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VRALGVLVGAVMALLMCAPSGVAQAAPAETARDVISIGDPGAPGQIELFVDPLCPFSGKMIQQQGAEIGR RIENGSLHVNLRFVNFLERLSASGTYDSRAIYAAFAVAGYSRDSGVTWRFVEQIFSAEQQPKEQGNTDLS NDQLAGLADRAGAPRLAQDLIRLGLFVGYDPVAIANSNQAALRQFAEPGVPTVVIDGRPYDGNSDWMSRL PR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1215 | - | - | 100% (212) | serine/threonine-protein kinase PknE, putative |
| M. smegmatis MC2 155 | MSMEG_1111 | - | 1e-11 | 29.82% (171) | hypothetical protein MSMEG_1111 |
| M. smegmatis MC2 155 | MSMEG_2410 | - | 5e-09 | 29.73% (148) | putative serine-threonine protein kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 2e-17 | 29.90% (194) | transmembrane serine/threonine-protein kinase E |
| M. gilvum PYR-GCK | Mflv_5261 | - | 2e-09 | 29.89% (174) | hypothetical protein Mflv_5261 |
| M. tuberculosis H37Rv | Rv1743 | pknE | 2e-17 | 29.90% (194) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4736 | - | 1e-68 | 59.43% (212) | hypothetical protein MAB_4736 |
| M. marinum M | MMAR_2581 | pknE | 1e-16 | 29.02% (193) | transmembrane serine/threonine-protein kinase E PknE |
| M. avium 104 | MAV_3813 | - | 2e-10 | 27.87% (183) | hypothetical protein MAV_3813 |
| M. thermoresistible (build 8) | TH_2711 | - | 4e-10 | 28.40% (169) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3180 | pknE | 3e-15 | 30.67% (150) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_5558 | - | 5e-11 | 27.23% (191) | DSBA oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
Rv1743|M.tuberculosis_H37Rv -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
MMAR_2581|M.marinum_M MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
MUL_3180|M.ulcerans_Agy99 MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 TLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
Rv1743|M.tuberculosis_H37Rv TLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
MMAR_2581|M.marinum_M TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
MUL_3180|M.ulcerans_Agy99 TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
Rv1743|M.tuberculosis_H37Rv DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
MMAR_2581|M.marinum_M DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
MUL_3180|M.ulcerans_Agy99 DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
Rv1743|M.tuberculosis_H37Rv DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
MMAR_2581|M.marinum_M DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
MUL_3180|M.ulcerans_Agy99 DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
Rv1743|M.tuberculosis_H37Rv ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
MMAR_2581|M.marinum_M ALACVLYECLTGSPPYRGDQLSVMGAHLSQPIPRPSAARPGIPAGFDNVI
MUL_3180|M.ulcerans_Agy99 ALACVLYECLTGSPPYRGDQLSVIGAHLSQPIPRPSAARPGIPAGFDNVI
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
Rv1743|M.tuberculosis_H37Rv ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
MMAR_2581|M.marinum_M ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
MUL_3180|M.ulcerans_Agy99 ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 PSTHP--------------VSPGTRWPQP--------------TPWAG--
Rv1743|M.tuberculosis_H37Rv PSTHP--------------VSPGTRWPQP--------------TPWAG--
MMAR_2581|M.marinum_M ASTPPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
MUL_3180|M.ulcerans_Agy99 ASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 ---------------------------------------MRALGVLVGAV
MAB_4736|M.abscessus_ATCC_1997 ------------------------------------MHAAKRLTTILGLL
Mb1772|M.bovis_AF2122/97 ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
Rv1743|M.tuberculosis_H37Rv ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
MMAR_2581|M.marinum_M GWGVGHTGTTGAPPWGQPP-PQPTVAAKTWPWIAAAVAVVVVIAGVLGVV
MUL_3180|M.ulcerans_Agy99 GWGVGHTGTTGAPPWGQPP-PEPTVAAKTWPWIAAAVAVVVVIAGVLGVV
Mflv_5261|M.gilvum_PYR-GCK ----------------------------------MRISRPLALVAALGLL
TH_2711|M.thermoresistible__bu -------------------------------------MRWLTLTAMLGVA
MAV_3813|M.avium_104 -----------MADNPKRPPRFDMKSASGGKSGRLVQIGGTAFVVIFAVA
Mvan_5558|M.vanbaalenii_PYR-1 -----------MSGSRRESVVKDLVFIGGLLILAVALIVYLVMGSEEVSD
:
MSMEG_1215|M.smegmatis_MC2_155 MALLMCAP-SGVAQAAPAETARDVIS--------------IGDPGAPGQI
MAB_4736|M.abscessus_ATCC_1997 TAVLIWGPNVGLARAAEAAPAGDVLS--------------IGAPEAPGQI
Mb1772|M.bovis_AF2122/97 LAHPWRSSGPRTSAPPPPPPADAVELRVLND------GVFVGSSVAPTTI
Rv1743|M.tuberculosis_H37Rv LAHPWRSSGPRTSAPPPPPPADAVELRVLND------GVFVGSSVAPTTI
MMAR_2581|M.marinum_M IAHPWRSPGPPTASAPPPPPPDAVQLRVLND------GVFIGSSAATTTI
MUL_3180|M.ulcerans_Agy99 IAHPWRSPGPPTASAPPPPPPDAVQLRVLND------GVFIGSSAATTTI
Mflv_5261|M.gilvum_PYR-GCK VGP-GCSRAVTG---TPRADPAPVPLAVAEDG----FGVVAGFDTAPAKI
TH_2711|M.thermoresistible__bu VLLSGCTVTVDGAASAPADAPGDATVVVAEDG----YGVELGYQFAPARI
MAV_3813|M.avium_104 LVFYIVTSHHKKAGPTGAGDTVRVTSSKLITQ--------PGSSNPKAVV
Mvan_5558|M.vanbaalenii_PYR-1 AASQPMSPQVSAPESNAPGGQVDAVTALSVERRTTGDPLAQGDPAAPVVM
. * . :
MSMEG_1215|M.smegmatis_MC2_155 ELFVDPLCPFSGKMIQQQGAE-IGRRIENGSLHVNLRFVNFLERLSASGT
MAB_4736|M.abscessus_ATCC_1997 DLYLDPLCPYSGKMVQDQGEE-IARLIESGRLHINLRFVDFLDKYSASGT
Mb1772|M.bovis_AF2122/97 DIFNEPICPPCGSFIRSYASD-IDTAVADKQLAVRYHLLNFLDDQSHSKN
Rv1743|M.tuberculosis_H37Rv DIFNEPICPPCGSFIRSYASD-IDTAVADKQLAVRYHLLNFLDDQSHSKN
MMAR_2581|M.marinum_M DIFNEPICPPCGAFIRSYASD-IDAAVANKKLAVRYHLLNFLDEQSHTKT
