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MTDAGTTTASEDGAARFVVAPEAWTTPERRALSQMARSFVEREIAPKLAEWEHVGEIPRDLHLNAAEVGL LGIGFPEEVGGSGGNAIDSALVTEAILAAGGSTGVCAALFTHGIALPHIAANGSDALIERYVRPTLAGKM IGSLGVTEPGAGSDVANLRTRAVREGDTYVVNGAKTFITSGVRADFVTTAVRTGGPGYGGVSLLVIDKNS PGFEVSRRLDKMGWRCSDTAELSFVDVRVPADNLVGAENSGFLQIMQQFQAERLGIAVQAYATAGRALDL AKSWARERETFGRPLTGRQIIRHKLAEMARQVDVACTYTRAVMQRWLAGEDVVAEVSMAKNTAVYACDYV VNEAVQIFGGMGYMRESEIERHYRDCRILGIGGGTNEIMNEVIAKRIGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2085 | - | - | 100% (399) | acyl CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1073c | - | e-136 | 62.57% (382) | acyl-CoA dehydrogenase FadE |
| M. abscessus ATCC 19977 | MAB_1851 | - | 3e-66 | 37.40% (361) | acyl-CoA dehydrogenase FadE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1000c | fadE13 | 1e-125 | 61.58% (354) | acyl-CoA dehydrogenase FADE13 |
| M. gilvum PYR-GCK | Mflv_4612 | - | 1e-140 | 64.74% (380) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 1e-136 | 62.77% (376) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-46 | 32.28% (378) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4532 | fadE13 | 1e-136 | 62.77% (376) | acyl-CoA dehydrogenase FadE13 |
| M. avium 104 | MAV_1091 | - | 1e-138 | 63.30% (376) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5491 | - | 1e-136 | 63.03% (376) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_2583 | - | 4e-68 | 40.75% (373) | PUTATIVE peptidase S1 and S6, chymotrypsin/Hap |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 1e-136 | 62.50% (376) | acyl-CoA dehydrogenase FadE13 |
| M. vanbaalenii PYR-1 | Mvan_4847 | - | 1e-136 | 62.11% (380) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2085|M.abscessus_ATCC_1997 MTDAGTTTASEDGAARFVVAPEAWTTPERRALSQMARSFVEREIAPKLAE
Mflv_4612|M.gilvum_PYR-GCK MKQP-------DQREAEAAAADPWMTPERISLRNLAMSFTQKEIVPHLQD
MMAR_4532|M.marinum_M --------------------MSIWNTPEREELRKTVRSFAEREVLPHIDE
MUL_4704|M.ulcerans_Agy99 --------------------MSIWNTPEREELRKSVRSFAEREVLPHIDE
MAV_1091|M.avium_104 --------------------MNLWTTPEREQLRKTVRSFAEREILPHVDE
Mb1000c|M.bovis_AF2122/97 --------------------MNIWTTPERQQLRKTVRAFAEREILPHVDE
Rv0975c|M.tuberculosis_H37Rv --------------------MNIWTTPERQQLRKTVRAFAEREILPHVDE
MSMEG_5491|M.smegmatis_MC2_155 --------------------MSIWTTAEREALRKTVRAFAEREVLPHAHE
Mvan_4847|M.vanbaalenii_PYR-1 --------------------MSIWTTPERDDLRKTVRAFVEREVLPHAGE
TH_2583|M.thermoresistible__bu --------MSGIDTGRAVFYDRTLFEPEHEMFRDSYRTFLKRSVAPYHQQ
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAAD
*: : :: ::.: * :
MAB_2085|M.abscessus_ATCC_1997 WEHVGEIPRDLHLNAAEVGLLGIGFPEEVGGSG-GNAIDSALVTEAILAA
Mflv_4612|M.gilvum_PYR-GCK WEDAGELPRELHRRAAAAGLLGIGFAEEIGGSG-GDLRDLVLLTEAVMEA
MMAR_4532|M.marinum_M WERTGELPRDLHRRAGAAGLLGAGLPESAGGGG-GDGADSVIICEQMHQS
MUL_4704|M.ulcerans_Agy99 WERTGELPLDLHRRAGAAGLLGAGLPESAGGGG-GDGADSVIICEQMHQS
MAV_1091|M.avium_104 WERSGELPRELHRSAGAAGLLGAGFPESVGGGG-GDGADAVIICEEMHQA
Mb1000c|M.bovis_AF2122/97 WERIGELPRGLHRLAGAAGLLGAGFPEAVGGGG-GDGADPVIICEEMHQA
Rv0975c|M.tuberculosis_H37Rv WERIGELPRGLHRLAGAAGLLGAGFPEAVGGGG-GDGADPVIICEEMHQA
MSMEG_5491|M.smegmatis_MC2_155 WERAGEIPRELHRKAAELGLLGAGFPEDAGGSG-GDGADPVVICEEMHYA
Mvan_4847|M.vanbaalenii_PYR-1 WERIGELPRELHRKAAEVGLLGAGFPESVGGGG-GDGADAVVICEEMHRA
TH_2583|M.thermoresistible__bu WEIDGIVDRGVWLEAGKQGFLGMGVPEEHGGGGVADFRYNAIVTEETTAA
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARV
: . . *: . ..* ** * .: :: *
MAB_2085|M.abscessus_ATCC_1997 GGSTGVCAALFTHGIALPHIAANGSDALIERYVRPTLAGKMIGSLGVTEP
Mflv_4612|M.gilvum_PYR-GCK GGSSGLLASLLTHHIAVPHMAAQGDPEQIRSFVAPTLAGEKIGSLGITEP
MMAR_4532|M.marinum_M GAPGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGDKIGALAITEP
MUL_4704|M.ulcerans_Agy99 GAPGGVFASLFTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALAITEP
MAV_1091|M.avium_104 GAPGGVFASLFTCGIAVPHMIASGDQRLIEEFVRPTLAGEKIGSLAITEP
Mb1000c|M.bovis_AF2122/97 GAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEP
Rv0975c|M.tuberculosis_H37Rv GAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEP
MSMEG_5491|M.smegmatis_MC2_155 GSPGGVYASLFTCGIAVPHMIASGDQRLIDTYVRPTLRGEKIGALAITEP
Mvan_4847|M.vanbaalenii_PYR-1 GAPGGVFASLFTSGIAVPHMIASGDEHLIDTYVRPTLRGEKIGALAITEP
TH_2583|M.thermoresistible__bu GFSG--LGFALHNDMVAPYLLRLATAEQKQRWLPRFCSGECITALAMTEP
MLBr_00737|M.leprae_Br4923 DASASLIPAVNKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSER
. . : . : : : .::*
MAB_2085|M.abscessus_ATCC_1997 GAGSDVANLRTRAVREGDTYVVNGAKTFITSGVRADFVTTAVRTG-GPGY
Mflv_4612|M.gilvum_PYR-GCK DTGSDVAGIRTTARRDGDHYVVNGAKLFITSGVRADFVTTAVRTG-GPGP
MMAR_4532|M.marinum_M GGGSDVGHLRTSAVRDGDHFIVNGAKTYITSGVRADFVVTAVRTG-GPGA
MUL_4704|M.ulcerans_Agy99 GGGSDVGHLRTSAVREGDHFIVNGAKTYITSGVRADFVVTAVRTG-GPGA
MAV_1091|M.avium_104 GGGSDVGHLRTSAVRDGDHYIVNGAKTYITSGVRADYVVTAVRTG-GPGA
Mb1000c|M.bovis_AF2122/97 GGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTG-GPGA
Rv0975c|M.tuberculosis_H37Rv GGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTG-GPGA
MSMEG_5491|M.smegmatis_MC2_155 GGGSDVGHLRTRADLDGDHYVINGAKTYITSGVRADYVVTAARTG-GPGA
Mvan_4847|M.vanbaalenii_PYR-1 GGGSDVGHLTTRAVKDGDCYILNGAKTFITSGVRADYVVTAVRTG-GPGA
TH_2583|M.thermoresistible__bu GAGSDLQGIRTRAVRDGDGWVLNGSKTFITNGINADLVIVFAQTDPDKGS
MLBr_00737|M.leprae_Br4923 EAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGA
*** : * * :** :::** * :**.* .: . . *. . *
MAB_2085|M.abscessus_ATCC_1997 GGVSLLVIDKN----SPGFEVSRRLDKMGWRCSDTAELSFVDVRVPADNL
Mflv_4612|M.gilvum_PYR-GCK SGISLLVVERG----ATGFLVSRALKKMGWLCSDTAELGFTDVRVPVVNL
MMAR_4532|M.marinum_M GGVSLLVVEKG----TPGFVVSRKLDKMGWRSSDTAELSYTDARVPAANL
MUL_4704|M.ulcerans_Agy99 GGVSLLVVEKG----TPGFVVSRKLDKMGWRSSDTAELSYTDARIPAANL
MAV_1091|M.avium_104 AGVSLLVVEKG----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVSNL
Mb1000c|M.bovis_AF2122/97 AGVSLLVVEKD----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNL
Rv0975c|M.tuberculosis_H37Rv AGVSLLVVEKD----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNL
MSMEG_5491|M.smegmatis_MC2_155 GGVSLIVVDKG----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVANL
Mvan_4847|M.vanbaalenii_PYR-1 GGISLIVVDKDGPGCSPGLQVTRKLDKMGWRSSDTAELSYTDARVPAGNL
TH_2583|M.thermoresistible__bu MGYSLLVVERG----MAGFERGRRLDKIGMTGQDTAELSFTDVRVPAENL
MLBr_00737|M.leprae_Br4923 NGISAFIVHKD----DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRI
* * :::.:. *: .*:* . *:** : . :* .:
MAB_2085|M.abscessus_ATCC_1997 VGAENSGFLQIMQQFQAERLGIAVQAYATAGRALDLAKSWARERETFGRP
Mflv_4612|M.gilvum_PYR-GCK VGPEGSGFLQIMQQFQVERAFIAVQCYATAQRCLDLTLDWVKKRETFGRP
MMAR_4532|M.marinum_M VGAENSGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRP
MUL_4704|M.ulcerans_Agy99 VGAENSGFAQIAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRP
MAV_1091|M.avium_104 VGAENTGFAQIAQAFVSERIGLAAQAYSSAQRCLDLTVQWCRDRETFGRP
Mb1000c|M.bovis_AF2122/97 VGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRP
Rv0975c|M.tuberculosis_H37Rv VGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRP
MSMEG_5491|M.smegmatis_MC2_155 VGSENTGFAQIAAAFVAERVGLATQAYAGAQRCLDLTVEWCRNRDTFGRP
Mvan_4847|M.vanbaalenii_PYR-1 VGAENTGFLQIAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRSRETFGKP
TH_2583|M.thermoresistible__bu LGKVGKGLLYLMQNLPQERLSIAVMSAAAMAATLESTLEYVQQRKAFGRP
MLBr_00737|M.leprae_Br4923 IGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGES
:* ..*: : * :.. . . *: : : :.*. **..
MAB_2085|M.abscessus_ATCC_1997 LTGRQIIRHKLAEMARQVDVACTYTRAVMQRWLAGED-VVAEVSMAKNTA
Mflv_4612|M.gilvum_PYR-GCK LSTRQVVRHKIVDIATAVDVARTYTRAAVDRIVAGDT-DVRMVSMAKNQA
MMAR_4532|M.marinum_M LISRQSVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTA
MUL_4704|M.ulcerans_Agy99 LISRQSVQNTLAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTA
MAV_1091|M.avium_104 LISRQSVQNTLAEMARRIDVARVYSRNVVERQLAGETNLIPQVCFAKNTA
Mb1000c|M.bovis_AF2122/97 LISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTA
Rv0975c|M.tuberculosis_H37Rv LISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTA
MSMEG_5491|M.smegmatis_MC2_155 LISRQAVQNTLAGMARRIDVARVYTRHVVERQLAGETNLIAEVCFAKNTA
Mvan_4847|M.vanbaalenii_PYR-1 LITRQSVQNTLAEMARRIDVARVYTHHVVERELAGETNLIAEVCFAKNTA
TH_2583|M.thermoresistible__bu IGSFQNSRFVLAELATEATAIRIMVDEFVRLHDAGKL-TAEQAAMAKWFA
MLBr_00737|M.leprae_Br4923 ISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFA
: * : :. :* . *. . :* *
MAB_2085|M.abscessus_ATCC_1997 VYACDYVVNEAVQIFGGMGYMRESEIERHYRDCRILGIGGGTNEIMNEVI
Mflv_4612|M.gilvum_PYR-GCK VEACALAVDTAVQLYGGMGYLRETEVERHYRDSRILGIGGGTTEIMKEII
MMAR_4532|M.marinum_M VEAGEWVANQAVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALA
MUL_4704|M.ulcerans_Agy99 VEAGEWVANQAVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALA
MAV_1091|M.avium_104 VEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALS
Mb1000c|M.bovis_AF2122/97 VQAGEWVANQAVQLFGGMGYMAESEAN----------ANTGTCESSVSEA
Rv0975c|M.tuberculosis_H37Rv VQAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALA
MSMEG_5491|M.smegmatis_MC2_155 VEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTSLA
Mvan_4847|M.vanbaalenii_PYR-1 VDAGEWVAHQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTSEILTALA
TH_2583|M.thermoresistible__bu TEAFVRLADRCLQLHGGYGYMREYPIAKSYLDARVQTIYGGTTEIMKEII
MLBr_00737|M.leprae_Br4923 SDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVM
. .:*:.** ** : ** :
MAB_2085|M.abscessus_ATCC_1997 AKRIGL--
Mflv_4612|M.gilvum_PYR-GCK AKQIGL--
MMAR_4532|M.marinum_M AKLLGYQS
MUL_4704|M.ulcerans_Agy99 AKLLGYQS
MAV_1091|M.avium_104 AKLLGFQS
Mb1000c|M.bovis_AF2122/97 APPK-Y--
Rv0975c|M.tuberculosis_H37Rv AKTLGYQS
MSMEG_5491|M.smegmatis_MC2_155 AKTLGFQS
Mvan_4847|M.vanbaalenii_PYR-1 AKTLGYQS
TH_2583|M.thermoresistible__bu GRRLCT--
MLBr_00737|M.leprae_Br4923 SRALLR--
.