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SSPMVARSLDVDLLARELGNWRTSSQTGPAYLGLADAIRLLIVDGRLPVGSRLPSERALADALRVSRTTV TAAFSKLREDGYLHARRGARSTTALPARPEVRIEAAQASVNLAAAALAAPSTAVLDAFAEAAKDVTAYLQ GPGHELMGAAPLREAIAERYCQRGLPTDPSQIMVTSGAQHAIGLILTTHTQPGDRVLVEQPTYHGALSAI STAGARAVPVALTDAGWELDAFHAAIRQLAPSLAYVIPDNHNPTGFTMAPDDRKRLGQIISDTRTRTIID ESIADMWVDHAPPEPLAASVGRHDLVLTIGSMSKSFWGGLRVGWIRAERSTLATIAAIRPSVDLGTPVLE QLTAARLLAMREQILRERRELLRTRRQALVSLLAEHLPDWQPGPGRGGMSLWVRLPAPMSTALAAAASRM GVDLPAGPRFGVDGTLERFVRVPYALPEPQLAEAVELLARAWHSITGTIGPQSQALVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2323 | - | - | 100% (479) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1043 | - | 0.0 | 100.00% (479) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_1572 | - | 4e-34 | 30.88% (421) | transcriptional regulator, GntR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0881c | - | 2e-19 | 31.15% (260) | aminotransferase |
| M. gilvum PYR-GCK | Mflv_4275 | - | 0.0 | 70.00% (480) | GntR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0858c | - | 2e-19 | 31.15% (260) | aminotransferase |
| M. leprae Br4923 | MLBr_01794 | - | 1e-08 | 23.80% (332) | aminotransferase |
| M. abscessus ATCC 19977 | MAB_3387 | - | 1e-149 | 56.66% (473) | GntR family regulatory protein |
| M. marinum M | MMAR_2376 | - | 3e-16 | 24.51% (408) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3214 | - | 8e-21 | 27.67% (430) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2032 | - | 2e-16 | 28.15% (270) | PLP-dependent aminotransferases |
| M. ulcerans Agy99 | MUL_1552 | - | 1e-16 | 24.75% (408) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2084 | - | 0.0 | 70.62% (480) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4275|M.gilvum_PYR-GCK ------------------------MTEALATRSLNVDLLARELGNWRTSS
Mvan_2084|M.vanbaalenii_PYR-1 MRHVANNLAHLACLSISSSAILASMTEAMVARSLDVDLLVRELGNWRTSS
MSMEG_2323|M.smegmatis_MC2_155 ------------------------MSSPMVARSLDVDLLARELGNWRTSS
MAB_3387|M.abscessus_ATCC_1997 ----------------------------MPDRVVTAETLARHLGQWRTAG
MMAR_2376|M.marinum_M --------------------------------------------MPVQYR
MUL_1552|M.ulcerans_Agy99 --------------------------------------------MPVQNR
MAV_3214|M.avium_104 --------------------------------------------MAVQKS
Mb0881c|M.bovis_AF2122/97 ---------------------------------------------MTVSR
Rv0858c|M.tuberculosis_H37Rv ---------------------------------------------MTVSR
TH_2032|M.thermoresistible__bu ---------------------------------------------MTVER
MLBr_01794|M.leprae_Br4923 ------------------------------------------MTSNPLEQ
Mflv_4275|M.gilvum_PYR-GCK RSGPAYHGLADAIRLLIVDGRLPVGARIPSERALSEALRVSRTTVTAAYT
Mvan_2084|M.vanbaalenii_PYR-1 RSGPAYHGLADAIRLLIIDGRLPVGARLPSERLLAEVLHVSRTTVTAAYA
MSMEG_2323|M.smegmatis_MC2_155 QTGPAYLGLADAIRLLIVDGRLPVGSRLPSERALADALRVSRTTVTAAFS
MAB_3387|M.abscessus_ATCC_1997 SAGPAYGALADAIRLLVIDGRLPLGVRIPSERALASALHVSRTTVTTAYA
MMAR_2376|M.marinum_M IAGGGAESIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MUL_1552|M.ulcerans_Agy99 IAGGGAGSIAASIESAISQGGLAPGDALPSIREVAGQLGVNPNTVAAAYR
MAV_3214|M.avium_104 ITGTGAESIAASIEAAISAGSLAPGDALPPVRELAARLGVNANTAAAAYR
Mb0881c|M.bovis_AF2122/97 LRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVN
Rv0858c|M.tuberculosis_H37Rv LRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVN
TH_2032|M.thermoresistible__bu LRPYATTIFAEMSALAARVGAVNLGQGFPDEDGPPAMLEIARDAIAEGMN
MLBr_01794|M.leprae_Br4923 LTIEQLQCRTSMKWRAHPEDVLPLWVAEMDVLLAPTVAEAVHRAVDNGDT
: . : . : .
