For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RYRTLGRHTGLRVSEYALGTAGFGTSSGEDARRVFRDFVDAGGTTIATSNIYRNGEAETLLGELMGSDRD HYVVVTKYTGSAGENTHPGTTGNSRKTMMRSLEASLRRLNTDYVDVYMPHFPDQVTPAEEIMAGFEDLVR SGKIRYGGFSNFPAWRIAGAAARADLLGMPRPICIETEYSLAERSADRELLPMAEAYGLGVLLYAPLAGG LLTGKYRRGETGRLSDRPSAMEKYSHQTAVVDEVLAIAEETGQTAAGVALEWLRYRAGLASTPLIPVIGP RTTTQLGGYLQPVDLDVRHYQRLDKASALRMGAPHDDVSGALLNGYDGDRSLLDAPVVPPI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1751 | - | - | 100% (342) | norsolorinic acid reductase |
| M. smegmatis MC2 155 | MSMEG_1304 | - | 7e-64 | 42.90% (331) | rhizopine catabolism protein |
| M. smegmatis MC2 155 | MSMEG_4654 | - | 5e-49 | 37.31% (327) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 6e-23 | 31.78% (321) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_4697 | - | 6e-07 | 22.76% (246) | 2,5-didehydrogluconate reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 6e-23 | 31.78% (321) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 2e-09 | 25.68% (183) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 2e-28 | 30.09% (329) | aldo/keto reductase |
| M. marinum M | MMAR_3520 | - | 3e-20 | 29.21% (315) | hypothetical protein MMAR_3520 |
| M. avium 104 | MAV_2496 | - | 2e-30 | 31.53% (333) | aldo/keto reductase |
| M. thermoresistible (build 8) | TH_1525 | - | 2e-07 | 23.69% (287) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 5e-20 | 29.11% (316) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 2e-09 | 25.53% (282) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQASGAFTLGGDLKVNRLGFGAMRLTGKG--
Mvan_2555|M.vanbaalenii_PYR-1 ----------MTSGSS----RTAPTFLLGGELPVNRLGFGAMRLTGPG--
MAB_4120c|M.abscessus_ATCC_199 ----------------------MKHTWLG-ELSVSRIGLGAMSMSAYYRA
MAV_2496|M.avium_104 ----------------------MKQAQLG-GLQVGRLGLGAMGMSVAY--
Mb2320|M.bovis_AF2122/97 ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
Rv2298|M.tuberculosis_H37Rv ----------------------MKYLDVDGIGQVSRIGLGTWQFGSRE--
MMAR_3520|M.marinum_M ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
MUL_2745|M.ulcerans_Agy99 ----------------------MKHLEVDGIGNVSRIGLGTWQFGSRE--
Mflv_4697|M.gilvum_PYR-GCK -------------------MTHVPAIELNDGASIPQLGFGVYQISPED--
TH_1525|M.thermoresistible__bu -----------------VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQ--
MSMEG_1751|M.smegmatis_MC2_155 --------------------MRYRTLGRHTGLRVSEYALGTAGFGTSS--
: . .:*. :
MLBr_00458|M.leprae_Br4923 -VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHPYK
Mvan_2555|M.vanbaalenii_PYR-1 -VWGPPADRDECLRVLRRAVDLGVDFIDTADSYGPYISEDLIREALHPYD
MAB_4120c|M.abscessus_ATCC_199 IGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAGRR
MAV_2496|M.avium_104 --AGAGTDDAESIRTVHRAIELGVTLIDTAEVYGPYINEELLARALRGRR
Mb2320|M.bovis_AF2122/97 WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
Rv2298|M.tuberculosis_H37Rv WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDR
MMAR_3520|M.marinum_M WGYGDRYASGAARDIVARARALGVTLFDTAEVYGLGKSERILGEALGDER
MUL_2745|M.ulcerans_Agy99 WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGDER
Mflv_4697|M.gilvum_PYR-GCK -----------TADVVRQALEVGYRHIDTAQMYQNEKGVGQGIRNSGIDR
TH_1525|M.thermoresistible__bu -----------TAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGLDR
MSMEG_1751|M.smegmatis_MC2_155 --------GEDARRVFRDFVDAGGTTIATSNIYRNGEAETLLGELMGSDR
. * : *:: * .
MLBr_00458|M.leprae_Br4923 G-LVIATKAGLLRTGRDVWIPLGN-PSYLRQELEMSLRRLNVDTIDLFQL
Mvan_2555|M.vanbaalenii_PYR-1 G-VVIATKAGLLRTAPDVWEPLGF-PAYLRQECEMSLRRLGTDTIDLFQL
MAB_4120c|M.abscessus_ATCC_199 DEVVLATKFGLVSHGNGASQVLDSTPGNISTAVEGSLRRLGVDHIDLYYQ
MAV_2496|M.avium_104 DRVVLATKFGLISHTG--RDGLDSSPANIRVAVDGSLRRLATDHIDLYYQ
Mb2320|M.bovis_AF2122/97 TEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPLYQI
Rv2298|M.tuberculosis_H37Rv TEVVVASKV----------FPVAPFPAVIKNRERASARRLQLNRIPLYQI
MMAR_3520|M.marinum_M AEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPLYQI
MUL_2745|M.ulcerans_Agy99 AEVVVASKI----------MPVAPFPAVVKQRERASARRLQLDRIPLYQI
Mflv_4697|M.gilvum_PYR-GCK GDVFVTSKLN----------NGFHTPEDARRAFDETLKALEFDYVDLFLI
TH_1525|M.thermoresistible__bu GEVFITSKLN----------NPYHRPDDARRAFDRTLTELGSDYVDLFLI
MSMEG_1751|M.smegmatis_MC2_155 DHYVVVTKYTGSAGENTHPGTTGNSRKTMMRSLEASLRRLNTDYVDVYMP
.:.:* : * : : ::
MLBr_00458|M.leprae_Br4923 HRIDPNFPLADQVG---ELFTLKNEGKIRHIGLSEINLDQLT----AAQQ
Mvan_2555|M.vanbaalenii_PYR-1 HRIAPKFPAEDQIG---ELAKLQQEGKVRHIGLSEVSVDQLT----AARA
MAB_4120c|M.abscessus_ATCC_199 HRVDPNVAIEDTIG---AVAELVQQGKVRYIGLSEAAAGTIR----RAHA
MAV_2496|M.avium_104 HRLDRQTPIEDTVG---ALAELVAAGKIRHIGLSEVGVNSIR----RAHA
Mb2320|M.bovis_AF2122/97 HQPNPVVPDSVIMP---GMRDLLDSGDIGAAGVSNYSLARWR----KADA
Rv2298|M.tuberculosis_H37Rv HQPNPVVPDSVIMP---GMRDLLDSGDIGAAGVSNYSLARWR----KADA
MMAR_3520|M.marinum_M HQPNPVVPDSVIMP---GMRELLDTGRIGAAGVSNYSLARWK----KADA
MUL_2745|M.ulcerans_Agy99 HQPNPVVPDSVIMP---GIRELLDIGRIGAAGVSNYSLARWK----KADA
Mflv_4697|M.gilvum_PYR-GCK HWPLPTLYDGDFVSTWKTLEEFTKDGRARSIGVSNFQVAHLQ----RLAD
TH_1525|M.thermoresistible__bu HWPLPMHYDGDFVSTWKTLEEFAADGRARSIGVSNFEPAHLD----LLAA
MSMEG_1751|M.smegmatis_MC2_155 HFPDQVTPAEEIMA---GFEDLVRSGKIRYGGFSNFPAWRIAGAAARADL
* : . : * *.*:
MLBr_00458|M.leprae_Br4923 IT--EIVSVQNMYNLSARAAEP-LLDAVTSRGIGFIPWSPLAAGPLAAPD
Mvan_2555|M.vanbaalenii_PYR-1 VA--PIVSVQNMYNLTMRAAEP-VLDACEADGIAFIPWFPLAAGPLAAAD
MAB_4120c|M.abscessus_ATCC_199 VH--PITALQNEYSLWTRDIEDEILPTIRELGIGLVAYSPLGRGFLTGAI
MAV_2496|M.avium_104 VH--PITAVQSEYSLWTRDQEDEILPVLRELGIGFVAYSPLGRGFLTGAI
Mb2320|M.bovis_AF2122/97 ALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKY
Rv2298|M.tuberculosis_H37Rv ALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKY
MMAR_3520|M.marinum_M ALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGGKY
MUL_2745|M.ulcerans_Agy99 ALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQGLLGGKY
Mflv_4697|M.gilvum_PYR-GCK ET--DTVPAVNQIEVHPYFANDEVRAYGTEHGIATEAWSPIAQGKVLD--
TH_1525|M.thermoresistible__bu ET--STVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKGRVAD--
MSMEG_1751|M.smegmatis_MC2_155 LGMPRPICIETEYSLAERSADRELLPMAEAYGLGVLLYAPLAGGLLTGKY
.: : . : *:. * :
MLBr_00458|M.leprae_Br4923 GP------------------------------LQRIAVNHHATPSQLALA
Mvan_2555|M.vanbaalenii_PYR-1 GP------------------------------LHRIAAEHHATPSQLALA
MAB_4120c|M.abscessus_ATCC_199 GSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATSAQVALA
MAV_2496|M.avium_104 RSAHELPDTDYRRTNPRFAEQNFAHNLRCADELRDIAADVGATPAQVALA
Mb2320|M.bovis_AF2122/97 GLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALA
Rv2298|M.tuberculosis_H37Rv GLENR--PGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALA
MMAR_3520|M.marinum_M GVDNR--PAGVRAVNPLFGTENLRRIEPLLQTLRAVATDVDAKPAQVALA
MUL_2745|M.ulcerans_Agy99 GVDNR--PAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKPAQVALA
Mflv_4697|M.gilvum_PYR-GCK -----------------------------DPVVTRIAEATGKTPAQVVLR
TH_1525|M.thermoresistible__bu -----------------------------DPVIAGIADRLGRTPAQVTLR
MSMEG_1751|M.smegmatis_MC2_155 RRGETG-----RLSDRPSAMEKYSHQTAVVDEVLAIAEETGQTAAGVALE
: :* ..: :.*
MLBr_00458|M.leprae_Br4923 WLLKRS----PVMLPIPGTSRVAHLEENVAAAEISLSDDE---FEMLSAA
Mvan_2555|M.vanbaalenii_PYR-1 WLLKRS----PVMLPIPGTSKVAHLEENVAAAQIDLTDAE---FETLGNA
MAB_4120c|M.abscessus_ATCC_199 WLLARG----DDIVPIPGTTKVSRVNENVGAVDIELLPEH---LVRLECL
MAV_2496|M.avium_104 WLLAKG----PDIVPIPGTKRVARLEENVGADALELTTEQ---LSRLDRL
Mb2320|M.bovis_AF2122/97 WLIS-L----PGVVAIPGASSVEQLEFNVAAADIELSAQS---RDALTDA
Rv2298|M.tuberculosis_H37Rv WLIS-L----PGVVAIPGASSVEQLEFNVAAADIELSAQS---RDALTDA
MMAR_3520|M.marinum_M WLIS-L----PGVVAIPGASSVEQLEFNVAAADIELSADA---RAALTEA
MUL_2745|M.ulcerans_Agy99 WLIS-L----PGVVAIPGASSVEQLEFNVAAADIELSADA---RAALTEA
Mflv_4697|M.gilvum_PYR-GCK WHIQ------RGDIVFPKSVTLQRIKDNFALFDFELGAED---FDAVSGL
TH_1525|M.thermoresistible__bu WHIQ------RGDIVLPKSVTPERVRSNIALFDFELSDAD---MAAISAL
MSMEG_1751|M.smegmatis_MC2_155 WLRYRAGLASTPLIPVIGPRTTTQLGGYLQPVDLDVRHYQRLDKASALRM
* : . . :: . :.:
MLBr_00458|M.leprae_Br4923 GAQ---------------------------
Mvan_2555|M.vanbaalenii_PYR-1 GAAAS-------------------------
MAB_4120c|M.abscessus_ATCC_199 AAAAGDRYNAEHLARLEG------------
MAV_2496|M.avium_104 TPPVGGHHADAQLAWIDR------------
Mb2320|M.bovis_AF2122/97 ARAFRPVSTGRFLTDMVREKVSRR------
Rv2298|M.tuberculosis_H37Rv ARAFRPVSTGRFLTDMVREKVSRR------
MMAR_3520|M.marinum_M ARAFHPVSARRFLTDTVREKLGRR------
MUL_2745|M.ulcerans_Agy99 ARAFHPVSARRFLTDTVREKLGRR------
Mflv_4697|M.gilvum_PYR-GCK DKGEAGRIGPNPDTFDYVPS----------
TH_1525|M.thermoresistible__bu DKGEAGRMGPHPDKFDMI------------
MSMEG_1751|M.smegmatis_MC2_155 GAPHDDVSGALLNGYDGDRSLLDAPVVPPI