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MPDRVVTAETLARHLGQWRTAGSAGPAYGALADAIRLLVIDGRLPLGVRIPSERALASALHVSRTTVTTA YAELRESGYLRGRQGARSTTALPGPDRTGSATTGLMSPMVDLQNAATAAPAAAVLEAYQAALTTLPTHLR GIGHELVGIPELRPRIAEHFSRRGLPTTEDQIMVTCGAQQAIALLLGAFVEPGDRVLVEQPTYHGALDAI SQRGARPVPVPMHTHERDSGWDMTGMETTIRQTAPNLAYLVLDNHNPTGLTMPLGQRKALADIISQTRTR TVVDESLVGVWHQNHTPAPMAALVSRPELVVTIGSMSKSFWGGMRVGWIRADRTTIARLAAVRSAMDTGT PILEQLAAAELLERAEEVEAAQRETLRARRALVVSELHRRLPEWELQEADGGLCIWARLPAPMSTALAAA AARLGVRIAAGPRFGVGGSLERFVRLPFTQHDDQLLRGVELLAQAWHTVTGALPLADSTMVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3387 | - | - | 100% (482) | GntR family regulatory protein |
| M. abscessus ATCC 19977 | MAB_0196c | - | 5e-23 | 27.67% (412) | GntR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0847c | - | 1e-20 | 28.81% (361) | aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3595 | aspB | 3e-20 | 28.45% (355) | aspartate aminotransferase |
| M. gilvum PYR-GCK | Mflv_4275 | - | 1e-147 | 54.91% (479) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3565 | aspB | 3e-20 | 28.45% (355) | aspartate aminotransferase |
| M. leprae Br4923 | MLBr_01488 | - | 1e-08 | 25.54% (368) | N-succinyldiaminopimelate aminotransferase |
| M. marinum M | MMAR_4678 | - | 7e-20 | 32.23% (242) | aminotransferase |
| M. avium 104 | MAV_0979 | - | 4e-20 | 28.96% (335) | aminotransferase |
| M. smegmatis MC2 155 | MSMEG_2323 | - | 1e-149 | 56.66% (473) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2032 | - | 2e-17 | 29.48% (251) | PLP-dependent aminotransferases |
| M. ulcerans Agy99 | MUL_0297 | - | 1e-19 | 31.82% (242) | aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 1e-146 | 56.36% (472) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4678|M.marinum_M ------------------------------------------MTVSRLQP
MUL_0297|M.ulcerans_Agy99 ------------------------------------------MTVSRLQP
MAV_0979|M.avium_104 ------------------------------------------MTVSRLRP
TH_2032|M.thermoresistible__bu ------------------------------------------MTVERLRP
Mb3595|M.bovis_AF2122/97 ------------------------------------------MTDRVALR
Rv3565|M.tuberculosis_H37Rv ------------------------------------------MTDRVALR