MUL_3180|M.ulcerans_Agy99 DIFNEPICPPCGAFIRSYASD-IDAAVANKKLAVRYHLLNFLDEQSHTKT
Mflv_5261|M.gilvum_PYR-GCK EIYTEPQCTHCGDLQREYGDE-LAYHITVGDLQVVYRPLTFLDDSY--DG
TH_2711|M.thermoresistible__bu EIYIEPLCPACARLQRRYGED-LRSAIERDELRVTYRPLTFLDRS---GG
MAV_3813|M.avium_104 TLYEDFLCPACGNFERTFGPT-VSKLIDLGAIAADYSMVSILDSPR-NQN
Mvan_5558|M.vanbaalenii_PYR-1 VMFADYRCPFCAKFSRDTEPDLVERFVDQGVLRLEWRDMPIFGEQS----
:: : *. .. : : : : : : ::
MSMEG_1215|M.smegmatis_MC2_155 YDSRAIYAAFAVAGYSRDSGVTWRFVEQIFSAEQQPKEQGNTDLSNDQLA
MAB_4736|M.abscessus_ATCC_1997 YDTRAIYASFVVADQSRSSETTWRFIQQIYAKDAQPKEEGDTDLTNDQLA
Mb1772|M.bovis_AF2122/97 YSTRAVAASYCVAG-QNDPKLYASFYSALFGSDFQPQENAASDRTDAELA
Rv1743|M.tuberculosis_H37Rv YSTRAVAASYCVAG-QNDPKLYASFYSALFGSDFQPQENAASDRTDAELA
MMAR_2581|M.marinum_M YSTRAVAASYCVAA-QDDPKVYTDFYAALFASDFQPQEAAASDRTDAELA
MUL_3180|M.ulcerans_Agy99 YSTRAVAASYCVAA-QDDPKVYTDFYAALFASDFQPQEAAASDRTDAELA
Mflv_5261|M.gilvum_PYR-GCK YSATVANALFAATEAKGEFPANGTQFQRFVEQLWVNQDPGGQPFAADELR
TH_2711|M.thermoresistible__bu YSKRVSNALFAAAEPGSD--AGATQVQAFVMQTYRLLSPVGDNLDARGLA
MAV_3813|M.avium_104 YSSRAGAAALCVAD--ESLDAFRRFHTALFSTAIQPSETGKTFPDNARLI
Mvan_5558|M.vanbaalenii_PYR-1 --MRAARAGRAAAE----QGKFWEFNHEVFAMS---PDRGHADLNEDALV
. * .: . . *
MSMEG_1215|M.smegmatis_MC2_155 GLADRAGAPRLAQDLIRL-----GLFVGYDPVAIANSNQAALRQFAEPGV
MAB_4736|M.abscessus_ATCC_1997 ALAERVHAPQGAQDLIRL-----GLPVPFDARAIAANNLPLLRAFPKSGV
Mb1772|M.bovis_AF2122/97 HLAQTVGAEPTAISCIKS-----GADLG-TAQTKATNASETLAGFNASGT
Rv1743|M.tuberculosis_H37Rv HLAQTVGAEPTAISCIKS-----GADLG-TAQTKATNASETLAGFNASGT
MMAR_2581|M.marinum_M HLAQTVGANGTATSCIKA-----GNDMG-TARTKAAAADATLSELNASGT
MUL_3180|M.ulcerans_Agy99 HLAQTVGANGTATSCIKA-----GNDMG-TARTKAAAADATLSELNAG--
Mflv_5261|M.gilvum_PYR-GCK RMADDAGLPGPVADRVAG-----GSEAV-DLVDMEDHNFEMLFEVDQITT
TH_2711|M.thermoresistible__bu AVAGDVGLPDDVVDLIAD-----NAPAV-DVEAMDSYNTERFEELTGKRA
MAV_3813|M.avium_104 ELARESGVVGKVPDCINS-----GKYIAKVTGEAAAAKIRATPTIKINGE
Mvan_5558|M.vanbaalenii_PYR-1 GFAEKAGVPDIDKFAASMRGNEFDAAIDADLAQGSSIGVPSTPAFVINGE
.* . .
MSMEG_1215|M.smegmatis_MC2_155 P-------TVVIDGRPYDGNSDWMSRLPR----
MAB_4736|M.abscessus_ATCC_1997 P-------MVVIGNQPVDGESDWLSRIPR----
Mb1772|M.bovis_AF2122/97 ------PFVWDGSMVVNYQDPSWLARLIG----
Rv1743|M.tuberculosis_H37Rv ------PFVWDGSMVVNYQDPSWLARLIG----
MMAR_2581|M.marinum_M ------PFVWDGSKSIDLQNPSWLTKLIG----
MUL_3180|M.ulcerans_Agy99 -----------------------LRRC------
Mflv_5261|M.gilvum_PYR-GCK GTP--TVYDLNAAEKLDIADSSWLADLVKS---
TH_2711|M.thermoresistible__bu YTP--MVFDLNARAEVDVDDPDWVADVIEGS--
MAV_3813|M.avium_104 DYDPSTPDALVGKIKEIVGDIPGLDGAVAPAAM
Mvan_5558|M.vanbaalenii_PYR-1 P---------VLGAQPTEEFVRVIDEAKDRT--
: