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MISALDGVVVLDFTQVYMGPSCTQMLADYGAEVIKVERPKVGDLSRNSFPDPAGQDNPVFFSINRNKRSI TVDTRTDAGKDVIRDLVRRADVVVSNFRHGVIERMGFGYEECKQLNPRIVWASGTGFGETGPYAHKGGQD AIAQAYSGVMWRRADDATPLTVYPTTLCDYTTGMHLAQGILLALLARDRTGEGQKVQVNMYDSMLHMQMQ EAAGQLNRGEEINWAAMPLTGVFETTDGAVCMVGAFKENPLRDISKALGFDEDLSTRPGFDTLEGQIEHR SELQEIFRRRFAQDTTEHFVSRLEEQDILCAPVRTLKEALDDQQTVCNGMVVEMHHPHAGTVKVLNAPIR LSGTPNTTRRPAPMLGEHNEEILRELGYSDEQVAALLDEGTVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1154 | - | - | 100% (393) | formyl-coenzyme A transferase |
| M. smegmatis MC2 155 | MSMEG_3981 | - | 3e-80 | 41.49% (388) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_0168 | - | 3e-59 | 35.51% (414) | formyl-coenzyme A transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 6e-38 | 29.72% (387) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4365 | - | 2e-50 | 33.83% (402) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 2e-38 | 29.97% (387) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0824 | - | 1e-49 | 34.23% (371) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 2e-44 | 31.06% (396) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_5204 | - | 2e-44 | 31.23% (381) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3339 | - | 2e-53 | 33.16% (395) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 6e-44 | 30.79% (393) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | 1e-51 | 32.91% (398) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1494|M.marinum_M --------MTEP--GALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEA
MUL_2446|M.ulcerans_Agy99 --------MTEP--GALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEA
TH_3339|M.thermoresistible__bu MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVKIED
MAB_0824|M.abscessus_ATCC_1997 --------MTAA---ALDGLLVVDFSRVLAGPYATMMLGDFGAEVIKIER
Mb3300|M.bovis_AF2122/97 -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
Rv3272|M.tuberculosis_H37Rv -------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEA
Mflv_4365|M.gilvum_PYR-GCK ------------MTGVLDGIRVLDYGRFIAAPWCSALLADMGADVIRVE-
Mvan_1979|M.vanbaalenii_PYR-1 -------------MGVLDGVRVLDYGRFIAAPWCAALLADMGADVIRVE-
MAV_5204|M.avium_104 ----------------MAGVRVIDLTAMVMGPYCTQIMADMGADVIKVE-
MSMEG_1154|M.smegmatis_MC2_155 ------------MISALDGVVVLDFTQVYMGPSCTQMLADYGAEVIKVER
: *. *:: .* :: * **:*:::*
MMAR_1494|M.marinum_M PGAPDPLRTWGQ-AEVDGHHVFWTVHARNKRAITLDLRRPQGRELFLELV
MUL_2446|M.ulcerans_Agy99 PGAPDPLRTWGQ-AEVDGHHVFWTVHARNKRAITLDLRRPQGRELFLELV
TH_3339|M.thermoresistible__bu PGKGDPLRQWGQ-NRPKGQSLWFSIVGRNKRSVTINLREPRGQELVRQLV
MAB_0824|M.abscessus_ATCC_1997 PVLGDDTRQWGPPYDSDGQATYFNSVNRNKQSVVLDLTSPDGQHRARELA
Mb3300|M.bovis_AF2122/97 PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
Rv3272|M.tuberculosis_H37Rv PGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLA
Mflv_4365|M.gilvum_PYR-GCK KREGGEDRWVQSIADSGEGGTFLQCN-RNKRSLTLDTTTAEGREVTRKLV
Mvan_1979|M.vanbaalenii_PYR-1 KREGGEDRWVQSVAEGGEGGTFLQCN-RNKRSLTLDSTTDEGKEITRKLV
MAV_5204|M.avium_104 PPQGDNTRYISVGPAPGMSGVFVNVN-RGKRSVVLDLQTDAGARALRGLV
MSMEG_1154|M.smegmatis_MC2_155 PKVGDLSRNSFPDPAGQDNPVFFSIN-RNKRSITVDTRTDAGKDVIRDLV
: : *.*:::.:: . *.
MMAR_1494|M.marinum_M DKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKA
MUL_2446|M.ulcerans_Agy99 DKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKA
TH_3339|M.thermoresistible__bu AEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQDGPYASRP
MAB_0824|M.abscessus_ATCC_1997 GRADVVVENFRAGTMEKFGLGYQSLKQLNPGLIYCAITGFGR-GAGADLP
Mb3300|M.bovis_AF2122/97 DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
Rv3272|M.tuberculosis_H37Rv DTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRP
Mflv_4365|M.gilvum_PYR-GCK AGADIVVANMPAVGMRTSGLDYDTLRTIKPDIILASATAYGEGGPYSDRI
Mvan_1979|M.vanbaalenii_PYR-1 AGADIVVANMPAAGMRSSGLDYETLRAVKPDIILASATAYGEGGPYSDRI
MAV_5204|M.avium_104 ETADVFIHSMRAKAIARLGFGYDDVAAINPAVVYTNCYGYGRRGPDRDRP
MSMEG_1154|M.smegmatis_MC2_155 RRADVVVSNFRHGVIERMGFGYEECKQLNPRIVWASGTGFGETGPYAHKG
:*:.: : : .:. . :* :: .:* *.
MMAR_1494|M.marinum_M GYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGAQGALAALYRR
MUL_2446|M.ulcerans_Agy99 GYASVAEAASGLRHLNGFPGGPPPRLALSLGDSLAGMFGPQGALAALYRR
TH_3339|M.thermoresistible__bu GYGAIGEAMGGLRYVVGDPSTPPSRVGISIGDTLAALFATIGALAALRER
MAB_0824|M.abscessus_ATCC_1997 GYDLLVQAVGGLMSVTGPDAAHPSKVGVALVDVLTALHALSGILAALSYR
Mb3300|M.bovis_AF2122/97 GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
Rv3272|M.tuberculosis_H37Rv GIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHR
Mflv_4365|M.gilvum_PYR-GCK GFDGAGQVMSG-AVYRQGLPDQPIRTVVPYADFGTALTLTIGVMMALYHR
Mvan_1979|M.vanbaalenii_PYR-1 GFDGAGQVMSG-AVYRQGLPDQPIRTVVPYADFGTALTLTIGVMMALFHR
MAV_5204|M.avium_104 AYDDTIQAECGLPAVQQQLTGQADYVGTIMADKIAGLTALYATTMALFHR
MSMEG_1154|M.smegmatis_MC2_155 GQDAIAQAYSGVMWRRADDATPLTVYPTTLCDYTTGMHLAQGILLALLAR
. . * * :. . ** *
MMAR_1494|M.marinum_M SVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLEG------
MUL_2446|M.ulcerans_Agy99 SVTGTGQVVDVALTESCLALQESTISDYDVGGVVRGPSGTRLKG------
TH_3339|M.thermoresistible__bu EISGRGQMVDSAIYEAVLGVMESLVPEWTVSGYQRERTGAILPK------
MAB_0824|M.abscessus_ATCC_1997 DRTGQGQRVDTDLMSVLLSSLVNQASGYLGAGVVPEALGNRHPS------
Mb3300|M.bovis_AF2122/97 ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKG
Rv3272|M.tuberculosis_H37Rv ERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKG
Mflv_4365|M.gilvum_PYR-GCK DRTGEGQHVEGALLPTAMMLSNAFLIERDLLGTDKPRMGNQGTSVA----
Mvan_1979|M.vanbaalenii_PYR-1 DRTGQGQHVEGALLPTALMLSNAFLIERELLGTDKPRMGNRGTSVA----
MAV_5204|M.avium_104 ERTGQGQEVEVAMFETMASFMLVEHANGALFDPPLGPAVYPRTVAP----
MSMEG_1154|M.smegmatis_MC2_155 DRTGEGQKVQVNMYDSMLHMQMQEAAGQLNRGEEIN-----WAAMP----
. .* .: *: :
MMAR_1494|M.marinum_M ----IAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPELATDDR-FAT
MUL_2446|M.ulcerans_Agy99 ----IAPSNIYRSADESWVVIAANQDTVFTRLCQAMGCPELATDDR-FAT
TH_3339|M.thermoresistible__bu ----IAPSNVYPTSDDTWILIAANQDTVFRRLAEAMGRPELAEDER-YAT
MAB_0824|M.abscessus_ATCC_1997 ----IAPYQTFETADR-PIAIAVGNDKQFRLLVQALEMPRLARDDR-FAT
Mb3300|M.bovis_AF2122/97 VGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQR-FAE
Rv3272|M.tuberculosis_H37Rv VGFATQPSDAFRTADG-YIVISAYVPKHWQKLCYLIGRPDLVEDQR-FAE
Mflv_4365|M.gilvum_PYR-GCK ------PCDLYRTSDDGWVLLQIAGPSMFRRWCRLVGRPELFDDPR-FAD
Mvan_1979|M.vanbaalenii_PYR-1 ------PCDLYRTRDDGWVLLQVAGPPMFKRWCRLVGRPELFDDPR-FAN
MAV_5204|M.avium_104 ------NRRPYRTS-DGYIAALIYNDKHWNAFMNAVRPP--WASEL-YAT
MSMEG_1154|M.smegmatis_MC2_155 ------LTGVFETTDGAVCMVGAFKENPLRDISKALGFDEDLSTRPGFDT
: : : :
MMAR_1494|M.marinum_M HRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVKD
MUL_2446|M.ulcerans_Agy99 HRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVVKD
TH_3339|M.thermoresistible__bu HVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYRPKEMLAD
MAB_0824|M.abscessus_ATCC_1997 NPLRVRHRGELVRVLEQRLREKNADDWYDTLTAVGVPAGPINDIAEAFR-
Mb3300|M.bovis_AF2122/97 QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
Rv3272|M.tuberculosis_H37Rv QRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDT
Mflv_4365|M.gilvum_PYR-GCK DDLRWQHGEELNGIMAQWCADKTKAEVLELLEAAKLPAAPMHSTQEVLED
Mvan_1979|M.vanbaalenii_PYR-1 DDLRWQHGDVLNDIMAQWCADKTKAEVLERLEAAKLPAAPMHSTQEVLDD
MAV_5204|M.avium_104 LEQRAAQIDTVYGLVAETMKERSTAEWLELLGELEIPAAPLNSPGALFDD
MSMEG_1154|M.smegmatis_MC2_155 LEGQIEHRSELQEIFRRRFAQDTTEHFVSRLEEQDILCAPVRTLKEALDD
: : : . . : : .
MMAR_1494|M.marinum_M RQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHND
MUL_2446|M.ulcerans_Agy99 RQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQHND
TH_3339|M.thermoresistible__bu PQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGPG-LGEHTD
MAB_0824|M.abscessus_ATCC_1997 ---FAERLGLDVAVTVPGSPEPQVANPISMSKTP-VVYRNGPPRLGQSRA
Mb3300|M.bovis_AF2122/97 PLFAESDLTLEVG---RGADTITVIRTPARYASFRAVVTDPPPTAGEHNA
Rv3272|M.tuberculosis_H37Rv PLFAENDLTLEVG---RGADTITVIRTPARYASFRAVVTDPPPTAGEHNA
Mflv_4365|M.gilvum_PYR-GCK PHVQAMGYLKRVPFPGTPKDVPLIETPFRLSATPGEIRR-RAPLLGEHTD
Mvan_1979|M.vanbaalenii_PYR-1 PHVQAMGFLQRVPFPGAPRDVPIIETPFRMSATPGQIRR-RAPLLGEHTD
MAV_5204|M.avium_104 PHLNAVGMFQTVDTPHGP--VRFPGVPTWFSQTPGRVAG-PAPELGAHTD
MSMEG_1154|M.smegmatis_MC2_155 QQTVCNGMVVEMHHPHAG-TVKVLNAPIRLSGTPNTTRR-PAPMLGEHNE
: . *
MMAR_1494|M.marinum_M DVYIGLLGKSIEELEQLRAEEVL
MUL_2446|M.ulcerans_Agy99 DVYIGLLGKSIEELEQLRAVEVL
TH_3339|M.thermoresistible__bu EVLR-QLGLSDEELQKLHDAGVV
MAB_0824|M.abscessus_ATCC_1997 -----------------------
Mb3300|M.bovis_AF2122/97 VFLARP-----------------
Rv3272|M.tuberculosis_H37Rv VFLARP-----------------
Mflv_4365|M.gilvum_PYR-GCK EILEEIGYSSEAVVGLRDRGVV-
Mvan_1979|M.vanbaalenii_PYR-1 EILGEIGYTGDQVARLRDRQVI-
MAV_5204|M.avium_104 EVLAEIGAREGKEL---------
MSMEG_1154|M.smegmatis_MC2_155 EILRELGYSDEQVAALLDEGTVR