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RTWFITGGTPGGFGMAFADAALDAGDRVALTVRRPEELDGWAREHGDRVLVVPLDVTDPEQVRVAVKATE ERFGGIDVLVNNAGRAWAGTVEGMDESELRAMFELNFFAVLSVLRAALPGMRARRGGWIVNVSSVAGLRG VTGFGHYSATKFAVEAITGVLRDEVAPWGINVMAVEPAAFRTRAYSGFADEPLREPVSEYRALLQGVREA MIAQDGMQPGDPRRGARAVLAAMAQDPPPHRLVLGGDGFDAVKAELEAALAELHENETLSRGADFPH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3508 | - | - | 100% (278) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0982 | - | 1e-42 | 38.17% (262) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5466 | - | 9e-39 | 36.96% (276) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 1e-23 | 33.33% (249) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0930 | - | 1e-108 | 68.48% (276) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1050 | - | 1e-23 | 33.33% (249) | oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-18 | 30.60% (183) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3405 | - | 7e-26 | 39.38% (193) | short chain dehydrogenase |
| M. marinum M | MMAR_1614 | - | 5e-51 | 40.00% (275) | short chain dehydrogenase |
| M. avium 104 | MAV_3827 | - | 6e-55 | 43.53% (278) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3302 | - | 8e-51 | 41.30% (276) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 4e-43 | 39.47% (266) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 2e-51 | 40.00% (275) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3508|M.vanbaalenii_PYR-1 -------MRTWFITGGTPGGFGMAFADAALDAGDRVALTVRRPEELDGWA
Mflv_0930|M.gilvum_PYR-GCK ------MSKRWFVTGGTPGGFGVAFAEAALEAGDRVVITSRRPHELAAWA
MMAR_1614|M.marinum_M -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLV
MUL_3423|M.ulcerans_Agy99 -------MSTWLITGCSTG-LGRALAEAVIDAGHHTVATARSVGGVADLA
MAV_3827|M.avium_104 -------MARWLITGCSTG-LGREIAGAALQAGHRVVVTARRADAVRGFA
MSMEG_3302|M.smegmatis_MC2_155 ---MAHETRTWFITGSSRG-FGRALVKAALDAGDNVAATARKPGQLADFA
TH_3670|M.thermoresistible__bu MGSNVWGSKVWFITGASRG-FGREWAIAALDRGDRVAATARDVSTLDDLR
Mb1079|M.bovis_AF2122/97 MARQRFRDQVVLITGASSG-IGEATAKAFAREGAVVALAARREGALRRVA
Rv1050|M.tuberculosis_H37Rv MARQRFRDQVVLITGASSG-IGEATAKAFAREGAVVALAARREGALRRVA
MAB_3405|M.abscessus_ATCC_1997 --MDKITGKNIAITGAARG-IGYATATALLRRGARVVIGDRDVEALGSAV
MLBr_01094|M.leprae_Br4923 --MEGFAGKVAVVTGAGSG-IGQALAIELARSGAKLAISDVDGEGLAQTE
:** * :* . * . :
Mvan_3508|M.vanbaalenii_PYR-1 ---REHGDRVLVVPLDVTDPEQVRVAVKATEERFGGIDVLVNNAGRAWAG
Mflv_0930|M.gilvum_PYR-GCK ---DGYDDRVLVVPLELTDAAQVQRVVQAAEEHFGGIDVLVNNAGRGWYG
MMAR_1614|M.marinum_M ---QRSPERVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAGYGYRA
MUL_3423|M.ulcerans_Agy99 ---QRSPERVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAGYGYRA
MAV_3827|M.avium_104 ---EEFGELALPVALDVTDRDQIAAAVAAADAAFGGIDVLVNNAGHGYLS
MSMEG_3302|M.smegmatis_MC2_155 ---ETYGDRVLALPLDVTDPSAARTAVATAREAFGRIDIVVNNAGYANVA
TH_3670|M.thermoresistible__bu ---DRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAGYGHFG
Mb1079|M.bovis_AF2122/97 REIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVG
Rv1050|M.tuberculosis_H37Rv REIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVG
MAB_3405|M.abscessus_ATCC_1997 EGLKEEGN-VDAHPLDVTDPASFKRFLEAASAG-GPIDVLVNNAGVMPIG
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAGIAFTG
. *:::. . * :: : **** .
Mvan_3508|M.vanbaalenii_PYR-1 TVEGMD-ESELRAMFELNFFAVLSVLRAALPGMRARRGGWIVNVSSVAG-
Mflv_0930|M.gilvum_PYR-GCK SIEGMD-ESSLRAMFELNFFAVLSVTRAVLPGMRARGSGWIVNVSSVAG-
MMAR_1614|M.marinum_M AVEEGD-DAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAV-
MUL_3423|M.ulcerans_Agy99 AVEEGD-DAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNISSIAV-
MAV_3827|M.avium_104 AVEEGE-DAEVRKLFDVNYFGAVDMIKAVLPGMRARGCGHIVNISSMTG-
MSMEG_3302|M.smegmatis_MC2_155 PIETGD-DEDFRTQFETNFWGVYNVSKAALPVLREQRGGLIIQFSSMGGR
TH_3670|M.thermoresistible__bu FVEELT-ETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVSSIGG-
Mb1079|M.bovis_AF2122/97 PVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVG-
Rv1050|M.tuberculosis_H37Rv PVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVG-
MAB_3405|M.abscessus_ATCC_1997 PFLSTS-DRAIRSMLEVNLYGVINGCQLALPEMVARRRGQVVNIASVAG-
MLBr_01094|M.leprae_Br4923 DVEVSH-FKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFG-
. . :: . .. : ** : * :::.:*:
Mvan_3508|M.vanbaalenii_PYR-1 LRGVTGFGHYSATKFAVEAITGVLRDEVAPWG--INVMAVEPAAFRTRAY
Mflv_0930|M.gilvum_PYR-GCK LVAAPGFGYYSATKFAIEAVTDALRDEVSTHG--ISVLAVEPGAFRTNAY
MMAR_1614|M.marinum_M ALTPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DF
MUL_3423|M.ulcerans_Agy99 ALTPVGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAFRT-DF
MAV_3827|M.avium_104 LVANPPNAYYSSTKFALEAVTEALAAEVRPLG--IKVTAIEPGAFRT-DW
MSMEG_3302|M.smegmatis_MC2_155 VGGSPGIGSYQAAKFAIDGFSRVLLAETAPFG--VKVLVVEPSGFAT-DW
TH_3670|M.thermoresistible__bu VSAFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGYAT-DW
Mb1079|M.bovis_AF2122/97 RKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQTPLL
Rv1050|M.tuberculosis_H37Rv RKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALTQTPLL
MAB_3405|M.abscessus_ATCC_1997 LMAVPGMAVYNASKFGVVGLSRALSDEFAPQG--VQVSAVLPTFTNTELI
MLBr_01094|M.leprae_Br4923 LFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIA
. * :: .: ..: * * * : * : * *
Mvan_3508|M.vanbaalenii_PYR-1 SGFA-------DEPLREPVSEYRALLQGVREAMIAQDGMQPGDPRRGARA
Mflv_0930|M.gilvum_PYR-GCK AGFA-------NKPVAETIPSYHDMLEEVRAAFVEMDGVQPGDPRRGARA
MMAR_1614|M.marinum_M AGRS-------LVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAA
MUL_3423|M.ulcerans_Agy99 AGRS-------LVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAA
MAV_3827|M.avium_104 ATRS-------MKESGTPIADYTDVAA-RKDLIKQFADHLPGDPRKVAEA
MSMEG_3302|M.smegmatis_MC2_155 AGAS-------MEVH-DIPADYADTVGGMSAIR-QSDSVTAGDPVRAAEI
TH_3670|M.thermoresistible__bu GGSS-------ARRS-ATMPEYAESRAEADRVR-SQRVARPGDPKASAAA
Mb1079|M.bovis_AF2122/97 ANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVG
Rv1050|M.tuberculosis_H37Rv ANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVG
MAB_3405|M.abscessus_ATCC_1997 AGTD---------STGAQKPVEPEDIAAAVVRIIEKPRVQVTVPKPLGAV
MLBr_01094|M.leprae_Br4923 RNAT-----------------AAEGLDVSKIASRFDTWVAHTSPQHAARI
*
Mvan_3508|M.vanbaalenii_PYR-1 VLAAMAQDPPPHRLVLG---GDGFD---------AVKAELEAALAELHEN
Mflv_0930|M.gilvum_PYR-GCK VIAAMAQDPPPRRLVLG---NSGYD---------AVIDALEQSLGDIRAN
MMAR_1614|M.marinum_M IITAVESPAPPAFLLLG---PDALM---------AYRHIAQRRDVEITDW
MUL_3423|M.ulcerans_Agy99 IITAVESPAPPAFLLLG---PDALM---------AYRHIAQRRDVEITDW
MAV_3827|M.avium_104 VLMVTGLDEPPLRLLLG---RDVLK---------AMRDKIAAMSASIDEW
MSMEG_3302|M.smegmatis_MC2_155 LVQMSRRDDIPYHLPIG---VHSVEGCLQQDEFLLGEDRKWAAVGRSADF
TH_3670|M.thermoresistible__bu LLKVVDAEKPPLRVFFG---ELPLQ--------IVNADY----QSRLQTW
Mb1079|M.bovis_AF2122/97 DAFSPRYGDRVVRLLESKIFGR-------------LIGSYRGSVYRHQPT
Rv1050|M.tuberculosis_H37Rv DAFSPRYGDRVVRLLESKIFGR-------------LIGSYRGSVYRHQPT
MAB_3405|M.abscessus_ATCC_1997 TTIVNSLPTGVRRFMSKKTGTDR-----------VFLDFDTSARTAYENR
MLBr_01094|M.leprae_Br4923 ILKAVRKKKARVLVGPDAKVAN-------------VVVRFSGGAGYQRLF
.
Mvan_3508|M.vanbaalenii_PYR-1 ETLSRGADFPH-------
Mflv_0930|M.gilvum_PYR-GCK ETLSRSADFPT-------
MMAR_1614|M.marinum_M EQLTAGTNLTP-------
MUL_3423|M.ulcerans_Agy99 EQLTAGTNLTP-------
MAV_3827|M.avium_104 EAVTKDVNFPGA------
MSMEG_3302|M.smegmatis_MC2_155 SEAYPVAFPPDTVSSSA-
TH_3670|M.thermoresistible__bu EEWQPIAVLAQG------
Mb1079|M.bovis_AF2122/97 ESAKAQAAQPERGYSSAR
Rv1050|M.tuberculosis_H37Rv ESAKAQAAQPERGYSSAR
MAB_3405|M.abscessus_ATCC_1997 AGSSLGVTKPDGE-----
MLBr_01094|M.leprae_Br4923 AQVASRLILNQR------