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MSSTAEVAEGHLKRALGLPSLVLFGLVYMVPLTVFTTYGIVTQTSGGRVPLSYLVTLAAMVFTARSYARM SVAYPVAGSAYTYTQKSFGAPVGFLAGWSLLLDYLFLPMINYLVIGLYLSAAIPAIPAWVFILIAIAIVT VLNIVGIVSVARANFVIIAVQAIFIVAFLILATSKVFSYGTVDLAAPFTGDGTAPGFSPVLAGAAILCLS FLGFDAVSTLSEEAKDPKRTVPRAIMIATLASGLIFVVLSYVAQVVFPSNEFSDVDSGSLDVMMTAGGNF LQVFFTAAYVAGATGSAITSQASVARILYAMGRDGVLPRPFFGHVSPRFSTPVYAILAVAVISLLAIVID LGILASVISFGALVAFSAVNLSVIKHYFVDHRERAGAQAINSLVLPLIGFALTVWLWFSLDGLALIIGLC WLAIGFVWLAGVTRGFQRPTPVLDMKE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0446 | - | - | 100% (447) | putrescine importer |
| M. smegmatis MC2 155 | MSMEG_2680 | - | 1e-66 | 33.41% (443) | amino acid transporter |
| M. smegmatis MC2 155 | MSMEG_1838 | - | 1e-35 | 28.10% (452) | cationic amino acid transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 7e-39 | 28.03% (446) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_4722 | - | 1e-36 | 28.19% (447) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 7e-39 | 28.03% (446) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01305 | ansP2 | 4e-19 | 21.69% (355) | putative L-asparagine permease |
| M. abscessus ATCC 19977 | MAB_3842 | - | 6e-39 | 28.60% (451) | cationic amino acid transport integral membrane protein |
| M. marinum M | MMAR_2243 | - | 1e-119 | 48.74% (437) | cationic amino acid transport integral membrane protein |
| M. avium 104 | MAV_2087 | - | 5e-36 | 28.54% (445) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 3e-37 | 27.09% (454) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_1244 | rocE | 4e-35 | 28.60% (458) | cationic amino acid transport integral membrane protein RocE |
| M. vanbaalenii PYR-1 | Mvan_1740 | - | 2e-40 | 28.19% (447) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0446|M.smegmatis_MC2_155 --------------------MSSTAEVAEGHLKRALGLPSLVLFGLVYMV
MMAR_2243|M.marinum_M --------------------MS--QPTGEPRLRRALGVAGLVAFGLAYID
Mb2347c|M.bovis_AF2122/97 MPTTSMSLRELMLRRRPVSGAPVASGASG-NLKRSFGTFQLTMFGVGATI
Rv2320c|M.tuberculosis_H37Rv MPTTSMSLRELMLRRRPVSGAPVASGASG-NLKRSFGTFQLTMFGVGATI
MUL_1244|M.ulcerans_Agy99 MPATSIRLREQMLRRRPAGGAPVAEGAAG-SLKRSFGTFELTMFGVGSTV
MAV_2087|M.avium_104 ----------------------MAPGTAD-HLRRGIGTFQLTMFGVGSTI
MAB_3842|M.abscessus_ATCC_1997 MAPSSPSLAQQLLRRRPTSGAPTAHGAGG-HLKQSMGTFQLTMIGVGATV
Mflv_4722|M.gilvum_PYR-GCK MTQEPVTQAPGRLRLKSVEQSIADTDEPGTKLRKDLNWWDLTVFGVSVVI
Mvan_1740|M.vanbaalenii_PYR-1 MVQEPGAQTVGRRRTKSVEQSIADTDEPSTRLRKELNWWDLTVFGVSVVI
TH_0471|M.thermoresistible__bu --------MTDRLRVKSVEQSIADTDEPDSRLRKDLSWWDLTVFGVSVVI
MLBr_01305|M.leprae_Br4923 ------MATLAESPEPKSGASRAGVLGEEAGYHKGLKPRQLQMIGIGGAI
:: : * :*:
