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NVTGAADRPFEHRRESVGARLLGFVLRPTAPPLKIGIAVALGCIAAESLLVHFLQKVAPESTFGTVFLLG VLVVSAGWDMRLSVATSLLTALVYVHFHMETHGALMPIYSEDIASIAVFIPVALLANILVGQARLRTAEA EQRTVEADRAAAAAQEAQKLIEASHAEVSELAAQQAALRRVATLVARGSPPEEVYPAAVDELAAGFGLDH VALLLFPGDGTSTVLASRDATGAPKFPVGERIPLDGDTVTTLVARTGAPARVDDYAVVGGAGAARIREVG IRSAVGAPILVDGRVYGVLLVGSSQPFEFPADTEVRVGDFADLVGTAITNAETRAALTASRARIVTAADQ ARRRFERDLHDGAQQRVISLGLGLRAVEASVPDDQLELRLQISRVVDGLSSLSTELQEFSRGIHPAILSK GGLGPALRALARRCPVPVDLEVDLPEPVPESVGVAAYYVVAEALTNAAKYAEAQAIVITATLGDDTLDLM IDDDGVGGAVAGGGSGLIGLKDRVEALSGELTITSPSGVGTTITARIPLHHD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0980 | - | - | 100% (543) | signal transduction histidine kinase |
| M. smegmatis MC2 155 | MSMEG_2248 | - | e-131 | 60.35% (401) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_3448 | - | 2e-73 | 44.96% (367) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 1e-18 | 28.64% (426) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_2281 | - | 5e-29 | 36.74% (215) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 2e-18 | 28.64% (426) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 2e-97 | 43.19% (514) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4781 | - | 9e-18 | 30.24% (248) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 9e-19 | 30.00% (220) | hypothetical protein MAV_0874 |
| M. thermoresistible (build 8) | TH_1533 | - | 6e-32 | 38.68% (212) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 6e-18 | 30.24% (248) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 1e-114 | 59.03% (371) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0980|M.smegmatis_MC2_155 ----------------MNVTGAADRPFEHRRESVGARLLGFVLRPTAPPL
Mvan_2071|M.vanbaalenii_PYR-1 ---------------------------------MPTRFLERVVRSPARPL
MAB_4499|M.abscessus_ATCC_1997 ----------------MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSA
Mflv_2281|M.gilvum_PYR-GCK --------------------MSAVTDTDTGADTAPVDVPDQSGAPSGRTR
TH_1533|M.thermoresistible__bu --------------------MVAVT-----AETAPAPAPT-------RTA
Mb3156c|M.bovis_AF2122/97 ----MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRD
Rv3132c|M.tuberculosis_H37Rv ----MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRD
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVG
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 KIG-IAVALGCIAAESLLVHFLQKVAPESTFGTVFLLGVLVVSAGWDMRL
Mvan_2071|M.vanbaalenii_PYR-1 GLG-IAVAAGFLAAEVLAVFALKKIAPENAFGALLLLGVLVVSAGWGFGL
MAB_4499|M.abscessus_ATCC_1997 RLG-IVAAVVLLVAESMLTIFLRTIAPTEHLAAVYLIGILVISVIWRLRL
Mflv_2281|M.gilvum_PYR-GCK TLS-VAASASMLVGGAAASVWFWIPL------AILVIGISSIPSVIGFLV
TH_1533|M.thermoresistible__bu RLG-VVPTASMVTGAAIALVWFWIPL------TILIVGISSIPSVIGFLL
Mb3156c|M.bovis_AF2122/97 RLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVL
Rv3132c|M.tuberculosis_H37Rv RLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVL
MMAR_4781|M.marinum_M ---------MVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MUL_0350|M.ulcerans_Agy99 SCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVG
MAV_0874|M.avium_104 --------MAVAGDAELERVRAVHQMRSYRIGSVLRVGVVGLMVAAMIIG
* .
MSMEG_0980|M.smegmatis_MC2_155 SVATSLLTALVYVHFHMETH---------GALMPIYSEDIASIAVFIPVA
Mvan_2071|M.vanbaalenii_PYR-1 SIATSLASAAVYAYLHLEGR---------DSLAP-------ALIIFLTLA
MAB_4499|M.abscessus_ATCC_1997 ALAMSIASAIVFDCIRNWPK---------ANPLSTESHNLITHLSFLAVT
Mflv_2281|M.gilvum_PYR-GCK AAVVFVYLMRGVDHVERVRN---------EAVFG------------MGIA
TH_1533|M.thermoresistible__bu AGVVFIYLIRGVEWVERIRS---------EAVFG------------MGIP
Mb3156c|M.bovis_AF2122/97 HFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFP
Rv3132c|M.tuberculosis_H37Rv HFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFP
MMAR_4781|M.marinum_M TPRREWGAQTALICVYAFAA-------------------------LWALA
MUL_0350|M.ulcerans_Agy99 TPRREWGAQTALICVYAFAA-------------------------LWALA
MAV_0874|M.avium_104 TARSEWPQESVLILLYGIIA-------------------------LGAVA
. ..
MSMEG_0980|M.smegmatis_MC2_155 LLANILVGQARLRTAEAEQRTVEADR------------------------
Mvan_2071|M.vanbaalenii_PYR-1 LLTNALVGQARLRAAEAEQRRREADLSADLARVMLRAPALGPALEDAGRR
MAB_4499|M.abscessus_ATCC_1997 LTASALAALARAGTIEAERRRREAAA------------------------
Mflv_2281|M.gilvum_PYR-GCK VPPRRLSHYTGFQR------------------------------------
TH_1533|M.thermoresistible__bu IPPRRLSPHTGFQR------------------------------------
Mb3156c|M.bovis_AF2122/97 PYHPPMRTFLGVPVRVRDESFGTLYLTDKTN-------------------
Rv3132c|M.tuberculosis_H37Rv PYHPPMRTFLGVPVRVRDESFGTLYLTDKTN-------------------
MMAR_4781|M.marinum_M LAFRRSRPMVSLDR------------------------------------
MUL_0350|M.ulcerans_Agy99 LAFRRSRPMVSLDR------------------------------------
MAV_0874|M.avium_104 LAFAPFRRWIGIGR------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 FADVLGLPYATLTVGGGATGADEMAIDLVDGAEHTGTLLVPRDLPLASVR
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 --------------------------------------------------
Rv3132c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 --------------AAAAAQEAQKLIEASHAEVS----------------
Mvan_2071|M.vanbaalenii_PYR-1 RIHRMVPSLQALLAAACDREDITAELEASRRELERFFAVASDLLFIGTYV
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 --------------GQPFSDDDEVLVQALAAAAG----------------
Rv3132c|M.tuberculosis_H37Rv --------------GQPFSDDDEVLVQALAAAAG----------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 ----------------------ELAA------------------------
Mvan_2071|M.vanbaalenii_PYR-1 DGVAQLTRVNPAFERALGYSAAELAARPLTEFIHPDDRDGTAAALDSVPQ
MAB_4499|M.abscessus_ATCC_1997 -----------------------IAQ------------------------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 ---------------------IAVAN------------------------
Rv3132c|M.tuberculosis_H37Rv ---------------------IAVAN------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 TDGATQFENRSLRRDGGVRWLEWNVVSDRGVLLGGARDVTERRREQDRLR
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 ------------------------------------------ARLYQQAK
Rv3132c|M.tuberculosis_H37Rv ------------------------------------------ARLYQQAK
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_0980|M.smegmatis_MC2_155 ----QQAALRRVATLVARGSPPEEVYPAAVDELAAGFGLDHVALLLFPGD
Mvan_2071|M.vanbaalenii_PYR-1 MARTQQAALRRVATLVARGAPLSEVYDVAVTELAHSLGVNHVTLLAFEAD
MAB_4499|M.abscessus_ATCC_1997 ----QQAALRRTATLVASNVSPVELYAKVVEEAARCFASPTAVLVQLMPG
Mflv_2281|M.gilvum_PYR-GCK ---WAHQLWLDISSARFWKAVAHHYVRLTYDALATALAAGLLAFAFLAPA
TH_1533|M.thermoresistible__bu ---WAHQLWLDISSARFWKAAAHHYLRMSYDMLAVGVAFALLAFAFLGPA
Mb3156c|M.bovis_AF2122/97 ARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDE
Rv3132c|M.tuberculosis_H37Rv ARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDE
MMAR_4781|M.marinum_M --------FANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLLPV
MUL_0350|M.ulcerans_Agy99 --------FANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLLIMTLLPV
MAV_0874|M.avium_104 --------LAGVGRLEPFAFTVVDILALTIFQLLSTNGIYPLLIMAMLPV
. . .
MSMEG_0980|M.smegmatis_MC2_155 GTSTVLA----SRDATGAPKFPVGERIPLDGDTVTTLVARTGAPARVDDY
Mvan_2071|M.vanbaalenii_PYR-1 DHAVVRA----ALKSAHQPGFAVGDRLSLDGGSISEQVHRTGLPARIDDY
MAB_4499|M.abscessus_ATCC_1997 DEGTIVA----GHGTEESRTPPAGKRFPLLD---SNNVAR----------
Mflv_2281|M.gilvum_PYR-GCK AAVATGH----SDPEAGLSFLPT---------------------------
TH_1533|M.thermoresistible__bu GAIAVRN----SDDNAGLTFLPP---------------------------
Mb3156c|M.bovis_AF2122/97 DMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRV
Rv3132c|M.tuberculosis_H37Rv DMPAADVGELLVIETVGSAVASIVGRTIPVAGAVLREVFVNGIPRRVDRV
MMAR_4781|M.marinum_M LVALDISSRRAAVVLALTLVG-----------------------------
MUL_0350|M.ulcerans_Agy99 LVALDISSRRAAVVLALTLVG-----------------------------
MAV_0874|M.avium_104 LLGLDVSSRRAAVVLIFSMLG-----------------------------
MSMEG_0980|M.smegmatis_MC2_155 AVVGGAGAARIREVGIRSAVGAPILVDGRVYGVLLVGSSQPFEFPADTEV
Mvan_2071|M.vanbaalenii_PYR-1 SEVPGRIATRLRELGIRSAAGSPLTVDGGTRGVLVVGSHAVQGVPDGTEA
MAB_4499|M.abscessus_ATCC_1997 ------------ELRLTPAVCAPIVVDAKHWGTLIVGSHTPAQRDQDIRA
Mflv_2281|M.gilvum_PYR-GCK ----------------PLAWLLAVVALAAAVAVVVFGP--------ALDA
TH_1533|M.thermoresistible__bu ----------------ALAVVLAVIAVAAAAAILFFAP--------AVDA
Mb3156c|M.bovis_AF2122/97 DLEG-----LDELADAGPALLLPLRARGTVAGVVVVLSQ------GGPGA
Rv3132c|M.tuberculosis_H37Rv DLEG-----LDELADAGPALLLPLRARGTVAGVVVVLSQ------GGPGA
MMAR_4781|M.marinum_M --------------FALALAQDPVVIRMNGWPEAIFRFG----LYAFLCA
MUL_0350|M.ulcerans_Agy99 --------------FGLALAQDPVVIRMNGWPEAIFRFG----LYAFLCA
MAV_0874|M.avium_104 --------------FAIAVLQDPVMSSSVRLPEAGFRFL----LYGFLCC
.: .
MSMEG_0980|M.smegmatis_MC2_155 RVGDFADLVGTAITNAETRAALTASRARIVTA-ADQARRRFERDLHDGAQ
Mvan_2071|M.vanbaalenii_PYR-1 HIGDFADLISTAIANAETRAELTASRARIVAA-ADEARRGFERDLHDGAQ
MAB_4499|M.abscessus_ATCC_1997 GVRDFADLVATAIANAATREELAASRARIVSA-SDTARRRLERDLHDGAQ
Mflv_2281|M.gilvum_PYR-GCK RIDRWLLPPSETAALQHEVSALADARAGAVTS-AQTERHRIERDLHDSVQ
TH_1533|M.thermoresistible__bu RIDRWLLPPSSTEALQHQVSALSDARAGAVSS-AQTERHRIERDLHDSVQ
Mb3156c|M.bovis_AF2122/97 FTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVI
Rv3132c|M.tuberculosis_H37Rv FTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVI
MMAR_4781|M.marinum_M TALMVVRSEERHARSVATLSVIREELLAQTMTASEVLQRRISESIHDGPL
MUL_0350|M.ulcerans_Agy99 TALMVVRSEERHARSVATLSVIREELLAQTMTASEVLQRRISESIHDGPL
MAV_0874|M.avium_104 AAFLVVRIEERHTRSVAGLSALREELLAQTMNASDVSQRRISEFIHDGPL
: : : . :**
MSMEG_0980|M.smegmatis_MC2_155 QRVISLGLGLRAVEASVPDDQLELRLQISRVVDGLSSLSTELQEFSRGIH
Mvan_2071|M.vanbaalenii_PYR-1 QRIVSLSLQLREAEAAVEGDE-ALRTQLSTVVNGLAGLHSDLQELSRGLH
MAB_4499|M.abscessus_ATCC_1997 QRLAYLRLKLGMVRAAVPATDAELTQELNNLDTDLTAVTRELQEFSRGLH
Mflv_2281|M.gilvum_PYR-GCK PRLVSLAMTIGLAQTKLDSDPPTARALIAEAHDEAKNALVELRNVVRGIA
TH_1533|M.thermoresistible__bu PRLVSLAMTIGLAQTKLDTDLPAAKKLIAEAHEDAKSALAELRDVVRGIA
