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RHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSSRSGPAYHGLADAIRLLIIDGR LPVGARLPSERLLAEVLHVSRTTVTAAYAQLRDDGYLNARRGARSTTALPLRPAAPAPLAPTGANLAAAT LAAPAAIAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTDPDEIMVTTGALHAIGLIL ATYTQPDDRVLVEQPTYHGALAAMASRGLRTVPVAMAPDGWELDAVEAAIRQLAPNLAYLVPDNHNPTGM TLPVPERKRLAHIISDTRTRTIVDETITDMWLDEPVPAPLAASMTGRRDLVLTVGSMSKSFWGGLRIGWI RAERSTLATVAVQRPAVDMGTPIFEQLAAAKLLASEDEVLPERREILRSRRALLLALLAEHLPDWRPAPG KGGLSLWVRLPAPMSSALSAAASRMGLEIPPGPRFGVDGSLERFIRVPYTLPDGQLVEAIELLARAWRSV TGMTASEPTAVVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | - | 100% (504) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5625 | - | 1e-23 | 28.31% (438) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5070 | - | 2e-17 | 31.14% (273) | aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0881c | - | 1e-18 | 32.39% (247) | aminotransferase |
| M. gilvum PYR-GCK | Mflv_4275 | - | 0.0 | 83.33% (480) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0858c | - | 2e-18 | 32.39% (247) | aminotransferase |
| M. leprae Br4923 | MLBr_01794 | - | 9e-08 | 24.33% (300) | aminotransferase |
| M. abscessus ATCC 19977 | MAB_3387 | - | 1e-146 | 56.36% (472) | GntR family regulatory protein |
| M. marinum M | MMAR_2376 | - | 1e-18 | 25.83% (422) | GntR family transcriptional regulator |
| M. avium 104 | MAV_0979 | - | 1e-19 | 30.45% (312) | aminotransferase |
| M. smegmatis MC2 155 | MSMEG_2323 | - | 0.0 | 70.62% (480) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2032 | - | 3e-18 | 31.16% (276) | PLP-dependent aminotransferases |
| M. ulcerans Agy99 | MUL_1552 | - | 1e-18 | 26.07% (422) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
MSMEG_2323|M.smegmatis_MC2_155 ------------------------MSSPMVARSLDVDLLARELGNWRTSS
MAB_3387|M.abscessus_ATCC_1997 ----------------------------MPDRVVTAETLARHLGQWRTAG
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
Mb0881c|M.bovis_AF2122/97 --------------------------------------------------
Rv0858c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0979|M.avium_104 --------------------------------------------------
TH_2032|M.thermoresistible__bu --------------------------------------------------
MLBr_01794|M.leprae_Br4923 --------------------------------------------------
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
MSMEG_2323|M.smegmatis_MC2_155 QTGPAYLGLADAIRLLIVDGRLPVGSRLPSERALADALRVSRTTVTAAFS
MAB_3387|M.abscessus_ATCC_1997 SAGPAYGALADAIRLLVIDGRLPLGVRIPSERALASALHVSRTTVTTAYA
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
Mb0881c|M.bovis_AF2122/97 --------------------------------MTVSRLRPYATTVFAEMS
Rv0858c|M.tuberculosis_H37Rv --------------------------------MTVSRLRPYATTVFAEMS
MAV_0979|M.avium_104 --------------------------------MTVSRLRPYATTVFAEMS
TH_2032|M.thermoresistible__bu --------------------------------MTVERLRPYATTIFAEMS
MLBr_01794|M.leprae_Br4923 --------------------------------MTSNPLEQLTIEQLQCRT
*
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLN--ARRGARS-TTALP---LRPAAPAPLAPTGANLAAATLAA
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLN--ARRGARS-TTALP---LTPTPALRPVTATANLAAATLAA
MSMEG_2323|M.smegmatis_MC2_155 KLREDGYLH--ARRGARS-TTALP---ARPEVRIEAAQASVNLAAAALAA
MAB_3387|M.abscessus_ATCC_1997 ELRESGYLR--GRQGARS-TTALPGPDRTGSATTGLMSPMVDLQNAATAA
MMAR_2376|M.marinum_M LLRDRGTVETAGRRGTRVRD-----------RPASTPRSSLDLGVPAGAR
MUL_1552|M.ulcerans_Agy99 LLRDRGTVETAGRRGTRVRD-----------RPASTPRSSLDLGVPAGAR
Mb0881c|M.bovis_AF2122/97 ALATR------------------------------IGAVNLGQGFPDEDG
Rv0858c|M.tuberculosis_H37Rv ALATR------------------------------IGAVNLGQGFPDEDG
MAV_0979|M.avium_104 ALAAR------------------------------VEAVNLGQGFPDEDG
TH_2032|M.thermoresistible__bu ALAAR------------------------------VGAVNLGQGFPDEDG
MLBr_01794|M.leprae_Br4923 SMKWR---------------------------AHPEDVLPLWVAEMDVLL
:
Mvan_2084|M.vanbaalenii_PYR-1 PAAIAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTD-
Mflv_4275|M.gilvum_PYR-GCK PASVTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARGLPTD-
MSMEG_2323|M.smegmatis_MC2_155 PSTAVLDAFAEAAKDVTAYLQGPGHELMGAAPLREAIAERYCQRGLPTD-
MAB_3387|M.abscessus_ATCC_1997 PAAAVLEAYQAALTTLPTHLRGIGHELVGIPELRPRIAEHFSRRGLPTT-
MMAR_2376|M.marinum_M DLSTGNPAPELLPLAAVGWPDGSVLPLLYGAPAMSAELVDYARAALAADG
MUL_1552|M.ulcerans_Agy99 DLSTGNPAPELLPLAAVGWPDGSVLPLLYGAPAMSAELVDYARAALAADG
Mb0881c|M.bovis_AF2122/97 PPKMLQAAQDAIAGGVNQYPPGP-----GSAPLRRAIAAQR-RRHFGVDY
Rv0858c|M.tuberculosis_H37Rv PPKMLQAAQDAIAGGVNQYPPGP-----GSAPLRRAIAAQR-RRHFGVDY
MAV_0979|M.avium_104 PAEMLKAAQEAIADGVNQYPPGI-----GIAPLRHAIAAQR-HRRYGIEY
TH_2032|M.thermoresistible__bu PPAMLEIARDAIAEGMNQYPPGI-----GIAPLRQAIAAQR-ERHYGVEY
MLBr_01794|M.leprae_Br4923 APTVAEAVHRAVDNGDTGYPYGT---------TFAEAISEFASQRWQWHD
.
Mvan_2084|M.vanbaalenii_PYR-1 --PDEIMVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMASRGLR
Mflv_4275|M.gilvum_PYR-GCK --VDEIMVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAAMASRGLR
MSMEG_2323|M.smegmatis_MC2_155 --PSQIMVTSGAQHAIGLILTTHTQPGDRVLVEQPTYHGALSAISTAGAR
MAB_3387|M.abscessus_ATCC_1997 --EDQIMVTCGAQQAIALLLGAFVEPGDRVLVEQPTYHGALDAISQRGAR
MMAR_2376|M.marinum_M VAADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLP
MUL_1552|M.ulcerans_Agy99 VAADHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLP
Mb0881c|M.bovis_AF2122/97 DPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAH
Rv0858c|M.tuberculosis_H37Rv DPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAH
MAV_0979|M.avium_104 DPDTEVLVTVGATEAIASAVIGLVEPGSEVLLIEPFYDSYSPVIAMASAQ
TH_2032|M.thermoresistible__bu DPDTEVLVTVGATEAIAGAVLGLVEPGSEVLLIEPFYDSYSPVIAMAGAH
MLBr_01794|M.leprae_Br4923 LDVSRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRR
. :. .. .: : .. * : * : :: .
Mvan_2084|M.vanbaalenii_PYR-1 TVPVAMA-----PDGWELDAVEAAIRQLAPN--LAYLVPDNHNPTGMTLP
Mflv_4275|M.gilvum_PYR-GCK PVPVAMA-----PDGWELDAVEAAIRQLAPE--LAYLIPDNQNPTGMTMP
MSMEG_2323|M.smegmatis_MC2_155 AVPVALT-----DAGWELDAFHAAIRQLAPS--LAYVIPDNHNPTGFTMA
MAB_3387|M.abscessus_ATCC_1997 PVPVPMHTHE-RDSGWDMTGMETTIRQTAPN--LAYLVLDNHNPTGLTMP
MMAR_2376|M.marinum_M VEPMGVD-----DDGPLVADLQRALGRGVR---AVVVTSRAQNPTGAALS
MUL_1552|M.ulcerans_Agy99 VEPMGVD-----DDGPLVADLQRALGRGVR---AVVVTSRAQNPTGAALS
Mb0881c|M.bovis_AF2122/97 RVTVPLVPD---GRGFALDADALRRAVTPRT--RALIINSPHNPTGAVLS
Rv0858c|M.tuberculosis_H37Rv RVTVPLVPD---GRGFALDADALRRAVTPRT--RALIINSPHNPTGAVLS
MAV_0979|M.avium_104 RVAVPLVPH---GRGFALDADALRRAVTPRT--RALIVNSPHNPTGTVLG
TH_2032|M.thermoresistible__bu RVAVPLVTD---GPGFAVDLDALRRAVTPRT--RAMIVNSPHNPTGMVLT
MLBr_01794|M.leprae_Br4923 VLEAPLGRDGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSVHT
: . . : :**** .
Mvan_2084|M.vanbaalenii_PYR-1 VPERKRLAHIISDTRTRTIVDETITDMWLDE---PVPAPLAASMTGRRDL
Mflv_4275|M.gilvum_PYR-GCK VGDRARLARIISETKTRTIIDETITDMWLDE---QVPPPLATEVTSRPDL
MSMEG_2323|M.smegmatis_MC2_155 PDDRKRLGQIISDTRTRTIIDESIADMWVDH---APPEPLAASVG-RHDL
MAB_3387|M.abscessus_ATCC_1997 LGQRKALADIISQTRTRTVVDESLVGVWHQN---HTPAPMAALVS-RPEL
MMAR_2376|M.marinum_M AARAEELREVLSQGAEEVLLVEDDHCAGIAG---VPLHTLAGATQ----H
MUL_1552|M.ulcerans_Agy99 AARAEELREVLSQGAEEVLLVEDDHCAGIAG---VPLHTLAGATQ----H
Mb0881c|M.bovis_AF2122/97 ATELAAIAEIAVAANLVVITDEVYEHLVFDH---ARHLPLAGFDG-MAER
Rv0858c|M.tuberculosis_H37Rv ATELAAIAEIAVAANLVVITDEVYEHLVFDH---ARHLPLAGFDG-MAER
MAV_0979|M.avium_104 ATELAAIAEVAVESDLLVITDEVYEHLVFDD---HRHLPLAGFDG-MAER
TH_2032|M.thermoresistible__bu EAELAGIAELAVSADLLVITDEVYEHLVYPSPAGRRHIPLASYPG-MAER
MLBr_01794|M.leprae_Br4923 VAELHGVAELARRFGVRVISDEIHAPLVLSG---ARFTPYLSIPG--AEN
: : .: * .
Mvan_2084|M.vanbaalenii_PYR-1 VLTVGSMSKSFWG-GLRIGWIRAERSTLATVA-VQRPAVDMGTPIFEQLA
Mflv_4275|M.gilvum_PYR-GCK VMTVGSMSKSFWG-GLRIGWIRAERSTLATIA-TLRPAIDMGTPIVEQLA
MSMEG_2323|M.smegmatis_MC2_155 VLTIGSMSKSFWG-GLRVGWIRAERSTLATIA-AIRPSVDLGTPVLEQLT
MAB_3387|M.abscessus_ATCC_1997 VVTIGSMSKSFWG-GMRVGWIRADRTTIARLA-AVRSAMDTGTPILEQLA
MMAR_2376|M.marinum_M WAFVRSAAKAYGP-DLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLA
MUL_1552|M.ulcerans_Agy99 WAFVRSAAKAYGP-DLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLA
Mb0881c|M.bovis_AF2122/97 TITISSAAKMFNCTGWKIGWACGPAELIAGVR-AAKQYLSYVGGAPFQPA
Rv0858c|M.tuberculosis_H37Rv TITISSAAKMFNCTGWKIGWACGPAELIAGVR-AAKQYLSYVGGAPFQPA
MAV_0979|M.avium_104 TITISSAAKMFNCTGWKIGWACGPAHLIAGVR-AAKQYLSYVGGAPFQPA
TH_2032|M.thermoresistible__bu TVTISSAAKMFNCTGWKIGWACGPSDLIAGVR-AAKQYLSYVGGAPFQPA
MLBr_01794|M.leprae_Br4923 AFALMSATKGWNLCGLKAAIAIAGREAAADLR-RIPKEVSHGPSHLGIIA
: * :* : . : . . : . :
Mvan_2084|M.vanbaalenii_PYR-1 AAKLLASEDE-VLPERREILRSRRALLLALLAEHLP--DWRPAPGKGGLS
Mflv_4275|M.gilvum_PYR-GCK AARLLAADEE-VLPERRDILRSRRALLLRLLAEHLP--DWQPVPGKGGMS
MSMEG_2323|M.smegmatis_MC2_155 AARLLAMREQ-ILRERRELLRTRRQALVSLLAEHLP--DWQPGPGRGGMS
MAB_3387|M.abscessus_ATCC_1997 AAELLERAEE-VEAAQRETLRARRALVVSELHRRLP--EWELQEADGGLC
MMAR_2376|M.marinum_M VRLFADDAATGLVRQAQERYADARGRLCAALSARG-----VAAHGRSGLN
MUL_1552|M.ulcerans_Agy99 VRLFADDAATGLVRQAQERYADARGRLCAALSARG-----VAAHGRSGLN
Mb0881c|M.bovis_AF2122/97 VALALDTEDA-WVAALRNSLRARRDRLAAGLTEIGF--AVHDSYGTYFLC
Rv0858c|M.tuberculosis_H37Rv VALALDTEDA-WVAALRNSLRARRDRLAAGLTEIGF--AVHDSYGTYFLC
MAV_0979|M.avium_104 VALALETQDA-WVADLRDRLRARRDRLAAGLIDIGF--EVHDSAGTYFLC
TH_2032|M.thermoresistible__bu VAHALDHEDA-WVAALRDSLQSRRDTLAAALTEIGF--EVHDSAGTYFLC
MLBr_01794|M.leprae_Br4923 HTAAFRTGSS-WLDALLQGLEANRALLRDLVTKHLPGVRYQRPQGTYLTW
: * : : .
Mvan_2084|M.vanbaalenii_PYR-1 LWVRLPAPMSSALSAAASRMGLEIPPGPRFGVDGSLERFIRVPYTLPDGQ
Mflv_4275|M.gilvum_PYR-GCK VWVRLPAPMSSALSAAASRMGLEIPPGPRFGVDGTLERFIRVPYTLPDAQ
MSMEG_2323|M.smegmatis_MC2_155 LWVRLPAPMSTALAAAASRMGVDLPAGPRFGVDGTLERFVRVPYALPEPQ
MAB_3387|M.abscessus_ATCC_1997 IWARLPAPMSTALAAAAARLGVRIAAGPRFGVGGSLERFVRLPFTQHDDQ
MMAR_2376|M.marinum_M VWI--PVPDETAAITRLLNRGWAAAPGARFRIRSAPG--IRVTIAGLS--
MUL_1552|M.ulcerans_Agy99 VWI--PVPDETAAITRLLNRGWAAAPGARFRVRSAPG--IRVTIAGLS--
Mb0881c|M.bovis_AF2122/97 ADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
Rv0858c|M.tuberculosis_H37Rv ADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
MAV_0979|M.avium_104 ADPRPLGYDDSVAFCAALPEKVGVAAIPLSPFCDPAG--AHGPADVWNHL
TH_2032|M.thermoresistible__bu ADPRPLGYPDSTEFCAGLPERVGVAAIPMSAFCDPAAP----HAEVWNHL
MLBr_01794|M.leprae_Br4923 LDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGH
. ..
Mvan_2084|M.vanbaalenii_PYR-1 LVEAIELLARAWRSVTGMTASEPTAVVV
Mflv_4275|M.gilvum_PYR-GCK LVEAIELLARAWRSVTGLTAPEPATVVV
MSMEG_2323|M.smegmatis_MC2_155 LAEAVELLARAWHSITGTIGPQSQALVV
MAB_3387|M.abscessus_ATCC_1997 LLRGVELLAQAWHTVTGALPLADSTMVG
MMAR_2376|M.marinum_M -AEEIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 -AEEIEPLADAIAGAIQRTGRPTV----
Mb0881c|M.bovis_AF2122/97 VRFTFCKRDDTLDEAIRRLSVLAERPAT
Rv0858c|M.tuberculosis_H37Rv VRFTFCKRDDTLDEAIRRLSVLAERPAT
MAV_0979|M.avium_104 VRFTFCKRDDTLDEAIRRLAALRGTG--
TH_2032|M.thermoresistible__bu VRFTFCKRPETLEEGIRRLGALRRG---
MLBr_01794|M.leprae_Br4923 VRVNFATSQAILIEALSRMGRALVNFR-
.