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LDVISEIENRLSDSSAKGLSQAVTRAIREGVLRPGDRLPPVRELAHQLALSPTTVSAAWALLVRAGTIQT AGRRGTIIMDLHTQRQVRYRNPANADRPYEFDLSTGAPDPRLLPDTTQAVQRALTGASRSGYTEGAVDPS LMEVLTATWPYEPPAITVVDGALDALDLLIRSRLRMGDRVIVETPTVRGLLDLLVWAGIEPVGVPMDEEG MVPEAFAAAMRTPTQMVFLQPRAHNPTGIAMTTPRARLLANIVKNTETLVVEDECGSAISAAREVTLGKL LPGQTVHVRSYSKSHGPDLRLAAMGGPEDVIAGIGHLRNLGQGWTSWLLQRVLRELLLDPRVTAQVEHAR AEYARRQTSFASVLAEHEIRTVGHDGLNAWVPVQDESAALMRMAVEGVGAAPGHLFTVGPGEKPHVRITV GLVTGDVEDVAERVVRAAHAGGWHSTVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2104 | - | - | 100% (449) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2323 | - | 2e-24 | 27.27% (451) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1043 | - | 2e-24 | 27.27% (451) | GntR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1183 | - | 3e-07 | 45.00% (60) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4275 | - | 4e-22 | 27.73% (458) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1152 | - | 3e-07 | 45.00% (60) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01794 | - | 3e-06 | 23.32% (373) | aminotransferase |
| M. abscessus ATCC 19977 | MAB_3387 | - | 2e-19 | 28.77% (424) | GntR family regulatory protein |
| M. marinum M | MMAR_2376 | - | 3e-58 | 34.67% (450) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 6e-60 | 35.76% (453) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2032 | - | 3e-06 | 24.86% (177) | PLP-dependent aminotransferases |
| M. ulcerans Agy99 | MUL_1552 | - | 8e-59 | 35.11% (450) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 7e-24 | 28.44% (436) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
MAV_3214|M.avium_104 --------------------------------------------MAVQKS
MSMEG_2104|M.smegmatis_MC2_155 ---------------------------------------MLDVISEIENR
Mb1183|M.bovis_AF2122/97 --------------------------------------MELRDWLRVDVK
Rv1152|M.tuberculosis_H37Rv --------------------------------------MELRDWLRVDVK
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
MAB_3387|M.abscessus_ATCC_1997 ----------------------------MPDRVVTAETLARHLGQWRTAG
TH_2032|M.thermoresistible__bu ---------------------------------------------MTVER
MLBr_01794|M.leprae_Br4923 -------------------------------------------------M
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MAV_3214|M.avium_104 ITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYR
MSMEG_2104|M.smegmatis_MC2_155 LSDSSAKGLSQAVTRAIREGVLRPGDRLPPVRELAHQLALSPTTVSAAWA
Mb1183|M.bovis_AF2122/97 AGKPLFDQLRTQVIDGVRAGALPPGTRLPTVRDLAGQLGVAANTVARAYR
Rv1152|M.tuberculosis_H37Rv AGKPLFDQLRTQVIDGVRAGALPPGTRLPTVRDLAGQLGVAANTVARAYR
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
MAB_3387|M.abscessus_ATCC_1997 SAGPAYGALADAIRLLVIDGRLPLGVRIPSERALASALHVSRTTVTTAYA
TH_2032|M.thermoresistible__bu LRPYATTIFAEMSALAARVGAVNLGQGFPDEDGPPAMLEIARDAIAEGMN
MLBr_01794|M.leprae_Br4923 TSNPLEQLTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHR
. : : .
MMAR_2376|M.marinum_M LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAG--ARDLSTGNPAP
MUL_1552|M.ulcerans_Agy99 LLRDRGTVETAGRRGTRVRDRPASTPRSSLDLGVPAG--ARDLSTGNPAP
MAV_3214|M.avium_104 LLRHRGAVETAGRRGTRVRHRPATTPRSLLGLDVPAG--VRDLSTGNPHP
MSMEG_2104|M.smegmatis_MC2_155 LLVRAGTIQTAGRRGTIIMDLHTQRQVRYRNPANADRPYEFDLSTGAPDP
Mb1183|M.bovis_AF2122/97 ELESAAIVETRGRFGTFISRFDP---------------------------
Rv1152|M.tuberculosis_H37Rv ELESAAIVETRGRFGTFISRFDP---------------------------
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLNARRGARSTTALP---LTPTPALRPVTATANLAAATLAAPAS
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLNARRGARSTTALP---LRPAAPAPLAPTGANLAAATLAAPAA
MAB_3387|M.abscessus_ATCC_1997 ELRESGYLRGRQGARSTTALPGPDRTGSATTGLMSPMVDLQNAATAAPAA
TH_2032|M.thermoresistible__bu QYPPGIGIAPLR--------------------------------------
MLBr_01794|M.leprae_Br4923 AVDNGDTGYPYG--------------------------------------
MMAR_2376|M.marinum_M ELLPLAAVG-WPDGS-VLPLLYGAPAMSAELVDYARAALAADG-VAADHL
MUL_1552|M.ulcerans_Agy99 ELLPLAAVG-WPDGS-VLPLLYGAPAMSAELVDYARAALAADG-VAADHL
MAV_3214|M.avium_104 ALLPLAAAAPARPAS-GRAVLYGEPAISPALAEYARAALSADG-VPADHL
MSMEG_2104|M.smegmatis_MC2_155 RLLPDTTQAVQRALTGASRSGYTEGAVDPSLMEVLTATWPYE----PPAI
Mb1183|M.bovis_AF2122/97 ----------------------TDAAMAAAAKEYVGVARALGL-TKSDAM
Rv1152|M.tuberculosis_H37Rv ----------------------TDAAMAAAAKEYVGVARALGL-TKSDAM
Mflv_4275|M.gilvum_PYR-GCK VTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARGLPTDVDEI
Mvan_2084|M.vanbaalenii_PYR-1 IAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTDPDEI
MAB_3387|M.abscessus_ATCC_1997 AVLEAYQAALTTLPTHLRGIGHELVGIPELRPRIAEHFSRRGLPTTEDQI
TH_2032|M.thermoresistible__bu ------------------------QAIAAQRERHYGVEYDPDT-----EV
MLBr_01794|M.leprae_Br4923 ------------------------TTFAEAISEFASQRWQWHD-LDVSRT
.
MMAR_2376|M.marinum_M AVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGV
MUL_1552|M.ulcerans_Agy99 AVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEPMGV
MAV_3214|M.avium_104 ALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEPVRV
MSMEG_2104|M.smegmatis_MC2_155 TVVDGALDALDLLIRSRLRMGDRVIVETPTVRGLLDLLVWAGIEPVGVPM
Mb1183|M.bovis_AF2122/97 RYLTHVPDD-----------------------------------------
Rv1152|M.tuberculosis_H37Rv RYLTHVPDD-----------------------------------------
Mflv_4275|M.gilvum_PYR-GCK MVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAAMASRGLRPVPVAM
Mvan_2084|M.vanbaalenii_PYR-1 MVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMASRGLRTVPVAM
MAB_3387|M.abscessus_ATCC_1997 MVTCGAQQAIALLLGAFVEPGDRVLVEQPTYHGALDAISQRGARPVPVPM
TH_2032|M.thermoresistible__bu LVTVGATEAIAGAVLGLVEPGSEVLLIEPFYDSYSPVIAMAGAHRVAVPL
MLBr_01794|M.leprae_Br4923 AIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLEAPL
.
MMAR_2376|M.marinum_M DDD-----GPLVADLQRALGRGVR---AVVVTSRAQNPTGAALSAARAEE
MUL_1552|M.ulcerans_Agy99 DDD-----GPLVADLQRALGRGVR---AVVVTSRAQNPTGAALSAARAEE
MAV_3214|M.avium_104 DDA-----GPLPEDLARALGRGAR---ALVLTTRAQNPTGAALSAERAAA
MSMEG_2104|M.smegmatis_MC2_155 DEE-----GMVPEAFAAAMRTPTQ---MVFLQPRAHNPTGIAMTTPRARL
Mb1183|M.bovis_AF2122/97 --------------------------------------------------
Rv1152|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK APD-----GWELDAVEAAIRQLAPE--LAYLIPDNQNPTGMTMPVGDRAR
Mvan_2084|M.vanbaalenii_PYR-1 APD-----GWELDAVEAAIRQLAPN--LAYLVPDNHNPTGMTLPVPERKR
MAB_3387|M.abscessus_ATCC_1997 HTHE-RDSGWDMTGMETTIRQTAPN--LAYLVLDNHNPTGLTMPLGQRKA
TH_2032|M.thermoresistible__bu VTDG-PGFAVDLDALRRAVTPRTR----AMIVNSPHNPTGMVLTEAELAG
MLBr_01794|M.leprae_Br4923 GRDGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSVHTVAELHG
MMAR_2376|M.marinum_M LREVLSQGAEEVLLVEDDHCAGIAGVP---LHTLAGATQ-HWAFVR---S
MUL_1552|M.ulcerans_Agy99 LREVLSQGAEEVLLVEDDHCAGIAGVP---LHTLAGATQ-HWAFVR---S
MAV_3214|M.avium_104 LRDLLSGRADDVLLVEDDHCAGISGAA---LHPVAGCTT-HWAFVR---S
MSMEG_2104|M.smegmatis_MC2_155 LANIVKN--TETLVVEDECGSAISAAR---EVTLGKLLPGQTVHVR---S
Mb1183|M.bovis_AF2122/97 --------------------------------------------------
Rv1152|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK LARIISETKTRTIIDETITDMWLDEQV---PPPLATEVTSRPDLVMTVGS
Mvan_2084|M.vanbaalenii_PYR-1 LAHIISDTRTRTIVDETITDMWLDEPV---PAPLAASMTGRRDLVLTVGS
MAB_3387|M.abscessus_ATCC_1997 LADIISQTRTRTVVDESLVGVWHQNHT---PAPMAALVS-RPELVVTIGS
TH_2032|M.thermoresistible__bu IAELAVSADLLVITDEVYEHLVYPSPAGRRHIPLASYPGMAERTVTISSA
MLBr_01794|M.leprae_Br4923 VAELARRFGVRVISDEIHAPLVLSGAR---FTPYLSIPGAENAFALMSAT
MMAR_2376|M.marinum_M AAKAYGPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFA--
MUL_1552|M.ulcerans_Agy99 AAKAYGPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLAVRLFA--
MAV_3214|M.avium_104 ASKAYGPDLRVAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLAVELWS--
MSMEG_2104|M.smegmatis_MC2_155 YSKSHGPDLRLAAMGGPEDVIAGIGHLRNLGQGWTSWLLQRVLRELLL--
Mb1183|M.bovis_AF2122/97 --------------------------------------------------
Rv1152|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK MSKSFWGGLRIGWIRAERSTLATIATLRPAIDMGTPIVEQLAAARLLAAD
Mvan_2084|M.vanbaalenii_PYR-1 MSKSFWGGLRIGWIRAERSTLATVAVQRPAVDMGTPIFEQLAAAKLLASE
MAB_3387|M.abscessus_ATCC_1997 MSKSFWGGMRVGWIRADRTTIARLAAVRSAMDTGTPILEQLAAAELLERA
TH_2032|M.thermoresistible__bu AKMFNCTGWKIGWACGPSDLIAGVRAAKQYLSYVGGAPFQPAVAHALDHE
MLBr_01794|M.leprae_Br4923 KGWNLCG-LKAAIAIAGREAAADLRRIPKEVSHGPSHLGIIAHTAAFRTG
MMAR_2376|M.marinum_M DDAATGLVRQAQERYADARGRLCAALSARGVAAHGRSGLNVWIP--VPDE
MUL_1552|M.ulcerans_Agy99 DDAATGLVRQAQERYADARGRLCAALSARGVAAHGRSGLNVWIP--VPDE
MAV_3214|M.avium_104 DTAASELVATAERRYADRRRRLCGALAERGVDAHGRSGLNVWVR--VPDE
MSMEG_2104|M.smegmatis_MC2_155 DPRVTAQVEHARAEYARRQTSFASVLAEHEIRTVGHDGLNAWVP--VQDE
Mb1183|M.bovis_AF2122/97 --------------------------------------------------
Rv1152|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK EEVLPERRDILRSRRALLLRLLAEHLPDWQPVP-GKGGMSVWVR--LPAP
Mvan_2084|M.vanbaalenii_PYR-1 DEVLPERREILRSRRALLLALLAEHLPDWRPAP-GKGGLSLWVR--LPAP
MAB_3387|M.abscessus_ATCC_1997 EEVEAAQRETLRARRALVVSELHRRLPEWELQE-ADGGLCIWAR--LPAP
TH_2032|M.thermoresistible__bu DAWVAALRDSLQSRRD----TLAAALTEIGFEVHDSAGTYFLCA--DPRP
MLBr_01794|M.leprae_Br4923 SSWLDALLQGLEANRALLRDLVTKHLPGVRYQRPQGTYLTWLDCRHLGFD
MMAR_2376|M.marinum_M T---AAITRLLNR--GWAAAPGARFRIRS--APGIRVTIAGLSAEEIEPL
MUL_1552|M.ulcerans_Agy99 T---AAITRLLNR--GWAAAPGARFRVRS--APGIRVTIAGLSAEEIEPL
MAV_3214|M.avium_104 A---VAVSRLLGA--GWAAAPGARFRMQT--PAGIRITIADLTPDEIEPL
MSMEG_2104|M.smegmatis_MC2_155 S---AALMRMAVE--GVGAAPGHLFTVGPGEKPHVRITVG-LVTGDVEDV
Mb1183|M.bovis_AF2122/97 --------------------------------------------------
Rv1152|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK M---SSALSAAASRMGLEIPPGPRFGVDGTLERFIRVPYTLPDAQLVEAI
Mvan_2084|M.vanbaalenii_PYR-1 M---SSALSAAASRMGLEIPPGPRFGVDGSLERFIRVPYTLPDGQLVEAI
MAB_3387|M.abscessus_ATCC_1997 M---STALAAAAARLGVRIAAGPRFGVGGSLERFVRLPFTQHDDQLLRGV
TH_2032|M.thermoresistible__bu LGYPDSTEFCAGLPERVGVAAIPMSAFCDPAAPHAEVWNHLVRFTFCKRP
MLBr_01794|M.leprae_Br4923 EQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGHVRVNFATSQ
MMAR_2376|M.marinum_M ADAIAEAIQRTGRPTV-------
MUL_1552|M.ulcerans_Agy99 ADAIAGAIQRTGRPTV-------
MAV_3214|M.avium_104 ADAVAQAVRPSGRPIV-------
MSMEG_2104|M.smegmatis_MC2_155 AERVVRAAHAGGWHSTVR-----
Mb1183|M.bovis_AF2122/97 -----------------------
Rv1152|M.tuberculosis_H37Rv -----------------------
Mflv_4275|M.gilvum_PYR-GCK ELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 ELLARAWRSVTGMTASEPTAVVV
MAB_3387|M.abscessus_ATCC_1997 ELLAQAWHTVTGALPLADSTMVG
TH_2032|M.thermoresistible__bu ETLEEGIRRLGALRRG-------
MLBr_01794|M.leprae_Br4923 AILIEALSRMGRALVNFR-----