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AEQVRGEILALAPGSRIASHRELVRRFHVSASTVADALSLLAQQGLIESRPGAGSFRTENRPVPRPGDTS WQETALELGPQEESPPGIRRVFDAPGLLSTLAPSAADVVDLNGGYLHPDLQPLSMLTASLARAARRPEAW DRPPPGGLPELRDWFAAELGGGLGRQDILICGAGQSALSTSLRALCQPGDPVLLESPCYPGATAAARAAG LRPIAIPLDINGIRPDRLNEALSHTNARAIVVQPLFQNPTGASLTPQRRDELREIARRHGAFLIEDDFAR YMAHDDGKPLVPPLISDDPDGTVVHIRSMTKVTSPNLRVGAIAARGPVMARLRAASVIDTMLVPAPLQYT TLEVVTSPSWRRGLATLGKTLKHRRATARDAIAAAFPTELTHYPRGGYHLWVSLPPQSDSRQFAAEALTR GVAITPGDNYFTSGGGRPHIRISYVAAPSPADISEGIRRLEPLVSKYIAEGAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0810c | - | - | 100% (474) | GntR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3582 | - | 8e-23 | 25.26% (479) | GntR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3387 | - | 2e-19 | 27.27% (440) | GntR family regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0881c | - | 1e-11 | 25.14% (350) | aminotransferase |
| M. gilvum PYR-GCK | Mflv_4275 | - | 3e-21 | 27.23% (448) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1178 | - | 1e-11 | 25.50% (349) | N-succinyldiaminopimelate aminotransferase |
| M. leprae Br4923 | MLBr_02502 | - | 1e-10 | 30.51% (177) | aminotransferase AlaT |
| M. marinum M | MMAR_2376 | - | 3e-21 | 26.51% (464) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 2e-22 | 26.93% (427) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0426 | - | 3e-69 | 36.40% (467) | transcriptional regulator, GntR family protein |
| M. thermoresistible (build 8) | TH_2032 | - | 2e-13 | 26.77% (396) | PLP-dependent aminotransferases |
| M. ulcerans Agy99 | MUL_1552 | - | 2e-21 | 25.98% (458) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 3e-19 | 25.98% (435) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0881c|M.bovis_AF2122/97 ----------------------------------------------MTVS
TH_2032|M.thermoresistible__bu ----------------------------------------------MTVE
MAB_0810c|M.abscessus_ATCC_199 ------------------------MAEQVRGEILALAPGSRIASHRELVR
MSMEG_0426|M.smegmatis_MC2_155 ----------------------------MRQWIAGAPPGAQLPSNRVLVA
MMAR_2376|M.marinum_M --------------------------MPVQYRIAGGGAESIAASIESAIS
MUL_1552|M.ulcerans_Agy99 --------------------------MPVQNRIAGGGAGSIAASIESAIS
MAV_3214|M.avium_104 --------------------------MAVQKSITGTGAESIAASIEAAIS
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
Rv1178|M.tuberculosis_H37Rv -----------------------------------------------MSA
MLBr_02502|M.leprae_Br4923 ------------------------MTLYQQISVDGSGTMSDVTTHQLPMH
Mb0881c|M.bovis_AF2122/97 RLRPYATTVFAEMSALATR-------------------------------
TH_2032|M.thermoresistible__bu RLRPYATTIFAEMSALAAR-------------------------------
MAB_0810c|M.abscessus_ATCC_199 RFHVSASTVADALSLLAQQGLIESRPGAGSFRTENRPVPRPGDTSWQETA
MSMEG_0426|M.smegmatis_MC2_155 QYGASPVTVASAMRTLRGLGLIETRPGVGTFVRATRSSRSP-DYAWQTAA
MMAR_2376|M.marinum_M QGGLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRD--RGTVETAGRRGT
MUL_1552|M.ulcerans_Agy99 QGGLAPGDALPSIREVAGQLGVNPNTVAAAYRLLRD--RGTVETAGRRGT
MAV_3214|M.avium_104 AGSLAPGDALPPVRELAARLGVNANTAAAAYRLLRH--RGAVETAGRRGT
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
Rv1178|M.tuberculosis_H37Rv SLPVFPWDTLADAKALAGAHP-----------------------------
MLBr_02502|M.leprae_Br4923 TPGYHRQRAFAQSSKLQDVLYEIRGPVSQHATRLET--------------
:
Mb0881c|M.bovis_AF2122/97 -------------------------------IGAVNLGQGFPDEDGPP--
TH_2032|M.thermoresistible__bu -------------------------------VGAVNLGQGFPDEDGPP--
MAB_0810c|M.abscessus_ATCC_199 LELGPQEESPPG-IRRVFDAPGLLSTLAPSAADVVDLNGGYLHPDLQPLS
MSMEG_0426|M.smegmatis_MC2_155 LGS-PRARIP------VLSAP-----MRYGAPDAVALHSGYPARELLPHR
MMAR_2376|M.marinum_M RVRDRPASTP----RSSLDLG--------VPAGARDLSTGNPAPELLP--
MUL_1552|M.ulcerans_Agy99 RVRDRPASTP----RSSLDLG--------VPAGARDLSTGNPAPELLP--
MAV_3214|M.avium_104 RVRHRPATTP----RSLLGLD--------VPAGVRDLSTGNPHPALLP--
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLNARRGARSTTALPLTPTPALRPVTATANLAAATLAAPASVTA
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLNARRGARSTTALPLRPAAPAPLAPTGANLAAATLAAPAAIAA
Rv1178|M.tuberculosis_H37Rv -------------------------------DGIVDLSVGTPVDPVAP--
MLBr_02502|M.leprae_Br4923 -----------------------------EGHRILKLNIGNPALFGFDAP
* .
Mb0881c|M.bovis_AF2122/97 -KMLQAAQDAIAGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDY--DPETE
TH_2032|M.thermoresistible__bu -AMLEIARDAIAEGMNQYPPGIGIAPLRQAIAAQRERHYGVEY--DPDTE
MAB_0810c|M.abscessus_ATCC_199 MLTASLARAARRPEAWDRPPPGGLPELRDWFAAELGGGL-------GRQD
MSMEG_0426|M.smegmatis_MC2_155 LVRAALTRAARSEAALSRSAVTGLPDLQAWFAQELAEAVPAGRSAPGPRD
MMAR_2376|M.marinum_M -----LAAVG-WPDGSVLPLLYGAPAMSAELVDYARAALAADG--VAADH
MUL_1552|M.ulcerans_Agy99 -----LAAVG-WPDGSVLPLLYGAPAMSAELVDYARAALAADG--VAADH
MAV_3214|M.avium_104 -----LAAAAPARPASGRAVLYGEPAISPALAEYARAALSADG--VPADH
Mflv_4275|M.gilvum_PYR-GCK RAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARGLPTD----VDE
Mvan_2084|M.vanbaalenii_PYR-1 RAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTD----PDE
Rv1178|M.tuberculosis_H37Rv ---LIQEALAAASAAPGYPATAGTARLRESVVAALARRYGITR---LTEA
MLBr_02502|M.leprae_Br4923 -DVIMRDMIQALPYAQGYSDSQGILPARRAVVTRYELVDGFPR--FDVDD
* ..
Mb0881c|M.bovis_AF2122/97 VLVTVGATEAIAAAVLGLVEPG--SEVLLIEPFYDSYSPVVAMAGAHRVT
TH_2032|M.thermoresistible__bu VLVTVGATEAIAGAVLGLVEPG--SEVLLIEPFYDSYSPVIAMAGAHRVA
MAB_0810c|M.abscessus_ATCC_199 ILICGAGQSALSTSLRALCQPG--DPVLLESPCYPGATAAARAAGLRPIA
MSMEG_0426|M.smegmatis_MC2_155 VVVLPGSQSGLSSAFRALVGHG--QPLLIESPTYWGAIIAAAQAGVRIVP
MMAR_2376|M.marinum_M LAVTNGALDGIERALSANLRPG--DRVAVEDPGWANLLDLLAALGLPVEP
MUL_1552|M.ulcerans_Agy99 LAVTNGALDGIERALSANLRPG--DRVAVEDPGWANLLDLLAALGLPVEP
MAV_3214|M.avium_104 LALTSGALDGIERALTAHLRPG--DRVAVEDPGWANLLDLLAALGFSAEP
Mflv_4275|M.gilvum_PYR-GCK IMVTTGALHAISLILATYTQPD--DRVLVEQPTYHGALAAMASRGLRPVP
Mvan_2084|M.vanbaalenii_PYR-1 IMVTTGALHAIGLILATYTQPD--DRVLVEQPTYHGALAAMASRGLRTVP
Rv1178|M.tuberculosis_H37Rv AVLPVIGTKELIAWLPTLLGLGGADLVVVPELAYPTYDVGARLAGTRVLR
MLBr_02502|M.leprae_Br4923 VYLGNGVSELITMTLQALLDNG--DQVLIPSPDYPLWTASTSLAGGTPVH
: : . . . : : . : *
Mb0881c|M.bovis_AF2122/97 VPLVPDGRGFALDADALRRAVTPRTRALIINSP--HNPTGAVLSATELAA
TH_2032|M.thermoresistible__bu VPLVTDGPGFAVDLDALRRAVTPRTRAMIVNSP--HNPTGMVLTEAELAG
MAB_0810c|M.abscessus_ATCC_199 IPLDINGI----RPDRLNEALSHTNARAIVVQPLFQNPTGASLTPQRRDE
MSMEG_0426|M.smegmatis_MC2_155 VPSGVEGP----DPDELARAFDDTGARVFYAQPNFANPTGAQWSTERVEQ
MMAR_2376|M.marinum_M MGVDDDGP----LVADLQRALG-RGVRAVVVTSRAQNPTGAALSAARAEE
MUL_1552|M.ulcerans_Agy99 MGVDDDGP----LVADLQRALG-RGVRAVVVTSRAQNPTGAALSAARAEE
MAV_3214|M.avium_104 VRVDDAGP----LPEDLARALG-RGARALVLTTRAQNPTGAALSAERAAA
Mflv_4275|M.gilvum_PYR-GCK VAMAPDGW----ELDAVEAAIRQLAPELAYLIPDNQNPTGMTMPVGDRAR
Mvan_2084|M.vanbaalenii_PYR-1 VAMAPDGW----ELDAVEAAIRQLAPNLAYLVPDNHNPTGMTLPVPERKR
Rv1178|M.tuberculosis_H37Rv A-------------DALTQLGPQSPALLYLNSP--SNPTGRVLGVDHLRK
MLBr_02502|M.leprae_Br4923 YLCDETQG-WQPDIADVESKITERTKALVVINP--NNPTGAVYSNEILNQ
: . ****
Mb0881c|M.bovis_AF2122/97 IAEIAVAANLVVITDEVYEHLVFDH---ARHLPLAGFDGMAERTITISSA
TH_2032|M.thermoresistible__bu IAELAVSADLLVITDEVYEHLVYPSPAGRRHIPLASYPGMAERTVTISSA
MAB_0810c|M.abscessus_ATCC_199 LREIARR--HGAFLIEDDFARYMAHDDGKPLVPPLISDDPDGTVVHIRSM
MSMEG_0426|M.smegmatis_MC2_155 ILDVVRT--RKAFLIDDNWAHDFGIDSTS---RPVAAHDDDGHVIYLRSL
MMAR_2376|M.marinum_M LREVLSQGAEEVLLVEDDHCAGIAG------VPLHTLAGATQHWAFVRSA
MUL_1552|M.ulcerans_Agy99 LREVLSQGAEEVLLVEDDHCAGIAG------VPLHTLAGATQHWAFVRSA
MAV_3214|M.avium_104 LRDLLSGRADDVLLVEDDHCAGISG------AALHPVAGCTTHWAFVRSA
Mflv_4275|M.gilvum_PYR-GCK LARIISETKTRTIIDETITDMWLDEQVPPP--LATEVTSRPDLVMTVGSM
Mvan_2084|M.vanbaalenii_PYR-1 LAHIISDTRTRTIVDETITDMWLDEPVPAP--LAASMTGRRDLVLTVGSM
Rv1178|M.tuberculosis_H37Rv VVEWARGRGVLVVSDECYLGLGWDAEPVS-VLHPSVCDGDHTGLLAVHSL
MLBr_02502|M.leprae_Br4923 IVDLARKHQLLLLADEIYDKILYDDTK----HISVASIAPDLLCLTFNGL
: . : . .
Mb0881c|M.bovis_AF2122/97 AKMFNCTGWKIGWACGPAE-----LIAGVRAAKQYLSYVGGAPFQPAVAL
TH_2032|M.thermoresistible__bu AKMFNCTGWKIGWACGPSD-----LIAGVRAAKQYLSYVGGAPFQPAVAH
MAB_0810c|M.abscessus_ATCC_199 TKVT-SPNLRVGAIAARGP-----VMARLRAASVIDTMLVPAPLQYTTLE
MSMEG_0426|M.smegmatis_MC2_155 TKSV-SPAMRVAAVIARGP-----VRERIVADRGAESMYVSGALQAAVLD
MMAR_2376|M.marinum_M AKAY-GPDLRLAVLAGDQR-----TVERVHGRLRLGPGWVSHILQDLAVR
MUL_1552|M.ulcerans_Agy99 AKAY-GPDLRLAVLAGDQR-----TVERVHGRLRLGPGWVSHILQDLAVR
MAV_3214|M.avium_104 SKAY-GPDLRVAVLAGDQR-----TVDRVHGRLRLGPGWVSHVLQQLAVE
Mflv_4275|M.gilvum_PYR-GCK SKSF-WGGLRIGWIRAERS-----TLATIATLRPAIDMGTPIVEQLAAAR
Mvan_2084|M.vanbaalenii_PYR-1 SKSF-WGGLRIGWIRAERS-----TLATVAVQRPAVDMGTPIFEQLAAAK
Rv1178|M.tuberculosis_H37Rv SKSSSLAGYRAGFVVGDLE-----IVAELLAVRKHAGMMVPAPVQAAMVA
MLBr_02502|M.leprae_Br4923 SKAYRVAGYRSGWLAITGPKDHASSFIGGINLLANMRLCPNVPAQHAIQV
:* : . *
Mb0881c|M.bovis_AF2122/97 ALDTEDA--WVAALRNSLRARRDRLAAGLTEIG----FAVHDSYGTYFLC
TH_2032|M.thermoresistible__bu ALDHEDA--WVAALRDSLQSRRDTLAAALTEIG----FEVHDSAGTYFLC