MSMEG_0446|M.smegmatis_MC2_155 PLTVFTTYG-IVTQTSGGRVPLSYLVTLAAMVFTARSYARMSVAYPVAGS
MMAR_2243|M.marinum_M PLAMFDTFG-VVSQTTHGHVPTAYVVTFVAMLFTAASYAVLVHAYPSAGS
Mb2347c|M.bovis_AF2122/97 GTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYAELASAVPISGS
Rv2320c|M.tuberculosis_H37Rv GTGIFFVLAQAVP-EAGPGVIVSFIIAGIAAGLAAICYAELASAVPISGS
MUL_1244|M.ulcerans_Agy99 GTGIFFVLAEAVP-EAGPAVIVSFIIAGVAAGLAAICCAELASAVPVSGS
MAV_2087|M.avium_104 GTGIFFVMSQAVP-EAGPAVIVSFLLAGVAAGLAAVCYAELASAVPVSGS
MAB_3842|M.abscessus_ATCC_1997 GTGIFFILAESVP-KAGPAVMASFLVAGLAAGLAALCYAELASAVPVSGS
Mflv_4722|M.gilvum_PYR-GCK GAGIFTITASTAANITGPAISLSFIFAAIACGLAALCYAEFASTVPVAGS
Mvan_1740|M.vanbaalenii_PYR-1 GAGIFTITASTAANITGPAISLSFIIAAIACGLAALCYAEFASTVPVAGS
TH_0471|M.thermoresistible__bu GAGIFTVTASTAGNITGPAISVSFIIAAIACGLAALCYAEFASTVPVAGS
MLBr_01305|M.leprae_Br4923 GTGLFLGAGGRLA-KAGPGLFLVYAVCGVFVFLILRALGELVLHRPSSGS
:* . : : : . : . . : * :**
MSMEG_0446|M.smegmatis_MC2_155 AYTYTQKSFGAPVGFLAGWSLLLDYLFLPMINYLVIGLYLS---------
MMAR_2243|M.marinum_M AYTFARRSFGGNVGFLTGWALMLDYLLLPLVNYLLIGIYLN---------
Mb2347c|M.bovis_AF2122/97 AYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGF
Rv2320c|M.tuberculosis_H37Rv AYSYAYTTLGEAVAMVVAACLLLEYGVATAAVAVGWSGYVNKLLSNLFGF
MUL_1244|M.ulcerans_Agy99 SYSYAYATLGEAVAMGVASCLLLEYGVATAAVAVGLSGYVNKLLHNVFGF
MAV_2087|M.avium_104 SYSYAYTTLGEVVAMGVAACLLLEYGVATAAVSVNWSGYLNKLLSNVVGF
MAB_3842|M.abscessus_ATCC_1997 SFSYAYTTLGELAAMVVAACLLLEYGVSAAAVAVGWSQYLDKLLVNLFGW
Mflv_4722|M.gilvum_PYR-GCK AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLG----TVFGF
Mvan_1740|M.vanbaalenii_PYR-1 AYTFSYATFGEFVAWIIGWDLILEFAVAAAVVAKGWSSYLG----TVFGF
TH_0471|M.thermoresistible__bu AYTFSYATFGEFVAWIIGWDLILEFSVAAAVVAKGWSSYLG----EVFEF
MLBr_01305|M.leprae_Br4923 FVSYAREFFGEKAAYVVGWLYFLDWAMTAIVDTTAIATYLHR--------
::: :* .. . :*:: . . . *:
MSMEG_0446|M.smegmatis_MC2_155 ---AAIPAIPAW------------VFILIAIAIVTVLNIVGIVSVARANF
MMAR_2243|M.marinum_M ---AQFPAVPAP------------VFCLAAIALVTTVNIVGVVIMNRLNF
Mb2347c|M.bovis_AF2122/97 QMPHVLSAAPWD-THPG----WVNLPAVILIGLCALLLIRGASESARVNA
Rv2320c|M.tuberculosis_H37Rv QMPHVLSAAPWD-THPG----WVNLPAVILIGLCALLLIRGASESARVNA
MUL_1244|M.ulcerans_Agy99 QLPQALSEAPWD-ERPGEAAGYLNLPAIILIGLCALLLIRGVSESAKVNA
MAV_2087|M.avium_104 QLPHALSAAPWD-AQPG----YVNLPAVMLIGMCALLLIRGASESAKVNA
MAB_3842|M.abscessus_ATCC_1997 HLPHAISAAPWDSADPAAPHPWLNLPAVLLIIMCAILLIRGTSESALVNT
Mflv_4722|M.gilvum_PYR-GCK AG-GTAEVAGFD----------LDWGALVIIAIVTAILAMGTKLSASVSL
Mvan_1740|M.vanbaalenii_PYR-1 AG-GTTEVAGFQ----------LDWGALVIIALVTLILVMGTKLSAGVSL
TH_0471|M.thermoresistible__bu AG-ATTRLGPIT----------LDWGALLIIGFVTVLLATGTKLSANVSL
MLBr_01305|M.leprae_Br4923 --WTIFTALPQW------------TLALLALAVVLVMNLISVEWFGELEF
: : . : . .
MSMEG_0446|M.smegmatis_MC2_155 VIIAVQAIFIVAFLILATSKVFSYGTVDLAAPFTGDG-------------
MMAR_2243|M.marinum_M ALVGLQLAFVLVFITVSLLYLRDHPDASLLQPLYSAG-------------
Mb2347c|M.bovis_AF2122/97 IMVLIKLGVLGMFMIIAFSAYSADHLKDFVP-------------------
Rv2320c|M.tuberculosis_H37Rv IMVLIKLGVLGMFMIIAFSAYSADHLKDFVP-------------------
MUL_1244|M.ulcerans_Agy99 IMVLIKLGVLGMFVILALTAYDTNHLKDFAP-------------------
MAV_2087|M.avium_104 IMVMVKLGVLVVFGILAFTAFDMHHLDDFAP-------------------
MAB_3842|M.abscessus_ATCC_1997 VMVLLKLAVLSVFAIIAFTAFHAGNFSDFAP-------------------
Mflv_4722|M.gilvum_PYR-GCK AITALKVSVVLLVVIVGAFYIKMENFSPFIPAPEPGEAGGTGAEQSLFSL
Mvan_1740|M.vanbaalenii_PYR-1 AITAVKVSVVLLVVIVGAFYIKAENFSPFVPAPEEGGSGGTGTEQSLFSL
TH_0471|M.thermoresistible__bu AITVIKVGVVLLVVIVGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSL
MLBr_01305|M.leprae_Br4923 WAALIKVCALMAFLVVGTIFLGGRYPVDGHNTGLSLWTSHGG--------
:: : . :.
MSMEG_0446|M.smegmatis_MC2_155 ------TAPGFSPVLAGAAILCLSFLGFDAVSTLSEEAKDPKRTVPRAIM
MMAR_2243|M.marinum_M ------FRGGD--ILGGAAVVALSFVGFDAVSTMAEEARNPRRTVPLAII
Mb2347c|M.bovis_AF2122/97 --------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALI
Rv2320c|M.tuberculosis_H37Rv --------FGVAGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALI
MUL_1244|M.ulcerans_Agy99 --------FGVAGVGAAAGTIFFSFIGLDAVSTAGEEVRNPQQSVPRALI
MAV_2087|M.avium_104 --------FGVAGVGTAAGTIFFSYIGLDAVSTAGDEVTNPQKTMPRALI
MAB_3842|M.abscessus_ATCC_1997 --------FGVSGIGAAAGTIFFTYVGLDTVSTAGEEVKDPQRTMPRALI
Mflv_4722|M.gilvum_PYR-GCK MTGAEGSHYGWYGLLAGASIVFFAFIGFDIVATTAEETKVPQRDVPRGIL
Mvan_1740|M.vanbaalenii_PYR-1 LTGAEGSHYGWYGVLAGASIVFFAFIGFDIVATTAEETRNPQRDVPRGIL
TH_0471|M.thermoresistible__bu ITGAEGSSYGWYGLLAGASIVFFAFIGFDIIATTAEETKNPQRDVARGIM
MLBr_01305|M.leprae_Br4923 -----LFPTGVAPLIVVSSGVMFAYAAVELVGTAAGETVEPKKIMPRAIN
* : :. : ::: ..: :.* . *. *:: :. .:
MSMEG_0446|M.smegmatis_MC2_155 IATLASGLIFVVLSYVAQVVFPSN-EFSDVDSGSLDVMMTAGG-NFLQVF
MMAR_2243|M.marinum_M LTVLIGGATFLSVSYCATLVEPDYRAITTPNSAALQIVVSAGG-HSLQTF
Mb2347c|M.bovis_AF2122/97 AALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILDNVTHGEWASTI
Rv2320c|M.tuberculosis_H37Rv AALVVVTGVYVLVALAALGTQPWQDFAEQETAGLAIILDNVTHGEWASTI
MUL_1244|M.ulcerans_Agy99 AALFVVTGVYVLVAFAALGTQPWQMFAGQEEAGLATILDNVTHSAWASTV
MAV_2087|M.avium_104 AALLTVTGVYVFVALAALGTQPWQDFGGQQEAGLATILDHVTHGSWASTI
MAB_3842|M.abscessus_ATCC_1997 AALLIVTAFYLVVALAALGAQPWKEFEGQ-SAGLALILDKVTGSTSASTF
Mflv_4722|M.gilvum_PYR-GCK ASLGIVTVLYVAVAIVLSGMVSYKDLRDA-ESPNLATAFSLNGVDWAAKV
Mvan_1740|M.vanbaalenii_PYR-1 ASLAIVTVLYVAVAVVLTGMVSYTELRDA-ETQNLATAFSLNGVDWAAKV
TH_0471|M.thermoresistible__bu ATLGIVTVLYVAVSLVLTGMVHYTELRAAGENANLATAFAANGIDWAAKV
MLBr_01305|M.leprae_Br4923 SVIARIAIFYVGSVILLALLLPYSAFKAS--ESPFVTFFSKVGFYGAGDL
:: .
MSMEG_0446|M.smegmatis_MC2_155 FTAAYVAGATGSAITSQASVARILYAMGRDGVLPRPFFGHVSPRFSTPVY
MMAR_2243|M.marinum_M FIIAYMCACSAAALSSQVSVTRILYAMGRDGVLPRAVFGRISRRFRTPIG
Mb2347c|M.bovis_AF2122/97 LAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP-ARFAKVNPRTMTPVH
Rv2320c|M.tuberculosis_H37Rv LAAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLP-ARFAKVNPRTMTPVH
MUL_1244|M.ulcerans_Agy99 LAMGAVISIFTVTLVTMYGQTRILFAMGRDGLLP-ARFAAVHPRFQTPVS
MAV_2087|M.avium_104 LAAGAVISIFSVTLVTMYGITRILFAMGRDGLLP-PRFARVNPRTMTPVN
MAB_3842|M.abscessus_ATCC_1997 LAAGAVISIFSITLVSMYGQTRILFAIGRDGLLP-SVFAQVNPRTLTPVN
Mflv_4722|M.gilvum_PYR-GCK ISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLP-RQLAKTGEH-GTPVR
Mvan_1740|M.vanbaalenii_PYR-1 ISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLP-RQLAKTGEH-GTPVR
TH_0471|M.thermoresistible__bu ISIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLP-RPLSKTGPR-GTPVR
MLBr_01305|M.leprae_Br4923 MNIVVLTAALSSLNAGLYATGRVMHSIAINGSGP--KFTARMSKNGVPYG
: : . . *::.::. :* * : : .*
MSMEG_0446|M.smegmatis_MC2_155 AILAVAVIS-LLAIVIDLGI------LASVISFGALVAFSAVNLSVIKHY
MMAR_2243|M.marinum_M AALVVSAVS-TLALIADLET------MASIVSFGALAAFTLVHLAVTKHF
Mb2347c|M.bovis_AF2122/97 NTVIVAIFASTLAAFIPLDS------LADMVSIGTLTAFSVVAVGVIVLR
Rv2320c|M.tuberculosis_H37Rv NTVIVAIFASTLAAFIPLDS------LADMVSIGTLTAFSVVAVGVIVLR
MUL_1244|M.ulcerans_Agy99 NTVVVAIAAAVLAALVPLNR------LADMVSIGTLTAFIVVSVGVIILR
MAV_2087|M.avium_104 NTVIVAVAAATLAAFIPLQN------LADMVSIGTLTAFVVVSVGVIVLR
MAB_3842|M.abscessus_ATCC_1997 NTIIVAVVVGFMAAFVPLDS------LANMVSIGTLTAFIVVSIGVIILR
Mflv_4722|M.gilvum_PYR-GCK ITLLVGAVVAVTATVFPIDK------LEEMVNIGTLFAFVLVSAGVIVLR
Mvan_1740|M.vanbaalenii_PYR-1 ITLIVGAVVAVTATVFPIGK------LEEMVNIGTLFAFVLVSAGVLVLR
TH_0471|M.thermoresistible__bu ITVLVGALVAIAASVFPVGN------LEEMVNIGTLFAFALVSAGVIVLR
MLBr_01305|M.leprae_Br4923 GILLAAVICLCGVALNAFNPGQAFEIVLSVAALGIIAGWGTIVLCQLRLH
: .. . . . : .: :* : .: :
MSMEG_0446|M.smegmatis_MC2_155 FVDHRERAGAQAINSLVLPLIGFALTVWLWFSLDGLALIIGLCWLAIG--
MMAR_2243|M.marinum_M LIDQRRRGWRSWALYAAMPAVGVVLTGWLWTSLSVGAFAIGFAWLGIG--
Mb2347c|M.bovis_AF2122/97 VREPDLPRGFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVA--
Rv2320c|M.tuberculosis_H37Rv VREPDLPRGFKVPGYPVTPVLSVLACGYILASLHWYTWLAFSGWVAVA--
MUL_1244|M.ulcerans_Agy99 VREPALPRGFWVPGYPVTPILSILACGYLLYSLHWYTWIAFGGWVGIA--
MAV_2087|M.avium_104 VREPDLPRGFRVPGYPVTPVLSIMACGYILASLHWYTWIAFSGWVLLA--
MAB_3842|M.abscessus_ATCC_1997 VREPELPRAFRVPGYPVTPVLSVIACGYILFSLPWITWIAFGAWVAIV--
Mflv_4722|M.gilvum_PYR-GCK RTRPDLKRGFRTPWVPVLPILSIIACVWLMLNLTGLTWIRFSVWMAIG--
Mvan_1740|M.vanbaalenii_PYR-1 RTRPDLKRGFRTPWVPLLPILAIAACVWLMLNLTGLTWIRFLIWMAIG--
TH_0471|M.thermoresistible__bu RTRPDLKRGFRVPFVPWLPLAAIAACLWLMLNLTGLTWVRFLGWMALG--
MLBr_01305|M.leprae_Br4923 KMAKAGIMRRPRFRMPLAPYSGYLTLAFLFAVLVVMAFDKPIGTWTVASL
* . :: * : :
MSMEG_0446|M.smegmatis_MC2_155 --------FVWLAGVTRGFQRPTPVLDMKE--------------------
MMAR_2243|M.marinum_M --------TSYLAVLTRGFRKPAPAVDFDADAAPIQTEIDLTKEGTLQ--
Mb2347c|M.bovis_AF2122/97 --------VIFYLMWGRHHSALNEEVP-----------------------
Rv2320c|M.tuberculosis_H37Rv --------VIFYLMWGRHHSALNEEVP-----------------------
MUL_1244|M.ulcerans_Agy99 --------LIFYLFWGRHHSRLNAPALHDNPTGEER--------------
MAV_2087|M.avium_104 --------LIFYFVWGRHHSALNDAAVD--PSGQER--------------
MAB_3842|M.abscessus_ATCC_1997 --------LVFYLVWGRHHSALNDLPSDPAELSEKEPV------------
Mflv_4722|M.gilvum_PYR-GCK --------VVLYFVYGRRHSLVARRQRERAGLHTDTP-------------
Mvan_1740|M.vanbaalenii_PYR-1 --------VVVYFLYGRRHSLVGRRMG-----------------------
TH_0471|M.thermoresistible__bu --------LVLYFFYGRHHSMLGRGMTDISARRTG---------------
MLBr_01305|M.leprae_Br4923 IVIVPALIAGWYSIRKRVMTIARERMGYTGPFPAIANPPVQPSERSHSQN
*
MSMEG_0446|M.smegmatis_MC2_155 -
MMAR_2243|M.marinum_M -
Mb2347c|M.bovis_AF2122/97 -
Rv2320c|M.tuberculosis_H37Rv -
MUL_1244|M.ulcerans_Agy99 -
MAV_2087|M.avium_104 -
MAB_3842|M.abscessus_ATCC_1997 -
Mflv_4722|M.gilvum_PYR-GCK -
Mvan_1740|M.vanbaalenii_PYR-1 -
TH_0471|M.thermoresistible__bu -
MLBr_01305|M.leprae_Br4923 P