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M. smegmatis MC2 155 MSMEG_2205 (-)

annotation: putative acyl-CoA dehydrogenase
coordinates: 2285144 - 2286337
length: 397

TGTVTDGQSAAEVGDEDFEEILAQARSFIRNAVVPRENEILATDKVPDDIREQAKNMGLFGYAIPQQWGG
LGLNLAQDVELAMEFGYTSLALRSMFGTNNGIAGQVLVGFGTDEQKQQWLEGIASGEVVASFALTEPGAG
SNPAGLRTKAVRDGSDWVINGQKRFITNAPTAGLFVVFARTRPADADGAGIAVFLVPADTPGVEVGPKDA
KMGQEGAWTADVNFTDVRVPAAALVGGSEDVGYRAAMTSLARGRVHIAALAVGTAQRALDESVAYAATAT
QGGQPIGNFQLVQAMIADQQTGVMAGRALVRDAAQKWVTGEDRRIAPSAAKLYCTEMAGTVADLAVQIHG
GTGYMREVPVERIYREVRLLRLYEGTSEIQRLIIGGGLVKAAQRQL*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_2205 - - 100% (397) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_1991 - 2e-62 37.27% (373) isovaleryl-CoA dehydrogenase
M. smegmatis MC2 155 MSMEG_1497 - 1e-61 36.91% (382) acyl-CoA dehydrogenase family protein member 8

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0221c fadE3 6e-62 37.11% (380) acyl-CoA dehydrogenase FADE3
M. gilvum PYR-GCK Mflv_4370 - 0.0 84.65% (391) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37Rv Rv2500c fadE19 1e-58 35.71% (392) acyl-CoA dehydrogenase
M. leprae Br4923 MLBr_00737 fadE25 2e-54 32.71% (376) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977 MAB_0065c - 7e-59 36.36% (374) acyl-CoA dehydrogenase FadE
M. marinum M MMAR_4034 fadE 0.0 81.87% (386) acyl-CoA dehydrogenase FadE
M. avium 104 MAV_1571 - 0.0 83.33% (384) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8) TH_3736 - 0.0 87.47% (391) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99 MUL_4024 fadE3 1e-59 36.34% (377) acyl-CoA dehydrogenase FadE3
M. vanbaalenii PYR-1 Mvan_1974 - 0.0 86.12% (389) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb0221c|M.bovis_AF2122/97           --------------------MRN-----ELNDDEAMLVATVRAFIDRDVK
MUL_4024|M.ulcerans_Agy99           -------------------MMNNDSPDSQLDEDEAMLVATVRAFIDRDVR
MSMEG_2205|M.smegmatis_MC2_155      MTGTVTDG---------------QSAAEVGDEDFEEILAQARSFIRNAVV
TH_3736|M.thermoresistible__bu      MYDIRRPGGVAIAPPGRTHKEKPMSTAEVSDEDFRQILRQTREFVRTAVV
Mflv_4370|M.gilvum_PYR-GCK          MASPPANAAEAG-----------IPSAEVNDEDFQAILAATREFVRTAVV
Mvan_1974|M.vanbaalenii_PYR-1       -----------------------MSTAEVGDEDFRQILAQTRQFVRTAVV
MMAR_4034|M.marinum_M               MT-----------------------APQVSDEDFAQILAQTRHFVRSVVL
MAV_1571|M.avium_104                MTSA--------------------EVAEVSEQDFGEILAQTRQFVRTAVV
MAB_0065c|M.abscessus_ATCC_199      ------------------------MQRTIYTEDHEAFRESVKAFVQRHVD
Rv2500c|M.tuberculosis_H37Rv        ---------------MT--TTTTTISGGILPKEYQDLRDTVADFARTVVA
MLBr_00737|M.leprae_Br4923          ---------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIA
                                                                   .:   :      :    : 

