPPVPPRPHGARVAPVHNLMPGSPDVAEFPRSQWAASARRAL
Mvan_5625|M.vanbaalenii_PYR-1       -------TPAHTPPRPHGVRVAPTHNLMPGSPDVAEFPRSQWLASTRRAL
MMAR_2376|M.marinum_M               ----STPRSSLDLGVPAGARDLSTGNPAPELLPLAAVG-WPDGSVLPLLY
MUL_1552|M.ulcerans_Agy99           ----STPRSSLDLGVPAGARDLSTGNPAPELLPLAAVG-WPDGSVLPLLY
MAV_3214|M.avium_104                ----TTPRSLLGLDVPAGVRDLSTGNPHPALLPLAAAAPARPASGRAVLY
Mb3595|M.bovis_AF2122/97            ----------DLVNLSAGQPSAGAPEPVR---AAAAAALHLNQLGYSVAL
Rv3565|M.tuberculosis_H37Rv         ----------DLVNLSAGQPSAGAPEPVR---AAAAAALHLNQLGYSVAL
TH_1831|M.thermoresistible__bu      ----------------------------VAPVIRAALAEASAAPGYPTTA
MLBr_02336|M.leprae_Br4923          --------------KPSPEQLNLSNQLLYLPGDDYRDSEGVDTRNYGGLH
                                                                                      

MSMEG_0426|M.smegmatis_MC2_155      GLPDLQAWFAQEL-----AEAVPAGRSAPGPRDVVVLPGSQSGLSSAFRA
MAB_0810c|M.abscessus_ATCC_199      GLPELRDWFAAEL-----GGGL-------GRQDILICGAGQSALSTSLRA
Mflv_1181|M.gilvum_PYR-GCK          THAPTDAFRMGDP-----RGRPELRS--ALAEYLARARGVRTSPESLVIC
Mvan_5625|M.vanbaalenii_PYR-1       GGAPTEALRMGDP-----RGRPELRS--ALAEYLARARGVRTSPESIVIC
MMAR_2376|M.marinum_M               GAPAMSAELVDYA-----RAALAADG--VAADHLAVTNGALDGIERALSA
MUL_1552|M.ulcerans_Agy99           GAPAMSAELVDYA-----RAALAADG--VAADHLAVTNGALDGIERALSA
MAV_3214|M.avium_104                GEPAISPALAEYA-----RAALSADG--VPADHLALTSGALDGIERALTA
Mb3595|M.bovis_AF2122/97            GIPELRDAIAADY-----QRRHGITV---EPDAVVITTGSSGGFLLAFLA
Rv3565|M.tuberculosis_H37Rv         GIPELRDAIAADY-----QRRHGITV---EPDAVVITTGSSGGFLLAFLA
TH_1831|M.thermoresistible__bu      GTPALRASAAAAL-----ERRYGITG--LTPDAVLPAIGTKELIAWLPTL
MLBr_02336|M.leprae_Br4923          GLPGLRAIFAELLGIPVPNLIAGINSSLELMHDLVVFLVLYGGLDSSRPW
                                      .                              :                

MSMEG_0426|M.smegmatis_MC2_155      L----------VGHGQPLLIESPTYWGAIIAAAQAGVRIVPVPSGVEGPD
MAB_0810c|M.abscessus_ATCC_199      L----------CQPGDPVLLESPCYPGATAAARAAGLRPIAIPLDINGIR
Mflv_1181|M.gilvum_PYR-GCK          AGVRHAVELLARTLGGPVAVEAYGLFVFRDAIAACGVQTVPIGVDDDGAV
Mvan_5625|M.vanbaalenii_PYR-1       AGVRHAVELLTRALGGPIAVESYGLFVFRDAIAAAGASTVPIGVDDRGAV
MMAR_2376|M.marinum_M               N----------LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPL
MUL_1552|M.ulcerans_Agy99           N----------LRPGDRVAVEDPGWANLLDLLAALGLPVEPMGVDDDGPL
MAV_3214|M.avium_104                H----------LRPGDRVAVEDPGWANLLDLLAALGFSAEPVRVDDAGPL
Mb3595|M.bovis_AF2122/97            C----------FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRF
Rv3565|M.tuberculosis_H37Rv         C----------FDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRF
TH_1831|M.thermoresistible__bu      LG---------LGGDDTVVVPELAYPTYDVGARLAGARVFRADSLTQLG-
MLBr_02336|M.leprae_Br4923          K----------DEASVKFLCPVPGYDRHFAITETMGIEMIPIPMRHDGPD
                                                  .  .                 *              

MSMEG_0426|M.smegmatis_MC2_155      PDELARAFD-DTGARVFYAQPNFANPTGAQWSTERVEQILDVVRTRKAFL
MAB_0810c|M.abscessus_ATCC_199      PDRLNEALS-HTNARAIVVQPLFQNPTGASLTPQRRDELREIARRHGAFL
Mflv_1181|M.gilvum_PYR-GCK          IADLD-----DTSARSVLLTPAHHNPLGMPLHPSRRAAVIEWATRTGGYI
Mvan_5625|M.vanbaalenii_PYR-1       VDELD-----GLDVPAVLLTPAHHNPLGMPLHSSRRTAVIEWAQRTGGFV
MMAR_2376|M.marinum_M               VADLQRAL--GRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEV
MUL_1552|M.ulcerans_Agy99           VADLQRAL--GRGVRAVVVTSRAQNPTGAALSAARAEELREVLSQGAEEV
MAV_3214|M.avium_104                PEDLARAL--GRGARALVLTTRAQNPTGAALSAERAAALRDLLSGRADDV
Mb3595|M.bovis_AF2122/97            QPTAQMLAE-IDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRL
Rv3565|M.tuberculosis_H37Rv         QPTAQMLAE-IDPPLRGVVVASPANPTGTVIPPEELAAIASWCDASDVRL
TH_1831|M.thermoresistible__bu      -----------PQTPALIYLNSPSNPTGRVLGVDHLRKVVGWARDRGVIV
MLBr_02336|M.leprae_Br4923          VELIEELVVVDPTIKGMWTVPVFGNPTGVTYSWETVRRLVQMRTAAPDFR
                                                            ** *          :           

MSMEG_0426|M.smegmatis_MC2_155      IDDNWAHDFGIDSTS-------RPVAAHDDDGHVIYLRSLTKSVSPA-MR
MAB_0810c|M.abscessus_ATCC_199      IEDDFARYMAHDDGKP----LVPPLISDDPDGTVVHIRSMTKVTSPN-LR
Mflv_1181|M.gilvum_PYR-GCK          LDDDYDGEFRYDRQP-------VGALQALRPDRVAYLGSTSKSLSQA-LR
Mvan_5625|M.vanbaalenii_PYR-1       LDDDYDGEFRYDRQP-------VGALQSLRPDRVAYLGSTSKSLSQT-LR
MMAR_2376|M.marinum_M               LLVEDDHCAGIAGVP-------LHTLAGAT-QHWAFVRSAAKAYGPD-LR
MUL_1552|M.ulcerans_Agy99           LLVEDDHCAGIAGVP-------LHTLAGAT-QHWAFVRSAAKAYGPD-LR
MAV_3214|M.avium_104                LLVEDDHCAGISGAA-------LHPVAGCT-THWAFVRSASKAYGPD-LR
Mb3595|M.bovis_AF2122/97            ISDEVYHGLVYQGAP-------QTSCAWQTSRNAVVVNSFSKYYAMTGWR
Rv3565|M.tuberculosis_H37Rv         ISDEVYHGLVYQGAP-------QTSCAWQTSRNAVVVNSFSKYYAMTGWR
TH_1831|M.thermoresistible__bu      ASDECYLGLGWDETPVS---VLHPTVCGGDHTNLLAIHSLSKTSSLAGYR
MLBr_02336|M.leprae_Br4923          LFWDNAYAVHTLTHDFIRQVDVLGLAAKAGNPHRPYVFASTSKITFAGGG
                                       :                                : : :.        

MSMEG_0426|M.smegmatis_MC2_155      VAAVIARGPVRERIVADRGAESMYVSGALQAAVLDVVTQPAWRSHLRDLR
MAB_0810c|M.abscessus_ATCC_199      VGAIAARGPVMARLRAASVIDTMLVPAPLQYTTLEVVTSPSWRRGLATLG
Mflv_1181|M.gilvum_PYR-GCK          LGWMALPAELVDQVVETAGGQQFHVDVVSQLTLADFLTAGHYDRHIRRMR
Mvan_5625|M.vanbaalenii_PYR-1       LGWMALPDNLIDAVLAAAGGQQFYVDAINQLTLADFIAGGHYDRHIRRMR
MMAR_2376|M.marinum_M               LAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQ
MUL_1552|M.ulcerans_Agy99           LAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFADDAATGLVRQAQ
MAV_3214|M.avium_104                VAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLAVELWSDTAASELVATAE
Mb3595|M.bovis_AF2122/97            LGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLA
Rv3565|M.tuberculosis_H37Rv         LGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLA
TH_1831|M.thermoresistible__bu      AGFVAGDPALVAELLAVRKHAGMMVPTPVQAAMVAALDDDAHE---RQQR
MLBr_02336|M.leprae_Br4923          VSFLGGSLGNIAWYLQYAGKKSIGPDKVNQLRHLRFFGDAEGVRLHMLRH
                                     . :                         *                    

MSMEG_0426|M.smegmatis_MC2_155      AQLRQRRDHLVACLADHVN---VARLEQVPPGGLHLWLRLPDQT-DLDRL
MAB_0810c|M.abscessus_ATCC_199      KTLKHRRATARDAIAAAF----PTELTHYPRGGYHLWVSLPPQS-DSRQF
Mflv_1181|M.gilvum_PYR-GCK          MRYRRRRDMLVSALSPFA------VGIGGLAAGVNLLVTLPDGA-EPELI
Mvan_5625|M.vanbaalenii_PYR-1       MRYRRRRDVLVSALSPFD------VGIGGLAAGVNLLVTLPDGA-EPEVM
MMAR_2376|M.marinum_M               ERYADARGRLCAALSARG------VAAHG-RSGLNVWIPVPD---ETAAI
MUL_1552|M.ulcerans_Agy99           ERYADARGRLCAALSARG------VAAHG-RSGLNVWIPVPD---ETAAI
MAV_3214|M.avium_104                RRYADRRRRLCGALAERG------VDAHG-RSGLNVWVRVPD---EAVAV
Mb3595|M.bovis_AF2122/97            S-YAINRSLLLDGLRRIG-----IDRLAPTDGAFYVYADVSDFTSDSLAF
Rv3565|M.tuberculosis_H37Rv         S-YAINRSLLLDGLRRIG-----IDRLAPTDGAFYVYADVSDFTSDSLAF
TH_1831|M.thermoresistible__bu      ERYQRRRRELLPALQQAG------FTVDHSEAGLYLWATRGE---PCRAT
MLBr_02336|M.leprae_Br4923          QQILAPKFALVEEILKQRLGDSNIASWSEPKGGYFINLDVLPG--TARRT
                                          :      :                 ..  :              

MSMEG_0426|M.smegmatis_MC2_155      VRDCEAEKVLVA------AGTEWFPAEPSGRYLRLN-FSGPEPDRFEEAA
MAB_0810c|M.abscessus_ATCC_199      AAEALTRGVAIT------PGDNYFTSGGGRPHIRISYVAAPSPADISEGI
Mflv_1181|M.gilvum_PYR-GCK          RRAGEAGIALVGLSMMRHPRAGSGVAERDGLIVGFAAAPEHAFPAAVSAL
Mvan_5625|M.vanbaalenii_PYR-1       RRAGESGLAVSGLSIMRHPMAGP--ADVDGLIVGFAAPPEHAFSAAVAAL
MMAR_2376|M.marinum_M               TRLLNRGWAAA-------PGARFRIRSAPGIRVTIAGLSAEEIEPLADAI
MUL_1552|M.ulcerans_Agy99           TRLLNRGWAAA-------PGARFRVRSAPGIRVTIAGLSAEEIEPLADAI
MAV_3214|M.avium_104                SRLLGAGWAAA-------PGARFRMQTPAGIRITIADLTPDEIEPLADAV
Mb3595|M.bovis_AF2122/97            CSKLLADTGVAIA-----PGIDFDTARGGS-FVRISFAGPSG--DIEEAL
Rv3565|M.tuberculosis_H37Rv         CSKLLADTGVAIA-----PGIDFDTARGGS-FVRISFAGPSG--DIEEAL
TH_1831|M.thermoresistible__bu      VDWLARRGILVAP--------GEFYGPRGAEHVRIALTAPDE--RITAAA
MLBr_02336|M.leprae_Br4923          VALAKAAGIAVTEAG--ASFPYRKDPDDKNIRVAPSYPSMSELRNAVDGL
                                                                    :               . 

MSMEG_0426|M.smegmatis_MC2_155      RVIGRSLRRQL------
MAB_0810c|M.abscessus_ATCC_199      RRLEPLVSKYIAEGAG-
Mflv_1181|M.gilvum_PYR-GCK          CEVLRASGL--------
Mvan_5625|M.vanbaalenii_PYR-1       CDVLRASGL--------
MMAR_2376|M.marinum_M               AEAIQRTGRPTV-----
MUL_1552|M.ulcerans_Agy99           AGAIQRTGRPTV-----
MAV_3214|M.avium_104                AQAVRPSGRPIV-----
Mb3595|M.bovis_AF2122/97            RRIGSWLPSQ-------
Rv3565|M.tuberculosis_H37Rv         RRIGSWLPSQ-------
TH_1831|M.thermoresistible__bu      ARLAQAG----------
MLBr_02336|M.leprae_Br4923          ATCALLAASESLLNARC