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MDMAETRPVNDDPAVPKNVGGKALSGVRVLDMTHVQSGPSATQLLAWLGADVIKLEAPKTGDITRNQLRD VPGVDSLYFTMLNCNKRSITVNMKSDAGKQIFTDLVSRVDILVENFGPGVVDRFGFPWERLQEINPRLIY ASIKGFGPGKYANFKAYEVIAQAMGGSMATTGFEHAPPTVTGAQIGDSGTGIHLVAGVLAALYQRVSTGR GQRVEVAMQEAVLNLCRVKLRDQQRLTHGPLAEYPNDNFTDEVPRAGNASGGGQPGWAVRTKGGGPNDYI YIIVQPQVWAPLAELIGHPELADHPDWARPENRLNKLDKMFALIEDWSERLSKWEALEALNALNVPCGPV LGTKELIEDETLAELGAVVEVEHPQRGSFKTVGSPLRLSDSPVEIVRSPLLGEHTDAICAELGYTPEQLE LFRVSGAI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0168 | - | - | 100% (428) | formyl-coenzyme A transferase |
| M. smegmatis MC2 155 | MSMEG_0158 | - | e-120 | 52.96% (406) | formyl-coenzyme A transferase |
| M. smegmatis MC2 155 | MSMEG_1154 | - | 3e-59 | 35.51% (414) | formyl-coenzyme A transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 6e-31 | 29.90% (418) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_2423 | - | 7e-43 | 29.69% (421) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 5e-31 | 29.90% (418) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 2e-40 | 28.37% (416) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_1494 | - | 3e-42 | 30.96% (407) | hypothetical protein MMAR_1494 |
| M. avium 104 | MAV_5261 | - | 3e-43 | 31.64% (433) | caib/baif family protein |
| M. thermoresistible (build 8) | TH_3339 | - | 8e-53 | 31.95% (410) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_2446 | - | 4e-42 | 31.05% (409) | hypothetical protein MUL_2446 |
| M. vanbaalenii PYR-1 | Mvan_1979 | - | 2e-44 | 32.27% (406) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK MPPVPEPPLAGYVVVDLSSGIAGGYCTKLLADGGAEVVKVEPPQGDPLRA
MAV_5261|M.avium_104 MGPAP---FAHWRVVEFSNGLAVSYCGKMFADAGADVVKVESPQGDSMRR
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK WSASGAHIIDGTDGALFSYLACSKRSVVAEPGSDDDLVDELLAGADAVIW
MAV_5261|M.avium_104 WSAG------GPPGALFGYLAAGKRSMVGRSRAE---VAPLLAGADLVLT
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK SRGPGIAQDAFTPGAIRDRHPHLTVTAITPFGLDGPWTDR--AATEFTLQ
MAV_5261|M.avium_104 DLTDGWTLDEITG----RTGPSAVVVAITPFGTTGPYVDQQVVANEFILQ
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK AWSGGIVGLGRGAPDRAPVYVGGQVGEYLAGAYASAATLASR----LRGG
MAV_5261|M.avium_104 ALCGSIA--GRGWPGDEPVQAGGRLGEWLAGTFAAAAAAATARHAARTGR
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK GELIDLSMLETSVLGLTYYPVSYYEMLGRP-WRDARRLTVPGIARAKDGL
MAV_5261|M.avium_104 GEVIDVSTYEAMVIAMGGLSAMSASVLGADSLLHERSLELPSIVPTADGM
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK VDIGCGTAQQWFDLCAMTGHVEWIDEDSPLSIT---QQANEKAEELYAWV
MAV_5261|M.avium_104 VGFCTITAQQFQDFLVMIDRADLVDDAELASFAGRVARRDEFLDMVSGWT
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK ADQTVDEIRDLATAFRIPNAPVANGANVESLDHFAARESFIVNPRDGFTQ
MAV_5261|M.avium_104 RTRTTQEIVDLAVAFRIPVAPIATPEILPKLDHFVQRGVFVESP-AGVLA
MMAR_1494|M.marinum_M --------------------------------------------------
MUL_2446|M.ulcerans_Agy99 --------------------------------------------------
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu --------------------------------------------------
Mb3300|M.bovis_AF2122/97 --------------------------------------------------
Rv3272|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0168|M.smegmatis_MC2_155 --------------------------------MDMAETRPVNDDPAVPKN