Mb3156c|M.bovis_AF2122/97 QRLFAIGLALQGAVPHE--RNPEVQQRLSDVVDDLQDVIQEIRTTIYDLH
Rv3132c|M.tuberculosis_H37Rv QRLFAIGLALQGAVPHE--RNPEVQQRLSDVVDDLQDVIQEIRTTIYDLH
MMAR_4781|M.marinum_M QDVLAARQELIELRAAAPHDQ-----RVSTALAGLQSASDLLRQATFELH
MUL_0350|M.ulcerans_Agy99 QDVLAARQELIELRAAAPHDQ-----RVSTALAGLQSASDLLRQATFELH
MAV_0874|M.avium_104 QDILAVRQELVELDAAVPDDE-----RIGRALAGLQLASERLRQATFELH
: : . : :: :
MSMEG_0980|M.smegmatis_MC2_155 PAILSKGGLGPALRALARRCP---VPVDLEVDLPEPVP-ESVGVAAYYVV
Mvan_2071|M.vanbaalenii_PYR-1 PAVLSRGGLKPAMRNLARRST---VPVELTVDIDRRLP-EPVEVAAYYVV
MAB_4499|M.abscessus_ATCC_1997 PAILSKG-LAPALRTLARRSL---IPVRTELELDQKYG-ESIEIAAYYVV
Mflv_2281|M.gilvum_PYR-GCK PTILADRGLDAALSSVVQRANNSGVSTTLSVHLPRRLP-DEVEACAYFVV
TH_1533|M.thermoresistible__bu PTILTDRGLDAALSAVVQRAETSGVPTTLNLHLPRRLP-EEVESVAYFVV
Mb3156c|M.bovis_AF2122/97 GASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVV
Rv3132c|M.tuberculosis_H37Rv GASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVV
MMAR_4781|M.marinum_M PAVLEQVGLGAAVEQLASFHAQR-SGIRITDDVDYPIR-DEIDPIVFGVA
MUL_0350|M.ulcerans_Agy99 PAVLEQVGLGAAVEQLASFHAQR-SGIRITDDVDYPIR-DEIDPIVFGVA
MAV_0874|M.avium_104 PAVLEQVGLGAAVQQLAEFTAQR-SGIEISTDIDYSGR-SAIDAVVFGVV
: * : . . : . *.
MSMEG_0980|M.smegmatis_MC2_155 AEALTNAAKYAEAQAIVITATLGDDT-----LDLMIDDDGVGGAVAGGGS
Mvan_2071|M.vanbaalenii_PYR-1 AESLTNVAKHAQADSVTVEIGLDDAPDGGTLLRLSVTDDGTGGASADGGS
MAB_4499|M.abscessus_ATCC_1997 AEALANTAKHSQASEVVIRAHEADDQ-----IHITISDDGIGGAKPRKGT
Mflv_2281|M.gilvum_PYR-GCK AEALTNVSRHSSASNAAVTVRLDEAAN---QLHVSVFDDGRGGARVVDGD
TH_1533|M.thermoresistible__bu AEALTNVVKHAQASQAVVTVRLNETDN---TLQVSVFDDGCGSAQISDRD
Mb3156c|M.bovis_AF2122/97 REAVSNAVRHAKASTLTVRVKVDDDLC------IEVTDNGRGLPDEFTGS
Rv3132c|M.tuberculosis_H37Rv REAVSNAVRHAKASTLTVRVKVDDDLC------IEVTDNGRGLPDEFTGS
MMAR_4781|M.marinum_M RELLSNVVQHSRARNASVALGISDGVC-----VLDVADDGVGVSGETMAR
MUL_0350|M.ulcerans_Agy99 RELLSNVVQHSRARNASVALGISDGVC-----VLDVADDGVGVSGETMAR
MAV_0874|M.avium_104 RELLSNVVQHSRARTAAIMLGRTDGTC-----VLHVVDDGVGFNQETVAR
* ::*. ::: * : : : : *:* *
MSMEG_0980|M.smegmatis_MC2_155 -------GLIGLKDRVEALSGELTITSPSGV-GTTITARIPLHHD-
Mvan_2071|M.vanbaalenii_PYR-1 -------GLVGLRDRVEALSGQLTVTSRPGD-GTSISATIPVD---
MAB_4499|M.abscessus_ATCC_1997 -------GLIGLTDRVTALGGRLDVHSASGR-GTTMTAIIPLHQSD
Mflv_2281|M.gilvum_PYR-GCK DT-VDATGLRGLDERVRAARGTFTVSSPPTG-PTIVTAVLPCGS--
TH_1533|M.thermoresistible__bu ----NATGLRGLAERVRAAHGTFTVSSPPTG-PTIVTAVLPCGS--
Mb3156c|M.bovis_AF2122/97 -------GLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ--
Rv3132c|M.tuberculosis_H37Rv -------GLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ--
MMAR_4781|M.marinum_M RLGQGHIGLASHRARVDAAGGSLVFLNTPTG--THVCVRIPLKG--
MUL_0350|M.ulcerans_Agy99 RLGQGHIGLASHRARVDAAGGSLVFLNTPTG--THVCVRIPLKG--
MAV_0874|M.avium_104 RLGEGHIGLASHRARVEAAGGELVFLDVPVG--THVCVEVPLRN--
** . *. * : . . . * : *