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TGVLDGIRVLDYGRFIAAPWCSALLADMGADVIRVEKREGGEDRWVQSIADSGEGGTFLQCNRNKRSLTL DTTTAEGREVTRKLVAGADIVVANMPAVGMRTSGLDYDTLRTIKPDIILASATAYGEGGPYSDRIGFDGA GQVMSGAVYRQGLPDQPIRTVVPYADFGTALTLTIGVMMALYHRDRTGEGQHVEGALLPTAMMLSNAFLI ERDLLGTDKPRMGNQGTSVAPCDLYRTSDDGWVLLQIAGPSMFRRWCRLVGRPELFDDPRFADDDLRWQH GEELNGIMAQWCADKTKAEVLELLEAAKLPAAPMHSTQEVLEDPHVQAMGYLKRVPFPGTPKDVPLIETP FRLSATPGEIRRRAPLLGEHTDEILEEIGYSSEAVVGLRDRGVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4365 | - | - | 100% (395) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. gilvum PYR-GCK | Mflv_4465 | - | 2e-53 | 33.01% (409) | Formyl-CoA transferase |
| M. gilvum PYR-GCK | Mflv_2423 | - | 3e-49 | 30.07% (409) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-39 | 30.37% (382) | hypothetical protein Mb3300 |
| M. tuberculosis H37Rv | Rv1866 | - | 2e-39 | 28.83% (385) | hypothetical protein Rv1866 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 2e-52 | 31.95% (410) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 4e-53 | 34.31% (408) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_0341 | - | 6e-56 | 33.84% (396) | caib/baif family protein |
| M. smegmatis MC2 155 | MSMEG_3391 | - | 7e-55 | 35.93% (398) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_3339 | - | 2e-61 | 35.01% (397) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 4e-53 | 34.49% (403) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | 0.0 | 88.55% (393) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv MVTRLLADLGADVLKVEPPGGSPGRHVRPTLAGTSIGFAMHNANKRSAVL
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv NPLDESDRRRFLDLAASADIVVDCGLPGQAAAYGASCAELADRYRHLVAL
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv SITDFGAAGPRSSWRATDPVLYAMSGALSRSGPTAGTPVLPPDGIASATA
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv AVQAAWAVLVAYFNRLRCGTGDYIDFSRFDAVVMALDPPFGAHGQVAAGI
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv RSTGRWRGRPKNQDAYPIYPCRDGYVRFCVMAPRQWRGLRRWLGEPEDFQ
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv DPKYDVIGARLAAWPQISVLVAKLCAEKTMKELVAAGQALGVPITAVLTP
Mflv_4365|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3391|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
MAV_0341|M.avium_104 --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv1866|M.tuberculosis_H37Rv SRILASEHFQAVGAITDAELVPGVRTGVPTGYFVVDGKRAGFRTPAPAAG
Mflv_4365|M.gilvum_PYR-GCK --------------------MTGVLDGIRVLDYGRFIAAPWCSALLADMG
