For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTEALATRSLNVDLLARELGNWRTSSRSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTT VTAAYTQLREDGYLNARRGARSTTALPLTPTPALRPVTATANLAAATLAAPASVTARAFTEAADMVAPYL QEIGIELTGVPPLRAAIAERYCARGLPTDVDEIMVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAA MASRGLRPVPVAMAPDGWELDAVEAAIRQLAPELAYLIPDNQNPTGMTMPVGDRARLARIISETKTRTII DETITDMWLDEQVPPPLATEVTSRPDLVMTVGSMSKSFWGGLRIGWIRAERSTLATIATLRPAIDMGTPI VEQLAAARLLAADEEVLPERRDILRSRRALLLRLLAEHLPDWQPVPGKGGMSVWVRLPAPMSSALSAAAS RMGLEIPPGPRFGVDGTLERFIRVPYTLPDAQLVEAIELLARAWRSVTGLTAPEPATVVV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4275 | - | - | 100% (480) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1181 | - | 3e-25 | 27.55% (432) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1476 | - | 3e-13 | 25.62% (363) | aspartate aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0881c | - | 4e-14 | 29.27% (246) | aminotransferase |
| M. tuberculosis H37Rv | Rv0858c | - | 4e-14 | 29.27% (246) | aminotransferase |
| M. leprae Br4923 | MLBr_02502 | - | 2e-07 | 24.62% (195) | aminotransferase AlaT |
| M. abscessus ATCC 19977 | MAB_3387 | - | 1e-147 | 54.91% (479) | GntR family regulatory protein |
| M. marinum M | MMAR_2376 | - | 8e-18 | 26.60% (421) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 2e-20 | 28.84% (430) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2323 | - | 0.0 | 70.00% (480) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2065 | aspB | 1e-13 | 26.87% (361) | POSSIBLE ASPARTATE AMINOTRANSFERASE ASPB (TRANSAMINASE A) |
| M. ulcerans Agy99 | MUL_1552 | - | 7e-18 | 26.84% (421) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 0.0 | 83.33% (480) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0881c|M.bovis_AF2122/97 ---------------------------------------------MTVSR
Rv0858c|M.tuberculosis_H37Rv ---------------------------------------------MTVSR
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
MSMEG_2323|M.smegmatis_MC2_155 ------------------------MSSPMVARSLDVDLLARELGNWRTSS
MAB_3387|M.abscessus_ATCC_1997 ----------------------------MPDRVVTAETLARHLGQWRTAG
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
MAV_3214|M.avium_104 --------------------------------------------MAVQKS
TH_2065|M.thermoresistible__bu --------------------------------------------MNDRTA
MLBr_02502|M.leprae_Br4923 ------------------------------------------MTLYQQIS
Mb0881c|M.bovis_AF2122/97 LRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVN
Rv0858c|M.tuberculosis_H37Rv LRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVN
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
MSMEG_2323|M.smegmatis_MC2_155 QTGPAYLGLADAIRLLIVDGRLPVGSRLPSERALADALRVSRTTVTAAFS
MAB_3387|M.abscessus_ATCC_1997 SAGPAYGALADAIRLLVIDGRLPLGVRIPSERALASALHVSRTTVTTAYA
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MAV_3214|M.avium_104 ITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYR
TH_2065|M.thermoresistible__bu LRAGIPPFYVMDVWLAAAERQRSHGDLVNLSAGQPSAGAPAPVRAAAAAT
MLBr_02502|M.leprae_Br4923 VDGSGTMSDVTTHQLPMHTPGYHRQRAFAQSSKLQDVLYEIRGPVSQHAT
. . :
Mb0881c|M.bovis_AF2122/97 QYPPG---------------------------------------------
Rv0858c|M.tuberculosis_H37Rv QYPPG---------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLNARRGARSTTALP---LTPTPALRPVTATANLAAATLAAPAS