Mflv_4275|M.gilvum_PYR-GCK QLREDGYLNARRGARSTTALP---LTPTPALRPVTATANLAAATLAAPAS
Mvan_2084|M.vanbaalenii_PYR-1 QLRDDGYLNARRGARSTTALP---LRPAAPAPLAPTGANLAAATLAAPAA
MSMEG_2323|M.smegmatis_MC2_155 KLREDGYLHARRGARSTTALP---ARPEVRIEAAQASVNLAAAALAAPST
MAB_3387|M.abscessus_ATCC_1997 ELRESGYLRGRQGARSTTALPGPDRTGSATTGLMSPMVDLQNAATAAPAA
MMAR_2376|M.marinum_M LLRDRGTVET-AGRRGTRVRD-----RPASTPRSSLDLGVPAGARDLSTG
MUL_1552|M.ulcerans_Agy99 LLRDRGTVET-AGRRGTRVRD-----RPASTPRSSLDLGVPAGARDLSTG
MAV_3214|M.avium_104 LLRHRGAVET-AGRRGTRVRH-----RPATTPRSLLGLDVPAGVRDLSTG
Mb0881c|M.bovis_AF2122/97 QYPPG---------------------------------------------
Rv0858c|M.tuberculosis_H37Rv QYPPG---------------------------------------------
TH_2032|M.thermoresistible__bu QYPPG---------------------------------------------
MLBr_01794|M.leprae_Br4923 GYPYG---------------------------------------------
Mflv_4275|M.gilvum_PYR-GCK VTARAFTEAADMVAPYLQEIGIELTGVPPLRAAIAERYCARGLPTD---V
Mvan_2084|M.vanbaalenii_PYR-1 IAARAFAEAAEEVTPYLHQIGVELTGVLPLRTAIAEKYCARGLPTD---P
MSMEG_2323|M.smegmatis_MC2_155 AVLDAFAEAAKDVTAYLQGPGHELMGAAPLREAIAERYCQRGLPTD---P
MAB_3387|M.abscessus_ATCC_1997 AVLEAYQAALTTLPTHLRGIGHELVGIPELRPRIAEHFSRRGLPTT---E
MMAR_2376|M.marinum_M NPAPELLPLAAVG-WPDGSVLPLLYGAPAMSAELVD-YARAALAADGVAA
MUL_1552|M.ulcerans_Agy99 NPAPELLPLAAVG-WPDGSVLPLLYGAPAMSAELVD-YARAALAADGVAA
MAV_3214|M.avium_104 NPHPALLPLAAAAPARPASGRAVLYGEPAISPALAE-YARAALSADGVPA
Mb0881c|M.bovis_AF2122/97 ------------------------PGSAPLRRAIAA-QRRRHFGVDYDPE
Rv0858c|M.tuberculosis_H37Rv ------------------------PGSAPLRRAIAA-QRRRHFGVDYDPE
TH_2032|M.thermoresistible__bu ------------------------IGIAPLRQAIAA-QRERHYGVEYDPD
MLBr_01794|M.leprae_Br4923 ---------------------------TTFAEAISEFASQR-WQWHDLDV
: :
Mflv_4275|M.gilvum_PYR-GCK DEIMVTTGALHAISLILATYTQPDDRVLVEQPTYHGALAAMASRGLRPVP
Mvan_2084|M.vanbaalenii_PYR-1 DEIMVTTGALHAIGLILATYTQPDDRVLVEQPTYHGALAAMASRGLRTVP
MSMEG_2323|M.smegmatis_MC2_155 SQIMVTSGAQHAIGLILTTHTQPGDRVLVEQPTYHGALSAISTAGARAVP
MAB_3387|M.abscessus_ATCC_1997 DQIMVTCGAQQAIALLLGAFVEPGDRVLVEQPTYHGALDAISQRGARPVP
MMAR_2376|M.marinum_M DHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEP
MUL_1552|M.ulcerans_Agy99 DHLAVTNGALDGIERALSANLRPGDRVAVEDPGWANLLDLLAALGLPVEP
MAV_3214|M.avium_104 DHLALTSGALDGIERALTAHLRPGDRVAVEDPGWANLLDLLAALGFSAEP
Mb0881c|M.bovis_AF2122/97 TEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVT
Rv0858c|M.tuberculosis_H37Rv TEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVT
TH_2032|M.thermoresistible__bu TEVLVTVGATEAIAGAVLGLVEPGSEVLLIEPFYDSYSPVIAMAGAHRVA
MLBr_01794|M.leprae_Br4923 SRTAIVPDVMLGVVEMLRLITDRGDGVIVSPPVYPPFYAFVTHDGRRVLE
. :. .. .: : .. * : * : :: *
Mflv_4275|M.gilvum_PYR-GCK VAMA----PDGWELDAVEAAIRQLAP------ELAYLIPDNQNPTGMTMP
Mvan_2084|M.vanbaalenii_PYR-1 VAMA----PDGWELDAVEAAIRQLAP------NLAYLVPDNHNPTGMTLP
MSMEG_2323|M.smegmatis_MC2_155 VALT----DAGWELDAFHAAIRQLAP------SLAYVIPDNHNPTGFTMA
MAB_3387|M.abscessus_ATCC_1997 VPMHTHERDSGWDMTGMETTIRQTAP------NLAYLVLDNHNPTGLTMP
MMAR_2376|M.marinum_M MGVD----DDGPLVADLQRALGRGVR------AVVVTSR-AQNPTGAALS
MUL_1552|M.ulcerans_Agy99 MGVD----DDGPLVADLQRALGRGVR------AVVVTSR-AQNPTGAALS
MAV_3214|M.avium_104 VRVD----DAGPLPEDLARALGRGAR------ALVLTTR-AQNPTGAALS
Mb0881c|M.bovis_AF2122/97 VPLVPDGRGFALDADALRRAVTPRTR------ALIINSP--HNPTGAVLS
Rv0858c|M.tuberculosis_H37Rv VPLVPDGRGFALDADALRRAVTPRTR------ALIINSP--HNPTGAVLS
TH_2032|M.thermoresistible__bu VPLVTDGPGFAVDLDALRRAVTPRTR------AMIVNSP--HNPTGMVLT
MLBr_01794|M.leprae_Br4923 APLG---RDGRLDLAALQDAFSRARRSSGPNGKVAYLLCNPHNPTGSVHT
: . :. : :**** . .
Mflv_4275|M.gilvum_PYR-GCK VGDRARLARIISETKTRTIIDETITDMWLDE---QVPPPLATEVTSRPDL
Mvan_2084|M.vanbaalenii_PYR-1 VPERKRLAHIISDTRTRTIVDETITDMWLDE---PVPAPLAASMTGRRDL
MSMEG_2323|M.smegmatis_MC2_155 PDDRKRLGQIISDTRTRTIIDESIADMWVDH---APPEPLAASVG-RHDL
MAB_3387|M.abscessus_ATCC_1997 LGQRKALADIISQTRTRTVVDESLVGVWHQN---HTPAPMAALVS-RPEL
MMAR_2376|M.marinum_M AARAEELREVLSQGAEEVLLVEDDHCAGIAG---VPLHTLAGATQ----H
MUL_1552|M.ulcerans_Agy99 AARAEELREVLSQGAEEVLLVEDDHCAGIAG---VPLHTLAGATQ----H
MAV_3214|M.avium_104 AERAAALRDLLSGRADDVLLVEDDHCAGISG---AALHPVAGCTT----H
Mb0881c|M.bovis_AF2122/97 ATELAAIAEIAVAANLVVITDEVYEHLVFDH---ARHLPLAGFDG-MAER
Rv0858c|M.tuberculosis_H37Rv ATELAAIAEIAVAANLVVITDEVYEHLVFDH---ARHLPLAGFDG-MAER
TH_2032|M.thermoresistible__bu EAELAGIAELAVSADLLVITDEVYEHLVYPSPAGRRHIPLASYPG-MAER
MLBr_01794|M.leprae_Br4923 VAELHGVAELARRFGVRVISDEIHAPLVLSG---ARFTPYLSIPG--AEN
: : .: * .
Mflv_4275|M.gilvum_PYR-GCK VMTVGSMSKSF-WGGLRIGWIRAERSTLATIA-TLRPAIDMGTPIVEQLA
Mvan_2084|M.vanbaalenii_PYR-1 VLTVGSMSKSF-WGGLRIGWIRAERSTLATVA-VQRPAVDMGTPIFEQLA
MSMEG_2323|M.smegmatis_MC2_155 VLTIGSMSKSF-WGGLRVGWIRAERSTLATIA-AIRPSVDLGTPVLEQLT
MAB_3387|M.abscessus_ATCC_1997 VVTIGSMSKSF-WGGMRVGWIRADRTTIARLA-AVRSAMDTGTPILEQLA
MMAR_2376|M.marinum_M WAFVRSAAKAY-GPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLA
MUL_1552|M.ulcerans_Agy99 WAFVRSAAKAY-GPDLRLAVLAGDQRTVERVHGRLRLGPGWVSHILQDLA
MAV_3214|M.avium_104 WAFVRSASKAY-GPDLRVAVLAGDQRTVDRVHGRLRLGPGWVSHVLQQLA
Mb0881c|M.bovis_AF2122/97 TITISSAAKMFNCTGWKIGWACGPAELIAGVR-AAKQYLSYVGGAPFQPA
Rv0858c|M.tuberculosis_H37Rv TITISSAAKMFNCTGWKIGWACGPAELIAGVR-AAKQYLSYVGGAPFQPA
TH_2032|M.thermoresistible__bu TVTISSAAKMFNCTGWKIGWACGPSDLIAGVR-AAKQYLSYVGGAPFQPA
MLBr_01794|M.leprae_Br4923 AFALMSATKGWNLCGLKAAIAIAGREAAADLR-RIPKEVSHGPSHLGIIA
: * :* : . : . . : . :
Mflv_4275|M.gilvum_PYR-GCK AARLLAADE-EVLPERRDILRSRRALLLRLLAEHLP--DWQPVPGKGGMS
Mvan_2084|M.vanbaalenii_PYR-1 AAKLLASED-EVLPERREILRSRRALLLALLAEHLP--DWRPAPGKGGLS
MSMEG_2323|M.smegmatis_MC2_155 AARLLAMRE-QILRERRELLRTRRQALVSLLAEHLP--DWQPGPGRGGMS
MAB_3387|M.abscessus_ATCC_1997 AAELLERAE-EVEAAQRETLRARRALVVSELHRRLP--EWELQEADGGLC
MMAR_2376|M.marinum_M VRLFADDAATGLVRQAQERYADARGRLCAALSARG-----VAAHGRSGLN
MUL_1552|M.ulcerans_Agy99 VRLFADDAATGLVRQAQERYADARGRLCAALSARG-----VAAHGRSGLN
MAV_3214|M.avium_104 VELWSDTAASELVATAERRYADRRRRLCGALAERG-----VDAHGRSGLN
Mb0881c|M.bovis_AF2122/97 VALALDTED-AWVAALRNSLRARRDRLAAGLTEIGF--AVHDSYGTYFLC
Rv0858c|M.tuberculosis_H37Rv VALALDTED-AWVAALRNSLRARRDRLAAGLTEIGF--AVHDSYGTYFLC
TH_2032|M.thermoresistible__bu VAHALDHED-AWVAALRDSLQSRRDTLAAALTEIGF--EVHDSAGTYFLC
MLBr_01794|M.leprae_Br4923 HTAAFRTGS-SWLDALLQGLEANRALLRDLVTKHLPGVRYQRPQGTYLTW
* : : .