Mvan_1979|M.vanbaalenii_PYR-1 ---------------------MGVLDGVRVLDYGRFIAAPWCAALLADMG
MSMEG_3391|M.smegmatis_MC2_155 -------------------MAPGALDGVTVLDLTTVVMGPFATSMLGDLG
MMAR_1494|M.marinum_M ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MUL_2446|M.ulcerans_Agy99 ------------------MTEPGALDGIRVLELGTLIAGPFAGRLLGDMG
MAB_4651c|M.abscessus_ATCC_199 --------------------MTGALDGIRVLELGTLIAGPFAGRLLGDMG
TH_3339|M.thermoresistible__bu --------MTTEVETTATQPTTGPLHGIRVVEMGSLLAGPIVGQMMGDLG
MAV_0341|M.avium_104 -----------------------MLDGLRVLDLATLAAAPLVATYLGEFG
Mb3300|M.bovis_AF2122/97 ---------------MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLG
Rv1866|M.tuberculosis_H37Rv QDEPRWLADPAPVPPPSGRVGGYPFEGLRILDLGIIVAGGELSRLFGDLG
:.*. ::: . : ::*
Mflv_4365|M.gilvum_PYR-GCK ADVIRVEK--REGGEDRWVQSIADSGEGGTFLQCNRNKRSLTLDTTTAEG
Mvan_1979|M.vanbaalenii_PYR-1 ADVIRVEK--REGGEDRWVQSVAEGGEGGTFLQCNRNKRSLTLDSTTDEG
MSMEG_3391|M.smegmatis_MC2_155 AEVIKVEA--LDGDITRRMGPQRNPGMTALTLGLQRNKRSIALDLKTAEG
MMAR_1494|M.marinum_M ADVIKVEAP-GAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQG
MUL_2446|M.ulcerans_Agy99 ADVIKVEAP-GAPDPLRTWGQAEVDGHHVFWTVHARNKRAITLDLRRPQG
MAB_4651c|M.abscessus_ATCC_199 AEVLKIEPP-GAPDPLRTWGQAEVDGHHVFWTVHARNKKAITLDLRTEAG
TH_3339|M.thermoresistible__bu ADVVKIEDP-GKGDPLRQWGQNRPKGQSLWFSIVGRNKRSVTINLREPRG
MAV_0341|M.avium_104 ADVIKVEEP-RHGDPIRGWGNQR-DGVGLMWKSISRNKKSITLDLRSADG
Mb3300|M.bovis_AF2122/97 AEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQA
Rv1866|M.tuberculosis_H37Rv AEVIKVES---ADHPDGLRQTRVGDAMSESFAWTHRNHLALGLDLRNSEG
*:*:::* *.: :: :: .
Mflv_4365|M.gilvum_PYR-GCK REVTRKLVAGADIVVANMPAVGMRTSGLDYDTLRTIKPDIILASATAYGE
Mvan_1979|M.vanbaalenii_PYR-1 KEITRKLVAGADIVVANMPAAGMRSSGLDYETLRAVKPDIILASATAYGE
MSMEG_3391|M.smegmatis_MC2_155 KEVLARLVRESDVVVSNLRPQSREDLGLSYPALRAIRADVILCTAQAYAE
MMAR_1494|M.marinum_M RELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQ
MUL_2446|M.ulcerans_Agy99 RELFLELVDKSDIVVENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQ
MAB_4651c|M.abscessus_ATCC_199 RALFLDLVDKSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQ
TH_3339|M.thermoresistible__bu QELVRQLVAEADVLVENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQ
MAV_0341|M.avium_104 QQLVRRLVEHADVAIFNTRPQTLRKWGLDYESLRAVNERLVMLHITGYGL
Mb3300|M.bovis_AF2122/97 KQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGG
Rv1866|M.tuberculosis_H37Rv KAIFGRLVAESDAVFANFKPGTLTSLGFSYDVLHAFNPRIVLAGSSAFGN
: *. :* . . .:. * . :: .:.
Mflv_4365|M.gilvum_PYR-GCK GGPYSDRIGFDGAGQVMSGAVYRQGLPD-QPIRT-------VVPYADFGT
Mvan_1979|M.vanbaalenii_PYR-1 GGPYSDRIGFDGAGQVMSGAVYRQGLPD-QPIRT-------VVPYADFGT
MSMEG_3391|M.smegmatis_MC2_155 ASPQRNEPAYDDMVQAASGLTSLVEAVDGVPRYA-------PYVIADKVS
MMAR_1494|M.marinum_M TGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRL-------ALSLGDSLA
MUL_2446|M.ulcerans_Agy99 TGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRL-------ALSLGDSLA
MAB_4651c|M.abscessus_ATCC_199 TGPDAHKAGYASVAEAASGLRHLNGFPGGPPPRM-------ALSIGDTLA
TH_3339|M.thermoresistible__bu DGPYASRPGYGAIGEAMGGLRYVVGDPSTPPSRV-------GISIGDTLA
MAV_0341|M.avium_104 SGPKSERPGFGTLGEAMSGFAHITGQAGAPPTLP-------PFMLADGVA
Mb3300|M.bovis_AF2122/97 NGPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQII-------PFQLVDNAS
Rv1866|M.tuberculosis_H37Rv RGPWSTRMGYGPLVRAATGVTRVWTSDEAQPDNSRHPFYDATTIFPDHVV
.* . . . * * *
Mflv_4365|M.gilvum_PYR-GCK ALTLTIGVMMALYHRDRTG-EGQHVEGALLPTAMMLSNAFLIERDLLGTD
Mvan_1979|M.vanbaalenii_PYR-1 ALTLTIGVMMALFHRDRTG-QGQHVEGALLPTALMLSNAFLIERELLGTD
MSMEG_3391|M.smegmatis_MC2_155 GLYIVIAVLSALMHRAATG-SGQHVEVPMVDAMVHFNLVEHLSGQTFAPP
MMAR_1494|M.marinum_M GMFGAQGALAALYRRSVTG-TGQVVDVALTESCLALQESTISDYDVGGVV
MUL_2446|M.ulcerans_Agy99 GMFGPQGALAALYRRSVTG-TGQVVDVALTESCLALQESTISDYDVGGVV
MAB_4651c|M.abscessus_ATCC_199 GMFAAQGALAALYRRTVTG-RGQVVDAALTESCLAVQESTIPDYDVGRVV
TH_3339|M.thermoresistible__bu ALFATIGALAALREREISG-RGQMVDSAIYEAVLGVMESLVPEWTVSGYQ
MAV_0341|M.avium_104 SLNAAYAVMMALYHRDVHGGPGQLIDVNLIDPLARLLEQTLLGYDQLGLV
Mb3300|M.bovis_AF2122/97 GHVLAQAVLAALLHRERNG-VADVVQVAMYDVAVGLQANQLMMHLNRAAS
Rv1866|M.tuberculosis_H37Rv GRVGALLALAALIHRDRTG-GGAHVHISQAEVVVNQLDTMFVAEAARATD
. .: ** .* * . :.
Mflv_4365|M.gilvum_PYR-GCK ----------KPRMGNQGTSVAPCDLYRTSDDGWVLLQIAGPSMFRRWCR
Mvan_1979|M.vanbaalenii_PYR-1 ----------KPRMGNRGTSVAPCDLYRTRDDGWVLLQVAGPPMFKRWCR
MSMEG_3391|M.smegmatis_MC2_155 ----------AGDFGWKRVLVPERAPYRTS-DGYVCILPYTDANWRGFFT
MMAR_1494|M.marinum_M ----------RGPSGTRLEGIAPSNIYRSADESWVVIAANQDTVFTRLCQ
MUL_2446|M.ulcerans_Agy99 ----------RGPSGTRLKGIAPSNIYRSADESWVVIAANQDTVFTRLCQ
MAB_4651c|M.abscessus_ATCC_199 ----------RGPSGTRLEGIAPSNIYQSADGSWVVIAANQDTVFRRLCE
TH_3339|M.thermoresistible__bu ----------RERTGAILPKIAPSNVYPTSDDTWILIAANQDTVFRRLAE
MAV_0341|M.avium_104 ----------PERSGNRWDISAPRNTYQTADGRWLAMSGSSPALALRVFR
Mb3300|M.bovis_AF2122/97 DQPKPEPAPKAKRRKGVGFATQPSDAFRTA-DGYIVISAYVPKHWQKLCY
Rv1866|M.tuberculosis_H37Rv ------------VAEIHPDTSVHAVYPCAGDDEWCVISIRSDDEWRRATS
: : :
Mflv_4365|M.gilvum_PYR-GCK LVGRPELFDDPRFADDDLRWQHGEELNGIMAQWCADKTKAEVLELLEAAK
Mvan_1979|M.vanbaalenii_PYR-1 LVGRPELFDDPRFANDDLRWQHGDVLNDIMAQWCADKTKAEVLERLEAAK
MSMEG_3391|M.smegmatis_MC2_155 LTGLTDLLTDPRFTDVDKRHQNMGYLHSMISRITPQRSTQEWLDLCRDND
MMAR_1494|M.marinum_M AMGCPELATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAG
MUL_2446|M.ulcerans_Agy99 AMGCPELATDDRFATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAG
MAB_4651c|M.abscessus_ATCC_199 AMGRPELSSDARFANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAG
TH_3339|M.thermoresistible__bu AMGRPELAEDERYATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHN
MAV_0341|M.avium_104 AIGRDDLLGDPDFSDPQRRLARAREVDTLVADWVAGKTLSEAMAVFEAHE
Mb3300|M.bovis_AF2122/97 LIGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANG
Rv1866|M.tuberculosis_H37Rv VFGQPELANDPRFGASRSRVANRSELVAAVSAWTSTRTPVQAAGALQAAG
* :* * : * . : : : :
Mflv_4365|M.gilvum_PYR-GCK LPAAPMHSTQEVLEDPHVQAMGYLKRVPFPGTPKDVPLIETPFRLSATPG
Mvan_1979|M.vanbaalenii_PYR-1 LPAAPMHSTQEVLDDPHVQAMGFLQRVPFPGAPRDVPIIETPFRMSATPG
MSMEG_3391|M.smegmatis_MC2_155 IPAARPLDLTRVTEDPYVMDHGVLQRNSHP-TEGDYFSALTPLRMSGSPV
MMAR_1494|M.marinum_M VIAGPINTVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPG
MUL_2446|M.ulcerans_Agy99 VIAGPINTVAEVVKDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPG
MAB_4651c|M.abscessus_ATCC_199 VIAGPINTVADVVQDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPG
TH_3339|M.thermoresistible__bu VPVGKIYRPKEMLADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRG
MAV_0341|M.avium_104 VAAAPVYDISDLVADEQLAHRGVFVSVDDQQLG-PMTVQAPVPRFSSASG
Mb3300|M.bovis_AF2122/97 LMACLAHTWKQVVDTPLFAESDLTLEVGRG--ADTITVIRTPARYASFRA
Rv1866|M.tuberculosis_H37Rv VAAGPMNRPSDILEDPQLIERNLFRDMVHPLIARPLPAETGPAPFRHIPQ
: . : .
Mflv_4365|M.gilvum_PYR-GCK EIRRRAPL-LGEHTDEILE-EIGYSSEAVVGLRDRGVV-------
Mvan_1979|M.vanbaalenii_PYR-1 QIRRRAPL-LGEHTDEILG-EIGYTGDQVARLRDRQVI-------
MSMEG_3391|M.smegmatis_MC2_155 SLRRHAPI-LGAHTAEVLS-ELGYTDDEITSLSDNAVVVIK----
MMAR_1494|M.marinum_M QVRSAGPARPGQHNDDVYIGLLGKSIEELEQLRAEEVL-------
MUL_2446|M.ulcerans_Agy99 QVRSAGPARPGQHNDDVYIGLLGKSIEELEQLRAVEVL-------
MAB_4651c|M.abscessus_ATCC_199 GVRNAGPARPGQDNDDVYVGLLGKSAQDIERLRAEGVL-------
TH_3339|M.thermoresistible__bu SIRWPGPG-LGEHTDEVLR-QLGLSDEELQKLHDAGVV-------
MAV_0341|M.avium_104 TVEHLGPR-LGEHNAEVYGELLGLTPDEIDQLRARGVV-------
Mb3300|M.bovis_AF2122/97 VVTDPPPT-AGEHNAVFLARP------------------------
Rv1866|M.tuberculosis_H37Rv APQRPAPL-PGQDSVQICRKLLGMTADETERLINERVMFGPAVTA
* * .. .