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MTVAEILALPVVLAGDPQVVGGGSLDRPVRWVHVSDVADLSGLLQGGELVLTTGGPLADPDACTRYLGGL FAAGAAGVVVELGTSLQAIPSGVAREADKLQLPVIALHRKIRFVDVTEQVHRSIVAEQYDEVAFARHVHE VFTELTMRRATLGEIVDACGQIAESAIVLEDLNRQVVAFTTHGDSPTGVIHDWERRSRLTPVLPETGETG PESWLTTPVGPGRQEWGRLIAPSGGSSLRGRMALERAAQALALHRMIEQHQTTLEQQAQSGLVEELRRGR IKDEAEASARARALGVKPALSYIPLTVRVREEPCADQVLLQRRQIRLLDAVRHAVRTARLSALTANPRPG QIDVLLSQTHASSAEEILTNVSSVIRASLQRLDDISRCVVGVGPASTRLIDAAVSLDDSAHVAEVALSLP DDAKAFHRASDTRLRGLLALIRSDPRVQAFAEVELRGVLENRARHGDDLFQLLREFLNTGGNKTELAKRL HLSRPTLYTKLAIVQRLLGVDLDDAESRTSLHTAMLVLDHVNP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4347 | - | - | 100% (533) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_4202c | - | 2e-14 | 24.28% (519) | putative regulatory protein |
| M. abscessus ATCC 19977 | MAB_0825 | - | 8e-14 | 21.43% (532) | peptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1226c | - | 0.0001 | 29.86% (144) | hypothetical protein Mb1226c |
| M. gilvum PYR-GCK | Mflv_0356 | - | 1e-127 | 46.72% (533) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2447 | - | 1e-137 | 50.47% (537) | regulatory protein |
| M. thermoresistible (build 8) | TH_2137 | - | 3e-06 | 24.85% (338) | putative DNA-binding protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1825 | - | 1e-124 | 49.13% (517) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0356|M.gilvum_PYR-GCK MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADLSTLLQGGE
Mvan_1825|M.vanbaalenii_PYR-1 --------------------MLSSGRWDEPIRWVHVGDVPDMSALLLGGE
MSMEG_2447|M.smegmatis_MC2_155 MIPTVRDVIGLPVVQAGDPEVVSAENLDCPVRWVHVSDMPDLAGLLHGGE
MAB_4347|M.abscessus_ATCC_1997 --MTVAEILALPVVLAGDPQVVGGGSLDRPVRWVHVSDVADLSGLLQGGE
TH_2137|M.thermoresistible__bu ----VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENAGGLRVTGD
Mb1226c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_0356|M.gilvum_PYR-GCK LVLTTGAAMAR--SPRTYLRGLAEAGAVGVVVEVGAVVPEVPPGVGGIAE
Mvan_1825|M.vanbaalenii_PYR-1 LVLTTGTALNT--APEVYLRGLADAGALGVVVELGTAMHEVPQSVTDLAR
MSMEG_2447|M.smegmatis_MC2_155 LVLTTGAGLAE--APDDYLERMTRAGAVGLVVELGTRVSRLPRGVSDVAR
MAB_4347|M.abscessus_ATCC_1997 LVLTTGGPLADPDACTRYLGGLFAAGAAGVVVELGTSLQAIPSGVAREAD
TH_2137|M.thermoresistible__bu VLLAVG------------AESVAEAVRWAETAQAVVVLTRAGPDASRSCS
Mb1226c|M.bovis_AF2122/97 ------------------MAWQQPSPRIRELIREGARIALNPS--PEWIE
: . . :