Mflv_4275|M.gilvum_PYR-GCK VWVRLP--APMSSALSAAASRMGLEIPPGPRFG--VDGTLERFIRVPYTL
Mvan_2084|M.vanbaalenii_PYR-1 LWVRLP--APMSSALSAAASRMGLEIPPGPRFG--VDGSLERFIRVPYTL
MSMEG_2323|M.smegmatis_MC2_155 LWVRLP--APMSTALAAAASRMGVDLPAGPRFG--VDGTLERFVRVPYAL
MAB_3387|M.abscessus_ATCC_1997 IWARLP--APMSTALAAAAARLGVRIAAGPRFG--VGGSLERFVRLPFTQ
MMAR_2376|M.marinum_M VWIPVP--DETAAITRLLNR--GWAAAPGARFR--IRSAPG--IRVTIAG
MUL_1552|M.ulcerans_Agy99 VWIPVP--DETAAITRLLNR--GWAAAPGARFR--VRSAPG--IRVTIAG
MAV_3214|M.avium_104 VWVRVP--DEAVAVSRLLGA--GWAAAPGARFR--MQTPAG--IRITIAD
Mb0881c|M.bovis_AF2122/97 ADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
Rv0858c|M.tuberculosis_H37Rv ADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHL
TH_2032|M.thermoresistible__bu ADPRPLGYPDSTEFCAGLPERVGVAAIPMSAFCDPAA----PHAEVWNHL
MLBr_01794|M.leprae_Br4923 LDCRHLGFDEQINEGLAAISDLSGPARWFLDHSRVALTSGHAFGTGGVGH
. .
Mflv_4275|M.gilvum_PYR-GCK PDAQLVEAIELLARAWRSVTGLTAPEPATVVV
Mvan_2084|M.vanbaalenii_PYR-1 PDGQLVEAIELLARAWRSVTGMTASEPTAVVV
MSMEG_2323|M.smegmatis_MC2_155 PEPQLAEAVELLARAWHSITGTIGPQSQALVV
MAB_3387|M.abscessus_ATCC_1997 HDDQLLRGVELLAQAWHTVTGALPLADSTMVG
MMAR_2376|M.marinum_M LS---AEEIEPLADAIAEAIQRTGRPTV----
MUL_1552|M.ulcerans_Agy99 LS---AEEIEPLADAIAGAIQRTGRPTV----
MAV_3214|M.avium_104 LT---PDEIEPLADAVAQAVRPSGRPIV----
Mb0881c|M.bovis_AF2122/97 VRFTFCKRDDTLDEAIRRLSVLAERPAT----
Rv0858c|M.tuberculosis_H37Rv VRFTFCKRDDTLDEAIRRLSVLAERPAT----
TH_2032|M.thermoresistible__bu VRFTFCKRPETLEEGIRRLGALRRG-------
MLBr_01794|M.leprae_Br4923 VRVNFATSQAILIEALSRMGRALVNFR-----
* .