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
MSMEG_2323|M.smegmatis_MC2_155 ------------------------MSSPMVARSLDVDLLARELGNWRTSS
MAB_3387|M.abscessus_ATCC_1997 ----------------------------MPDRVVTAETLARHLGQWRTAG
MLBr_01488|M.leprae_Br4923 ------------------------------------------MSPFGRVS
:
MMAR_4678|M.marinum_M YATTVFAEMSALAARIG-------AVNLGQGFPDEDGPPAMLKAAQEAIA
MUL_0297|M.ulcerans_Agy99 YATTVFAEMSALAARIG-------AVNLGQGFPDEDGPPAMLKAAQEAIA
MAV_0979|M.avium_104 YATTVFAEMSALAARVE-------AVNLGQGFPDEDGPAEMLKAAQEAIA
TH_2032|M.thermoresistible__bu YATTIFAEMSALAARVG-------AVNLGQGFPDEDGPPAMLEIARDAIA
Mb3595|M.bovis_AF2122/97 AGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPEPVRAAAAAALH
Rv3565|M.tuberculosis_H37Rv AGVPPFYVMDVWLAAAERQRTHGDLVNLSAGQPSAGAPEPVRAAAAAALH
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDG----RLPVGARIPSERALSEALRVSRTTVT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDG----RLPVGARLPSERLLAEVLHVSRTTVT
MSMEG_2323|M.smegmatis_MC2_155 QTGPAYLGLADAIRLLIVDG----RLPVGSRLPSERALADALRVSRTTVT
MAB_3387|M.abscessus_ATCC_1997 SAGPAYGALADAIRLLVIDG----RLPLGVRIPSERALASALHVSRTTVT
MLBr_01488|M.leprae_Br4923 ATLPVFPWDTLADAKAVAESHPDGIVDLSVGTPVDPVAPLIQEALAAASS
. : : :. * :
MMAR_4678|M.marinum_M AGANQYPPG-----------------------------------------
MUL_0297|M.ulcerans_Agy99 AGANQYPPG-----------------------------------------
MAV_0979|M.avium_104 DGVNQYPPG-----------------------------------------
TH_2032|M.thermoresistible__bu EGMNQYPPG-----------------------------------------
Mb3595|M.bovis_AF2122/97 LNQLGYSVA-----------------------------------------
Rv3565|M.tuberculosis_H37Rv LNQLGYSVA-----------------------------------------
Mflv_4275|M.gilvum_PYR-GCK AAYTQLREDGYLNARRGARSTTALP---LTPTPALRPVTATANLAAATLA
Mvan_2084|M.vanbaalenii_PYR-1 AAYAQLRDDGYLNARRGARSTTALP---LRPAAPAPLAPTGANLAAATLA
MSMEG_2323|M.smegmatis_MC2_155 AAFSKLREDGYLHARRGARSTTALP---ARPEVRIEAAQASVNLAAAALA
MAB_3387|M.abscessus_ATCC_1997 TAYAELRESGYLRGRQGARSTTALPGPDRTGSATTGLMSPMVDLQNAATA
MLBr_01488|M.leprae_Br4923 VAGYPTTAG-----------------------------------------
MMAR_4678|M.marinum_M ----------------------------MGIPALRQAIAAQRRRRFGVEY