Mvan_1979|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_2423|M.gilvum_PYR-GCK PAAPYRISGATLRHPEPAPRLGEHTDLYRSRNCHHGSEAAAGATVSAVSR
MAV_5261|M.avium_104 PRVPYRSDAITTRPPSEPPALGAD-----NGRVHWPPRPGPARGEDAG--
MMAR_1494|M.marinum_M -------------------------------------------------M
MUL_2446|M.ulcerans_Agy99 -------------------------------------------------M
MAB_4651c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3339|M.thermoresistible__bu ---------------------------------------MTTEVETTATQ
Mb3300|M.bovis_AF2122/97 ----------------------------------------------MPTS
Rv3272|M.tuberculosis_H37Rv ----------------------------------------------MPTS
MSMEG_0168|M.smegmatis_MC2_155 VGGKALSGVRVLDMTHVQSGPSATQLLAWLGADVIKLEAPKTGDITRNQL
Mvan_1979|M.vanbaalenii_PYR-1 MG--VLDGVRVLDYGRFIAAPWCAALLADMGADVIRVEK-REGGEDRWVQ
Mflv_2423|M.gilvum_PYR-GCK SDTLPFAGLRVVDMTTFWAGPSCTHLLAMLGADVIHVESTRHPDGTRLIA
MAV_5261|M.avium_104 --TLPLSGIRVTDLTAFWAGPVATQLLGALGADVIKIEGVRRPDGMRFSA
MMAR_1494|M.marinum_M TEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEAPGAPDPLRTWG
MUL_2446|M.ulcerans_Agy99 TEPGALDGIRVLELGTLIAGPFAGRLLGDMGADVIKVEAPGAPDPLRTWG
MAB_4651c|M.abscessus_ATCC_199 -MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPDPLRTWG
TH_3339|M.thermoresistible__bu PTTGPLHGIRVVEMGSLLAGPIVGQMMGDLGADVVKIEDPGKGDPLRQWG
Mb3300|M.bovis_AF2122/97 NPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITS
Rv3272|M.tuberculosis_H37Rv NPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITS
: *.** : :.* :: :**:*:::* :
MSMEG_0168|M.smegmatis_MC2_155 RDVPGVDSLY-----FTMLNCNKRSITVNMKSDAGKQIFTDLVSRVDILV
Mvan_1979|M.vanbaalenii_PYR-1 SVAEGGEGGT-----FLQCNRNKRSLTLDSTTDEGKEITRKLVAGADIVV
Mflv_2423|M.gilvum_PYR-GCK GIPVTEDQWWERSPIFSGLNTNKRGITLNLSSDTGRDLLKRLIATADVLV
MAV_5261|M.avium_104 GRPPDWDQWWEWGPVFLCSNNNKRGISVDLGTEAGRSIALGLIAASDLVV
MMAR_1494|M.marinum_M QAEVDGHHVF-----WTVHARNKRAITLDLRRPQGRELFLELVDKSDIVV
MUL_2446|M.ulcerans_Agy99 QAEVDGHHVF-----WTVHARNKRAITLDLRRPQGRELFLELVDKSDIVV
MAB_4651c|M.abscessus_ATCC_199 QAEVDGHHVF-----WTVHARNKKAITLDLRTEAGRALFLDLVDKSDVIV
TH_3339|M.thermoresistible__bu QNRPKGQSLW-----FSIVGRNKRSVTINLREPRGQELVRQLVAEADVLV
Mb3300|M.bovis_AF2122/97 VLPGRPPLAT----YFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVL
Rv3272|M.tuberculosis_H37Rv VLPGRPPLAT----YFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVL
: .*:.:::: .: * *:::
MSMEG_0168|M.smegmatis_MC2_155 ENFGPGVVDRFGFPWERLQEINPRLIYASIKGFGPG-KYANFKAYEVIAQ
Mvan_1979|M.vanbaalenii_PYR-1 ANMPAAGMRSSGLDYETLRAVKPDIILASATAYGEGGPYSDRIGFDGAGQ
Mflv_2423|M.gilvum_PYR-GCK ENFTPRVTESMGLTYDAVKAVKPDIVMVRMPGFGLDGPWRDNPAFAYVIE
MAV_5261|M.avium_104 ENFSPRVMANFGLEWDAVRAANPRAVMIRMPAFGLDGPWRDRVGFAQTME
MMAR_1494|M.marinum_M ENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKAGYASVAE
MUL_2446|M.ulcerans_Agy99 ENFRPGTLEKWDLGYDVLRERNPGIILVRVSGYGQTGPDAHKAGYASVAE
MAB_4651c|M.abscessus_ATCC_199 ENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYASVAE
TH_3339|M.thermoresistible__bu ENFRPGTMERWGLGYSDLAEINPRLVIVRVSGFGQDGPYASRPGYGAIGE
Mb3300|M.bovis_AF2122/97 EAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVA
Rv3272|M.tuberculosis_H37Rv EAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVA
: . .: . : : : .:* .
MSMEG_0168|M.smegmatis_MC2_155 AMGGSMATTGFEHAPPTVTGAQIGDSGTGIHLVAGVLAALYQRVSTGRGQ
Mvan_1979|M.vanbaalenii_PYR-1 VMSGAVYRQGLPDQP-IRTVVPYADFGTALTLTIGVMMALFHRDRTGQGQ
Mflv_2423|M.gilvum_PYR-GCK AAAGISWLTGYPDRNP-FEPYSVGDPNAGVHALNAILLALEHRRRTGEGA
MAV_5261|M.avium_104 QATGMAWMTGHPDGPP-VIPRGVCDPIAGLHAAFAAVAALTVRDREGTGM
MMAR_1494|M.marinum_M AASGLRHLNGFPGGPPPRLALSLGDSLAGMFGAQGALAALYRRSVTGTGQ
MUL_2446|M.ulcerans_Agy99 AASGLRHLNGFPGGPPPRLALSLGDSLAGMFGPQGALAALYRRSVTGTGQ
MAB_4651c|M.abscessus_ATCC_199 AASGLRHLNGFPGGPPPRMALSIGDTLAGMFAAQGALAALYRRTVTGRGQ
TH_3339|M.thermoresistible__bu AMGGLRYVVGDPSTPPSRVGISIGDTLAALFATIGALAALREREISGRGQ
Mb3300|M.bovis_AF2122/97 AEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVAD
Rv3272|M.tuberculosis_H37Rv AEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVAD
* * :. . : ** * * .
MSMEG_0168|M.smegmatis_MC2_155 RVEVAMQEAVLNLCRVKLRDQQRLTHGPLAEYPNDNFTDEVPRAGNASGG
Mvan_1979|M.vanbaalenii_PYR-1 HVEGALLPTALMLSNAFLIERELLGT-------------DKPRMGNRGTS
Mflv_2423|M.gilvum_PYR-GCK MVEAAMVDAALNVAAEQVIEYSAYGAV-------------LQRDGNRGPT
MAV_5261|M.avium_104 QVEATMVEAALNVAAEMLVEYSCNGIA-------------LRRNGNRGPG
MMAR_1494|M.marinum_M VVDVALTESCLALQESTISDYDVGGVV-------------RGPSGTRLEG
MUL_2446|M.ulcerans_Agy99 VVDVALTESCLALQESTISDYDVGGVV-------------RGPSGTRLKG
MAB_4651c|M.abscessus_ATCC_199 VVDAALTESCLAVQESTIPDYDVGRVV-------------RGPSGTRLEG
TH_3339|M.thermoresistible__bu MVDSAIYEAVLGVMESLVPEWTVSGYQ-------------RERTGAILPK
Mb3300|M.bovis_AF2122/97 VVQVAMYDVAVGLQANQLMMHLNRAAS---DQPKPEPAPKAKRRKGVGFA
Rv3272|M.tuberculosis_H37Rv VVQVAMYDVAVGLQANQLMMHLNRAAS---DQPKPEPAPKAKRRKGVGFA
*: :: : : :
MSMEG_0168|M.smegmatis_MC2_155 GQPGWAVRTKGGGP-----NDYIYIIVQPQVWAPLAELIGHPELADHPDW
Mvan_1979|M.vanbaalenii_PYR-1 VAPCDLYRTRDDG-------WVLLQVAGPPMFKRWCRLVGRPELFDDPRF
Mflv_2423|M.gilvum_PYR-GCK AAPQNLYLSNEIDEFGRLDSWIAVAVTTDDQWSGLRDALGDPQWATDDEL
MAV_5261|M.avium_104 ASPQGVYRCRGD------DAWVALAALDDTARASLARLLGRAEPGD----
MMAR_1494|M.marinum_M IAPSNIYRSADE-------SWVVIAANQDTVFTRLCQAMGCPELATDDRF
MUL_2446|M.ulcerans_Agy99 IAPSNIYRSADE-------SWVVIAANQDTVFTRLCQAMGCPELATDDRF
MAB_4651c|M.abscessus_ATCC_199 IAPSNIYQSADG-------SWVVIAANQDTVFRRLCEAMGRPELSSDARF
TH_3339|M.thermoresistible__bu IAPSNVYPTSDD-------TWILIAANQDTVFRRLAEAMGRPELAEDERY
Mb3300|M.bovis_AF2122/97 TQPSDAFRTADG--------YIVISAYVPKHWQKLCYLIGRPDLVEDQRF
Rv3272|M.tuberculosis_H37Rv TQPSDAFRTADG--------YIVISAYVPKHWQKLCYLIGRPDLVEDQRF
* :* .:
MSMEG_0168|M.smegmatis_MC2_155 ARPENRLNKLDKMFALIEDWSERLSKWEALEALNALNVPCGPVLGTKELI
Mvan_1979|M.vanbaalenii_PYR-1 ANDDLRWQHGDVLNDIMAQWCADKTKAEVLERLEAAKLPAAPMHSTQEVL
Mflv_2423|M.gilvum_PYR-GCK STFAGRRAHHDLIDRHLAAWCAERTRDEIVEALWTRDVPVAKVLQPHRQT
MAV_5261|M.avium_104 ---TGWDEHADDVDKLISDWAAGRTVADAVDALRAAGVAAAPVTPAAALL
MMAR_1494|M.marinum_M ATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVV
MUL_2446|M.ulcerans_Agy99 ATHRARGRNQDELDKIIGAWAAQRQPDEIIETLSAAGVIAGPINTVAEVV
MAB_4651c|M.abscessus_ATCC_199 ANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVV
TH_3339|M.thermoresistible__bu ATHVARGEHQAELDEIVAEFTRRHTAAEVEALMHKHNVPVGKIYRPKEML
Mb3300|M.bovis_AF2122/97 AEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVV
Rv3272|M.tuberculosis_H37Rv AEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVV
: : : : : :
MSMEG_0168|M.smegmatis_MC2_155 EDETLAELGAVVEVEHP-QRGSFKTVGSPLRLSDSP-VEIVR-SPLLGEH
Mvan_1979|M.vanbaalenii_PYR-1 DDPHVQAMGFLQRVPFPGAPRDVPIIETPFRMSATP-GQIRRRAPLLGEH
Mflv_2423|M.gilvum_PYR-GCK EIPQLAARGFFESVEHPVNP-PTPHSTLPFRSSRGPDRVHTAPAPLLGEH
MAV_5261|M.avium_104 ADPQLHARGFWETVDHPVAG-SFLCTGMPFAFLGKPRRWLRRVPPRYGEH
MMAR_1494|M.marinum_M KDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQH
MUL_2446|M.ulcerans_Agy99 KDRQLRARGMLVEHYDERIGRNVLGPGIVPALSESPGQVRSAGPARPGQH
MAB_4651c|M.abscessus_ATCC_199 QDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQD
TH_3339|M.thermoresistible__bu ADPQFRARESITSVDHPVLG-EIQMQNVFPRLSRTRGSIRWPGPG-LGEH
Mb3300|M.bovis_AF2122/97 DTPLFAESDLTLEVGRGADTITVIRT---PARYASFRAVVTDPPPTAGEH
Rv3272|M.tuberculosis_H37Rv DTPLFAENDLTLEVGRGADTITVIRT---PARYASFRAVVTDPPPTAGEH
. . *:.
MSMEG_0168|M.smegmatis_MC2_155 TDAICAELG-YTPEQLELFRVSGAI-------
Mvan_1979|M.vanbaalenii_PYR-1 TDEILGEIG-YTGDQVARLRDRQVI-------
Mflv_2423|M.gilvum_PYR-GCK NRDILAELG-CSEDEIRQLEEDGVIGTAPAR-
MAV_5261|M.avium_104 TAEVLTELLGHSDADLAELRASGTISDRPAGL
MMAR_1494|M.marinum_M NDDVYIGLLGKSIEELEQLRAEEVL-------
MUL_2446|M.ulcerans_Agy99 NDDVYIGLLGKSIEELEQLRAVEVL-------
MAB_4651c|M.abscessus_ATCC_199 NDDVYVGLLGKSAQDIERLRAEGVL-------
TH_3339|M.thermoresistible__bu TDEVLR-QLGLSDEELQKLHDAGVV-------
Mb3300|M.bovis_AF2122/97 NAVFLARP------------------------
Rv3272|M.tuberculosis_H37Rv NAVFLARP------------------------
. .