Mflv_0356|M.gilvum_PYR-GCK QLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDR----RVHETFTD
Mvan_1825|M.vanbaalenii_PYR-1 SLGLALVALRRQIKFVDVTEAVHRQIVAAQFDEVAFDR----KVHETFTE
MSMEG_2447|M.smegmatis_MC2_155 SLGLPLVLLHRQTRFVEITEAVHRLIVADQYEELAFAH----RTHETFTD
MAB_4347|M.abscessus_ATCC_1997 KLQLPVIALHRKIRFVDVTEQVHRSIVAEQYDEVAFAR----HVHEVFTE
TH_2137|M.thermoresistible__bu DGAVAVLTVEPEVSWSELAAVVYGLVLEGRETESGRGPTDLFALADNLAD
Mb1226c|M.bovis_AF2122/97 ELDRATIAANPAIANDPVLAKVVQTANRAN------------LVYWAAAN
. . : . : * . ::
Mflv_0356|M.gilvum_PYR-GCK LSMKRASLSGIVDAAAKLLGEHVVLEDLSHQALVASTG--IPADLLTDWA
Mvan_1825|M.vanbaalenii_PYR-1 LSVRRASVSSIVDAAARILDQPVVLEDLAHQALAVSARGEPAAELLKNWE
MSMEG_2447|M.smegmatis_MC2_155 LSMRRASLADIVRAAADMINESVVLEDLSHQVLAISPRGEAATAVLAEWQ
MAB_4347|M.abscessus_ATCC_1997 LTMRRATLGEIVDACGQIAESAIVLEDLNRQVVAFTTHGDSPTGVIHDWE
TH_2137|M.thermoresistible__bu AVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEPLRRLFEQLG
Mb1226c|M.bovis_AF2122/97 LRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRTGEHIGWRFWMG-
. : : .. :
Mflv_0356|M.gilvum_PYR-GCK RRSRRS---------PGGGAGAEPWSATDVGPRFEQWGRLVVPYAPADAT
Mvan_1825|M.vanbaalenii_PYR-1 RRSRRN---------PTEGGGAEPWVITSVGLRGEEWGRLLIPSPPAEPG
MSMEG_2447|M.smegmatis_MC2_155 RRSR---------------AMAEPWITTSVGPRTEEWGRLIIPHTPAAPA
MAB_4347|M.abscessus_ATCC_1997 RRSRLTP-----VLPETGETGPESWLTTPVGPGRQEWGRLIAPSG-GSSL
TH_2137|M.thermoresistible__bu VSEHLAAGDDPLFIAARPGHDLTGRTVIAVRAGRELLGSVWVVTPEPLDD
Mb1226c|M.bovis_AF2122/97 -------------------------IAFELTSDPQELRELLDVSARSVND
: : :
Mflv_0356|M.gilvum_PYR-GCK RAATVLERAAAALAMHRMVEQNRTGLQHQAQSGLIDDVLRGRVVDDRDAA
Mvan_1825|M.vanbaalenii_PYR-1 RARMVLERAATALALHRMIEQNRTGLHQQAQSGLIDDVLQGRIADEREIA
MSMEG_2447|M.smegmatis_MC2_155 RAKTVLERAAQALALHRMAERGRSGLEHQAQSGLIEDVLGGRIADDREAA
MAB_4347|M.abscessus_ATCC_1997 RGRMALERAAQALALHRMIEQHQTTLEQQAQSGLVEELRRGRIKDEAEAS
TH_2137|M.thermoresistible__bu GRRRALADGARTVALHLLRSRASADLERQVESDLVLRLLEG----TSDAA
Mb1226c|M.bovis_AF2122/97 FIEATLTGIAAQVQSEHDELTRSTHAERLEVVGLILDGAPIS------PE
.* * : . : .: .*:
Mflv_0356|M.gilvum_PYR-GCK ARAQALGLRSNAQYLPVVVRVARPAEIDDPVAGHRRNVAVLDAVAHTVNA
Mvan_1825|M.vanbaalenii_PYR-1 ARAHALGLRKVPRYLPMVVRVDGLAGGVDPVAAQRLNVNLLETVVHTVNA
MSMEG_2447|M.smegmatis_MC2_155 ARAEALGLRAGGPYLPVTVRTEAPAERLDPVGVQRRNIRILDAVTHSVRS
MAB_4347|M.abscessus_ATCC_1997 ARARALGVKPALSYIPLTVRVRE-EPCADQVLLQRRQIRLLDAVRHAVRT
TH_2137|M.thermoresistible__bu GAAARLGLPQEALRIIAVR----------ARSGVDRQGPLLLAFEHATTG
Mb1226c|M.bovis_AF2122/97 RAEAKLGYPLSRAHTAAIIWS----------DELDGDHSYLDRAADLFCH
** : * .
Mflv_0356|M.gilvum_PYR-GCK CGHTGLFSLRGDGEVGAVLSLKDSRTRSVDQALGALARRIHTEIRRVDGS
Mvan_1825|M.vanbaalenii_PYR-1 SGHTGLFSVRGPGEIGGLVALNPGR-ASADKALSEIGQQLRRDIGRSTGG
MSMEG_2447|M.smegmatis_MC2_155 QGHTAICSIRRDGEIGFVLALTPRRNLTADAALARLAEGLRESVTRSGVT
MAB_4347|M.abscessus_ATCC_1997 ARLSALTANPRPGQIDVLLSQTHAS--SAEEILTNVSSVIRASLQRLDDI
TH_2137|M.thermoresistible__bu FGWSRAGRSALAGDT-VYTVLPADHAATARRWVEGLQAALPSEVTVSAGI
Mb1226c|M.bovis_AF2122/97 AVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPGARIAIGTTA
: * : :
Mflv_0356|M.gilvum_PYR-GCK D-RVVVTLGPSARNVTDAIAGLAEAIDTAEVALSLR----GDVRDFYRTS
Mvan_1825|M.vanbaalenii_PYR-1 K-RSVCAVAQPGVEIADSIRGLAEAAHIAEVALAMGD---AEARDFHRAA
MSMEG_2447|M.smegmatis_MC2_155 T-KVVVAVANNATAFADAVHGLREAAHIAEVALPMAGTARLSGRAFVRAS
MAB_4347|M.abscessus_ATCC_1997 S-RCVVGVGPASTRLIDAAVSLDDSAHVAEVALSLPD----DAKAFHRAS
TH_2137|M.thermoresistible__bu SGIADHTELPDARREADECLALHDALHDARPDTGSPDSD-SDALAAVVYD
Mb1226c|M.bovis_AF2122/97 N----------------GVEGFRRSHLEALITQRTLS----RLRSTQRVA
.: : *
Mflv_0356|M.gilvum_PYR-GCK DIRLRGLISLLRDDPRIRRFAET-ELRALLAHDAGAEP--SNISVLREYL
Mvan_1825|M.vanbaalenii_PYR-1 DVRLRGLISLLRDDPRVQQFAET-ELKAMLAEDPAAHHGLTDLQVLRAYL
MSMEG_2447|M.smegmatis_MC2_155 DVRLRGLITLMSDDPRVQTFAET-ELRSLLIHDADHGE--DDMAVLRGYL
MAB_4347|M.abscessus_ATCC_1997 DTRLRGLLALIRSDPRVQAFAEV-ELRGVLENRARHGD--DLFQLLREFL
TH_2137|M.thermoresistible__bu ESWHDVLLQRLRTAARAGRIPSRGPIAALHEHDLRHAT--QYVATLRSWL
Mb1226c|M.bovis_AF2122/97 FFADVKMVALISQNPDAASEFITSTLGDLESASPDLQT------ALLTFI
:: : . : : * ::
Mflv_0356|M.gilvum_PYR-GCK RLAGNKSALAERLHMSRPALYKRLRGIEDALGVDLDDGESMTSLHVAVMV
Mvan_1825|M.vanbaalenii_PYR-1 QLGGNKVALAKRLHVSRPALYKRLAAISDKLGVPLDDAESMTSLHVAMMV
MSMEG_2447|M.smegmatis_MC2_155 ELAGNKSALAKRLHMSRPALYSRLAAIQRRLGVDLDDGESMTSLHVALLI
MAB_4347|M.abscessus_ATCC_1997 NTGGNKTELAKRLHLSRPTLYTKLAIVQRLLGVDLDDAESRTSLHTAMLV
TH_2137|M.thermoresistible__bu AAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQLDLQDPDKRLAMMIELAA
Mb1226c|M.bovis_AF2122/97 NEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQ
: . * . :. :* *:. . ::
Mflv_0356|M.gilvum_PYR-GCK LDSLTG------SG-------
Mvan_1825|M.vanbaalenii_PYR-1 QDARRRRESPAPSG-------
MSMEG_2447|M.smegmatis_MC2_155 LDTHRSANPEPAR--------
MAB_4347|M.abscessus_ATCC_1997 LDHVNP---------------
TH_2137|M.thermoresistible__bu IEGPPILSG------------
Mb1226c|M.bovis_AF2122/97 WRGNKAHALSSPGRRSNSVPA