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DPALAELAADLPAHALLTDPDQIEGYRRDAAADPLAGRPRAVVRATCTADVQSVMRWATRHRVAVVPRGA GSGLSGGASAVDGCVVLSTERMRAIRIDPATRVAVVQPGALNAEVKQAAAEHSLWYPPDPASVDISSIGG NAATNAGGLCCVKYGVTTDYVLGMQVVLADGTAVTLGGPRLKDVAGLSLTKLFVGSEGILGVITEVTLRL IPAQASPSTVVAMFDTVQDAANAVVAITASVRPAMLELMDHASINAVEDYGRMGLDRSAQALLLVQSDAP GDAASEVAHIVEACEKSGASEVFATDDPAEGAGFTAARRLVAPALMQLGTVLLEDVTVPIPTLPALLAGI NRISAECDVLICVVAHAGDGNTHPVVVFDPDDAESQARAERAFSEVMDLAIAMGGTITGEHGVGRLKRDW LPKQLGDDVMWVTRRVKDALDPLGILNPGAVLRP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0301 | - | - | 100% (455) | oxidoreductase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_5037 | - | e-165 | 64.30% (451) | oxidoreductase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_0374 | - | 2e-66 | 35.45% (409) | glycolate oxidase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2301 | - | 2e-54 | 33.26% (448) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2230 | - | 1e-167 | 64.67% (450) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1257c | - | 1e-159 | 63.33% (450) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 1e-157 | 62.44% (450) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_1407c | - | 1e-159 | 62.75% (451) | oxidoreductase |
| M. marinum M | MMAR_4183 | - | 1e-163 | 64.96% (448) | oxidoreductase |
| M. avium 104 | MAV_1405 | - | 1e-163 | 65.26% (449) | oxidoreductase, FAD-binding |
| M. thermoresistible (build 8) | TH_3358 | - | 1e-163 | 64.38% (452) | PUTATIVE FAD linked oxidase domain protein |
| M. ulcerans Agy99 | MUL_4485 | - | 1e-162 | 64.96% (448) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4464 | - | 1e-167 | 64.44% (450) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4183|M.marinum_M MNADVLASLIAGLPDGMVVTDPTVTEGYRQDRALDPSAGKPLAVVRPRCT
MUL_4485|M.ulcerans_Agy99 MNADVLASLIAGLPDGMAVTDPTVTEGYRQDRALDPSAGKPLAVVRPRCT
MAV_1405|M.avium_104 MSSEALASLIADLPDGTVVTDPTVTEGYRQDRAFDPSAGKPLAVVRPRRT
Rv1257c|M.tuberculosis_H37Rv MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRT
MLBr_01103|M.leprae_Br4923 --MGVLTSLIAGLPDGMVVTDSAVTDGYRHDRALDPSAGKPLAVVQPRRT
Mflv_2230|M.gilvum_PYR-GCK --MQPLASLIADLPDGTVVTDPDILESYRQDRAADPAAGTPLAVVRPRRT
Mvan_4464|M.vanbaalenii_PYR-1 --MQPLASLIAELPDGTVVTDPDIVASYRQDRAADPSAGTPIAVVRPRRT
TH_3358|M.thermoresistible__bu -VSAALSALIAELPDGTVVTDPDILASYRQDRARDPDAGTPLAVVRPRRT
MAB_1407c|M.abscessus_ATCC_199 MSRDALHALTAVLGEGAVITDPDITASYRQDRAFDPDAGMPLAVVRPRST
MSMEG_0301|M.smegmatis_MC2_155 -MDPALAELAADLPAHALLTDPDQIEGYRRDAAADPLAGRPRAVVRATCT
Mb2301|M.bovis_AF2122/97 -MSEMTARFSEIVGNANLLTGDAIPEDYAHDEELTGPPQKPAYAAKPATP
: : :*. .* :* . * :. .
MMAR_4183|M.marinum_M EEVQTILRWAGANRVAVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITI
MUL_4485|M.ulcerans_Agy99 EEVQTILRWAGANRVAVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITI
MAV_1405|M.avium_104 EEVQTVLRWASAHGVPVVTRGAGSGLSGGATALDNGIVLSTEKMR-DITV
Rv1257c|M.tuberculosis_H37Rv EEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMR-DITV
MLBr_01103|M.leprae_Br4923 DEVQTVLRWASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITV
Mflv_2230|M.gilvum_PYR-GCK EEVQTVLRWAGTHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
Mvan_4464|M.vanbaalenii_PYR-1 EEVQATLRWATAHRIAVVPRGMGTGLSGGATALDGGIVLSTEKMR-DITV
TH_3358|M.thermoresistible__bu EEVQTVLRWANAHRVPVVPRGAGTGLSGGASALDGGIVLSTEKMR-DITV
MAB_1407c|M.abscessus_ATCC_199 EEVSATLKWASAHHISVVPRGAGTGLSGGSTAQDGAVVLSTERMR-TITI
MSMEG_0301|M.smegmatis_MC2_155 ADVQSVMRWATRHRVAVVPRGAGSGLSGGASAVDGCVVLSTERMR-AIRI
Mb2301|M.bovis_AF2122/97 EEVAQLLKAASENGVPVTARGSGCGLSGAARPVEGGLLISFDRMNKVLEV
:* :: * : :.*..** * ****.: . :. :::* ::*. : :
MMAR_4183|M.marinum_M DPVTRIAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MUL_4485|M.ulcerans_Agy99 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MAV_1405|M.avium_104 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNIATNAG
Rv1257c|M.tuberculosis_H37Rv DPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MLBr_01103|M.leprae_Br4923 DPVTRTAVCQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAG
Mflv_2230|M.gilvum_PYR-GCK DPVTRTAVVQPGLLNAEVKKVVAEHGLWYPPDPSSFEICSIGGNIATNAG
Mvan_4464|M.vanbaalenii_PYR-1 DPVTRTAVAQPGLLNAEVKKAVAEYGLWYPPDPSSFEICSIGGNIATNAG
TH_3358|M.thermoresistible__bu DPVTRTAVVQPGLLNAEVKQAAAEHGLWYPPDPSSFEICSIGGNIATNAG
MAB_1407c|M.abscessus_ATCC_199 DTATRVAITQPGALNAEVKAAAAAQGLWYPPDPSSFEICSIGGNIATNAG
MSMEG_0301|M.smegmatis_MC2_155 DPATRVAVVQPGALNAEVKQAAAEHSLWYPPDPASVDISSIGGNAATNAG
Mb2301|M.bovis_AF2122/97 DTANQVAVVQPGVALTDLDAATADTGLRYTVYPGELSSS-VGGNVGTNAG
*...: *: *** :::. ..* .* *. *.... . :*** .****
MMAR_4183|M.marinum_M GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MUL_4485|M.ulcerans_Agy99 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
MAV_1405|M.avium_104 GLCCVKYGVTTDYVLGMQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Rv1257c|M.tuberculosis_H37Rv GLCCVKYGVTGDYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSE
MLBr_01103|M.leprae_Br4923 GLCCVKYGVTGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Mflv_2230|M.gilvum_PYR-GCK GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
Mvan_4464|M.vanbaalenii_PYR-1 GLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSE
TH_3358|M.thermoresistible__bu GLCCVKYGVTTDYVMGLQVVLADGTAVRLGGPRIKDVAGLPLTKLFVGSE
MAB_1407c|M.abscessus_ATCC_199 GLCCVKYGVTTDYVLGMQVVLADGTVLKLGGPRLKDVAGLSLTKLFVGSE
MSMEG_0301|M.smegmatis_MC2_155 GLCCVKYGVTTDYVLGMQVVLADGTAVTLGGPRLKDVAGLSLTKLFVGSE
Mb2301|M.bovis_AF2122/97 GMRAVKYGVARHNVLGLQAVLPTGEIIRTGGRMAKVSTGYDLTQLIIGSE
*: .*****: . *:*:*.**. * : ** * :* **:*::***
MMAR_4183|M.marinum_M GTLGVITEVTLRLLPAQNAAAVVVASFASVESAVDAVLGVSAR-IRPSML
MUL_4485|M.ulcerans_Agy99 GTLGVITEVTLRLLPAQNAAAVVVASFASVESAVDAVLGVSAR-IRPSML
MAV_1405|M.avium_104 GTLGVITEVTLRLVPKQNTSSVVVASFATVEDAVGAVLGVTGR-LRPSML
Rv1257c|M.tuberculosis_H37Rv GTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVTGR-LRPAML
MLBr_01103|M.leprae_Br4923 GTLGIITEVTLRLLPTQNTSSIVVATFASVQAAVDAVLGVAAR-LRPAML
Mflv_2230|M.gilvum_PYR-GCK GTLGVVTEVTLKLLPAQHPACTVVATFDSVESAADAVVEITGR-IRPSML
Mvan_4464|M.vanbaalenii_PYR-1 GTLGVVTEVTLKLLPAQSGACTVVATFDSVEDAANAVVTITGK-IRPSML
TH_3358|M.thermoresistible__bu GTLGVVTEVTLRLLPPQHQASTVVATFASVEAAAESVLAITAR-IRPSML
MAB_1407c|M.abscessus_ATCC_199 GTLGVITEVTLRLLPCQPTPCTVVATFSSVHDATDAVLAITAQ-IRPSML
MSMEG_0301|M.smegmatis_MC2_155 GILGVITEVTLRLIPAQASPSTVVAMFDTVQDAANAVVAITAS-VRPAML
Mb2301|M.bovis_AF2122/97 GTLALVTEVIVKLHPRLDHNASVLAPFADFDQVMAAVPKILASGLAPDIL
* *.::*** ::* * . *:* * .. . :* : . : * :*
MMAR_4183|M.marinum_M EFMDSVAINAVEDTLRMDL-------DRGAAAMLVASSDERGQAGRDDAE
MUL_4485|M.ulcerans_Agy99 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVASSDERGQADRDDAE
MAV_1405|M.avium_104 EFMDSVAINAVEDTLRMDL-------DRGAAAMLVAGSDERGRAGSEDAE
Rv1257c|M.tuberculosis_H37Rv EFMDSVAINAVEDTLRMDL-------DRDAAAMLVAGSDERGRAATEDAA
MLBr_01103|M.leprae_Br4923 EFMDSVAINAVEDTFRMGL-------DREAAAMLVAGSDELGHAGTDEAK
Mflv_2230|M.gilvum_PYR-GCK EFMDSTAINAVEDKLKMGL-------DRDAAAMMVAASDDRGAAGAQDAE
Mvan_4464|M.vanbaalenii_PYR-1 EFMDSAAINAVEDKLKMGL-------DRSAAAMMVAASDDRGPSGAQDAE
TH_3358|M.thermoresistible__bu EFMDAVAINAVEDKLRMGL-------DRSAAAMMVAASDDRGPAGAEDAE
MAB_1407c|M.abscessus_ATCC_199 EFMDSVAINAVEDKLKMGL-------DRAAGAMLVARSDERGHTSTEDAE
MSMEG_0301|M.smegmatis_MC2_155 ELMDHASINAVEDYGRMGL-------DRSAQALLLVQSDAPGDAAS-EVA
Mb2301|M.bovis_AF2122/97 EYIDNTSMAALISTQNLELGIPDQIRDSCEAYLLVALENRIADRLFEDIQ
* :* .:: *: . .: * * :::. .: . :
MMAR_4183|M.marinum_M LMAAVFAEHGATEVFSTTDPDEGEAFVAARRFCIPAVEAKGSLLLEDVGV
MUL_4485|M.ulcerans_Agy99 LMAAVFAEHGATEVFSTTDPDEGEPFVAARRFCIPAVEAKGSLLLEDVGV
MAV_1405|M.avium_104 IMAKVFAENAATEVFSTDDPDEGEAFVVARRFCIPAVEAKGSLLLEDVGV
Rv1257c|M.tuberculosis_H37Rv VMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGV
MLBr_01103|M.leprae_Br4923 LIGAVFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGV
Mflv_2230|M.gilvum_PYR-GCK YMARVFTEHGATEVFSTSDPDEGDAFVAARRFAIPAVESKGSLLLEDVGV
Mvan_4464|M.vanbaalenii_PYR-1 FMAGVFTEHGAREVFSTSDPDEGEAFVAARRFAIPAVEARGALLLEDVGV
TH_3358|M.thermoresistible__bu FMAQVFTEHGATEVFSTADPDEGEAFVAARRFAIPAVEAKGALLLEDVGV
MAB_1407c|M.abscessus_ATCC_199 LIARIFTDHHAAEVFSTDDEEEGEAFVAARRFAIPAVEAKGSLLLEDVGV
MSMEG_0301|M.smegmatis_MC2_155 HIVEACEKSGASEVFATDDPAEGAGFTAARRLVAPALMQLGTVLLEDVTV
Mb2301|M.bovis_AF2122/97 TVGEMLMELGAVDAYVLEG-GSARKLIEAREKAFWAAKALGADDIIDTVV
: . * :. . .. : **. * *: : *. *
MMAR_4183|M.marinum_M PLPNLGKLVTGIARIAQERDLMISVIAHAGDGNTHPLLVYDPSDAAMAER
MUL_4485|M.ulcerans_Agy99 PLPNLRKLVTGIARIAQERDLMISVIAHAGDGNTHPLLVYDPSDAAMAER
MAV_1405|M.avium_104 PLPALGRLVTGIAAIAAERDLMISVIAHAGDGNTHPLIVYDPADADMTER
Rv1257c|M.tuberculosis_H37Rv PLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLER
MLBr_01103|M.leprae_Br4923 PLPALGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTER
Mflv_2230|M.gilvum_PYR-GCK PLPALAELVGGVEKIAAARDVMISVIAHAGDGNTHPLIVFDPSDTAMEQR
Mvan_4464|M.vanbaalenii_PYR-1 PLPALAELVGGVEKIAGHHELMISVIAHAGDGNTHPLIVFDPDDPDMERR
TH_3358|M.thermoresistible__bu PLPALADLVGGVARLADHHELTISVIAHAGDGNTHPLIVYDPADAAMAER
MAB_1407c|M.abscessus_ATCC_199 PLPKLAQLVEGVEAIAAQHRLLISVIAHAGDGNTHPLIVHDPTDPDESRR
MSMEG_0301|M.smegmatis_MC2_155 PIPTLPALLAGINRISAECDVLICVVAHAGDGNTHPVVVFDPDDAESQAR
Mb2301|M.bovis_AF2122/97 PRASMPKFLSTARGLAAAADGAAVGCGHAGDGNVHMAIACKDPE-----K
* . : :: :: .******.* :. . : :
MMAR_4183|M.marinum_M AQLAYGEIMDLAVSLGGTITGEHGVGRLKRPWLEGYLGPDVMDLNRRIKQ
MUL_4485|M.ulcerans_Agy99 AQLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLEGYLGPDVMDLNRRIKQ
MAV_1405|M.avium_104 AHLAFGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPEVMDLNRRIKQ
Rv1257c|M.tuberculosis_H37Rv AHLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQ
MLBr_01103|M.leprae_Br4923 AHRAFGEIMDMAVGLGGTITGEHGVGRLKRPWLDDYLGPDVMELNQRIKH
Mflv_2230|M.gilvum_PYR-GCK AQQAFGEIMDLAVSLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
Mvan_4464|M.vanbaalenii_PYR-1 AQQAFGEIMDLAIGLGGTITGEHGVGRLKRPWLAGQLGPEAMELNRRIKQ
TH_3358|M.thermoresistible__bu AAQAFGEIMELAIDLGGTITGEHGVGRLKRPWLADQIGPEAMELHRRIKD
MAB_1407c|M.abscessus_ATCC_199 AQTAFGQIMDLAISLGGTITGEHGVGRLKKPWLGDQVGPEVLEVNRRIKQ
MSMEG_0301|M.smegmatis_MC2_155 AERAFSEVMDLAIAMGGTITGEHGVGRLKRDWLPKQLGDDVMWVTRRVKD
Mb2301|M.bovis_AF2122/97 KKKLMTDIFALAMELGGAISGEHGVGRAKTGYFLELEDPVKISLMRRIKQ
::: :*: :**:*:******* * :: . : : :*:*.
MMAR_4183|M.marinum_M ALDPLDILNPGSGI---
MUL_4485|M.ulcerans_Agy99 ALDPLDILNPGSGI---
MAV_1405|M.avium_104 ALDPQGILNPGSGI---
Rv1257c|M.tuberculosis_H37Rv ALDPQGILNPGSAI---
MLBr_01103|M.leprae_Br4923 ALDPYGILNPGAAI---
Mflv_2230|M.gilvum_PYR-GCK ALDPDGILNPGAAI---
Mvan_4464|M.vanbaalenii_PYR-1 ALDPDGILNPGAAI---
TH_3358|M.thermoresistible__bu ALDPNGILNPGAGF---
MAB_1407c|M.abscessus_ATCC_199 ALDPDGILNPGTLI---
MSMEG_0301|M.smegmatis_MC2_155 ALDPLGILNPGAVLRP-
Mb2301|M.bovis_AF2122/97 SFDPAGILNPGVVFGDT
::** .***** :