MAB_0810c|M.abscessus_ATCC_199 VVTSPSWRRGLATLGKTLKHRRATARDAIAAAF-PTELTHYPRGGYHLWV
MSMEG_0426|M.smegmatis_MC2_155 VVTQPAWRSHLRDLRAQLRQRRDHLVACLADHVNVARLEQVPPGGLHLWL
MMAR_2376|M.marinum_M LFADDAATGLVRQAQERYADARGRLCAALSARG----VAAHGRSGLNVWI
MUL_1552|M.ulcerans_Agy99 LFADDAATGLVRQAQERYADARGRLCAALSARG----VAAHGRSGLNVWI
MAV_3214|M.avium_104 LWSDTAASELVATAERRYADRRRRLCGALAERG----VDAHGRSGLNVWV
Mflv_4275|M.gilvum_PYR-GCK LLAADEE--VLPERRDILRSRRALLLRLLAEHLP-DWQPVPGKGGMSVWV
Mvan_2084|M.vanbaalenii_PYR-1 LLASEDE--VLPERREILRSRRALLLALLAEHLP-DWRPAPGKGGLSLWV
Rv1178|M.tuberculosis_H37Rv ALDDDAHE---RQQRERYAQRRAALLPALGSAG---FAVDYSDAGLYLWA
MLBr_02502|M.leprae_Br4923 ALGGHQSIEDLVLPGGRLLEQRDVAWTKLNEIPG--VSCVKPTGALYAFP
* : .
Mb0881c|M.bovis_AF2122/97 ADPRPLG-YDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNH
TH_2032|M.thermoresistible__bu ADPRPLG-YPDSTEFCAGLPERVGVAAIPMSAFCDPAA----PHAEVWNH
MAB_0810c|M.abscessus_ATCC_199 SLPP-----QSDSRQFAAEALTRGVAITPGDNYFTSGG--GRPHIRISYV
MSMEG_0426|M.smegmatis_MC2_155 RLPD-----QTDLDRLVRDCEAEKVLVAAGTEWFPAEP--SGRYLRLN-F
MMAR_2376|M.marinum_M PVP--------DETAAITRLLNRGWAAAPGARFRIRSA--PGIRVTIAGL
MUL_1552|M.ulcerans_Agy99 PVP--------DETAAITRLLNRGWAAAPGARFRVRSA--PGIRVTIAGL
MAV_3214|M.avium_104 RVP--------DEAVAVSRLLGAGWAAAPGARFRMQTP--AGIRITIADL
Mflv_4275|M.gilvum_PYR-GCK RLP------APMSSALSAAASRMGLEIPPGPRFGVDGT--LERFIRVPYT
Mvan_2084|M.vanbaalenii_PYR-1 RLP------APMSSALSAAASRMGLEIPPGPRFGVDGS--LERFIRVPYT
Rv1178|M.tuberculosis_H37Rv TRGE-------PCRDSAAWLAQRGILVAPGDFYGPGGA----QHVRVALT
MLBr_02502|M.leprae_Br4923 RLDPEVYGIVDDEQLVLDLLLQEKILVTQGSGFNWPAP----DHLRLVTL
: :
Mb0881c|M.bovis_AF2122/97 LVRFTFCKRDDTLDEAIRRLSVLAERPAT----
TH_2032|M.thermoresistible__bu LVRFTFCKRPETLEEGIRRLGALRRG-------
MAB_0810c|M.abscessus_ATCC_199 AAPS-----PADISEGIRRLEPLVSKYIAEGAG
MSMEG_0426|M.smegmatis_MC2_155 SGPE-----PDRFEEAARVIGRSLRRQL-----
MMAR_2376|M.marinum_M SAEE-----IEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 SAEE-----IEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 TPDE-----IEPLADAVAQAVRPSGRPIV----
Mflv_4275|M.gilvum_PYR-GCK LPDAQLVEAIELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 LPDGQLVEAIELLARAWRSVTGMTASEPTAVVV
Rv1178|M.tuberculosis_H37Rv ATDER-------VAAAVGRLTC-----------
MLBr_02502|M.leprae_Br4923 PWSR-------DLAAAIDRLGNFLVSYRQ----
. .