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SGSRRESVVKDLVFIGGLLILAVALIVYLVMGSEEVSDAASQPMSPQVSAPESNAPGGQVDAVTALSVER RTTGDPLAQGDPAAPVVMVMFADYRCPFCAKFSRDTEPDLVERFVDQGVLRLEWRDMPIFGEQSMRAARA GRAAAEQGKFWEFNHEVFAMSPDRGHADLNEDALVGFAEKAGVPDIDKFAASMRGNEFDAAIDADLAQGS SIGVPSTPAFVINGEPVLGAQPTEEFVRVIDEAKDRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5558 | - | - | 100% (248) | DSBA oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0667 | - | 6e-12 | 28.48% (165) | Na+/H+ antiporter NhaA |
| M. vanbaalenii PYR-1 | Mvan_3237 | - | 3e-09 | 28.40% (169) | DSBA oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2993c | - | 2e-07 | 25.00% (228) | hypothetical protein Mb2993c |
| M. gilvum PYR-GCK | Mflv_0238 | - | 2e-13 | 27.65% (170) | Na+/H+ antiporter NhaA |
| M. tuberculosis H37Rv | Rv2969c | - | 2e-07 | 25.00% (228) | hypothetical protein Rv2969c |
| M. leprae Br4923 | MLBr_01667 | - | 2e-07 | 24.00% (225) | hypothetical protein MLBr_01667 |
| M. abscessus ATCC 19977 | MAB_4285 | - | 8e-58 | 46.06% (241) | hypothetical protein MAB_4285 |
| M. marinum M | MMAR_1747 | - | 5e-06 | 26.02% (246) | hypothetical protein MMAR_1747 |
| M. avium 104 | MAV_3813 | - | 1e-06 | 25.11% (227) | hypothetical protein MAV_3813 |
| M. smegmatis MC2 155 | MSMEG_1215 | - | 7e-11 | 27.23% (191) | serine/threonine-protein kinase PknE, putative |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1990 | - | 1e-05 | 25.33% (229) | hypothetical protein MUL_1990 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK MTVTEPATQRGFPLLPSRLSRGSKATRTTDNTAAALLLTFTVVAILWANS
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK PWAHTYSALLDTHVGFSFGSHHAEMTVKHVVNDALMTFFFFIVGLEVTRE
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK FTIGELTDRSRAAVPVVAAAAGLILPAVVFLAFNPSGENAHAWGVVISTD
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK TAFLVGALAIIKPKFPARVRLFLLTLAVVDDVGALIAIAVLYSDNIQVAP
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK LVVAVALLGALALVRYLPKARGPAYAVLGAALWIALYLAGIHPTLAGVAV
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK ALLIPVFTPERAPVERAVQQIRAFRQSPNSRYARAASRSLRDSISINERL
Mb2993c|M.bovis_AF2122/97 --------------------------------------------------
Rv2969c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1747|M.marinum_M --------------------------------------------------
MUL_1990|M.ulcerans_Agy99 --------------------------------------------------
MAV_3813|M.avium_104 --------------------------------------------------
MLBr_01667|M.leprae_Br4923 --------------------------------------------------
Mvan_5558|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4285|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_1215|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0238|M.gilvum_PYR-GCK QTAVSPVVSFVILPLFALVNAGVLLDGPSLTAALRSPLTWGIVAGLVVGK
Mb2993c|M.bovis_AF2122/97 ----------MADKSKRPPRFDLKSADG-SFGRLVQIGGTTIVVVFAVVL
Rv2969c|M.tuberculosis_H37Rv ----------MADKSKRPPRFDLKSADG-SFGRLVQIGGTTIVVVFAVVL
MMAR_1747|M.marinum_M ----------MADKNKRPPRIDLNSPDG-KFGRLIQIGGTAFVVFFAVAL
MUL_1990|M.ulcerans_Agy99 ----------MADKNKRPTRIDLNSPDG-KFGRLIQIGGTAFVVFFAVAL
MAV_3813|M.avium_104 ----------MADNPKRPPRFDMKSASGGKSGRLVQIGGTAFVVIFAVAL
MLBr_01667|M.leprae_Br4923 ----MRISEPVADNRKRLQRFDLKSVDG-RSGRAVVIAGTVIVAIFAVVV
Mvan_5558|M.vanbaalenii_PYR-1 ----------MSGSRRESVVKDLVFIGG---LLILAVALIVYLVMGSEEV
MAB_4285|M.abscessus_ATCC_1997 ----------MR--RSENGKRDIWIAGI---LGVVIVALATYLLVDHRSQ
MSMEG_1215|M.smegmatis_MC2_155 ----------------------MRALG-------VLVGAVMALLMCAPS-
Mflv_0238|M.gilvum_PYR-GCK FVGIAGATWLIRRTGLGVLAPGLTLRRIAGGAALSGIGFTISLFIVDIAI
: :. : .
Mb2993c|M.bovis_AF2122/97 VFYIVTSRDDKKDGVA-----------------------GPGDAVRVTSS
Rv2969c|M.tuberculosis_H37Rv VFYIVTSRDDKKDGVA-----------------------GPGDAVRVTSS
MMAR_1747|M.marinum_M VFYIVTSHQKKGGGAA-----------------------GPDDSVRVTSS
MUL_1990|M.ulcerans_Agy99 VFYIVTSHQKKGGGAA-----------------------GPDDSVRVTSS
MAV_3813|M.avium_104 VFYIVTSHHKK-AGPT-----------------------GAGDTVRVTSS
MLBr_01667|M.leprae_Br4923 VFAVMKSQHAKQDGAAP--------------------LTGSGDTVRVTSS
Mvan_5558|M.vanbaalenii_PYR-1 SDAASQPMSPQVSAPESNAPGGQ------------VDAVTALSVERRTTG
MAB_4285|M.abscessus_ATCC_1997 STASTD--SPTVTGHSS-------------------------SLARLRPL
MSMEG_1215|M.smegmatis_MC2_155 ---------------------------------------GVAQAAPAETA
Mflv_0238|M.gilvum_PYR-GCK DDPSRQDQARIGVLAASVLAFALGWAIFRITDWLSPPEPVGLKLLRPIDP
.
Mb2993c|M.bovis_AF2122/97 KLVTQPGTSNPKAVVSFYEDFLCPACGIFERGFGP-TVSKLVDIGAVAAD
Rv2969c|M.tuberculosis_H37Rv KLVTQPGTSNPKAVVSFYEDFLCPACGIFERGFGP-TVSKLVDIGAVAAD
MMAR_1747|M.marinum_M KLVTQPGTQDPKVVMTFYEDFLCPACGMFERAFGP-TVSRLVDIGAVAAD
MUL_1990|M.ulcerans_Agy99 KLVTQPGTQDPKVVMTFYEDFLCPACGMFERAFGP-TVSRLVDIGAVAAD
MAV_3813|M.avium_104 KLITQPGSSNPKAVVTLYEDFLCPACGNFERTFGP-TVSKLIDLGAIAAD
MLBr_01667|M.leprae_Br4923 KLVTQPGTHDPKVVMSFYEDFLCPGCGDFERNFGP-TVSKLIDIGAIAAD
Mvan_5558|M.vanbaalenii_PYR-1 DPLAQ-GDPAAPVVMVMFADYRCPFCAKFSRDTEPDLVERFVDQGVLRLE
MAB_4285|M.abscessus_ATCC_1997 DPLAL-GPVDAPVVLIIYSDYRCPFCAKFSRDTEPQLIERYVNTGKLRIE
MSMEG_1215|M.smegmatis_MC2_155 RDVISIGDPGAPGQIELFVDPLCPFSGKMIQQQGA-EIGRRIENGSLHVN
Mflv_0238|M.gilvum_PYR-GCK ERDHVRGRPDAPLTLVEYGDFECPFCSRVTGAIDE---VRAHFGDDLLYV
* . : : * ** .. . : . :
Mb2993c|M.bovis_AF2122/97 YTMVAILDSASNQ-HYSSRAAAAAYCVADES--IEAFRRFHAALFSKDIQ
Rv2969c|M.tuberculosis_H37Rv YTMVAILDSASNQ-HYSSRAAAAAYCVADES--IEAFRRFHAALFSKDIQ
MMAR_1747|M.marinum_M YTMVDILSSPRNQ-NYSARAAAAAYCVADES--IDAFRRFHTAMFSKDIQ
MUL_1990|M.ulcerans_Agy99 YTMVDILSSPRNQ-NYSARAAATAYCVADES--IDAFRRFHTAMFSKDIQ
MAV_3813|M.avium_104 YSMVSILDSPRNQ-NYSSRAGAAALCVADES--LDAFRRFHTALFSTAIQ
MLBr_01667|M.leprae_Br4923 YSVVSILDHPRNH-NYPSRAGAASLCVADES--MDAYRRFRAALYSRSFQ
Mvan_5558|M.vanbaalenii_PYR-1 WRDMPIFGEQ------SMRAARAGRAAAEQ----GKFWEFNHEVFAMSP-
MAB_4285|M.abscessus_ATCC_1997 WRDLPIFGTQ------SVQAAKAGRAAAEQ----GRFWEFNRAVYRHAP-
MSMEG_1215|M.smegmatis_MC2_155 LRFVNFLERLSASGTYDSRAIYAAFAVAGYSRDSGVTWRFVEQIFSAEQQ
Mflv_0238|M.gilvum_PYR-GCK WRHFPLERAHPR----AFDAARASEAAALQG----RFWEMTHELFTHQD-
. : * :. ..* .: ::
Mb2993c|M.bovis_AF2122/97 PAELGKDFPDNARLIELAREAGV--VGKVPDCINSGKYIEKVDG---LAA
Rv2969c|M.tuberculosis_H37Rv PAELGKDFPDNARLIELAREAGV--VGKVPDCINSGKYIEKVDG---LAA
MMAR_1747|M.marinum_M PSEVGKTFPDNAKLIEIAREAGA--AGTVPDCINSGKYLDKVNG---LAV
MUL_1990|M.ulcerans_Agy99 PSEVGKTFPDNAKLIEIAREAGA--AGTVPDCINSGKYLDKVNG---LAV
MAV_3813|M.avium_104 PSETGKTFPDNARLIELARESGV--VGKVPDCINSGKYIAKVTG---EAA
MLBr_01667|M.leprae_Br4923 PSELASSFPENAKLIEIAREAGV--VGKVPDCINSGKYLAKVTA---EAA
Mvan_5558|M.vanbaalenii_PYR-1 --DRGHADLNEDALVGFAEKAGVPDIDKFAASMRGNEFDAAIDADLAQGS
MAB_4285|M.abscessus_ATCC_1997 --DRGHAELTDKILLDRAREAEVPDLARFQTAVESDRLLPAVQQDIQEAV
MSMEG_1215|M.smegmatis_MC2_155 PKEQGNTDLSNDQLAGLADRAGAPRLAQDLIRLGLFVGYDPVAIANSNQA
Mflv_0238|M.gilvum_PYR-GCK --DLEWSDMYRYAVAAGCDIEQF----DQDVRVHSSKVLHRVSDDAEDAD
: : . : :
Mb2993c|M.bovis_AF2122/97 AVNVHATP---TVRVNGTEYEWSTPAALVAKIKEIVGDVPGIDSAAATAT
Rv2969c|M.tuberculosis_H37Rv AVNVHATP---TVRVNGTEYEWSTPAALVAKIKEIVGDVPGIDSAAATAT
MMAR_1747|M.marinum_M AANVHATP---TVKINGEEYEWSTPEALVAKIKEIVGPIPGIDAVAANAT
MUL_1990|M.ulcerans_Agy99 AANVHATP---TVKINGEEYEWSTPKALVAKIKEIVGPIPGIDAVAANAT
MAV_3813|M.avium_104 AAKIRATP---TIKINGEDYDPSTPDALVGKIKEIVGDIPGLDGAVAPAA
MLBr_01667|M.leprae_Br4923 LAKISATP---TIKINGDEYDPLTPEALVAKIKAIVGAVPGIDVAVTATT
Mvan_5558|M.vanbaalenii_PYR-1 SIGVPSTP---AFVINGEPVLGAQPTEEFVRVIDEAKDRT----------
MAB_4285|M.abscessus_ATCC_1997 AIGAASTP---VFLINDQPVVGAQPLDVFISVIEQAQR------------
MSMEG_1215|M.smegmatis_MC2_155 ALRQFAEPGVPTVVIDGRPYDGNS--DWMSRLPR----------------
Mflv_0238|M.gilvum_PYR-GCK AMDLNATP---TLFVNGKRHRGPWDAASLIRALEAGRG------------
: * .. ::. .
Mb2993c|M.bovis_AF2122/97 S
Rv2969c|M.tuberculosis_H37Rv S
MMAR_1747|M.marinum_M S
MUL_1990|M.ulcerans_Agy99 S
MAV_3813|M.avium_104 M
MLBr_01667|M.leprae_Br4923 T
Mvan_5558|M.vanbaalenii_PYR-1 -
MAB_4285|M.abscessus_ATCC_1997 -
MSMEG_1215|M.smegmatis_MC2_155 -
Mflv_0238|M.gilvum_PYR-GCK -