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MHAAKRLTTILGLLTAVLIWGPNVGLARAAEAAPAGDVLSIGAPEAPGQIDLYLDPLCPYSGKMVQDQGE EIARLIESGRLHINLRFVDFLDKYSASGTYDTRAIYASFVVADQSRSSETTWRFIQQIYAKDAQPKEEGD TDLTNDQLAALAERVHAPQGAQDLIRLGLPVPFDARAIAANNLPLLRAFPKSGVPMVVIGNQPVDGESDW LSRIPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4736 | - | - | 100% (216) | hypothetical protein MAB_4736 |
| M. abscessus ATCC 19977 | MAB_3089c | - | 2e-12 | 31.07% (177) | hypothetical protein MAB_3089c |
| M. abscessus ATCC 19977 | MAB_3269c | - | 1e-07 | 29.41% (119) | hypothetical protein MAB_3269c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 3e-19 | 31.22% (189) | transmembrane serine/threonine-protein kinase E |
| M. gilvum PYR-GCK | Mflv_4202 | - | 2e-10 | 28.99% (169) | hypothetical protein Mflv_4202 |
| M. tuberculosis H37Rv | Rv1743 | pknE | 3e-19 | 31.22% (189) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2581 | pknE | 6e-18 | 31.02% (187) | transmembrane serine/threonine-protein kinase E PknE |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1215 | - | 2e-68 | 59.43% (212) | serine/threonine-protein kinase PknE, putative |
| M. thermoresistible (build 8) | TH_2711 | - | 1e-10 | 31.05% (190) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3180 | pknE | 2e-15 | 32.14% (140) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_2163 | - | 9e-11 | 29.63% (162) | hypothetical protein Mvan_2163 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
MUL_3180|M.ulcerans_Agy99 MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
Mb1772|M.bovis_AF2122/97 -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
Rv1743|M.tuberculosis_H37Rv -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
MUL_3180|M.ulcerans_Agy99 TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
Mb1772|M.bovis_AF2122/97 TLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
Rv1743|M.tuberculosis_H37Rv TLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
MUL_3180|M.ulcerans_Agy99 DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
Mb1772|M.bovis_AF2122/97 DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
Rv1743|M.tuberculosis_H37Rv DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
MUL_3180|M.ulcerans_Agy99 DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
Mb1772|M.bovis_AF2122/97 DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
Rv1743|M.tuberculosis_H37Rv DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M ALACVLYECLTGSPPYRGDQLSVMGAHLSQPIPRPSAARPGIPAGFDNVI
MUL_3180|M.ulcerans_Agy99 ALACVLYECLTGSPPYRGDQLSVIGAHLSQPIPRPSAARPGIPAGFDNVI
Mb1772|M.bovis_AF2122/97 ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
Rv1743|M.tuberculosis_H37Rv ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
MUL_3180|M.ulcerans_Agy99 ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
Mb1772|M.bovis_AF2122/97 ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
Rv1743|M.tuberculosis_H37Rv ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2581|M.marinum_M ASTPPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
MUL_3180|M.ulcerans_Agy99 ASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
Mb1772|M.bovis_AF2122/97 PSTHP--------------VSPGTRWPQP--------------TPWAG--
Rv1743|M.tuberculosis_H37Rv PSTHP--------------VSPGTRWPQP--------------TPWAG--
Mflv_4202|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2163|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MAB_4736|M.abscessus_ATCC_1997 ------------------------------------MHAAKRLTTILGLL
MSMEG_1215|M.smegmatis_MC2_155 ---------------------------------------MRALGVLVGAV
MMAR_2581|M.marinum_M GWGVGHTGTTGAPPWGQPP-PQPTVAAKTWPWIAAAVAVVVVIAGVLGVV
MUL_3180|M.ulcerans_Agy99 GWGVGHTGTTGAPPWGQPP-PEPTVAAKTWPWIAAAVAVVVVIAGVLGVV
Mb1772|M.bovis_AF2122/97 ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
Rv1743|M.tuberculosis_H37Rv ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
Mflv_4202|M.gilvum_PYR-GCK ---------MASKPKKNARYDLKAADRKRNLLIQIGLTAVVVIFAVALVL
Mvan_2163|M.vanbaalenii_PYR-1 ---------MATKPKKNARYDLKAADRKRNLLVQIGLTAVVVIFAVTLVL
TH_2711|M.thermoresistible__bu -------------------------------------MRWLTLTAMLGVA
:
MAB_4736|M.abscessus_ATCC_1997 TAVLIWGPNVGLARAAEAAPAGDVLS----------IGAPEAPGQIDLYL
MSMEG_1215|M.smegmatis_MC2_155 MALLMCAP-SGVAQAAPAETARDVIS----------IGDPGAPGQIELFV
MMAR_2581|M.marinum_M IAHPWRSPGPPTASAPPPPPPDAVQLRVLND--GVFIGSSAATTTIDIFN
MUL_3180|M.ulcerans_Agy99 IAHPWRSPGPPTASAPPPPPPDAVQLRVLND--GVFIGSSAATTTIDIFN
Mb1772|M.bovis_AF2122/97 LAHPWRSSGPRTSAPPPPPPADAVELRVLND--GVFVGSSVAPTTIDIFN
Rv1743|M.tuberculosis_H37Rv LAHPWRSSGPRTSAPPPPPPADAVELRVLND--GVFVGSSVAPTTIDIFN
Mflv_4202|M.gilvum_PYR-GCK YIVGSADDKPTAGESRGIRVESTSVIKK--------EGTDEPKAVVSMYE
Mvan_2163|M.vanbaalenii_PYR-1 YIVLSADDKPTAGESRAIRVESTSVIKK--------DGTDEPKAVLSMYE
TH_2711|M.thermoresistible__bu VLLSGCTVTVDGAASAPADAPGDATVVVAEDGYGVELGYQFAPARIEIYI
. . * . :.::
MAB_4736|M.abscessus_ATCC_1997 DPLCPYSGKMVQDQGEEIARLIESGRLHINLRFVDFLDKYSASGTYDTRA
MSMEG_1215|M.smegmatis_MC2_155 DPLCPFSGKMIQQQGAEIGRRIENGSLHVNLRFVNFLERLSASGTYDSRA
MMAR_2581|M.marinum_M EPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRA
MUL_3180|M.ulcerans_Agy99 EPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRA
Mb1772|M.bovis_AF2122/97 EPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRA
Rv1743|M.tuberculosis_H37Rv EPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRA
Mflv_4202|M.gilvum_PYR-GCK DFLCPHCGAFEQQFGPTINKLVDAGAIAADYYMVGILDR-PQNQNYPARA
Mvan_2163|M.vanbaalenii_PYR-1 DFLCPHCGAFEQQFGPTISKLIDSGAIAADYYMVGILDR-SQNQNYPSRA
TH_2711|M.thermoresistible__bu EPLCPACARLQRRYGEDLRSAIERDELRVTYRPLTFLDR---SGGYSKRV
: :** .. : : . : : : : :*: . * *.
MAB_4736|M.abscessus_ATCC_1997 IYASFVVADQSRSSETTWRFIQQIYAKDAQPKEEGDTDLTNDQLAALAER
MSMEG_1215|M.smegmatis_MC2_155 IYAAFAVAGYSRDSGVTWRFVEQIFSAEQQPKEQGNTDLSNDQLAGLADR
MMAR_2581|M.marinum_M VAASYCVAAQD-DPKVYTDFYAALFASDFQPQEAAASDRTDAELAHLAQT
MUL_3180|M.ulcerans_Agy99 VAASYCVAAQD-DPKVYTDFYAALFASDFQPQEAAASDRTDAELAHLAQT
Mb1772|M.bovis_AF2122/97 VAASYCVAGQN-DPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQT
Rv1743|M.tuberculosis_H37Rv VAASYCVAGQN-DPKLYASFYSALFGSDFQPQENAASDRTDAELAHLAQT
Mflv_4202|M.gilvum_PYR-GCK GGAAYCVADES--IDAFKRFHAALYAQ--QPGETGSTYPDNARLIEIARQ
Mvan_2163|M.vanbaalenii_PYR-1 GGAAYCVADES--VDAFRRFHAALYAQ--QPSEAGSAYPDNARLIEVARQ
TH_2711|M.thermoresistible__bu SNALFAAAEPG--SDAGATQVQAFVMQTYRLLSPVGDNLDARGLAAVAGD
* : .* . : : . * :*
MAB_4736|M.abscessus_ATCC_1997 VHAPQGAQDLIRLGLPVPFDARAIAANNL---PLLRAFPKSGVPMVVIGN
MSMEG_1215|M.smegmatis_MC2_155 AGAPRLAQDLIRLGLFVGYDPVAIANSNQ---AALRQFAEPGVPTVVIDG
MMAR_2581|M.marinum_M VGANGTATSCIKAGNDMG-TARTKAAAAD---ATLSELNASGTPFVWDGS
MUL_3180|M.ulcerans_Agy99 VGANGTATSCIKAGNDMG-TARTKAAAAD---ATLSELNAG---------
Mb1772|M.bovis_AF2122/97 VGAEPTAISCIKSGADLG-TAQTKATNAS---ETLAGFNASGTPFVWDGS
Rv1743|M.tuberculosis_H37Rv VGAEPTAISCIKSGADLG-TAQTKATNAS---ETLAGFNASGTPFVWDGS
Mflv_4202|M.gilvum_PYR-GCK SGATGGVPECINKGTYVDMVGGLARATEI---KSTPTVRINGEEYQYSTP
Mvan_2163|M.vanbaalenii_PYR-1 SGAAGAVPECINKGTYVDMVAGLASATGV---KSTPSVRINGEDYQYSTP
TH_2711|M.thermoresistible__bu VGLPDDVVDLIADNAPAVDVEAMDSYNTERFEELTGKRAYTPMVFDLNAR
. . * .
MAB_4736|M.abscessus_ATCC_1997 QPVD-GESDWLSRIPR----------------
MSMEG_1215|M.smegmatis_MC2_155 RPYD-GNSDWMSRLPR----------------
MMAR_2581|M.marinum_M KSIDLQNPSWLTKLIG----------------
MUL_3180|M.ulcerans_Agy99 ----------LRRC------------------
Mb1772|M.bovis_AF2122/97 MVVNYQDPSWLARLIG----------------
Rv1743|M.tuberculosis_H37Rv MVVNYQDPSWLARLIG----------------
Mflv_4202|M.gilvum_PYR-GCK DALVAKIKEIVGDVPGLEAAPPAPAPQPAPAS
Mvan_2163|M.vanbaalenii_PYR-1 EALVTKIKEIVGDVPGLEAAPPAPAPQPAPAS
TH_2711|M.thermoresistible__bu AEVDVDDPDWVADVIEGS--------------
: