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MRISRPLALVAALGLLVGPGCSRAVTGTPRADPAPVPLAVAEDGFGVVAGFDTAPAKIEIYTEPQCTHCG DLQREYGDELAYHITVGDLQVVYRPLTFLDDSYDGYSATVANALFAATEAKGEFPANGTQFQRFVEQLWV NQDPGGQPFAADELRRMADDAGLPGPVADRVAGGSEAVDLVDMEDHNFEMLFEVDQITTGTPTVYDLNAA EKLDIADSSWLADLVKS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5261 | - | - | 100% (227) | hypothetical protein Mflv_5261 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1772 | pknE | 7e-09 | 25.00% (224) | transmembrane serine/threonine-protein kinase E |
| M. tuberculosis H37Rv | Rv1743 | pknE | 7e-09 | 25.00% (224) | transmembrane serine/threonine-protein kinase E |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3089c | - | 2e-17 | 30.45% (220) | hypothetical protein MAB_3089c |
| M. marinum M | MMAR_2581 | pknE | 2e-08 | 24.11% (224) | transmembrane serine/threonine-protein kinase E PknE |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1111 | - | 9e-47 | 43.36% (226) | hypothetical protein MSMEG_1111 |
| M. thermoresistible (build 8) | TH_2711 | - | 5e-41 | 43.81% (226) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3180 | pknE | 1e-05 | 24.00% (175) | transmembrane serine/threonine-protein kinase E PknE |
| M. vanbaalenii PYR-1 | Mvan_0977 | - | 3e-82 | 65.62% (224) | hypothetical protein Mvan_0977 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
Rv1743|M.tuberculosis_H37Rv -MDGTAESREGTQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSE
MMAR_2581|M.marinum_M MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
MUL_3180|M.ulcerans_Agy99 MSDATADSREGSQFGPYRLRRIVGRGAMGDVYEAEDTVRERVVALKLMSQ
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 TLSSDPDFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
Rv1743|M.tuberculosis_H37Rv TLSSDPVFRTRMQREARTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGV
MMAR_2581|M.marinum_M TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
MUL_3180|M.ulcerans_Agy99 TLSNDPVFRTRMQREARTAGRLQEPHVVPIHDYGEIDGQLYVDMRLIDGK
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
Rv1743|M.tuberculosis_H37Rv DLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSA
MMAR_2581|M.marinum_M DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
MUL_3180|M.ulcerans_Agy99 DLAAMLKRYGPLPPPRAVAITRQIGSALDAAHAAGVTHRDVKPENILVSH
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
Rv1743|M.tuberculosis_H37Rv DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYRADIY
MMAR_2581|M.marinum_M DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
MUL_3180|M.ulcerans_Agy99 DDFAYLVDFGIASATSDEKLTQLGSTVGTLYYMAPERFSSGDVTYRADIY
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
Rv1743|M.tuberculosis_H37Rv ALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI
MMAR_2581|M.marinum_M ALACVLYECLTGSPPYRGDQLSVMGAHLSQPIPRPSAARPGIPAGFDNVI
MUL_3180|M.ulcerans_Agy99 ALACVLYECLTGSPPYRGDQLSVIGAHLSQPIPRPSAARPGIPAGFDNVI
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
Rv1743|M.tuberculosis_H37Rv ARGMAKNPEDRYVTCGDLSAAAHAALATADQDRATDILRRSQVAKLPV--
MMAR_2581|M.marinum_M ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
MUL_3180|M.ulcerans_Agy99 ARGMAKDPADRYATCGDLSAAAYSALATPDQDRATDILQRSQVAQLPAGF
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0977|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2711|M.thermoresistible__bu --------------------------------------------------
MSMEG_1111|M.smegmatis_MC2_155 --------------------------------------------------
Mb1772|M.bovis_AF2122/97 PSTHP--------------VSPGTRWPQP--------------TPWAG--
Rv1743|M.tuberculosis_H37Rv PSTHP--------------VSPGTRWPQP--------------TPWAG--
MMAR_2581|M.marinum_M ASTPPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
MUL_3180|M.ulcerans_Agy99 ASTSPGGFAPSSPAVPVPGSAPSTGWPAPSVPGAPVAPSAPVPTPWAGVP
MAB_3089c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5261|M.gilvum_PYR-GCK ----------------------------------MRISRPLALVAALG-L
Mvan_0977|M.vanbaalenii_PYR-1 ----------------------------------MHWIRPLAALSAFGLL
TH_2711|M.thermoresistible__bu -------------------------------------MRWLTLTAMLGVA
MSMEG_1111|M.smegmatis_MC2_155 ---------------------------MPAKVAAMRMTRVLG-AVLAAVV
Mb1772|M.bovis_AF2122/97 ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
Rv1743|M.tuberculosis_H37Rv ----------GAPPWGPPSSPLPRSARQPWLWVGVAVAVVVALAGGLGIA
MMAR_2581|M.marinum_M GWGVGHTGTTGAPPWGQPP-PQPTVAAKTWPWIAAAVAVVVVIAGVLGVV
MUL_3180|M.ulcerans_Agy99 GWGVGHTGTTGAPPWGQPP-PEPTVAAKTWPWIAAAVAVVVVIAGVLGVV
MAB_3089c|M.abscessus_ATCC_199 ------------------------------MSAPGAAGVPKVLLLAAIVL
Mflv_5261|M.gilvum_PYR-GCK LVGPGCSRAVTGTPRADPAP---VPLAVAEDGFGVVAGFDTAPAKIEIYT
Mvan_0977|M.vanbaalenii_PYR-1 LTAVGCAKQVTGVARVDATG---APLAVTEDGFGIVAGFDDAPVKIEIYT
TH_2711|M.thermoresistible__bu VLLSGCTVTVDGAASAPADAPGDATVVVAEDGYGVELGYQFAPARIEIYI
MSMEG_1111|M.smegmatis_MC2_155 LTTAGCARVVEGTPQANTDP---PGSEITEDGSGILIGYHAAPVRIEIFA
Mb1772|M.bovis_AF2122/97 LAHPWRSSGPRTSAPPPPPPADAVELRVLNDG--VFVGSSVAPTTIDIFN
Rv1743|M.tuberculosis_H37Rv LAHPWRSSGPRTSAPPPPPPADAVELRVLNDG--VFVGSSVAPTTIDIFN
MMAR_2581|M.marinum_M IAHPWRSPGPPTASAPPPPPPDAVQLRVLNDG--VFIGSSAATTTIDIFN
MUL_3180|M.ulcerans_Agy99 IAHPWRSPGPPTASAPPPPPPDAVQLRVLNDG--VFIGSSAATTTIDIFN
MAB_3089c|M.abscessus_ATCC_199 LVLTGCARTVEGTASAPVEA---AGWGNSQGAGVTVGGAGDVAAGITVFL
: : . :.. * ... * ::
Mflv_5261|M.gilvum_PYR-GCK EPQCTHCGDLQREYGDELAYHITVGDLQVVYRPLTFLDDSY--DGYSATV
Mvan_0977|M.vanbaalenii_PYR-1 EPQCTHCSDLQHEFGEQLADSISVGTLQVTYRPLTFLDDDY--DGYSAKV
TH_2711|M.thermoresistible__bu EPLCPACARLQRRYGEDLRSAIERDELRVTYRPLTFLDRS---GGYSKRV
MSMEG_1111|M.smegmatis_MC2_155 EPQCPPCGRLQRDYGDEIAEYVGEGRLAVVYRPMTFLDLDG--PGYSAHV
Mb1772|M.bovis_AF2122/97 EPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRA
Rv1743|M.tuberculosis_H37Rv EPICPPCGSFIRSYASDIDTAVADKQLAVRYHLLNFLDDQSHSKNYSTRA
MMAR_2581|M.marinum_M EPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRA
MUL_3180|M.ulcerans_Agy99 EPICPPCGAFIRSYASDIDAAVANKKLAVRYHLLNFLDEQSHTKTYSTRA
MAB_3089c|M.abscessus_ATCC_199 DFQCPFCQRFEAQYGEDITTYVTEGRLQVTYRPVSFLDRISASGDYSSRA
: *. * : :..:: : * * *: :.*** ** .
