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MYGLSDEDLRIRDTASAFAESLMPYEAEAEAAGGKMPKELTEKLQARAIELGLYATNIPKSAGGPGCTAL QQVLVQEQVGRVTNGLAWVMHTPPQWWVDVATDHQLQRWLLPTVRGEKHEAYAITEEFAGSDVSDLAATA RREGDEYVINAVKWHVTSFNLADYVFVQAVLENGDHAGDHVLLVVDLPSPGIEVVRTPQYSHHIADEHPI VAFADVRVPTTHLVGAEGQGMTFTQDWFRFERLMVAARCVGAAQRLLDETTAFAQTRIVDGKPLGNHQLV AGMLADSATELFAARTMLYEVARSIDAGLDRKTLHGQASMAKLYCSEMAGRAADRAVQVFGGRGYMRENV AERMFRELRVERIWEGASEIQRLIVARQLMNRGPQALLGTAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0667 | - | - | 100% (392) | butyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4076 | - | 1e-78 | 41.15% (384) | butyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2205 | - | 3e-51 | 37.03% (397) | putative acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2528c | fadE19 | 1e-40 | 31.15% (382) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4370 | - | 4e-47 | 34.45% (389) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 2e-44 | 35.06% (385) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-33 | 25.78% (384) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2085 | - | 5e-44 | 33.24% (373) | acyl CoA dehydrogenase |
| M. marinum M | MMAR_4034 | fadE | 3e-47 | 36.39% (349) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1571 | - | 1e-49 | 36.17% (376) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3736 | - | 2e-51 | 36.39% (393) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 1e-42 | 34.04% (376) | acyl-CoA dehydrogenase FadE13 |
| M. vanbaalenii PYR-1 | Mvan_1974 | - | 3e-47 | 35.48% (389) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4370|M.gilvum_PYR-GCK -----------MASPPANAAEAGIPSAEVNDEDFQAILAATREFVRTAVV
Mvan_1974|M.vanbaalenii_PYR-1 -----------------------MSTAEVGDEDFRQILAQTRQFVRTAVV
TH_3736|M.thermoresistible__bu MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
MMAR_4034|M.marinum_M --------------------MT---APQVSDEDFAQILAQTRHFVRSVVL
MAV_1571|M.avium_104 --------------------MTSAEVAEVSEQDFGEILAQTRQFVRTAVV
Mb2528c|M.bovis_AF2122/97 ---------------MT--TTTTTISGGILPKEYQDLRDTVADFARTVVA
MLBr_00737|M.leprae_Br4923 ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
Rv0975c|M.tuberculosis_H37Rv -------------------------MNIWTTPERQQLRKTVRAFAEREIL
MUL_4704|M.ulcerans_Agy99 -------------------------MSIWNTPEREELRKSVRSFAEREVL
MAB_2085|M.abscessus_ATCC_1997 -----MTDAGTTTASEDGAARFVVAPEAWTTPERRALSQMARSFVEREIA
MSMEG_0667|M.smegmatis_MC2_155 ----------------------MYGLSDEDLRIRDTASAFAESLMPYEAE
:
Mflv_4370|M.gilvum_PYR-GCK PREQEILSTDQVPDDLREQTKSMGLFGYAIPQEWGGLGLNLAQDVELAME
Mvan_1974|M.vanbaalenii_PYR-1 PREQEILTTDRVPDELREQAKSMGLFGYAIPQEWGGLGLDLTQDVELAME
TH_3736|M.thermoresistible__bu PRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGGLGLDLAQDVELAME
MMAR_4034|M.marinum_M PREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGGLGLNLVQDVELAME
MAV_1571|M.avium_104 PREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGGLGLNLMQDVELAME
Mb2528c|M.bovis_AF2122/97 PVSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEE
MLBr_00737|M.leprae_Br4923 PHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEE
Rv0975c|M.tuberculosis_H37Rv PHVDEWERIGELPRGLHRLAGAAGLLGAGFPEAVGGGGGDGADPVIICEE
MUL_4704|M.ulcerans_Agy99 PHIDEWERTGELPLDLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQ
MAB_2085|M.abscessus_ATCC_1997 PKLAEWEHVGEIPRDLHLNAAEVGLLGIGFPEEVGGSGGNAIDSALVTEA
MSMEG_0667|M.smegmatis_MC2_155 AEAAGGKMPKELTEKLQARAIELGLYATNIPKSAGGPGCTALQQVLVQEQ
. .. *: . .* ** * :
Mflv_4370|M.gilvum_PYR-GCK LGYTSLALRSMFGTNNG-IAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1 LGYTSLALRSMFGTNNG-IAGQVLVGYGTDEQKSTWLERIASGEVVASFA
TH_3736|M.thermoresistible__bu LGYTSLALRSMFGTNNG-IAGQVLVGFGTEEQKARWLEPIASGEVVASFA
MMAR_4034|M.marinum_M LGYTSLAVRSMFGTNNG-IAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MAV_1571|M.avium_104 LGYTSLALRSMFGTNNG-IAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
Mb2528c|M.bovis_AF2122/97 LGKVDQSVAITLEAAVG-LGAMPIYRFGTEEQKQKWLPDLTSGRALAGFG
MLBr_00737|M.leprae_Br4923 VARVDASASL-IPAVNK-LGTMGLILRGSEELKKQVLPSLAAEGAMASYA
Rv0975c|M.tuberculosis_H37Rv MHQAGAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALA
MUL_4704|M.ulcerans_Agy99 MHQSGAPGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALA
MAB_2085|M.abscessus_ATCC_1997 ILAAGGSTGVCAALFTHGIALPHIAANGSDALIERYVRPTLAGKMIGSLG
MSMEG_0667|M.smegmatis_MC2_155 VGRVTN-----GLAWVMHTPPQWWVDVATDHQLQRWLLPTVRGEKHEAYA
: . : : . .
Mflv_4370|M.gilvum_PYR-GCK LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPN--ADLFVT
Mvan_1974|M.vanbaalenii_PYR-1 LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPN--ANLFVT
TH_3736|M.thermoresistible__bu LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPV--ADLFVV
MMAR_4034|M.marinum_M LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPV--ADLFVV
MAV_1571|M.avium_104 LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPV--ANLFVV
Mb2528c|M.bovis_AF2122/97 LTEPGAGSDAGSTRTTARLEGD----EWIINGSKQFITNSGTDITSLVTV
MLBr_00737|M.leprae_Br4923 LSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGK--STWYTV
Rv0975c|M.tuberculosis_H37Rv ITEPGGGSDVGHLRTSAVRDGD----HYVINGAKTYITSGVR--ADYVVT
MUL_4704|M.ulcerans_Agy99 ITEPGGGSDVGHLRTSAVREGD----HFIVNGAKTYITSGVR--ADFVVT
MAB_2085|M.abscessus_ATCC_1997 VTEPGAGSDVANLRTRAVREGD----TYVVNGAKTFITSGVR--ADFVTT
MSMEG_0667|M.smegmatis_MC2_155 ITEEFAGSDVSDLAATARREGD----EYVINAVKWHVTSFNL--ADYVFV
::* .**. . : * :*. :::.. * :*. : .
Mflv_4370|M.gilvum_PYR-GCK FARSRPAD---DKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNF
Mvan_1974|M.vanbaalenii_PYR-1 FARSRPAD---DKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNF
TH_3736|M.thermoresistible__bu FARSRPAD---ERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTF
MMAR_4034|M.marinum_M FARTRPAS---DKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSF
MAV_1571|M.avium_104 FARTRPAD---DQGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSF
Mb2528c|M.bovis_AF2122/97 TAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTF
MLBr_00737|M.leprae_Br4923 MAVTDPD----KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYF
Rv0975c|M.tuberculosis_H37Rv -AVRTGGP----GAAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCY
MUL_4704|M.ulcerans_Agy99 -AVRTGGP----GAGGVSLLVVEKGTPGFVVSRKLDKMGWRSSDTAELSY
MAB_2085|M.abscessus_ATCC_1997 -AVRTGGP----GYGGVSLLVIDKNSPGFEVSRRLDKMGWRCSDTAELSF
MSMEG_0667|M.smegmatis_MC2_155 QAVLENGD----HAGDHVLLVVDLPSPGIEVVRTPQYSHHIADEHPIVAF
* ::: *. : : :
Mflv_4370|M.gilvum_PYR-GCK TDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVA
Mvan_1974|M.vanbaalenii_PYR-1 TDVRVPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVT
TH_3736|M.thermoresistible__bu TDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
MMAR_4034|M.marinum_M TDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVA
MAV_1571|M.avium_104 DDVRVGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVS
Mb2528c|M.bovis_AF2122/97 ADARVPRENLLG-ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVK
MLBr_00737|M.leprae_Br4923 DKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
Rv0975c|M.tuberculosis_H37Rv TDVAVPATNLVG-AENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQ
MUL_4704|M.ulcerans_Agy99 TDARIPAANLVG-AENSGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQ
MAB_2085|M.abscessus_ATCC_1997 VDVRVPADNLVG-AENSGFLQIMQQFQAERLGIAVQAYATAGRALDLAKS
MSMEG_0667|M.smegmatis_MC2_155 ADVRVPTTHLVG-AEGQGMTFTQDWFRFERLMVAARCVGAAQRLLDETTA
. : ::* . * : * :.. . . * :* :
Mflv_4370|M.gilvum_PYR-GCK YAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQD--
Mvan_1974|M.vanbaalenii_PYR-1 YAATATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGED--
TH_3736|M.thermoresistible__bu YAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGED--
MMAR_4034|M.marinum_M YASTATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGAD--
MAV_1571|M.avium_104 YASTATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGED--
Mb2528c|M.bovis_AF2122/97 YANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP--
MLBr_00737|M.leprae_Br4923 YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPD-
Rv0975c|M.tuberculosis_H37Rv WCRDRETFGRPLISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGET--
MUL_4704|M.ulcerans_Agy99 WCRDRETFGRPLISRQSVQNTLAEMARRIDVARVYSRSVVERQLAGEH--
MAB_2085|M.abscessus_ATCC_1997 WARERETFGRPLTGRQIIRHKLAEMARQVDVACTYTRAVMQRWLAGE---
MSMEG_0667|M.smegmatis_MC2_155 FAQTRIVDGKPLGNHQLVAGMLADSATELFAARTMLYEVARSIDAGLDRK
: * .: * : :* .. . *
Mflv_4370|M.gilvum_PYR-GCK -RRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLR
Mvan_1974|M.vanbaalenii_PYR-1 -RRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLR
TH_3736|M.thermoresistible__bu -RRVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLR
MMAR_4034|M.marinum_M -RRIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLR
MAV_1571|M.avium_104 -RRVAPSAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLR
Mb2528c|M.bovis_AF2122/97 -FKKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLE
MLBr_00737|M.leprae_Br4923 -LGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQ
Rv0975c|M.tuberculosis_H37Rv DLIAQVCFAKNTAVQAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILG
MUL_4704|M.ulcerans_Agy99 DLIPQVCFAKNTAVEAGEWVANQAVQLFGGMGYMAESEIERQYRDMRILG
MAB_2085|M.abscessus_ATCC_1997 DVVAEVSMAKNTAVYACDYVVNEAVQIFGGMGYMRESEIERHYRDCRILG
MSMEG_0667|M.smegmatis_MC2_155 TLHGQASMAKLYCSEMAGRAADRAVQVFGGRGYMRENVAERMFRELRVER
. :* . *.*:.** *: * *: ::
Mflv_4370|M.gilvum_PYR-GCK LYEGTSEIQKLIIGGGLVKGAKGK------
Mvan_1974|M.vanbaalenii_PYR-1 LYEGTSEIQRLIIGGGLVKGAKAR------
TH_3736|M.thermoresistible__bu LYEGTSEIQRLIIGGGLVKAAQRQTN----
MMAR_4034|M.marinum_M LYEGTSEIQQLIIGSNLIKAANR-------
MAV_1571|M.avium_104 LYEGTSEIQRLIIGSNLVKAAQRATTTKER
Mb2528c|M.bovis_AF2122/97 IGEGTTEVQLMLIARSLGLQ----------
MLBr_00737|M.leprae_Br4923 IYEGTNQIQRVVMSRAL-LR----------
Rv0975c|M.tuberculosis_H37Rv IGGGTTEILTALAAKTLGYQS---------
MUL_4704|M.ulcerans_Agy99 IGGGTTEILTALAAKLLGYQS---------
MAB_2085|M.abscessus_ATCC_1997 IGGGTNEIMNEVIAKRIGL-----------
MSMEG_0667|M.smegmatis_MC2_155 IWEGASEIQRLIVARQLMNRGPQALLGTAG
: *:.:: : . :