Mb0221c|M.bovis_AF2122/97           PTVREVEHANSYPEAWIEQMKHIGIYGLAIDEQYGG-SPVSMPCYVQVTQ
MUL_4024|M.ulcerans_Agy99           PSVREVEHANTYPQAWIEQMKRIGIYGLAIGEAYGG-SPVSMPCYVQVTQ
MSMEG_2205|M.smegmatis_MC2_155      PRENEILATDKVPDDIREQAKNMGLFGYAIPQQWGG-LGLNLAQDVELAM
TH_3736|M.thermoresistible__bu      PRELEILNEDRVPDDLREQAKQMGLFGYAIPQQWGG-LGLDLAQDVELAM
Mflv_4370|M.gilvum_PYR-GCK          PREQEILSTDQVPDDLREQTKSMGLFGYAIPQEWGG-LGLNLAQDVELAM
Mvan_1974|M.vanbaalenii_PYR-1       PREQEILTTDRVPDELREQAKSMGLFGYAIPQEWGG-LGLDLTQDVELAM
MMAR_4034|M.marinum_M               PREQQILDEDRVPEDLRDQAKQMGLFGYAIPPQWGG-LGLNLVQDVELAM
MAV_1571|M.avium_104                PREQEILDGDRVPDDLRDQAKKMGLFGYAIPQQWGG-LGLNLMQDVELAM
MAB_0065c|M.abscessus_ATCC_199      PRAETFIEQRYIDRELWEEAGKQGYLGLDVPEEFGGSSAGDYRYNAVLQE
Rv2500c|M.tuberculosis_H37Rv        PVSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGG-MGGDYFALSLVLE
MLBr_00737|M.leprae_Br4923          PHAADVDQRARFPEEALAALNASGFNAIHVPEEYGG-QGADSVAACIVIE
                                    *                      *  .  .   :**    .      :  

Mb0221c|M.bovis_AF2122/97           ELARGWMSLAGAMGG-HTVVAKLLTLFGTEEQRRTYLPPMASGELRATMA
MUL_4024|M.ulcerans_Agy99           ELARGWMSLAGAMGG-HTVVAKLLMLFGTDEQKSTYLPAMATGELRATMA
MSMEG_2205|M.smegmatis_MC2_155      EFGYTSLALRSMFGTNNGIAGQVLVGFGTDEQKQQWLEGIASGEVVASFA
TH_3736|M.thermoresistible__bu      ELGYTSLALRSMFGTNNGIAGQVLVGFGTEEQKARWLEPIASGEVVASFA
Mflv_4370|M.gilvum_PYR-GCK          ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKKTWLERIASGEIVASFA
Mvan_1974|M.vanbaalenii_PYR-1       ELGYTSLALRSMFGTNNGIAGQVLVGYGTDEQKSTWLERIASGEVVASFA
MMAR_4034|M.marinum_M               ELGYTSLAVRSMFGTNNGIAGQVLVGFGTDEQKARWLEPIASGDVVASFA
MAV_1571|M.avium_104                ELGYTSLALRSMFGTNNGIAGQVLVGFGTEAQKARWLEPMAAGDVVASFA
MAB_0065c|M.abscessus_ATCC_199      ELARSSAALASSMSIHFDIVAPYLVELTTDEQKQRWLPKFCSGEMITAIG
Rv2500c|M.tuberculosis_H37Rv        ELGKVDQSVAITLEAAVGLGAMPIYRFGTEEQKQKWLPDLTSGRALAGFG
MLBr_00737|M.leprae_Br4923          EVARVDASASL-IPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYA
                                    *..    :    :     :    :    ::  :   *  : :    :  .

Mb0221c|M.bovis_AF2122/97           LTEPGGGSDLQNMSTTALADGPEGSAGLLINGCKTWISNARR--SGLFAV
MUL_4024|M.ulcerans_Agy99           LTEPGGGSDLQNMSTTAMADGPDQ---LLITGAKTWISNARR--SGLIAL
MSMEG_2205|M.smegmatis_MC2_155      LTEPGAGSNPAGLRTKAVRDGS----DWVINGQKRFITNAPT--AGLFVV
TH_3736|M.thermoresistible__bu      LTEPGAGSNPAGLRSRAVRDGSGADADWIINGQKRFITNAPV--ADLFVV
Mflv_4370|M.gilvum_PYR-GCK          LTEPGAGSNPSGLRTKAVRDGDGPHSGWILNGQKRFITNAPN--ADLFVT
Mvan_1974|M.vanbaalenii_PYR-1       LTEPGAGSNPSGLRTKAVRDGDGSCSGWIINGQKRFITNAPN--ANLFVT
MMAR_4034|M.marinum_M               LTEPGAGSSPAGLRTKAVRDGD----DWLITGQKRFITNAPV--ADLFVV
MAV_1571|M.avium_104                LTEPGAGSNPAGLRTKAVADGD----NWVISGQKRFITNAPV--ANLFVV
MAB_0065c|M.abscessus_ATCC_199      MTEPSGGSDLAALKTTAVKDGD----DWVINGSKTFITNGAR--ADLVVV
Rv2500c|M.tuberculosis_H37Rv        LTEPGAGSDAGSTRTTARLEGD----EWIINGSKQFITNSGTDITSLVTV
MLBr_00737|M.leprae_Br4923          LSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGK--STWYTV
                                    ::*  .**.     : *  :*       ::.* * :*:*.    :   . 

Mb0221c|M.bovis_AF2122/97           LCKTDPN---ATPRHQGMSIVLVEPGPGLTVSRDLPKLGYKGVESCELSF
MUL_4024|M.ulcerans_Agy99           LCKTDPH---ATPRHHGISIVLVEPGPGLNISADLPKLGYKGVEACELSF
MSMEG_2205|M.smegmatis_MC2_155      FARTRPA---DADGAGIAVFLVPADTPGVEVGPKDAKMGQEGAWTADVNF
TH_3736|M.thermoresistible__bu      FARSRPA---DERGAGIAVFLVPADAPGVEVGAKDAKMGQEGAWTADVTF
Mflv_4370|M.gilvum_PYR-GCK          FARSRPA---DDKGAGIAVFLVPADTPGVDIGAKDKKMGQEGAWTADVNF
Mvan_1974|M.vanbaalenii_PYR-1       FARSRPA---DDKGAGIAVFLVPADTPGVEVGAKDKKMGQEGAWTADVNF
MMAR_4034|M.marinum_M               FARTRPA---SDKSPGIAVFLVPAQSAGVEVGAKDAKMGQEGAWTADVSF
MAV_1571|M.avium_104                FARTRPA---DDQGPGIAVFLVPADAAGVQIGAKDAKMGQEGAWTADVSF
MAB_0065c|M.abscessus_ATCC_199      AARTAP----ELKAKGITLFAVEEGMPGFERGRKLDKVGQPEADTAELFF
Rv2500c|M.tuberculosis_H37Rv        TAVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTF
MLBr_00737|M.leprae_Br4923          MAVTDPD----KGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYF
                                     . : .             : :     *.       *:*     :  : *

Mb0221c|M.bovis_AF2122/97           DNLRVPVSAILGGAMGQGFSQMMKGLETGRIQVAARALGVATAALEDSLA
MUL_4024|M.ulcerans_Agy99           DNYRAPTSAILGGQPGQGFSQMMKGLETGRIQVAARALGVASAALDDALA
MSMEG_2205|M.smegmatis_MC2_155      TDVRVPAAALVGGSEDVGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
TH_3736|M.thermoresistible__bu      TDVRVPASALVGGEEDIGYRAAMTSLARGRVHIAALAVGTAQRALDESVA
Mflv_4370|M.gilvum_PYR-GCK          TDVEVPDTALVGGSEDLGYRAAMTSLARGRVHIAALAVGAAQRALDESVA
Mvan_1974|M.vanbaalenii_PYR-1       TDVRVPDAALVGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVT
MMAR_4034|M.marinum_M               TDVRVDDAALVGGSEDIGYRAAMTSLARGRVHIAAIAVGAAQRALDESVA
MAV_1571|M.avium_104                DDVRVGGDALIGGSEDIGYRAAMTSLARGRVHIAALAVGAAQRALDESVS
MAB_0065c|M.abscessus_ATCC_199      TDVRVPAENVIG-EVNQGFISMMQRLPQERMGCAVANIAHAVAVLEETVE
Rv2500c|M.tuberculosis_H37Rv        ADARVPRENLLG-ARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVK
MLBr_00737|M.leprae_Br4923          DKCRIPGDRIIG-EPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIV
                                     . .     ::*   . *:   :  *   *   ..   . *   :: :: 