MUL_0297|M.ulcerans_Agy99 ----------------------------MGIPALRQAIAAQRRRRFGVEY
MAV_0979|M.avium_104 ----------------------------IGIAPLRHAIAAQRHRRYGIEY
TH_2032|M.thermoresistible__bu ----------------------------IGIAPLRQAIAAQRERHYGVEY
Mb3595|M.bovis_AF2122/97 ----------------------------LGIPELRDAIAADYQRRHGITV
Rv3565|M.tuberculosis_H37Rv ----------------------------LGIPELRDAIAADYQRRHGITV
Mflv_4275|M.gilvum_PYR-GCK APASVTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCAR-GLPT
Mvan_2084|M.vanbaalenii_PYR-1 APAAIAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCAR-GLPT
MSMEG_2323|M.smegmatis_MC2_155 APSTAVLDAFAEAAKDVTAYLQGPGHELMGAAPLREAIAERYCQR-GLPT
MAB_3387|M.abscessus_ATCC_1997 APAAAVLEAYQAALTTLPTHLRGIGHELVGIPELRPRIAEHFSRR-GLPT
MLBr_01488|M.leprae_Br4923 ------------------------------TARLREAAVAALDRRYGITG
** . : *:
MMAR_4678|M.marinum_M DPDTEVLVTVGATEAIAAAVLGL-VEPGSEVLLIEPFYDSYAPVIAMAGA
MUL_0297|M.ulcerans_Agy99 DPDTEVLVTVGATEAIAAAVRGL-VEPGSEVLLIEPFYDSYAPVIAMAGA
MAV_0979|M.avium_104 DPDTEVLVTVGATEAIASAVIGL-VEPGSEVLLIEPFYDSYSPVIAMASA
TH_2032|M.thermoresistible__bu DPDTEVLVTVGATEAIAGAVLGL-VEPGSEVLLIEPFYDSYSPVIAMAGA
Mb3595|M.bovis_AF2122/97 EPD-AVVITTGSSGGFLLAFLAC-FDAGDRVAMASPGYPCYRNILSALGC
Rv3565|M.tuberculosis_H37Rv EPD-AVVITTGSSGGFLLAFLAC-FDAGDRVAMASPGYPCYRNILSALGC
Mflv_4275|M.gilvum_PYR-GCK DVD-EIMVTTGALHAISLILATY-TQPDDRVLVEQPTYHGALAAMASRGL
Mvan_2084|M.vanbaalenii_PYR-1 DPD-EIMVTTGALHAIGLILATY-TQPDDRVLVEQPTYHGALAAMASRGL
MSMEG_2323|M.smegmatis_MC2_155 DPS-QIMVTSGAQHAIGLILTTH-TQPGDRVLVEQPTYHGALSAISTAGA
MAB_3387|M.abscessus_ATCC_1997 TED-QIMVTCGAQQAIALLLGAF-VEPGDRVLVEQPTYHGALDAISQRGA
MLBr_01488|M.leprae_Br4923 LTEAAVLPVIGTKELIAWLPTLLGLRAGDVVVVPELAYPTYNVGARLAGA
. :: . *: : ... * : . * .
MMAR_4678|M.marinum_M KRVAVPLVP--DGRGFALDADALRRAVTPKTRALIVNSPHNPTGAVLRRA
MUL_0297|M.ulcerans_Agy99 KRVAVPLVP--DGRGFALDADALRRAVTPKTRALIVNSPHNPTGAVLSRA
MAV_0979|M.avium_104 QRVAVPLVP--HGRGFALDADALRRAVTPRTRALIVNSPHNPTGTVLGAT
TH_2032|M.thermoresistible__bu HRVAVPLVT--DGPGFAVDLDALRRAVTPRTRAMIVNSPHNPTGMVLTEA
Mb3595|M.bovis_AF2122/97 EVVEIPCGP--QTR--FQPTAQMLAEIDPPLRGVVVASPANPTGTVIPPE
Rv3565|M.tuberculosis_H37Rv EVVEIPCGP--QTR--FQPTAQMLAEIDPPLRGVVVASPANPTGTVIPPE
Mflv_4275|M.gilvum_PYR-GCK RPVPVAMA----PDGWELDAVEAAIRQLAPELAYLIPDNQNPTGMTMPVG
Mvan_2084|M.vanbaalenii_PYR-1 RTVPVAMA----PDGWELDAVEAAIRQLAPNLAYLVPDNHNPTGMTLPVP
MSMEG_2323|M.smegmatis_MC2_155 RAVPVALT----DAGWELDAFHAAIRQLAPSLAYVIPDNHNPTGFTMAPD
MAB_3387|M.abscessus_ATCC_1997 RPVPVPMHTHERDSGWDMTGMETTIRQTAPNLAYLVLDNHNPTGLTMPLG
MLBr_01488|M.leprae_Br4923 R---------------VLRADSLTQLGLQSPALFYLNSPSNPTGQVLAVN
. : . **** .:
MMAR_4678|M.marinum_M ELAAIAEIAVAADLLVITDEVYEHLVFTSPTGHQHLPLAGFDGMAQR-TV
MUL_0297|M.ulcerans_Agy99 ELAAIAEIAVAADLLVITDEVYEHLVFTSPTGHQHLPLAGFDGMAQR-TV
MAV_0979|M.avium_104 ELAAIAEVAVESDLLVITDEVYEHLVFDD---HRHLPLAGFDGMAER-TI
TH_2032|M.thermoresistible__bu ELAGIAELAVSADLLVITDEVYEHLVYPSPAGRRHIPLASYPGMAER-TV
Mb3595|M.bovis_AF2122/97 ELAAIASWCDASDVRLISDEVYHGLVYQG------APQTSCAWQTSRNAV
Rv3565|M.tuberculosis_H37Rv ELAAIASWCDASDVRLISDEVYHGLVYQG------APQTSCAWQTSRNAV
Mflv_4275|M.gilvum_PYR-GCK DRARLARIISETKTRTIIDETITDMWLDEQV---PPPLATEVTSRPDLVM
Mvan_2084|M.vanbaalenii_PYR-1 ERKRLAHIISDTRTRTIVDETITDMWLDEPV---PAPLAASMTGRRDLVL
MSMEG_2323|M.smegmatis_MC2_155 DRKRLGQIISDTRTRTIIDESIADMWVDHAP---PEPLAASVG-RHDLVL
MAB_3387|M.abscessus_ATCC_1997 QRKALADIISQTRTRTVVDESLVGVWHQNHT---PAPMAALVS-RPELVV
MLBr_01488|M.leprae_Br4923 HLRKMVGWARNRGVVVVSDECYLGLGWDAEP--FSVLHPLVCDGNHTGLL
. : : ** : . :
MMAR_4678|M.marinum_M TISSAAKMFNCTGWKIGWACGPQELIAGVRAAKQYMSYVGGAPLQPAVAL
MUL_0297|M.ulcerans_Agy99 TISSAAKMFNCTGWKIGWACGLKELIAGVRAAKQYMSYVGGAPLQPAVAL
MAV_0979|M.avium_104 TISSAAKMFNCTGWKIGWACGPAHLIAGVRAAKQYLSYVGGAPFQPAVAL
TH_2032|M.thermoresistible__bu TISSAAKMFNCTGWKIGWACGPSDLIAGVRAAKQYLSYVGGAPFQPAVAH
Mb3595|M.bovis_AF2122/97 VVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVS
Rv3565|M.tuberculosis_H37Rv VVNSFSKYYAMTGWRLGWLLVPTVLRRAVDCLTGNFTICPPVLSQIAAVS
Mflv_4275|M.gilvum_PYR-GCK TVGSMSKSFWG-GLRIGWIRAERSTLATIATLRPAIDMGTPIVEQLAAAR
Mvan_2084|M.vanbaalenii_PYR-1 TVGSMSKSFWG-GLRIGWIRAERSTLATVAVQRPAVDMGTPIFEQLAAAK
MSMEG_2323|M.smegmatis_MC2_155 TIGSMSKSFWG-GLRVGWIRAERSTLATIAAIRPSVDLGTPVLEQLTAAR
MAB_3387|M.abscessus_ATCC_1997 TIGSMSKSFWG-GMRVGWIRADRTTIARLAAVRSAMDTGTPILEQLAAAE
MLBr_01488|M.leprae_Br4923 AVHSLSKSSSLAGYRAGFVAGDPDLVAELLAVRKHAGMMVPTPVQAAMVA
.: * :* * : *: : * : .
MMAR_4678|M.marinum_M ALDSED-AWVAALRTSLQARRDRLAAGLSEIGFG--VHDSHGTYFLCADP
MUL_0297|M.ulcerans_Agy99 ALDSED-AWVVALRTSLQARRDRLAAGLSEIGFG--VHDSHGTYFLCADP
MAV_0979|M.avium_104 ALETQD-AWVADLRDRLRARRDRLAAGLIDIGFE--VHDSAGTYFLCADP
TH_2032|M.thermoresistible__bu ALDHED-AWVAALRDSLQSRRDTLAAALTEIGFE--VHDSAGTYFLCADP
Mb3595|M.bovis_AF2122/97 AFTPEATAEADGNLASYAINRSLLLDGLRRIGIDR-LAPTDGAFYVYADV
Rv3565|M.tuberculosis_H37Rv AFTPEATAEADGNLASYAINRSLLLDGLRRIGIDR-LAPTDGAFYVYADV
Mflv_4275|M.gilvum_PYR-GCK LLAADE-EVLPERRDILRSRRALLLRLLAEHLPDWQPVPGKGGMSVWVRL
Mvan_2084|M.vanbaalenii_PYR-1 LLASED-EVLPERREILRSRRALLLALLAEHLPDWRPAPGKGGLSLWVRL
MSMEG_2323|M.smegmatis_MC2_155 LLAMRE-QILRERRELLRTRRQALVSLLAEHLPDWQPGPGRGGMSLWVRL
MAB_3387|M.abscessus_ATCC_1997 LLERAE-EVEAAQRETLRARRALVVSELHRRLPEWELQEADGGLCIWARL
MLBr_01488|M.leprae_Br4923 ALGDDA--HEREQRDRYARRRDVLLPAVVSAGFT--VDHSEAGLYLWASR
: .* : : . : .
MMAR_4678|M.marinum_M RPLGYDDSTAFCAALPEKVGVAAIPMSAFCDPVAEHASTQADIWNHLVRF
MUL_0297|M.ulcerans_Agy99 RPLGYDDSTAFCAALPERVGVAAIPMSAFCDPVAEHAPTQADIWNHLVRF
MAV_0979|M.avium_104 RPLGYDDSVAFCAALPEKVGVAAIPLSPFCDPAGAHGP--ADVWNHLVRF
TH_2032|M.thermoresistible__bu RPLGYPDSTEFCAGLPERVGVAAIPMSAFCDPAAPHAE----VWNHLVRF
Mb3595|M.bovis_AF2122/97 SDFTS-DSLAFCSKLLADTGVAIAPGIDFDTARG----------GSFVRI
Rv3565|M.tuberculosis_H37Rv SDFTS-DSLAFCSKLLADTGVAIAPGIDFDTARG----------GSFVRI
Mflv_4275|M.gilvum_PYR-GCK P----APMSSALSAAASRMGLEIPPGPRFGVDGT---------LERFIRV
Mvan_2084|M.vanbaalenii_PYR-1 P----APMSSALSAAASRMGLEIPPGPRFGVDGS---------LERFIRV
MSMEG_2323|M.smegmatis_MC2_155 P----APMSTALAAAASRMGVDLPAGPRFGVDGT---------LERFVRV
MAB_3387|M.abscessus_ATCC_1997 P----APMSTALAAAAARLGVRIAAGPRFGVGGS---------LERFVRL
MLBr_01488|M.leprae_Br4923 G-----EPCRDSVEWFAQRGILVALGEFYGPGGC-----------QHVRV
*: : :*.
MMAR_4678|M.marinum_M TFCKREDTLDEAIKRLAALRDAA-------------
MUL_0297|M.ulcerans_Agy99 TFCKREDTLDEAIKRLAALRDAA-------------
MAV_0979|M.avium_104 TFCKRDDTLDEAIRRLAALRGTG-------------
TH_2032|M.thermoresistible__bu TFCKRPETLEEGIRRLGALRRG--------------
Mb3595|M.bovis_AF2122/97 SFAGPSGDIEEALRRIGSWLPSQ-------------
Rv3565|M.tuberculosis_H37Rv SFAGPSGDIEEALRRIGSWLPSQ-------------
Mflv_4275|M.gilvum_PYR-GCK PYTLPDAQLVEAIELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 PYTLPDGQLVEAIELLARAWRSVTGMTASEPTAVVV
MSMEG_2323|M.smegmatis_MC2_155 PYALPEPQLAEAVELLARAWHSITGTIGPQSQALVV
MAB_3387|M.abscessus_ATCC_1997 PFTQHDDQLLRGVELLAQAWHTVTGALPLADSTMVG
MLBr_01488|M.leprae_Br4923 ALTASDERIAAVVARLS-------------------
. : : :.