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLNARRGARSTTALP---LRPAAPAPLAPTGANLAAATLAAPAA
MSMEG_2323|M.smegmatis_MC2_155 KLREDGYLHARRGARSTTALP---ARPEVRIEAAQASVNLAAAALAAPST
MAB_3387|M.abscessus_ATCC_1997 ELRESGYLRGRQGARSTTALPGPDRTGSATTGLMSPMVDLQNAATAAPAA
MMAR_2376|M.marinum_M LLRDRGTVET-AGRRGTRVRD-----RPASTPRSSLDLGVPAGARDLSTG
MUL_1552|M.ulcerans_Agy99 LLRDRGTVET-AGRRGTRVRD-----RPASTPRSSLDLGVPAGARDLSTG
MAV_3214|M.avium_104 LLRHRGAVET-AGRRGTRVRH-----RPATTPRSLLGLDVPAGVRDLSTG
TH_2065|M.thermoresistible__bu LERNQ---------------------------------------------
MLBr_02502|M.leprae_Br4923 RLETEGHRILKLNIGNPALFG-----------------------------
Mb0881c|M.bovis_AF2122/97 ------------------------PGSAPLRRAIAA-QRRRH-FGVDYDP
Rv0858c|M.tuberculosis_H37Rv ------------------------PGSAPLRRAIAA-QRRRH-FGVDYDP
Mflv_4275|M.gilvum_PYR-GCK VTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARG-LPTD---
Mvan_2084|M.vanbaalenii_PYR-1 IAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARG-LPTD---
MSMEG_2323|M.smegmatis_MC2_155 AVLDAFAEAAKDVTAYLQGPGHELMGAAPLREAIAERYCQRG-LPTD---
MAB_3387|M.abscessus_ATCC_1997 AVLEAYQAALTTLPTHLRGIGHELVGIPELRPRIAEHFSRRG-LPTT---
MMAR_2376|M.marinum_M NPAPELLPLAAVG-WPDGSVLPLLYGAPAMSAELVD-YARAA-LAADGVA
MUL_1552|M.ulcerans_Agy99 NPAPELLPLAAVG-WPDGSVLPLLYGAPAMSAELVD-YARAA-LAADGVA
MAV_3214|M.avium_104 NPHPALLPLAAAAPARPASGRAVLYGEPAISPALAE-YARAA-LSADGVP
TH_2065|M.thermoresistible__bu ------------------LGYTVALGIPELREAIAAGYQSRYGLSVG---
MLBr_02502|M.leprae_Br4923 FDAPDVIMRDMIQALPYAQGYSDSQGILPARRAVVTRYELVDGFPRFD--
* :. :
Mb0881c|M.bovis_AF2122/97 ETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRV
Rv0858c|M.tuberculosis_H37Rv ETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRV
Mflv_4275|M.gilvum_PYR-GCK VDEIMVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAAMASRGLRPV
Mvan_2084|M.vanbaalenii_PYR-1 PDEIMVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMASRGLRTV
MSMEG_2323|M.smegmatis_MC2_155 PSQIMVTSGAQHAIGLILTTHTQPGDRVLVEQPTYHGALSAISTAGARAV
MAB_3387|M.abscessus_ATCC_1997 EDQIMVTCGAQQAIALLLGAFVEPGDRVLVEQPTYHGALDAISQRGARPV
MMAR_2376|M.marinum_M ADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVE
MUL_1552|M.ulcerans_Agy99 ADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVE
MAV_3214|M.avium_104 ADHLALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAE
TH_2065|M.thermoresistible__bu ADEVVITTGSSGGFLLAFLACFDVGDRVAIASPGYPCYRNILSALGCEVV
MLBr_02502|M.leprae_Br4923 VDDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPV
.: : * : . ...* : .* : : *
Mb0881c|M.bovis_AF2122/97 TVPLVPD--GRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELA
Rv0858c|M.tuberculosis_H37Rv TVPLVPD--GRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELA
Mflv_4275|M.gilvum_PYR-GCK PVAMA----PDGWELDAVEAAIRQLAPELAYLIPDNQNPTGMTMPVGDRA
Mvan_2084|M.vanbaalenii_PYR-1 PVAMA----PDGWELDAVEAAIRQLAPNLAYLVPDNHNPTGMTLPVPERK
MSMEG_2323|M.smegmatis_MC2_155 PVALT----DAGWELDAFHAAIRQLAPSLAYVIPDNHNPTGFTMAPDDRK
MAB_3387|M.abscessus_ATCC_1997 PVPMHTHERDSGWDMTGMETTIRQTAPNLAYLVLDNHNPTGLTMPLGQRK
MMAR_2376|M.marinum_M PMGVD----DDGPLVADLQRALGRGVRAVVVTSR-AQNPTGAALSAARAE
MUL_1552|M.ulcerans_Agy99 PMGVD----DDGPLVADLQRALGRGVRAVVVTSR-AQNPTGAALSAARAE
MAV_3214|M.avium_104 PVRVD----DAGPLPEDLARALGRGARALVLTTR-AQNPTGAALSAERAA
TH_2065|M.thermoresistible__bu ELQCG----PQTRFQPTARMLAELDPPVRGVIVASPANPTGTVIPPEELA
MLBr_02502|M.leprae_Br4923 HYLCD---ETQGWQPDIADVESKITERTKALVVINPNNPTGAVYSNEILN
**** . .
Mb0881c|M.bovis_AF2122/97 AIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDG-MAERTITISSAA
Rv0858c|M.tuberculosis_H37Rv AIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDG-MAERTITISSAA
Mflv_4275|M.gilvum_PYR-GCK RLARIISETKTRTIIDETITDMWLDEQVPPPLATEVTSRPDLVMTVGSMS
Mvan_2084|M.vanbaalenii_PYR-1 RLAHIISDTRTRTIVDETITDMWLDEPVPAPLAASMTGRRDLVLTVGSMS
MSMEG_2323|M.smegmatis_MC2_155 RLGQIISDTRTRTIIDESIADMWVDHAPPEPLAASVG-RHDLVLTIGSMS
MAB_3387|M.abscessus_ATCC_1997 ALADIISQTRTRTVVDESLVGVWHQNHTPAPMAALVS-RPELVVTIGSMS
MMAR_2376|M.marinum_M ELREVLSQGAEEVLLVEDDHCAGIAGVPLHTLAGATQ----HWAFVRSAA
MUL_1552|M.ulcerans_Agy99 ELREVLSQGAEEVLLVEDDHCAGIAGVPLHTLAGATQ----HWAFVRSAA
MAV_3214|M.avium_104 ALRDLLSGRADDVLLVEDDHCAGISGAALHPVAGCTT----HWAFVRSAS
TH_2065|M.thermoresistible__bu AIARWCEDNDVRLISDEVYHGLVYPGAPETSCAWQTS---REAVVVNSFS
MLBr_02502|M.leprae_Br4923 QIVDLARKHQLLLLADEIYDKILYDDTKHISVASIAP--DLLCLTFNGLS
: : * . * . . :
Mb0881c|M.bovis_AF2122/97 KMFNCTGWKIGWACGP------AELIAGVR-AAKQYLSYVGGAPFQPAVA
Rv0858c|M.tuberculosis_H37Rv KMFNCTGWKIGWACGP------AELIAGVR-AAKQYLSYVGGAPFQPAVA
Mflv_4275|M.gilvum_PYR-GCK KSF-WGGLRIGWIRAE------RSTLATIA-TLRPAIDMGTPIVEQLAAA
Mvan_2084|M.vanbaalenii_PYR-1 KSF-WGGLRIGWIRAE------RSTLATVA-VQRPAVDMGTPIFEQLAAA
MSMEG_2323|M.smegmatis_MC2_155 KSF-WGGLRVGWIRAE------RSTLATIA-AIRPSVDLGTPVLEQLTAA
MAB_3387|M.abscessus_ATCC_1997 KSF-WGGMRVGWIRAD------RTTIARLA-AVRSAMDTGTPILEQLAAA
MMAR_2376|M.marinum_M KAY-GPDLRLAVLAGD------QRTVERVHGRLRLGPGWVSHILQDLAVR
MUL_1552|M.ulcerans_Agy99 KAY-GPDLRLAVLAGD------QRTVERVHGRLRLGPGWVSHILQDLAVR
MAV_3214|M.avium_104 KAY-GPDLRVAVLAGD------QRTVDRVHGRLRLGPGWVSHVLQQLAVE
TH_2065|M.thermoresistible__bu KYFAMTGWRLGWLLVP------PALLRAVD-RLTGNFTICPPALAQVAAV
MLBr_02502|M.leprae_Br4923 KAYRVAGYRSGWLAITGPKDHASSFIGGIN--LLANMRLCPNVPAQHAIQ
* : . : . : : : :
Mb0881c|M.bovis_AF2122/97 LALD-TED-AWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCAD-
Rv0858c|M.tuberculosis_H37Rv LALD-TED-AWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCAD-
Mflv_4275|M.gilvum_PYR-GCK RLLA-ADE-EVLPERRDILRSRRALLLRLLAEHLPDWQPVPGKGGMSVW-
Mvan_2084|M.vanbaalenii_PYR-1 KLLA-SED-EVLPERREILRSRRALLLALLAEHLPDWRPAPGKGGLSLW-
MSMEG_2323|M.smegmatis_MC2_155 RLLA-MRE-QILRERRELLRTRRQALVSLLAEHLPDWQPGPGRGGMSLW-
MAB_3387|M.abscessus_ATCC_1997 ELLE-RAE-EVEAAQRETLRARRALVVSELHRRLPEWELQEADGGLCIW-
MMAR_2376|M.marinum_M LFAD-DAATGLVRQAQERYADARGRLCAALSARG---VAAHGRSGLNVW-
MUL_1552|M.ulcerans_Agy99 LFAD-DAATGLVRQAQERYADARGRLCAALSARG---VAAHGRSGLNVW-
MAV_3214|M.avium_104 LWSD-TAASELVATAERRYADRRRRLCGALAERG---VDAHGRSGLNVW-
TH_2065|M.thermoresistible__bu EAFH-PESIAEAEALLDHYATNRRLLIDGLRSLGIDRLAPADGAFYVYA-
MLBr_02502|M.leprae_Br4923 VALGGHQSIEDLVLPGGRLLEQRDVAWTKLNEIPGVSCVKPTGALYAFPR
* *
Mb0881c|M.bovis_AF2122/97 --PRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
Rv0858c|M.tuberculosis_H37Rv --PRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
Mflv_4275|M.gilvum_PYR-GCK --VRLP--APMSSALSAAASRMGLEIPPGPRFG--VDGTLERFIRVPYTL
Mvan_2084|M.vanbaalenii_PYR-1 --VRLP--APMSSALSAAASRMGLEIPPGPRFG--VDGSLERFIRVPYTL
MSMEG_2323|M.smegmatis_MC2_155 --VRLP--APMSTALAAAASRMGVDLPAGPRFG--VDGTLERFVRVPYAL
MAB_3387|M.abscessus_ATCC_1997 --ARLP--APMSTALAAAAARLGVRIAAGPRFG--VGGSLERFVRLPFTQ
MMAR_2376|M.marinum_M --IPVP--DETAAITRLLNR--GWAAAPGARFR--IRSAPG--IRVTIAG
MUL_1552|M.ulcerans_Agy99 --IPVP--DETAAITRLLNR--GWAAAPGARFR--VRSAPG--IRVTIAG
MAV_3214|M.avium_104 --VRVP--DEAVAVSRLLGA--GWAAAPGARFR--MQTPAG--IRITIAD
TH_2065|M.thermoresistible__bu --DVSRYTEDSIEFCSKLLADTGVAIAPGIDFD----------TVHGDRF
MLBr_02502|M.leprae_Br4923 LDPEVYGIVDDEQLVLDLLLQEKILVTQGSGFN-----------WPAPDH
*
Mb0881c|M.bovis_AF2122/97 VRFTFCKRDDTLDEAIRRLSVLAERPAT----
Rv0858c|M.tuberculosis_H37Rv VRFTFCKRDDTLDEAIRRLSVLAERPAT----
Mflv_4275|M.gilvum_PYR-GCK PDAQLVEAIELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 PDGQLVEAIELLARAWRSVTGMTASEPTAVVV
MSMEG_2323|M.smegmatis_MC2_155 PEPQLAEAVELLARAWHSITGTIGPQSQALVV
MAB_3387|M.abscessus_ATCC_1997 HDDQLLRGVELLAQAWHTVTGALPLADSTMVG
MMAR_2376|M.marinum_M LS---AEEIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 LS---AEEIEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 LT---PDEIEPLADAVAQAVRPSGRPIV----
TH_2065|M.thermoresistible__bu VRFSFAGATSDIEEALRRIGGWLA--------
MLBr_02502|M.leprae_Br4923 LRLVTLPWSRDLAAAIDRLGNFLVSYRQ----
: *