Mflv_5261|M.gilvum_PYR-GCK ANALFAATEAKGEFPANGTQFQRFVEQLWVNQDPGGQP-FAADELRRMAD
Mvan_0977|M.vanbaalenii_PYR-1 ANALFLATEAVDNSAATGTQLQRFVEELWINQDPGGAV-FTADELRDMAV
TH_2711|M.thermoresistible__bu SNALFAAAEPGSD--AGATQVQAFVMQTYRLLSPVGDN-LDARGLAAVAG
MSMEG_1111|M.smegmatis_MC2_155 SNALFLAAGPDTD----ATTFQKFVQTVWSNQEPEGSAGPSDDELADMAS
Mb1772|M.bovis_AF2122/97 VAASYCVAGQNDPKLYASFYSALFGSDFQPQENAASDR--TDAELAHLAQ
Rv1743|M.tuberculosis_H37Rv VAASYCVAGQNDPKLYASFYSALFGSDFQPQENAASDR--TDAELAHLAQ
MMAR_2581|M.marinum_M VAASYCVAAQDDPKVYTDFYAALFASDFQPQEAAASDR--TDAELAHLAQ
MUL_3180|M.ulcerans_Agy99 VAASYCVAAQDDPKVYTDFYAALFASDFQPQEAAASDR--TDAELAHLAQ
MAB_3089c|M.abscessus_ATCC_199 AAALFLIDKAGAT----DAVILGFIGEMFRRQPVEGVGNLTNLQISEIAA
* : * . : :*
Mflv_5261|M.gilvum_PYR-GCK DAGLPGPVADRVAGGSEAVDLVDMEDHNFEMLFEVDQITTGTPTVYDLNA
Mvan_0977|M.vanbaalenii_PYR-1 SAGLPEAVADHVATDSEAVDVAEMDDTNFGLLFDIDRVDTGTPTVFDLDA
TH_2711|M.thermoresistible__bu DVGLPDDVVDLIADNAPAVDVEAMDSYNTERFEELTGKRAYTPMVFDLNA
MSMEG_1111|M.smegmatis_MC2_155 ESGISADLVDRIRSGDEGVDIDMMAEQNIQYLTDAAGVAA-TPAVYDLNE
Mb1772|M.bovis_AF2122/97 TVGAEPTAISCIKSGADLGTAQTKATNASETLAGFNASGT----PFVWDG
Rv1743|M.tuberculosis_H37Rv TVGAEPTAISCIKSGADLGTAQTKATNASETLAGFNASGT----PFVWDG
MMAR_2581|M.marinum_M TVGANGTATSCIKAGNDMGTARTKAAAADATLSELNASGT----PFVWDG
MUL_3180|M.ulcerans_Agy99 TVGANGTATSCIKAGNDMGTARTKAAAADATLSELNAG------------
MAB_3089c|M.abscessus_ATCC_199 GAGVTGEVLREISSLQVNEVDRQRTAGNEQQLTDHGLGGVPG---VIDNS
* : :
Mflv_5261|M.gilvum_PYR-GCK AEKLDIADSSWLADLVKS---
Mvan_0977|M.vanbaalenii_PYR-1 GEKLDIFDDEWLSSLLRSH--
TH_2711|M.thermoresistible__bu RAEVDVDDPDWVADVIEGS--
MSMEG_1111|M.smegmatis_MC2_155 DTLVPLRD-DWLSDLMLGLGS
Mb1772|M.bovis_AF2122/97 SMVVNYQDPSWLARLIG----
Rv1743|M.tuberculosis_H37Rv SMVVNYQDPSWLARLIG----
MMAR_2581|M.marinum_M SKSIDLQNPSWLTKLIG----
MUL_3180|M.ulcerans_Agy99 -----------LRRC------
MAB_3089c|M.abscessus_ATCC_199 GEMIDPSDSGWLSRLVGAR--
: