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LTHVPAIELNDGASIPQLGFGVYQISPEDTADVVRQALEVGYRHIDTAQMYQNEKGVGQGIRNSGIDRGD VFVTSKLNNGFHTPEDARRAFDETLKALEFDYVDLFLIHWPLPTLYDGDFVSTWKTLEEFTKDGRARSIG VSNFQVAHLQRLADETDTVPAVNQIEVHPYFANDEVRAYGTEHGIATEAWSPIAQGKVLDDPVVTRIAEA TGKTPAQVVLRWHIQRGDIVFPKSVTLQRIKDNFALFDFELGAEDFDAVSGLDKGEAGRIGPNPDTFDYV PS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4697 | - | - | 100% (282) | 2,5-didehydrogluconate reductase |
| M. gilvum PYR-GCK | Mflv_4205 | - | 2e-61 | 45.13% (277) | 2,5-didehydrogluconate reductase |
| M. gilvum PYR-GCK | Mflv_1329 | - | 2e-15 | 26.99% (289) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2996 | - | 1e-62 | 46.49% (271) | oxidoreductase |
| M. tuberculosis H37Rv | Rv2971 | - | 7e-62 | 46.13% (271) | oxidoreductase |
| M. leprae Br4923 | MLBr_01669 | - | 3e-60 | 43.37% (279) | putative oxidoreductase of Aldo/keto reductase family |
| M. abscessus ATCC 19977 | MAB_1528c | - | 9e-79 | 52.21% (272) | oxidoreductase |
| M. marinum M | MMAR_1744 | - | 1e-57 | 42.86% (273) | oxidoreductase |
| M. avium 104 | MAV_1085 | - | 1e-123 | 73.31% (281) | morphine 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2408 | - | 2e-77 | 52.00% (275) | 2,5-diketo-D-gluconic acid reductase A |
| M. thermoresistible (build 8) | TH_1525 | - | 1e-119 | 70.71% (280) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_1987 | - | 1e-57 | 42.49% (273) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1769 | - | 1e-148 | 87.54% (281) | 2,5-didehydrogluconate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4697|M.gilvum_PYR-GCK ------MTHVPAIELNDGASIPQLGFGVYQISPEDTADVVRQALEVGYRH
Mvan_1769|M.vanbaalenii_PYR-1 ------MSNTPTIELNDGTGIPQLGFGVFQIPPDDTAAAVRSALEIGYRH
MAV_1085|M.avium_104 ------MSKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRH
TH_1525|M.thermoresistible__bu ----VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQTAAAVRTALDAGYRH
MAB_1528c|M.abscessus_ATCC_199 ------------MTLNSGTTIPQLGYGVWQVPDDQARAAVSAALQVGYRS
MSMEG_2408|M.smegmatis_MC2_155 ------MS--PRITLNDGNSIPQVGLGVWQTPAEDTERAVAAALQAGYRH
Mb2996|M.bovis_AF2122/97 MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRL
Rv2971|M.tuberculosis_H37Rv MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRL
MLBr_01669|M.leprae_Br4923 MMPSTPRTSIPSITLNDENTMPLLGLGVAELSEDETERAVLAALEIGCRL
MMAR_1744|M.marinum_M -MPGAPSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEIGCRL
MUL_1987|M.ulcerans_Agy99 MMPGAPSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEIGCRL
: **. :* :* ** ::: .* **: * *
Mflv_4697|M.gilvum_PYR-GCK IDTAQMYQNEKGVGQGIRNSGIDRGDVFVTSKLNNGFHTPEDARRAFDET
Mvan_1769|M.vanbaalenii_PYR-1 IDTAEMYQNERGVGQGIRDAGIDRAEVYVTSKLNNGFHKPDDARRAFDAT
MAV_1085|M.avium_104 IDTAEMYGNEREVAQGIRDAGLDRSEVFVTSKLNNGFHEPDAARRAFDAT
TH_1525|M.thermoresistible__bu IDTAQMYGNERGVAEGIRDAGLDRGEVFITSKLNNPYHRPDDARRAFDRT
MAB_1528c|M.abscessus_ATCC_199 IDTAKIYDNEAGTGAAIAESGIPRGDVFLTTKLWNSDQGYDNALRAFDAS
MSMEG_2408|M.smegmatis_MC2_155 IDTAAAYRNETETGRAIANSGVPREDIFLVTKLWNSDQGYDATLAAFDAS
Mb2996|M.bovis_AF2122/97 IDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRAS
Rv2971|M.tuberculosis_H37Rv IDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRAS
MLBr_01669|M.leprae_Br4923 IDTAAAYGNEAAVSRAIAASGIPRAQLFVTTKLATPDQGFTKSQDACNAS
MMAR_1744|M.marinum_M IDTAAAYGNEAAVGRAIAASGIPRAELFVTTKVATADHGFTASREACKAS
MUL_1987|M.ulcerans_Agy99 IDTAAAYGNEAAVGRALAASGIPRAELFVTTKVATADHGFTASREACKAS
**** * ** .. .: :*: * ::::.:*: . : : * :
Mflv_4697|M.gilvum_PYR-GCK LKALEFDYVDLFLIHWPLPTLYDGDFVSTWKTLEEFTKDGRARSIGVSNF
Mvan_1769|M.vanbaalenii_PYR-1 LKALDFDYVDLFLIHWPLPTLYDGDFVSTWKTLEEFKKDGRARSIGVSNF
MAV_1085|M.avium_104 LKALGSDYVDLFLIHWPLPTLYGGDFVSTWRVLEEFARDGRARSIGVSNF
TH_1525|M.thermoresistible__bu LTELGSDYVDLFLIHWPLPMHYDGDFVSTWKTLEEFAADGRARSIGVSNF
MAB_1528c|M.abscessus_ATCC_199 LERLGTDYVDLYLIHWPVPELD--EYVASFKALQRIQADGRAKAIGVSNF
MSMEG_2408|M.smegmatis_MC2_155 VQRLGVDYLDLYLIHWPVPENN--KFVDTFKAFAHLRDQGRIRSIGVSNF
Mb2996|M.bovis_AF2122/97 LDRLGLDYVDLYLIHWPAPPVG--KYVDAWGGMIQSRGEGHARSIGVSNF
Rv2971|M.tuberculosis_H37Rv LDRLGLDYVDLYLIHWPAPPVG--KYVDAWGGMIQSRGEGHARSIGVSNF
MLBr_01669|M.leprae_Br4923 LDRLGMDYVDLYLIHWPAPPVG--QYVDAWGGMIQSRGEGHARSIGVCNF
MMAR_1744|M.marinum_M LDRLGLDYVDLYLIHWPAPAAG--KYVDAFGGLIQARGEGFTRSIGVSNF
MUL_1987|M.ulcerans_Agy99 LDRLGLDYVDLYLIHWPAPAVG--KYVDAFGGLIQARGEGFTRSIGVSNF
: * **:**:***** * .:* :: : . :* ::***.**
Mflv_4697|M.gilvum_PYR-GCK QVAHLQRLADETDTVPAVNQIEVHPYFANDEVRAYGTEHGIATEAWSPIA
Mvan_1769|M.vanbaalenii_PYR-1 QVAHLQRLAEETDTVPAVNQIEVHPYFANDEVRAYGREHGIATEAWSPIA
MAV_1085|M.avium_104 QVPHLERLATETDTVPAVNQVEVHPYFTNEKVRGYAREHGIAIEAWSPIA
TH_1525|M.thermoresistible__bu EPAHLDLLAAETSTVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIA
MAB_1528c|M.abscessus_ATCC_199 TVDNLKRLIDETGEVPALNQIELHPRFTQPELRAFHAEYGIATEAWSPLG
MSMEG_2408|M.smegmatis_MC2_155 EPEHLTTLIEETGIVPAVNQIELHPLLPQQELRDVHAKLGIATEAWSPLG
Mb2996|M.bovis_AF2122/97 TAEHIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLA
Rv2971|M.tuberculosis_H37Rv TAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLA
MLBr_01669|M.leprae_Br4923 TEEHLSAIIDLTFVTPAVNQIELHPLLNQDEMRKSNAQHNVITQSYTPLV
MMAR_1744|M.marinum_M TEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTPLA
MUL_1987|M.ulcerans_Agy99 TEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTPLA
:: : * .**:**:*:** : : .:* : : ::: *:
Mflv_4697|M.gilvum_PYR-GCK QGKVLDDPVVTRIAEATGKTPAQVVLRWHIQRGDIVFPKSVTLQRIKDNF
Mvan_1769|M.vanbaalenii_PYR-1 QGKVLDDPVVTRIAETVGKSPAQVVLRWHIQRGDIVFPKSVTLQRIKDNF
MAV_1085|M.avium_104 QGDVLGDAVINRIADGLGRTAAPVVLRWHIQRGDIVFPKTVNPDRMKSNF
TH_1525|M.thermoresistible__bu KGRVADDPVIAGIADRLGRTPAQVTLRWHIQRGDIVLPKSVTPERVRSNI
MAB_1528c|M.abscessus_ATCC_199 QGTILEDATIGAIAQAHDVSAAQVILRWHLQLGNVVIPKSVTPARIAANF
MSMEG_2408|M.smegmatis_MC2_155 QGSLLADPVITGIAEQHGKTPAQVLIRWHIQLGNIVIPKSVNPERIASNF
Mb2996|M.bovis_AF2122/97 LGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNF
Rv2971|M.tuberculosis_H37Rv LGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNF
MLBr_01669|M.leprae_Br4923 LGRLMDNSTLTAIAAEYGKTPAQVLLRWNLQLGNAVVFRSAKAEHIASNF
MMAR_1744|M.marinum_M LGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIATNL
MUL_1987|M.ulcerans_Agy99 LGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIVTNL
* : :..: ** :.: * :**::* *: *. : :: *:
Mflv_4697|M.gilvum_PYR-GCK ALFDFELGAEDFDAVSGLDKGEAGRIGPNPDTFDYVPS
Mvan_1769|M.vanbaalenii_PYR-1 ALFDFELGADDFAAISGLDQGEAGRIGPNPDTFDYIP-
MAV_1085|M.avium_104 ELFDFELDERAMEAISALDRGESGRRGPNPDTFDYIPR
TH_1525|M.thermoresistible__bu ALFDFELSDADMAAISALDKGEAGRMGPHPDKFDMI--
MAB_1528c|M.abscessus_ATCC_199 DVFGFELSTDEVERITALDASD-GRIGPDPTTFNLH--
MSMEG_2408|M.smegmatis_MC2_155 DVFDFELSGQDITSIASLETGK--RLGPDPRTFNFTG-
Mb2996|M.bovis_AF2122/97 DVFDFELAAEHMDALGGLNDGT--RVREDPLTYAGT--
Rv2971|M.tuberculosis_H37Rv DVFDFELAAEHMDALGGLNDGT--RVREDPLTYAGT--
MLBr_01669|M.leprae_Br4923 DVFDFELAVNHMDAMNELHDGT--RLRPDPETYAGS--
MMAR_1744|M.marinum_M DVFEFELASQHMDAINGLNDGT--RLREDPMTFAGV--
MUL_1987|M.ulcerans_Agy99 DVFEFELASQHMDAINGLNDGT--RLREDPMTFAGV--
:* *** . : *. . * .* .: