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TSYLEPLEQQSTPSLIADKLRQAIGAREFKPGQQLSEAALAQKLGVSRGPLREGMQRLTQEGLLVSIRHR GLFVIEMTPDEVCDMYLAREAIERAAAAKILRGDHVAAGDALLEIVEQMTKARTPAENSEVDIRFHIRLV ELSDSPRLSRMHQTFITETQMCIHALDESYSVSDFRSEEHRAIAAAIKAGDRELTDELLIAHMDDALNRL IPPDGNGNGDGSGKGKGKRKGNSDGGGKG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2489 | - | - | 100% (240) | transcriptional regulator, GntR family protein, putative |
| M. smegmatis MC2 155 | MSMEG_0179 | - | 2e-19 | 34.59% (159) | transcriptional regulator, GntR family protein |
| M. smegmatis MC2 155 | MSMEG_4057 | - | 7e-19 | 29.08% (196) | transcriptional regulator, GntR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0505 | - | 2e-10 | 27.47% (233) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 2e-11 | 27.68% (224) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv0494 | - | 2e-10 | 27.47% (233) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4411c | - | 7e-42 | 47.85% (209) | GntR family transcriptional regulator |
| M. marinum M | MMAR_2244 | - | 5e-17 | 26.32% (209) | GntR family transcriptional regulator |
| M. avium 104 | MAV_5020 | - | 5e-09 | 24.06% (212) | transcriptional regulator, GntR family protein |
| M. thermoresistible (build 8) | TH_1959 | - | 2e-11 | 27.40% (208) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (GNTR-FAMILY) |
| M. ulcerans Agy99 | MUL_1833 | - | 6e-17 | 26.32% (209) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2282 | - | 3e-12 | 28.38% (222) | regulatory protein GntR, HTH |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2489|M.smegmatis_MC2_155 ---MTSYL------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 ---MTTLVPE----------------------------------------
Mb0505|M.bovis_AF2122/97 ------MVEPMNQ-------------------------------------
Rv0494|M.tuberculosis_H37Rv ------MVEPMNQ-------------------------------------
Mflv_4061|M.gilvum_PYR-GCK ----MAAPDPADS------------------------------SD-----
Mvan_2282|M.vanbaalenii_PYR-1 ---MSAVPEPTDERLREEQTASDERLREEQTASDERLREEQTASDGADAT
MMAR_2244|M.marinum_M MLEEEAVVIPRADS------------------------------------
MUL_1833|M.ulcerans_Agy99 MLEEEAVVIPRADS------------------------------------
TH_1959|M.thermoresistible__bu --------------------------------------------------
MAV_5020|M.avium_104 ---MSMQPRSR---------------------------------------
MSMEG_2489|M.smegmatis_MC2_155 ----------EPLEQQSTPSLIADKLRQAIGAREFKPGQQLS-EAALAQK
MAB_4411c|M.abscessus_ATCC_199 --------EFAPLERQSTAELIAERLRIAIMRGVLAPGAQLG-EASLAAQ
Mb0505|M.bovis_AF2122/97 ------SSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAER
Rv0494|M.tuberculosis_H37Rv ------SSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAER
Mflv_4061|M.gilvum_PYR-GCK ----ASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAAR
Mvan_2282|M.vanbaalenii_PYR-1 AEQIAADALLRPVRPLNAFEDTVERLLQTIRLGVLRPGESLPPERELATR
MMAR_2244|M.marinum_M ----PDQTCGRLPARGTIGEQVADLIQESILSGEAKRGAPLR-EELIADR
MUL_1833|M.ulcerans_Agy99 ----PDQTCGRLPARGTVGEQVADLIQESILSGEAKRGSPLR-EELIADR
TH_1959|M.thermoresistible__bu -------MALQPVNRRSVPEDVFDQIVGEVLSGQMQPGDALPSERRLAEV
MAV_5020|M.avium_104 ----------RPLRRAQLSDEVAGHLRAAIMSGALRPGTFIR-LDETAAE
. : : * : *
MSMEG_2489|M.smegmatis_MC2_155 LGVSRGPLREGMQRLTQEGLLVSIRHRG---LFVIEMTPDEVCDMYLARE
MAB_4411c|M.abscessus_ATCC_199 FAVSRGPLREAMQRLVSEGLLRSERNRG---IFVIELTDDDVLDVYRSRS
Mb0505|M.bovis_AF2122/97 LGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKL
Rv0494|M.tuberculosis_H37Rv LGVNRTSLRQGLARLQQMGLIEVRHGSGSVVRDPEGLTHPAVVEALVRKL
Mflv_4061|M.gilvum_PYR-GCK LGVSRDTVREAIKSLADAGYLVSRRGRYGGTFLADALPAPRADGTEMHRD
Mvan_2282|M.vanbaalenii_PYR-1 LGVSRDTVREAIKSLADAGYLVSRRGRYGGTFIADALPAPRTGDVAFSRT
MMAR_2244|M.marinum_M YQVSRRTVRDALRVLESNGLVRHQRHKG---STVVDFSAEDITDMYRSRE
MUL_1833|M.ulcerans_Agy99 YQVSRRTVRDALRVLESNGLVRHQRHKG---STVVDFSAGDITDMYRSRE
TH_1959|M.thermoresistible__bu LGVSRPAVREALKRLSAAGLVEVRQGEITTVRDYRRHAGLDLLPRLLFRA
MAV_5020|M.avium_104 LGVSVTPVREALLKLRGEGMVQLEPHRG---HVVLPLTRQDIEDIFWLQA
*. .:*:.: * * : . :
MSMEG_2489|M.smegmatis_MC2_155 AIERAAAAKILRGDH---------VAAGDA----LLEIVEQMTKARTP--
MAB_4411c|M.abscessus_ATCC_199 AIERAALECIMTGDT---------VTAYRR----LLVPVAVMTEAAARGD
Mb0505|M.bovis_AF2122/97 GPDFLVELLEIRAALGP---LIGRLAAARS-TPEDAEALCAALEVVQQAD
Rv0494|M.tuberculosis_H37Rv GPDFLVELLEIRAALGP---LIGRLAAARS-TPEDAEALCAALEVVQQAD
Mflv_4061|M.gilvum_PYR-GCK DIDDAVRLREILEVG------AARMAAVRTLAAVEREALRSRLTDVRGAD
Mvan_2282|M.vanbaalenii_PYR-1 DIDDALRLREILETG------AARMAACRTLSATEREALWSRLLDVRGAA
MMAR_2244|M.marinum_M VLELDAAKRWCRAGE---------VDSGYR-FHRLTEALGRLEQASRGTD
MUL_1833|M.ulcerans_Agy99 VLELDAAKRWCRAGE---------VDSGYR-FHRLTEALGRLEQASRGTD
TH_1959|M.thermoresistible__bu GELDVTVVRSILETRLHNGPKVAELAARRRPPGLGALLDEAVQTLAAETD
MAV_5020|M.avium_104 TIAKELAAAATDHIT-------------DTEIDELDRINDALAAAVGSGD
MSMEG_2489|M.smegmatis_MC2_155 -AENSEVDIRFHIRLVELSD-SPRLSRMHQTFITETQMCIHALDESYS--
MAB_4411c|M.abscessus_ATCC_199 VVAVTDADQDFHEVLVDCSG-SPRLRRAMRTLLLETRMLLGELQGAYP--
Mb0505|M.bovis_AF2122/97 TAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYD--
Rv0494|M.tuberculosis_H37Rv TAAARQAADLAYFRVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYD--
Mflv_4061|M.gilvum_PYR-GCK PADYRRLDSRLHLAIAEAAG-VPSLVPLVAQNRMRLNELLDRIPLMTR--
Mvan_2282|M.vanbaalenii_PYR-1 PQDYRRLDSRLHLAITEAAG-VPSLVPLVAQNRMRLNEMLDCIPLLPR--
MMAR_2244|M.marinum_M SGLIVKSDLDFHAAIIGLLD-SPRVDRFFAAIEAEMLYALAILEASEGEY
MUL_1833|M.ulcerans_Agy99 SGLIVKSDLDFHAAIIGLLD-SPRVDRFFAAIEAEMLYALAILEASEGEY
TH_1959|M.thermoresistible__bu PVERQRHALRFWDHVVDGAD-SIAFRLMYNTLRATYEPALPALATMMA--
MAV_5020|M.avium_104 AETIAGLEFGFHRVFNQASG-RIKLAWFLLNAARYMPVLVYAADPQWG--
. .
MSMEG_2489|M.smegmatis_MC2_155 --VSDFRSEEHRAIAAAIKAGDRELTDELLIAHMDDALNRLIPPDGNGNG
MAB_4411c|M.abscessus_ATCC_199 --DLSEQVREHEVLCAAIGAGDAPAAYRLIDEHMHDAVTRLMARRDPGSV
Mb0505|M.bovis_AF2122/97 --DADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA-
Rv0494|M.tuberculosis_H37Rv --DADPVLTDLRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA-
Mflv_4061|M.gilvum_PYR-GCK --NIAHSDEQHEAIVSAILAGDADTAAQTMAAHVWGSAA-LLHGFLD---
Mvan_2282|M.vanbaalenii_PYR-1 --NIAHSDEQHEAIVMAILAGDADGAAQTMAAHVWGSAA-LLHGFLD---
MMAR_2244|M.marinum_M KTDAAKAFGEHKAMYEALRDRDEQRSTQLISEHLRINRDVLIRIVAS---
MUL_1833|M.ulcerans_Agy99 KTDAAKAFGEHKAMYEALRDRDEQRSTQLISEHLRINRDVLIRIVAS---
TH_1959|M.thermoresistible__bu --AEVGRPQAYRALAAAIEAGDPTAAEQSARDLLEPATAALLSALDELEA
MAV_5020|M.avium_104 ----RAAVDNHRQLIAALRRRDTAAVIEHTVWQFTDAAARLTAMRDRTGT
. : *: * . :
MSMEG_2489|M.smegmatis_MC2_155 DGSGKGKGKRKGNSDGGGKG
MAB_4411c|M.abscessus_ATCC_199 E-------------------
Mb0505|M.bovis_AF2122/97 --------------------
Rv0494|M.tuberculosis_H37Rv --------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------
MMAR_2244|M.marinum_M --------------------
MUL_1833|M.ulcerans_Agy99 --------------------
TH_1959|M.thermoresistible__bu QK------------------
MAV_5020|M.avium_104 PSNRG---------------