Mb0221c|M.bovis_AF2122/97           YAQQRESFGRPIWQHQAVGNYLADMATKLTAARQLTRYAAERYDSGQR-C
MUL_4024|M.ulcerans_Agy99           YAQQRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYDSGQR-C
MSMEG_2205|M.smegmatis_MC2_155      YAATATQGGQPIGNFQLVQAMIADQQTGVMAGRALVRDAAQKWVTGED-R
TH_3736|M.thermoresistible__bu      YAASATQGGTPIGQFQLVQAMLADQQTGVMAGRALVRDAARKWVSGED-R
Mflv_4370|M.gilvum_PYR-GCK          YAATATQGGTPIGDFQLVQAMLADQQTGVMAGRALVRDAARLWVTGQD-R
Mvan_1974|M.vanbaalenii_PYR-1       YAATATQGGTAIGDFQLVQAMLADQQTGVMAGRALVRETARQWVTGED-R
MMAR_4034|M.marinum_M               YASTATQGGVTIGSFQLVQAMLADQQTGVLAGRALVRDAARMWVSGAD-R
MAV_1571|M.avium_104                YASTATQGGTPIGNFQLVQAMLADQQTEVLAGRALVREAARLWVTGED-R
MAB_0065c|M.abscessus_ATCC_199      YAKERKAFGQQIGSLQYNKFLIAELVTKLEAAQVYVDQAVLAHSKGEL-T
Rv2500c|M.tuberculosis_H37Rv        YANQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-F
MLBr_00737|M.leprae_Br4923          YTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDL
                                    *:      *  *   *     :*       ..:     :.     *    

Mb0221c|M.bovis_AF2122/97           DMEAGMAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMILG
MUL_4024|M.ulcerans_Agy99           DMEAGMAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRDAPLMIVG
MSMEG_2205|M.smegmatis_MC2_155      RIAPSAAKLYCTEMAGTVADLAVQIHGGTGYMREVPVERIYREVRLLRLY
TH_3736|M.thermoresistible__bu      RVAPSAAKLFCTEMAGQVADLAVQIHGGTGYMREVPVERIYRDVRLLRLY
Mflv_4370|M.gilvum_PYR-GCK          RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
Mvan_1974|M.vanbaalenii_PYR-1       RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMREVPVERIYRDVRLLRLY
MMAR_4034|M.marinum_M               RIAPSAAKLFCTEMAGKVADLAVQIHGGSGYMRGVPVERIYRDVRLLRLY
MAV_1571|M.avium_104                RVAPSAAKLYCTEMAGRVADLAVQVHGGSGYMRGVPVERIYRDVRLLRLY
MAB_0065c|M.abscessus_ATCC_199      AIDAAKAKWWSSQVQNEVIDACVQLHGGYGYMKEYRVARAWMDARVTKIW
Rv2500c|M.tuberculosis_H37Rv        KKEAAIAKMISSEAAMDNSRDATQIHGGYGFMNEYPVARHYRDSKVLEIG
MLBr_00737|M.leprae_Br4923          GFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIY
                                       .. :*  .::        ..::.** *:     * *   :  :  : 

Mb0221c|M.bovis_AF2122/97           EGTNEIQRNVIAGQLVARGGI-------
MUL_4024|M.ulcerans_Agy99           EGTNEIQRNVIARQLIARGGI-------
MSMEG_2205|M.smegmatis_MC2_155      EGTSEIQRLIIGGGLVKAAQRQL-----
TH_3736|M.thermoresistible__bu      EGTSEIQRLIIGGGLVKAAQRQTN----
Mflv_4370|M.gilvum_PYR-GCK          EGTSEIQKLIIGGGLVKGAKGK------
Mvan_1974|M.vanbaalenii_PYR-1       EGTSEIQRLIIGGGLVKGAKAR------
MMAR_4034|M.marinum_M               EGTSEIQQLIIGSNLIKAANR-------
MAV_1571|M.avium_104                EGTSEIQRLIIGSNLVKAAQRATTTKER
MAB_0065c|M.abscessus_ATCC_199      AGSNEIMKELIGRDLGF-----------
Rv2500c|M.tuberculosis_H37Rv        EGTTEVQLMLIARSLGLQ----------
MLBr_00737|M.leprae_Br4923          EGTNQIQRVVMSRAL-LR----------
                                     *:.::   ::.  *

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_2205	-	-	100% (397)	putative acyl-CoA dehydrogenase
M. smegmatis MC2 155	MSMEG_1991	-	2e-62	37.27% (373)	isovaleryl-CoA dehydrogenase
M. smegmatis MC2 155	MSMEG_1497	-	1e-61	36.91% (382)	acyl-CoA dehydrogenase family protein member 8